etiologies of cushing s syndrome

... hypotheses The cause of DS has been sought in disturbances during stages of oogenesis, including the period of meiotic arrest of the oocyte [51] This has generated several hypotheses One possibility ... A study of 41 mothers of DS infants found a statistically significant increase in plasma homocystine (Hcy) compared to controls [8] Hcy is a sensitive marker of folate status that is inversely ... Nicolaides, personal communication) Similarly, a metaanalysis of four second trimester amniocentesis series totalling 4,953 pregnancies found an excess of 0.54% [3] A meta-analysis of 433 livebirths...

Ngày tải lên: 02/11/2012, 11:12

... ‘‘active’’ tics), we can consider these ‘‘blocking’’ tics These events should be differentiated from seizures or other paroxysmal episodes of loss of awareness There is never loss of awareness with blocking ... CONCLUSION In summary, the natural history of TS reveals the complexities of this disorder At the present time, much of our understanding of this illness stems from the study of more severely symptomatic ... behavior This paroxysmal nature of tics is characteristic, and only in severe states of tics, such as prolonged tics or tics status, are the tics continual This paroxysmal feature is a most helpful...

Ngày tải lên: 28/03/2014, 22:21

... about Cushing' s Syndrome Ectopic Cushing' s Syndrome tends to present with less impressive classic features, but more dramatic hypertension and loss of potassium, sometimes in the setting of weight ... Syndrome from taking steroid medication is extremely common because of the widespread use of these medicines in treating many illnesses Spontaneous Cushing' s Syndrome and Cushing' s disease can occur ... Cushing' s disease is the name given to a type of Cushing' s Syndrome caused by too much ACTH production in the pituitary Dr Harvey Cushing first described a woman with signs and symptoms of...

Ngày tải lên: 29/07/2014, 02:21

... primary cause of the Cushing' s Syndrome is always the best, if possible HOW NORMAL IS A CUSHING' S PATIENT 'S LIFE? The symptoms, disabilities and life-style of a person with Cushing' s Syndrome depend ... Frequent calls and visits to physicians are necessary If the Cushing' s Syndrome is curable, or if iatrogenic Cushing' s Syndrome must remain, these individuals will have to cope with persistent fatigue, ... the treatment of these diseases All of the types of spontaneous Cushing' s Syndrome should be carefully evaluated by an endocrinologist (a specialist in hormonal disease) who has the knowledge...

Ngày tải lên: 29/07/2014, 02:21

... nghiệm cortisol tự do, 17hydroxycorticosteroid đo mẫu cortisol máu lúc 8h Ngày thứ cho bệnh nhân uống dexamethason 2mg/6h S có khả xảy ra: Nếu bệnh Cushing cortisol máu 17hydroxycorticosteroid ... loãng xương thường thấy cột s ng, xương s ờn xương dài, gãy xương bệnh lý xương s ng xương s ờn, xẹp đốt s ng phát nhờ chụp X quang - Tiêu hoá: tăng tiết HCl pepsin dày nên thường hay bị loét dày, ... thận, giảm bình thường có u lành (adenoma), cường s n vỏ thượng thận bình thường tăng + Các xét nghiệm để chẩn đoán phân biệt hội chứng Cushing bệnh Cushing (do cường thùy trước tuyến yên) - Định...

Ngày tải lên: 05/08/2014, 20:22

... autoimmune diseases supports a hypothesis that, in some cases, clinically distinct autoimmune diseases may be controlled by a common set of susceptibility genes [32] Sjögren s syndrome is considered ... sufficient for disease expression This makes the genetics behind these diseases more complicated than those of diseases with a simple Mendelian character Sjögren s syndrome is major histocompatility ... M, Skarstein K, Bolstad AI, Johannessen AC, Jonsson R: Fas-induced apoptosis is a rare event in Sjögren s syndrome Lab Invest 2001, 81:95-105 Ohlsson M, Jonsson R, Brokstad K: Subcellular redistribution...

