european documents for the regulation of human tissue research and biobanking

... Proposal for a regulation of the European Parliament and of the Council on nutrition and health claims on foods COM (2003) 424 final; 16/07/2003 cf Gerard Hastings et al: Review of research into the ... and sedentariness and the role of sport in the context of education and as a means of restoring the balance" http://europa.eu.int/comm/sport /documents/ lotpaderborn.pdf these include dietary therapy ... report by the Netherlands Institute for Public Health and the Environment, RIVM, examined unfavourable dietary composition and health loss One of the conclusions is that an excessive intake of the...

Ngày tải lên: 14/02/2014, 13:20

... treatment for chronic low back pain C4 (F) Thermotherapy Summary of evidence • There is no evidence for the effectiveness of thermotherapy compared with sham/placebo treatments in the treatment of chronic ... one of the diagnostic standards and is widely used Until there is a standard procedure for 36 carrying out and interpreting the PSLR, with known reliability and validity, clinicians and researchers ... data on the normal configuration of paraspinal motor units (Travlos et al 1995) The role of the paraspinal muscles for the stabilisation and movement of the spine was assessed in some of the earliest...

Ngày tải lên: 08/03/2014, 14:20

... and the practice of accepted therapy on the other, in order to know what activities ought to undergo review for the protection of human subjects of research The distinction between research and ... appropriate guidelines for the selection of human subjects for participation in such research, and (iv) the nature and definition of informed consent in various research settings The Belmont Report ... 1974, the National Research Act (Public Law 93348) was signed into law, thereby creating the National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research One of the...

Ngày tải lên: 22/03/2014, 15:21

... and demand for training and handling information, as well as for standardization and professionalization of training and handling methods The misapplication and incorrect handling of cadaver ... basics of understanding scent, canine olfaction, and the ABC’s of training and training equipment Chapters and are focused on the forensic context, including the demands of professionalism and the ... the dog’s behavior In other words, the dog’s efforts are only as good as the quality of the pre-search investigation, and the handler’s skills; and they are dependent as well on the weather and...

Ngày tải lên: 03/06/2014, 01:36

... University of California [5,6] provided a tremendous resource of knowledge related to the mechanics of human movement The work at the University of California formed the basis for many of the fundamental ... improving the efficiency of troop movement During the 1950s there was a need for an improved understanding of locomotion for the treatment of World War II veterans The classic work at the University of ... Journal of NeuroEngineering and Rehabilitation 2006, 3:6 the capture and analysis of human movement For example, the Weber brothers (1836) reported one of the first quantitative studies of the temporal...

Ngày tải lên: 19/06/2014, 10:20

... 105 pfu per eye of HSV-1 strain KOS-GFP or GFP relationship of the genotype and phenotype of these mice is defined in Table c The mean ± standard error of the mean of the logarithm of infectious ... satisfactorily prove the accuracy of a new in vivo paradigm of HSV-1 gene regulation On the other hand, the need for an improved in vivo model is clear A model is needed which identifies the host and/ or viral ... compromised the integrity of the tissue Thus, consistent with other results, the Stat signaling pathway was essential to restrict the spread of wild-type HSV-1 from the site of inoculation to the TG...

Ngày tải lên: 20/06/2014, 01:20

... part of the literature review and contributed in drafting of the manuscript and in the interpretation of data SL, AM, EV and OS performed part of the literature review and contributed in the manuscript ... adequate movement of the flaps without any tension at the periphery of the flap and the skin edges [24,25] In certain areas such as the frontal area of the knee where other types of skin or fasciocutaneous ... in the presence of factors that affect local vascularity to the soft tissues [8,13] Skin vascularity over the knee affects the rate of healing postoperatively and the risk of necrosis Since the...

Ngày tải lên: 20/06/2014, 04:20

... part of the literature review and contributed in drafting of the manuscript and in the interpretation of data SL, AM, EV and OS performed part of the literature review and contributed in the manuscript ... adequate movement of the flaps without any tension at the periphery of the flap and the skin edges [24,25] In certain areas such as the frontal area of the knee where other types of skin or fasciocutaneous ... in the presence of factors that affect local vascularity to the soft tissues [8,13] Skin vascularity over the knee affects the rate of healing postoperatively and the risk of necrosis Since the...

Ngày tải lên: 20/06/2014, 07:20

... IP-10, a CXCR3 ligand, may be expressed in the inflamed synovium of RA, and appears to play an important role in the recruitment of Th1-type cells into the joint Thus, the aim of the present study ... samples The cDNA was amplified after determining the optimal number of cycles The mixture was first incubated for at 94°C; it was then cycled 35 times at 95°C for 30 s and at 58°C for 60 s, and elongated ... to be tested whether other adhesion molecules are involved in the induction of IP-10 mediated by the interaction of RA FLSs and leukocytes This pathway cannot solely account for the response, however,...

