evaluating response to therapy for lung cancer patients

... therapeutic protocol for BM patients The inclusion criteria for this retrospective analysis were: 1) patients with - brain metastasis; 2) KPS ≥ 50; 3) age ≤ 80 years; 4) No previous radiotherapy to the ... radiosurgery for patients with nonsmall cell lung carcinoma metastatic to the brain Cancer 1997, 80:2075-2083 24 Ma S, Xu Y, Deng Q, Yu X: Treatment of brain metastasis from non-small cell lung cancer ... influence of total dose on duration of survival in this cohort of patients with metastatic lung cancer was the main finding of this analysis (Fig 3) The addition of a RTB to WBRT appeared to substantially...

Ngày tải lên: 09/08/2014, 08:22

... tinely for lung cancer patients in all stages During the past years, this technique has continuously been evolved with regard to optimizing the procedures for quality assurance and raising conformity ... and left lung and V25 both lungs is 37%, 19% and 25%, respectively D(max) for the heart is Gy The mean dose to the primary tumor of these six patients amounts to 81,9 Gy (79,2 – 90,0 Gy), to macroscopically ... former "taboos" in radiotherapy of lung cancer: Minimizing the dose to the ipsilateral (i.e tumor bearing) lung In many cases the ipsilateral lung will be the first organ to reach the dose constraint...

Ngày tải lên: 09/08/2014, 10:20

... chemotherapy were found to improve the local control for lung cancer and thus improve the overall survival of lung cancer patients [1-4] However, the tolerance of the surrounding normal tissues to ... ECOG performance status was or for 29 patients (75%) Twenty-six patients (78%) had a smoking history Chemotherapy was done before radiation in 21 patients (62%), and concurrent chemoradiotherapy ... in lung cancer patients Radiother Oncol 2004, 71:183-189 Kong FM, Washington MK, Jirtle RL, Anscher MS: Plasma transforming growth factor-β1 reflects disease status in patients with lung cancer...

Ngày tải lên: 09/08/2014, 10:20

... cells are formed and how they work What Lung Cancer Can Do to Bone Radiation, chemotherapy, and steroids are treatments for lung cancer that can weaken bone To determine whether the skeleton is ... of cancer cells leads to the destruction of additional bone Lung cancer that has spread to bone can cause: • Bone pain Since pain is often the first sign that lung cancer has spread to bone, patients ... Hypercalcemia – What Patients Need to Know on page 5.) Treating Bone Affected by Lung Cancer The following therapies are used to treat bones affected by lung cancer: • Lung cancer treatment The...

Ngày tải lên: 15/02/2014, 05:20

... way to estimate adherence among individual patients As we know, factors that may affect adherence to medication fall into several categories related to medication, patient, doctor and other factors ... and psychosocial profile The doctor-related factors include doctor-patient relationship including doctor-patient communication The examples for miscellaneous factors are healthcare access and ... analyses It is noninvasive, easy to use and allows large numbers of patient records to be examined [19] The MPR is considered a reasonable screening tool to determine patients with poor adherence...

Ngày tải lên: 11/08/2014, 16:22

... factors) Categorical factors are used to divide study population into subgroups (between-subjects factors) and 96 continuous variables are used as control variables (covariates) Taking into account ... epigenetic factors must be taken into account [7,15] For this reason, we attempted to model tacrolimus kinetics based on both genotype and epigenetic factors Disparity exists in the literature as to which ... homozygotes for CYP3A5*3 are non-expressors [15-18] There are grave indications that pharmacogenetic testing for CYP3A5 prior to transplantation improves the individualization of immunosuppressive therapy...

Ngày tải lên: 26/10/2012, 09:32

... decided to further investigate the use of H19 regulatory sequences for driving toxin gene expression in a therapeutic vector for ovarian cancer The level of H19 transcript in human ovarian cancer ... factors [7,8] We developed a novel therapy approach based on patientspecific gene expression profiles in each cancer tailored to individual patients by using selected transcriptional regulatory ... sequences for DNA-based therapy This enables the directing of a tumor-selective expression of a toxin, delivered by a non-viral vector Non-viral vectors appear promising due to their potential to overcome...

