eugenics the genome and human rights
the mit encyclopedia of the cognitive sciences
... kinds, and that the sciences strive to identify them, and scientific realism, the view that the entities in mature sciences, whether they are observable or not, exist and our theories about them ... questions about COMPUTATION AND THE BRAIN, the traditional computational theory of the mind, and the rules and representations approach to understanding the mind The evolutionary path, by contrast, ... hand with NATIVISM about both the source of human knowledge and the structure of the human mind If some ideas are innate (and so not need to be derived from experience), then it follows that the...
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Tài liệu Báo cáo khoa học: Molecular basis of glyphosate resistance – different approaches through protein engineering doc
... the size of the side chain, directly increasing the volume of the active site, and enhance the flexibility of loops 20 and 130, allowing them to open wider to accommodate longer ligands When these ... Fig The shikimate pathway that leads to the biosynthesis of aromatic amino acids, and the mode of action of glyphosate on the reaction catalyzed by EPSPS under the Roundup Ready brand in the ... a2–a3 loop, see arrows [49] For the sake of clarity, only the FAD and the ligand belonging to the wild-type GO structure are shown, and Arg329 is omitted observed for the best GO variants is largely...
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Tài liệu Báo cáo khoa học: EGF receptor in relation to tumor development: molecular basis of responsiveness of cancer cells to EGFR-targeting tyrosine kinase inhibitors docx
... ⁄ and the PI3K ⁄ Akt pathways results, in turn, in the inactivation of pro-apoptotic Bcl-2 proteins (e.g PUMA, Bax, Bim and Bad), Fas, and CDK inhibitors (e.g p27KIP1, p21WAF1 and p15INK4b), and ... inhibitors, including those of the kinase inhibitor proteins (KIP) family and the INK4 family (Fig 3) The KIP family consists of p27KIP1, p21WAF1 ⁄ CIP1 and p57KIP2; and the INK4 family consists of ... 2009 The Authors Journal compilation ª 2009 FEBS K Takeuchi and F Ito whereas others promote apoptosis The balance between these pro-apoptotic and anti-apoptotic Bcl-2 family members determines the...
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Tài liệu Báo cáo khoa học: Basis of recognition between the NarJ chaperone and the N-terminus of the NarG subunit from Escherichia coli nitrate reductase pdf
... coupled to the absorption or release of protons by the protein or the ligand If this is the case, the binding enthalpy is dependent on the ionization enthalpy of the buffer in which the reaction ... mM MgCl2, 100 mM NaCl The upper panels show the raw data for the heat effect during the titrations; the lower panels are the binding isotherms model The results indicated the existence of a minor ... NarG(1–28)] and solved their structures by NMR; NarG(1–15) corresponding to the predicted N-terminal helix and NarG(1–28), which included both the N-terminal helix and the b-sheet present in the mature...
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Tài liệu Towards a framework for the study of the neural correlates of aesthetic preference pdf
... disproved On the other hand, none of these studies asserted that the areas they had identified were the exclusive neural correlates aesthetic preference In fact they all acknowledged that these areas ... difference between the study by Jacobsen et al (2006) and the rest resides in the stimuli presented to the participants Vartanian and Goel (2004) and Kawabata and Zeki (2004) asked their participants ... other stimuli whose symmetry is less prominent For these reasons, the remainder of the present work we will concentrate on the studies by Kawabata and Zeki (2004), Vartanian and Goel (2004) and...
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Tài liệu The Basis of Early Christian Theism ppt
... and that are, and this revolution in which now revolve the stars and the sun and the moon and the air and the ổther that are separated off."[3] This, however, amounts to no argument, and it is extremely ... general, and the reasons for the belief in the existence of the gods (for the Greek schools never transcended polytheism when they speak of {theos} they mean simply the abstract divinity of the many ... hoi theoi, to theion} and {ta theia} They never conceive of their {theos} as anything more than a rather larger and more majestic member of the innumerable family of the divinities of which the...
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Molecular Basis of Pulmonary Disease Insights from Rare Lung Disorders pdf
... to the lungs Other disorders affect the lungs and other organ systems For these processes, the key to the diagnosis is the recognition of associated constellations of symptoms that affect the ... designs In the former, participants are randomized to a treatment arm for a period at the end of which the outcome is assessed and then the subjects are “crossed over” to the other treatment The cross-over ... object to the concept of randomization and many investigators feel that randomization, in of it itself, is unethical (5) Randomization requires that the investigator and the subject consider themselves...
