etoposide all trans retinoic acid butyric acid

... for amino acids and nucleic acids may also provide a targeting strategy for nanoparticles That many classical anti-cancer agents function by interfering with amino acid or nucleic acid incorporation ... added benefit of potentially depriving cancer cells of these critical materials whereas targeting strategies using amino acids and nucleic acids will probably not affect the overall influx of these ... activities of cancer cells relative to normal cells All too frequently, normal cells can undergo processes (e.g., wound repair) that will transiently transform them into a cell with surface properties...

Ngày tải lên: 04/06/2014, 14:30

... multidish (30 mm) Transient transfections were carried out using the JetPEI cationic polymer transfection reagent (mean molecular weight of 22 kDa; Polyplus, Illkirsh, France) The transfection was ... levels in several different human tumor types, but is only marginally or not at all expressed in normal adult tissues http://www.translational-medicine.com/content/7/1/69 [10,11] Its precise function ... from our group and others, transcriptional regulatory sequences of the H19 gene have emerged as candidates for cancer gene therapy H19 is a paternally-imprinted, maternally expressed, oncofetal...

Ngày tải lên: 18/06/2014, 15:20

... contains exons (E1-9) and introns [10,11], and is transcribed from different promoters (P1-P4) producing different transcripts [11-13] All four transcripts share a common coding region and a common ... expression plasmids were cloned by GENEART™, (Germany) Transfection Cationic polymer (jetPEI) transient transfection The in vitro jetPEI™transfection reagent compact the DNA into positively charged ... normal bladder mucosa interferes with the plasmid transfection [36], it is not present in the bladder tumor, allowing efficient transfection of principally the tumor urothelium In the same way an...

Ngày tải lên: 18/06/2014, 16:20

... inhibits (-)benzo(a)pyrene-7R -trans- 7,8-dihydrodiol bioactivation in oral squamous cell carcinoma cells and oral mucosa Cancer Res 2002;62(19):5451–6 191 34 Walle T, Walle UK Novel methoxylated ... matrix metalloproteinase (MMP)-2/9.25 The oncogenic significance of activated signal-transducer-andactivator-of-transcription-3 (STAT3) molecules stems from their effects on the development and ... N, Myers JN, Aggarwal BB Targeting constitutive and interleukin6-inducible signal transducers and activators of transcription pathway in head and neck squamous cell carcinoma cells by curcumin...

Ngày tải lên: 01/07/2014, 13:23

... retinaldehyde to retinoic acid (Zhao et al., 1996; Wang et al., 1996) It has high affinity for the oxidation of both all trans and 9–cis–retinal (Yoshida et al., 1992) Retinoic acid regulates gene ... saline RA Retinoic acid RAR Retinoic acid receptor RT Room temperature SDS Sodium dodecyl sulfate siRNA Small–interfering RNA SLS ... (Esterbauer et al., 1991) Amino acid catabolism generates several aldehyde intermediates, including glutamate γ–semialdehyde, while neurotransmitters, such as gamma–aminobutyric acid (GABA), serotonin,...

Ngày tải lên: 24/08/2014, 09:51

... and mechanisms 1.2.3 1.2.3.1 Pharmacodynamically synergistic combinations 1.2.3.2 Pharmacodynamically additive combinations 1.2.3.3 Pharmacodynamically potentiative combinations 1.2.3.4 Combinations ... codelivery of small molecule drugs and nucleic acids/proteins against cancer These particles can encapsulate hydrophobic drugs in the core and bind to biomolecules such as nucleic acids or proteins ... regulation of drug transport or permeation, distribution or localization and metabolism Improvements of the transport of drug into target cells or organelles occur via the disruption of transport 11...

Ngày tải lên: 30/09/2015, 05:59

... are necessary Ideally, drug combinations used should demonstrate the advantages such as broader spectrum of activity, possibility of synergy, less toxicity and potentially smaller dose if synergistic ... derivatives of oxygen such as hydrogen peroxide (H2O2) ROS are generally small, short-lived and highly reactive molecules Specifically, O2·- and OH· are extremely unstable whereas H2O2 are freely ... electron transport chain During respiration, about 1-2% of oxygen consumed is not completely reduced to water (H2O), but is instead partially reduced to O2·- along the respiratory electron transport...

Ngày tải lên: 11/09/2015, 10:02

... These include small protein domains, known as affibodies, that can be engineered to bind specifically to different target proteins in a conformational-sensitive manner Other small proteins that ... including intracellular proteins, transmembrane proteins, soluble proteins, carbohydrates, and small molecule drugs Several aptamers have also been developed to bind specifically to receptors on cancer ... (MPS), provides additional challenges for translating these carriers to the clinic Given their long history, liposome-based carriers serve as a classic example of the challenges encountered in the...

Ngày tải lên: 28/05/2014, 15:07

... Imbalance Omega fats (alpha-linolenic acid, EPA, DHA) have been shown in animal studies to be protect from cancer, while omega fats (linoleic acid, arachidonic acid) have been found to be cancer ... seed Flax seed provides all of the nutrients from this small brown or golden hard-coated seed It is an excellent source of dietary fiber, omega fat (as alpha-linolenic acid) , and lignans The lignans ... effect Allium vegetables, carrots, green vegetables, cruciferous vegetables, and tomatoes also had a fairly consistent protective effect [81] Allium vegetables (garlic, onion, leeks, and scallions)...

Ngày tải lên: 06/03/2014, 02:21

... commercially available antibodies can be analyzed Furthermore, immunoreactivity with post-translationally modified antigens cannot be differentiated unless antibodies that can specifically and ... complex mixture of proteins, and its efficacy in distinguishing post-translationally modified proteins and protein isoforms is unparalleled Consequently, when coupled with western blotting for serological ... distinguish between patients with small cell lung cancer and nonsmall cell lung cancer Nagashio et al [210] screened sera from patients with adenocarcinoma and small cell lung carcinoma by 2D immunoblotting...