Ngày tải lên: 09/08/2014, 01:21

... against La-antigen; hLFS, lymphocytic focus score ≥ 1.0 in sublabial minor salivary glands biopsy DM, dermatomyositis; Pt, patient; SSc, systemic sclerosis; SLE, systemic lupus erythematosus aIgA, ... techniques Besides that, the observed sensitivity of these classic autoantibodies is higher than that of anti-α-fodrin antibodies, regardless of the anti-fodrin ELISA system (Hanover versus Nijmegen ... M, Shoenfeld Y, Skopouli FN, Smolen JS, Soromenho F, Tishler M, Wattiaux MJ: Assessment of the European classification criteria for Sjogren s syndrome in a series of clinically defined cases:...

Ngày tải lên: 09/08/2014, 01:23

... Morquio s syndrome, three hours after a Tc-99m methylene diphosphonate injection Focal increased uptake is seen in the right sacroiliac joint and sacral body, consistent with fractures, and most likely ... Journal of Medical Case Reports 2011, 5:42 http://www.jmedicalcasereports.com/content/5/1/42 Page of Figure Localized posterior bone scan view of the pelvis and lumbar spine of a 46-year-old Caucasian ... most likely representing the cause of the patient s pain Figure Anterior and posterior whole body bone scan views of a 46-year-old Caucasian man with Morquio s syndrome complaining of lower back...

Ngày tải lên: 11/08/2014, 00:22

... symptoms (data not shown) Figure and scores VASseven of measured subjective symptoms in weeks one VAS scores of measured subjective symptoms in weeks one and seven * indicates statistically significant ... University Hospital KEVO grants References Statistical analysis SPSS for Windows Release 11.5.1 (SPSS Inc., Chicago, IL, USA) was used for the statistical analysis Since the number of the marked scores ... of Negative Results in BioMedicine 2007, 6:11 of the disease is often stable with slow initiation and progression of sicca symptoms Primary SS is a separate disease entity, while secondary SS...

Ngày tải lên: 11/08/2014, 08:21

... risk of inadvertent gastrointestinal injury due to the presence of adhesions Bouveret s syndrome is a rare complication of gallstone disease [1], and is characterized by passage of a large stone ... endoscopic disimpaction may be possible, but surgery is frequently necessary Cholecystectomy carries no benefit in these cases, and is often very difficult and should be avoided This case is an ... patients unfit for surgery [4] Surgical exploration of the common bile duct is necessary where endoscopic and percutaneous techniques are unsuccessful Reoperation in these patients poses a significant...

Ngày tải lên: 11/08/2014, 17:21

... the obviously malignant cases in which the diagnosis is based on common clinicopathologic features universally valid for tumors of any site, such as distant metastases, surgical unresectability ... neoplasm He was symptomatic and admitted to the hospital because of suspected Cushing' s syndrome The laboratory findings were compatible with the syndrome, and further investigation revealed a mass ... behavior of adrenocortical oncocytic neoplasms The Weiss system is the most widely used and accepted histological scheme to distinguish benign from malignant adrenal tumors [11] According to this system,...

Ngày tải lên: 11/08/2014, 21:22

... compartment in SS-non-susceptible mice The presence of LF and loss of saliva secretion raises an interesting question about the possible role of IL-17A in B cell activation As BAFF is capable of inducing ... possible role of BAFF and IL17A in this phenomenon needs to be better defined in SS pathogenesis Conclusions The capability of IL-17A to induce features of SS in SSnon-susceptible mice demonstrates ... consistent with the concept that SS develops along specific biological processes in a sequential fashion and interference with this process alters development of disease [1-3] Therefore, this study...