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GENOMIC DISORDERS The Genomic Basis of Disease doc
... genotype one allele had the double density of the other There was also no consistency because in one patient it was the upper band and in another patient the lower band revealing the increased dosage ... the point of insertion The left half of Alu contains the A and B boxes of the RNA polymerase III promoter The two halves of the Alu dimer are separated by an A-rich region and the 3' end of the ... at their homes to collect blood samples Gisèle made the first contact with the patients and relatives to explain the aims of the study and to ask whether she could visit again, but now with the...
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Báo cáo khoa học: Protein–protein interactions and selection: generation of molecule-binding proteins on the basis of tertiary structural information potx
... flexible and stable framework with hypervariable sequences and lengths in the six-loop CDR (Fig 1A) that bind to the antigen The first study of grafting into the CDR replaced the CDR loops in a human ... L1 and CDR L2) to study the potential of Fv as a scaffold protein for grafting They investigated deviations in the amino acid sequences of the CDRs of 1330 human light chains to identify the candidate ... fragments (A) Replacement of the candidate location in NCS for grafting with the CDR loop of VHH (B) Insertion of the CDR 1-containing loop of the heavy chain in Fv into the candidate location in TOP...
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Báo cáo khoa học: Molecular basis of perinatal hypophosphatasia with tissue-nonspecific alkaline phosphatase bearing a conservative replacement of valine by alanine at position 406 Structural importance of the crown domain potx
... [11–15] However, the extent to which each TNSALP mutant protein reaches the cell surface varies from one mutation to another, depending on the position of the mutation in the gene and the amino acid ... interact with each other in the crown domain Nevertheless, it is worth noting that the overall homology of the crown domain between TNSALP and the placental isoenzyme is around 72% at the amino acid ... (Endo H) digestion The wild-type enzyme was synthesized as the 66-kDa Endo H-sensitive form, which quickly became the 80-kDa Endo Hresistant form The processing of the newly synthesized wild-type...
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Báo cáo khoa học: "Clustering Hungarian Verbs on the Basis of Complementation Patterns" pot
... and b) individual verb lemmata in rows The first step of the evaluation process is to fill in the cells with the semantic roles the given suffix can code in the context of the verb We consider the ... reinforcement of the usability of the Semantic Base Hypothesis for language analysis Our further work will emphasize both the refinement of the clustering methods and the linguistic interpretation of the resulting ... source in the environment of movement verbs Both cases having the same semantic role, the decision between them is determined by the semantics of the corresponding NP These cases code an other semantic...
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Báo cáo khoa học: "Shallow parsing on the basis of words only: A case study" pptx
... features (the columns) and the functionchunk code for the focus word The features describe the focus word and its local context For the chunk part of the code, we adopt the “Inside”, “Outside”, and ... between the two instances’ values at the th feature The classes of the nearest neighbors then determine the class of the new case focus POS For the experiments with both words and POS, the switch ... from (Ramshaw and Marcus, 1995) For the function part of the code, the value is either the function for the head of a chunk, or the dummy value NOFUNC for all non-heads For creating the POS-based...
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Báo cáo khoa học: "Predicting Strong Associations on the Basis of Corpus Data" pdf
... Thus, the lower the rank, the better the performance of the system While there are obviously many more ways of assembling a test set and scoring the several systems, we found these all gave very ... results to the ones reported here tween them This measure is more or less standard in the literature and leads to state-of -the- art results (Sch¨ tze, 1998; Pad´ and Lapata, 2007; u o Bullinaria and ... brought together all the associations in a set of candidate associations, and complemented it with 1000 random words from the corpus with a frequency of at least 200 From these candidate words,...
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Molecular basis of heredity
... stable DNA can be boiled and even autoclaved without degrading! 5’ and 3’ The ends of the DNA or RNA chain are not the same One end of the chain has a 5’ carbon and the other end has a 3’ carbon ... bond Covalent bond between the phosphate group (attached to 5’ carbon) of one nucleotide and the 3’ carbon of the sugar of another nucleotide This bond is very strong, and for this reason DNA is ... in a right-handed (clockwise) double-helix Nucleotide chains are anti-parallel: Sugar-phosphate backbones are on the outside of the double helix, and the bases are oriented towards the central...