Ngày tải lên: 23/03/2014, 04:20

... hydrolysable tannins contain gallotannins or ellagictannins Upon hydrolysis, gallotannins yield glucose and gallic acid, whereas the ellagictannins produce ellagic acid as a degradation product ... ())-Epigallocatechin-3-gallate (EGCG) and other tea polyphenols are potential chemopreventative agents, able to modulate multiple intracellular signal transduction pathways, such as NF-kB signalling ... activities: one cleaving preferentially after branched-chain amino acids (BrAAP activity) and the other cleaving after small neutral amino acids (SNAAP activity) [41,42] During an acute immune response...

Ngày tải lên: 30/03/2014, 02:20

... bisphosphonates and palliative radiotherapy of non target lesions, were allowed Page of (page number not for citation purposes) Journal of Translational Medicine 2008, 6:65 All patients gave written ... agents, cisplatin has historically been considered the most effective in both the palliative treatment of metastatic disease and the combined-modality therapy of locally advanced disease In stage ... progression (TTP) (A) and overall survival (OS) (B) Time to Time to progression (TTP) (A) and overall survival (OS) (B) Page of (page number not for citation purposes) Journal of Translational Medicine...

Ngày tải lên: 18/06/2014, 15:20

... stable transduction High efficiency stable transduction of lymphocytes is generally regarded as technically demanding Transfection typically has an unacceptably low efficiency and retroviral transduction ... 15 amino acid hinge to allow correct scFv refolding and reconstitution the antigen binding site Two thirds of the hinge sequence was attached using specifically designed PCR primers, allowing ... signal, transmitted by interaction between CD28 on the lymphocyte and CD80 (B7-1)/86 (B7-2), generally present on professional antigen presenting cells [14] Like many T cell receptors, signal transduction...

Ngày tải lên: 19/06/2014, 08:20

... stable transduction High efficiency stable transduction of lymphocytes is generally regarded as technically demanding Transfection typically has an unacceptably low efficiency and retroviral transduction ... 15 amino acid hinge to allow correct scFv refolding and reconstitution the antigen binding site Two thirds of the hinge sequence was attached using specifically designed PCR primers, allowing ... signal, transmitted by interaction between CD28 on the lymphocyte and CD80 (B7-1)/86 (B7-2), generally present on professional antigen presenting cells [14] Like many T cell receptors, signal transduction...

Ngày tải lên: 20/06/2014, 04:20

... stearic acid, is a low molecular weight surfactant and recommended as non-ionic solubilizing agent to be added to injection solutions [22] Its relatively bulky lipophilic portion might allow it ... formulations was comparable thereafter Overall, quick release rate for mixed micelles might produce a favorable pharmacological effect for drugs, especially for propofol, which exhibits rapid sleep ... conceived of the study and involved in revising the manuscript critically XL carried design and coordination of study, anticipated all of experiments, and wrote the manuscript YZ participated in the...

Ngày tải lên: 21/06/2014, 04:20

... optimal for all copolymers, the length of hydrophobic chains is a vital one In case of our experiment, all micelles were prepared in the same conditions, which may not be optimal for all copolymers, ... initially used  100%: Particle Size and Morphology Analysis The average hydrodynamic radius of the micelles was determined by dynamic light scattering (DLS) (Zetasizer ZEN 3500, Malvern, UK) All ... nanoparticles was also observed by transmission electron microscopy (TEM) (Hitachi-500, Hitachi, Japan) To improve the contrast, the samples were treated with a wt% phosphotungstic acid solution for h, deposited...

Ngày tải lên: 22/06/2014, 00:20

... to therapy allows resurgence of estrogenic stimulation leading to restoration of sensitivity to letrozole on its reintroduction In locally advanced and advanced breast cancer, ideally, inhibitors ... continue to provide antagonistic activity on ER nuclear signalling activity but may act as an Page of agonist on the ER membrane signalling activity which could explain the loss of continuing ... an in-vivo study [12], athymic mice were transplanted with ER positive tumor cells and then exposed to tamoxifen or placebo The tumors regressed initially over months but started to grow towards...

Ngày tải lên: 09/08/2014, 02:21

... significantly smaller than those in the control group (P < 0.05) The SVF and BM-MNC groups had better fractional shortening and ejection fraction than the control group Cell transplants PKH26 labelled transplanted ... JD, Beyer WM, Egalka MC, Guinan EC: Suppression of allogeneic T-cell proliferation by human marrow stromal cells: implications in transplantation Transplantation 2003, 75:389-397 24 Prabhu SD: Cytokine-induced ... suspended in culture medium were subepicardially implanted at points of the border zone In BM-MNC group (n = 11), × 10 bone marrow mono nuclear cells were transplanted Control group (n = 10) received...

Ngày tải lên: 10/08/2014, 09:21

... neuroblastoma xenografts in vivo, alone and synergistically with alltrans retinoic acid Cancer Res 2001, 61:3591-3594 30 Edwards A, Li J, Atadja P, Bhalla K, Haura EB: Effect of the histone deacetylase ... actively studied Abbreviations AML: Acute myeloid leukemia; ALL: Acute lymphocyte leukemia; AR: Androgen receptor; ATRA: All- trans retinoic acid; CLL: Chronic lymphocyte leukemia; CML-BC: Chronic ... Bordeleau L, Jurisica I, Minden MD: The histone deacetylase inhibitor valproic acid alters sensitivity towards all trans retinoic acid in acute myeloblastic leukemia cells Leukemia 2005, 19:1161-1168...

Ngày tải lên: 10/08/2014, 22:20