Ngày tải lên: 09/08/2014, 01:21

... cost and increased achievable throughput and accuracy of sample handling and picking; for example, through the use of automation (Figure 2) It also limits the impact of analytical variability and ... requirements for human genome epidemiology Int J Epidemiol 2009, 38:263-273 Elliott P, Peakman T: The UK Biobank sample handling and storage protocol for the collection, processing and archiving of human ... 24.6  h (standard deviation = 2.6), close to the target of 24 h based on pilot studies [9] Centralize and standardize as much as possible and limit the impact of variability As noted, the degree...

Ngày tải lên: 11/08/2014, 12:21

... expression of the viral E6 and E7 oncoproteins, which cause deregulation of the cell cycle by inactivating p53 and pRb respectively [9] Integration often disrupts the integrity and expression of the ... pg/ml of sample Interpretation of Cut off value (RLU of specimen/mean RLU of PC) Cut-off ratio of to 0.99 is negative for HR HPV; Cutoff ratio greater than 1.0 positive for HR HPV The cut off ratio ... was to compare the efficacy of HC-II assay and PCR for the detection of specific HPV type (HPV 16 E6) in OSMF and OSCC cases as well as find out the prevalence rate of the HR-HPV in these lesions...

Ngày tải lên: 12/08/2014, 01:22

... foreign tissues, therefore allowing the engraftment of human cells and/ or tissues This model represents the landmark experiment that sparked further development of humanized mice for the study of human ... experimental model Here, we focus on the development of each of these models for the study of human retroviral infection, i.e., with HIV-1 and HTLV-1 The comparison of all of these models in historical ... highlight of the noteworthy events of humanized mouse model system development over the past 30 years The bottom half of the timeline denotes the emergence of key humanized mouse models The top half of...

Ngày tải lên: 12/08/2014, 23:22

... Table listing the identity of the PCR primers used for the production of the amplicons, their exact coordinates on the genomes, the sizes of the probes generated and the success of the amplification ... calculated for both the experimental and control and the ratio of these was used as a scaling factor to adjust the values of all fluorescence measures for the viral genes represented on the array For the ... data and printed the arrays NM printed the arrays and participated in some of the expression studies AP performed many of the expression studies and the ChIP-chip analysis VL performed the ChIP-chip...

Ngày tải lên: 13/08/2014, 13:20

... Transcriptional regulation of genes Genomic DNA is the ultimate template of our heredity In spite of the completion of the human genome project, many challenges remain in understanding the regulation of genetic ... TFIIA then binds to TBP and stabilizes its interaction with the DNA Binding of TBP to TATA box distorts the DNA and allows binding of TFIIB that provides the platform for the recruitment of RNA ... in the melting of the DNA TFIIH has kinase and helicase activity The kinase activity of this factor is required for the phosphorylation of the C-terminus domain (CTD) of Pol II that consists of...

Ngày tải lên: 24/08/2014, 12:22

... center of the input target RNA The asterisk indicates the input target RNA; the arrow indicates the digested product bands The amount of digested product obtained is indicated at the bottom of the ... of gene expression in human cells in vivo ACKNOWLEDGEMENTS We thank Dr K Fluiter for performing the tritium labeling of the ODN, Prof J M B V de Jong for critical reading of the manuscript, and ... in the transfectants overexpressing the coding region of the 1.2-kb RNase H2 mRNA suggests that at least the activity encoded by the 1.2kb mRNA can be assayed in vitro On the other hand, the...

Ngày tải lên: 08/03/2014, 10:20

... latitudes of 23° north and south and separate the fertile tropical zone from the subtropical and temperate zones About half of the about 90million-km2 fertile global land areas are forests; the rest of ... the char pore system and eventually solidified there This reduces the pore volume and the amount of liquid required for slurry preparation later on After the removal of the char crumbs from the ... in 1996 for the further development of their hazardous waste conversion process [34] The photo in Figure 22 shows the top and bottom sections of the pilot gasifier The KIT has rented the pilot...

Ngày tải lên: 14/03/2014, 19:20

... which treats of the nature of words, their forms, and their uses and relations in the sentence The work it will cover This will take in the usual divisions, "The Parts of Speech" (with their inflections), ... used as the feminine of fox by the Southern-English For fox they said vox; for fromthey said vram; and for the older word fat they said vat, as in wine vat Hence vixen is for fyxen, from the masculine ... form of a word, expressing the relations of nominative and objective; the other is formed by adding 's to the simple form, making the possessive singular To form the possessive plural, only the...

Ngày tải lên: 22/03/2014, 16:22

... result of the absence of a disulfide bond between Cys191 and Cys220, which is conserved in the neutrophil serine proteases HNE and PR3 The presence of a Glu at position 226 at the bottom of the CG ... S1¢ pocket on the top of the Cys42-Cys58 loop is bordered by His57 to the west and the aliphatic part of the Lys40 side-chain to the east [2] (Fig 1) As a result, the P1¢ specificity of chymase could ... by Hof et al [1] indicate that the side-chain of Arg41 located on the 30S insertion loop in CG projects from the molecular surface to the east of the active site in accordance with the standard...

Ngày tải lên: 28/03/2014, 22:20