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Molecular basis of heredity - Bio Cơ sở phân tử của di truyền - sinh học
... stable DNA can be boiled and even autoclaved without degrading! 5’ and 3’ The ends of the DNA or RNA chain are not the same One end of the chain has a 5’ carbon and the other end has a 3’ carbon ... bond Covalent bond between the phosphate group (attached to 5’ carbon) of one nucleotide and the 3’ carbon of the sugar of another nucleotide This bond is very strong, and for this reason DNA is ... in a right-handed (clockwise) double-helix Nucleotide chains are anti-parallel: Sugar-phosphate backbones are on the outside of the double helix, and the bases are oriented towards the central...
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Báo cáo khoa học: Molecular basis of toxicity of Clostridium perfringens epsilon toxin ppt
... anti-parallel) The third domain is a b-sandwich composed of one fourstranded sheet and one three-stranded sheet, the latter of which contains the only parallel strand in the structure The overall fold of the ... facilitating the toxin’s entry into the bloodstream and its spread into various organs including the brain, lungs and kidneys, thereby causing severe oedema [6] While the infection of the central ... arrangements (Fig 2) in their two C-terminal domains (domains III and IV in aerolysin, and domains II and III in the others) All these proteins form pores, though aerolysin and e-toxin are predicted...
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Báo cáo khoa học: Molecular basis of cytokine signalling – theme and variations docx
... receptor of the ligand, whereas the main core structure binds into the epitope for the type II receptor of the BMP ligand Therefore, the binding of the receptors of both subtypes is blocked and BMP ... 2) Step is the binding of the solute ligand at the high-affinity site and in step the second chain is recruited in the membrane to form the signalling oligomer The cytosolic parts of the homodimer ... 2H64 [11]) and were therefore not modelled (B) A top view of (A) showing the two-fold symmetry of the ligand– receptor complex imposed by the symmetrical ligand homodimer to the membrane The binding...
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MORAL PRINCIPLES AND MEDICAL PRACTICE, THE BASIS OF MEDICAL JURISPRUDENC potx
... dominion over the fishes of the sea, and the fowls of the air, and the beasts, and the whole earth, and every creeping creature that creepeth upon the earth.” And later on in history, after the deluge, ... would be right and praiseworthy, and others wrong and worthy of condemnation; even there Doctors and patients and their relatives would have certain rights and duties In such a land, the lecturer ... likely to so, then the good effect is greater and more immediate or direct than the bad effect; then give the medicine to save the mother, and permit the probable death of the child If the medicine...
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Báo cáo khoa học: Molecular basis of the unusual catalytic preference for GDP/GTP in Entamoeba histolytica 3-phosphoglycerate kinase doc
... of Gly312 in the pig enzyme On the other hand, the Leu residue present in the horse and yeast enzymes is conserved in the majority of PGK sequences reported to date; however, in the EhPGK, it ... Madison, WI, USA) and sequenced to verify the presence of the mutation and the absence of any other substitution introduced during the PCR Mutated genes were further cloned in the pET28 expression ... parameters in the forward reaction The Vm, Km and catalytic efficiency (Vm ⁄ Km) values for nucleotides were determined in the forward and reverse reactions for the wild-type and the five EhPGK...
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Báo cáo Y học: The expression of glutathione reductase in the male reproductive system of rats supports the enzymatic basis of glutathione function in spermatogenesis doc
... immunohistochemistry (data not shown) As the activity difference was small, the difference in intensity of the bands for the protein and the mRNA were faint Effects of inhibitors of cGCS and GR on primary cultured ... investigate the contribution of de novo synthesis and the recycling of GSH to the intracellular glutathione pool, the Ó FEBS 2002 1574 T Kaneko et al (Eur J Biochem 269) Fig GR activity and the protein ... cells, and the GR activities and GSH contents are below the detectable level in the spermatozoa of the rat [22] However, the spermatogenic cells contain quite high levels of GSH (Fig 5) If the reducing...
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