Ngày tải lên: 18/06/2014, 15:20

... specific regulatory sequence Therefore, we further investigated the combination use of H19 and IGF2 regulatory sequences for driving toxin gene expression in therapeutic vectors for bladder cancer treatment ... heterotopic and orthotopic mouse models Heterotopic bladder cancer model was used to evaluate tumor growth inhibition of the double promoter vectors compared to that of the single promoter vectors ... different cancers, therefore we propose a double promoter expression approach for targeted cancer therapy According to this approach patients will be treated with specific double promoter expression toxin...

Ngày tải lên: 18/06/2014, 16:20

... immune response to allergens To determine if CIN therapy affects the activity of antigen-specific CD8+ T cells, C57BL/6-OT1 mice carrying the transgene for the T-cell receptor specific for the ... et al, Chitosan Interferon-c Nanogene Therapy for Lung Disease 103 Figure Chitosan interferon-c nanogene (CIN) treatment induces changes in gene expression in lung dendritic cells A, Total ribonucleic ... pH 5.4, to a final concentration of 0.02% were separately heated for 10 minutes at 55uC After heating, the chitosan and DNA were mixed, vortexed vigorously for 20 to 30 seconds, and stored at...

Ngày tải lên: 08/08/2014, 21:20

... described the histopathologic type of pancreatic cancer Of these, almost all enrolled patients histopathologic types were ductal adenocarcinomas except for two patients One patient’s histopathological ... pancreatic cancer Page of 13 treatment of pancreatic cancer has not been addressed With more effective chemotherapy for systemic treatment of pancreatic cancer, effective local therapy to both tumor/surgical ... subgroups of lymph nodes for Page of 13 patients with pancreatic head cancer were listed in Table (not including paraaortic lymph nodes) For patients with pancreatic head cancer, commonly involved...

Ngày tải lên: 09/08/2014, 08:23

... small cell lung cancer (NSCLC) All patients Karnofsky performance status (KPS) was 80 Five patients had induction chemotherapy, and had concurrent chemotherapy The 12 lung cancer patients clinical ... Clinical characteristics of the 12 lung cancer patients Patient Sex Age Histology Stagea KPS Induction chemotherapy Concurrent chemotherapy F 51 small cell lung cancer IIIa T1N2M0 80 CE No F 50 ... dose threshold for RRP or/and a time lag effect Clinically, these patients symptoms were considered to be triggered by chemotherapy Both radiotherapy and chemotherapy contributed to the development...

Ngày tải lên: 09/08/2014, 09:20

... or the abdomen to prevent radiation injury to small bowel (Table 1) All of these were inserted at open laparotomy Lasser first described its use prior to radiotherapy for rectal cancer [9] Many ... available, brachytherapy or cryotherapy may be reasonable alternatives to external beam radiotherapy Where external beam radiotherapy is the preferred or only option, various methods for removing ... into the pelvis to exclude small bowel from the pelvis to prevent injury from post-operative radiotherapy[8] Sugarbaker described covering the implant with a mesh which was sutured to the peritoneum...

Ngày tải lên: 09/08/2014, 09:20

... graphical presentation are automatized for each respiratory phase In this process, “Myrian®” is unable to perform an automatic propagation of TV and OAR delineated from one phase to the other nine So, ... Discussion Physiological respiratory motion is a major challenge for lung cancer RT The range of motion can reach an average up to 12 ± mm for tumors in the lower lung lobes [18] Giraud et al., ... can help to determine the optimal respiratory phase for gated RT based on a few simple morphological parameters Easy to apply in daily routine, it may be a useful tool for selecting patients...

Ngày tải lên: 09/08/2014, 09:20

... of SRT for lung cancer has yet to be standardized So, our results cannot be simply applied to other institutions Conclusion Rib fracture is seen with high frequency after SRT for lung cancer ... Hultén U: Stereotactic hypofractionated radiotherapy for stage I non-small cell lung cancer mature results for medically inoperable patients Lung Cancer 2006, 51:97-103 Zimmermann FB, Geinitz ... good survival rate for patients with non-small cell lung carcinoma, comparable to those of surgery [10] SRT has now been applied not only to medically inoperable patients but also to operable ones...