Ngày tải lên: 12/08/2014, 15:22

... problems as initial symptoms Thus a high index of suspicion of Cushing s syndrome is essential for its diagnosis in children with obesity, retarded growth, and behavioral changes Two patients (cases ... dexamethasone for children in the low-dose dexamethasone suppression test may be too high in some children with Cushing s disease The results of dexamethasone suppression tests in children with Cushing s ... The diagnosis of Cushing s disease is based on the clinical suspicion and biochemical confirmation of hypercortisolism Lack of a diurnal rhythm in serum cortisol levels is the most sensitive index...

Ngày tải lên: 22/03/2014, 10:20

... diagnosis of primary SjS [6] This is because antibodies to SSA and SSB are not specific to SjS, but are also found in other rheumatological diseases including systemic lupus erythematosus (SLE), ... the same samples, which measures antibodies to both Ro52 and Ro60 proteins, had 72% sensitivity but included ELISA borderline positive cases These results suggest that QLIPS Ro52-Δ2 test shows similar ... antibodies associated with infectious agents, the detection of autoantibodies associated with autoimmunity requires more sensitive tests than ELISAs or other solid phase immunoassays such as protein...

Ngày tải lên: 18/06/2014, 15:20

... prevalence of depression in PSS is consistent with that of previous studies Valtysdottir measured psychological status in a Swedish cohort (N = 67) of PSS patients and reported that possible depression ... details on this scale see Additional file 1, Table S1 ); and, depressed mood with the Center for Epidemiologic Studies Depression Scale(CESD) [16] The PROFAD-SSI was also used to assess sicca severity ... cohorts [7,22] The mean time to diagnosis of years in our patients is not unusual for PSS possibly due to the nonspecific nature of the presenting symptoms or to poor physician awareness of PSS in...

Ngày tải lên: 18/06/2014, 18:20

... general, this consideration holds for all autoimmune diseases Psychiatric presentation of primary SS also suggests that mental disorders not occur only as a response to a psychological distress or a ... the present article, we report two cases of mental disorders as clinical presentations of primary SS, suggesting that psychiatrists should keep in mind that SS can be a potential cause of psychiatric ... neuropathological mechanisms of SS are unknown In CNS-SS, the most serious neuropsychiatric disorder appears to result from ischaemic damage caused by vasculitis [7], but the role of anti-Ro/SS-A alone or...

Ngày tải lên: 08/08/2014, 23:21

... GC structures in patients with pSS, despite evidence of clonally expanded B cells in the tissue Analysis of B cell subsets in Sjögren s syndrome allows differentiation from SLE Several groups, ... found to be expressed in these cells On the basis of the available data on the distribution of B cell subsets in SLE versus pSS, there is increasing evidence that diseases associated with immunologic ... Sjögren s Syndrome Assessment of the European classification criteria for Sjögren s syndrome in a series of clinically defined cases: results of a prospective multicentre study The European Study...

Ngày tải lên: 09/08/2014, 01:21

... (mycobacterium-induced systemic lupus erythematosus 1) This might suggest shared disease pathways in different models for autoimmune diseases controlled by the same genes within this interval On the basis of potential ... homeostasis of lipids, lipoproteins, cholesterols, and fatty acids Secondary effects of impaired lipid homeostasis could result in inflammation and cell death Results from a recent gene-expression study ... on chromosome [1] Dissections of disease loci in models for autoimmune diseases have shown that one locus can contain more than one gene linked to disease [5,6] In one study, a locus of approximately...

Ngày tải lên: 09/08/2014, 01:22

... autoimmune diseases such as RA and Crohn 's disease [13,28,29,39] make this cytokine a prime candidate also in the pathogenesis of SS Increased serum levels and salivary gland expression of IL18 in ... increased in SS patients with anti-SSA/Ro+ and anti-SSB/ La+ antibodies The strength of this association was further emphasized by the positive correlation of IL-18 serum levels with both anti-SSA/Ro ... macrophages, an observation that suggests an activation state of macrophages These observations reinforce an otherwise underestimated role of this cell type in the pathogenesis of SS, as also recently...

Ngày tải lên: 09/08/2014, 01:23