Ngày tải lên: 09/08/2014, 09:21

... image-guided radiotherapy (IGRT) has allowed for more accurate tumor targeting, so it is rapidly replacing conventional radiotherapy for lung cancer [2] In order to account for tumor motion, ... chart review protocol We studied 27 consecutive patients with non-small -lung cancer (NSCLC) who underwent 4-D CT simulation for treatment planning and received definitive radiotherapy at our institution ... underestimation was 17.3% for IGTVMIP, 19.3% for IGTV2Phases, and 5.3% for IGTVMIP-Modified in stage I tumors and 12.1% for IGTVMIP, 8.9% for IGTV2Phases, and 4.2% for Figure illustrates the...

Ngày tải lên: 09/08/2014, 09:22

... Strategy for dose escalation using 3dimensional conformal radiation therapy for lung cancer Ann Oncol 1995, 6:693-7 Armstrong J: Target volume definition for three-dimensional conformal radiation therapy ... three-dimensional conformal radiation therapy for non-small cell lung cancer Radiother Oncol 1997, 44:17-22 Beckendorf V, Elles S, Madelis G: Postoperative radiation therapy in lung cancer: clinical ... center on Brazil Methods Chest CT scans of all the patients with non-small-cell lung cancer, not submitted to surgery and referred to conformal radiotherapy of Hospital A C Camargo (São Paulo, Brazil)...

Ngày tải lên: 09/08/2014, 10:20

... smokers with suspected lung cancer could be used as a lung cancer biomarker In this data set, genes were confirmed to be differentially expressed between cancerous samples and non-cancerous samples ... microarrays comparing 60 smokers with lung cancer and 69 smokers without lung cancer This experiment was designed to determine if gene expression in histologically normal large-airway epithelial ... data from various types of cancer [6] In this study, it is used to identify potential biomarkers for lung cancer from microarray data Other feature selection methods For comparison with BMI, we...

Ngày tải lên: 10/08/2014, 09:22

... P, Todesco S, Doria A: Clinical implications of autoantibody screening in patients with autoimmune myositis Autoimmunity 2006, 39:217-221 11 Levine SM: Cancer and myositis: new insights into ... autoimmune polymyositis, although anti-Jo-1 antibodies are found in 18% to 55% of these patients, anti-Mi-2 antibodies are found in 4% to 9%, anti-SRP antibodies are found in 4.8% to 11% of patients ... 134:1087-1095 Stockton D, Doherty VR, Brewster DH: Risk of cancer in patients with dermatomyositis or polymyositis, and follow-up implications: a Scottish population-based cohort study Br J Cancer 2001,...

Ngày tải lên: 10/08/2014, 23:20

... and most patients die within one year of presentation When untreated, patients survive only for one to three months after diagnosis Survival is short even when patients are treated, due to the ... syndromes, compressions to the spinal cord and, very rarely, skin metastases [3] According to the literature, the various types of lung cancer lead to cutaneous metastases in 1.5% to 2.6% of cases Furthermore, ... necessary for its early detection The aim is to start treatment as soon as possible before widespread visceral metastases occur Therefore, close inspection of new skin lesions in patients with a history...

Ngày tải lên: 11/08/2014, 19:21

... required before HCV-infected patients undergo IFN therapy In our study, dental problems delayed the initiation of IFN therapy for a maximum of 105 days HCV-infected patients treated with IFN therapy ... required for HCV-infected patients and dental practitioners [15] We distributed a questionnaire to 209 patients who visited our hospital for liver disease treatment to determine whether patients ... 2) These six patients could not commence IFN therapy, despite their admission for this treatment, and their therapy was deferred for 61.3 ± 47.7 days Patient no had an acute odontogenic periostitis,...

Ngày tải lên: 12/08/2014, 04:20