et 743 in sts soft tissue sarcoma

... Brennan MF: Soft tissue sarcomas Curr Probl Surg 1996, 33(10):817-872 Miettinen M, Sarlomo-Rikala M, Sobin LH, Lasota J: Gastrointestinal stromal tumors and leiomyosarcomas in the colon: a clinicopathologic, ... All authors reviewed the manuscript and approved the final version Competing interests The authors declare that they have no competing interests Received: 26 April 2010 Accepted: 12 September 2010 ... surgery for intraabdominal or retroperitoneal sarcoma comparing primary and first recurrence sarcomas undergoing radical (R0) and non-radical (R1 + R2) surgery Radicality, but not whether the sarcoma...

Ngày tải lên: 09/08/2014, 03:22

... distant metastases, explaining why local control only partly translates to overall disease control According to the latest meta-analysis concerning adjuvant chemotherapy in resected soft tissue sarcoma, ... this article as: Eckert et al., Definitive radiotherapy and Single-Agent radiosensitizing Ifosfamide in Patients with localized, irresectable Soft Tissue Sarcoma: A retrospective analysis Radiation ... Clin North Am 2008, 88:629-646 viii Thornton K: Chemotherapeutic management of soft tissue sarcoma Surg Clin North Am 2008, 88:647-660 viii Raut CP, Pisters PW: Retroperitoneal sarcomas: Combined-modality...

Ngày tải lên: 09/08/2014, 09:20

... assessment in a prospective study Competing interests The authors declare that they have no competing interests Authors' contributions GAV carried out the search, acquisition and interpretation ... an interesting option to multidisciplinary management of STS In the current study we report our experience treating STS with HBRT in 18 patients who were submitted to BRT alone or in combination ... subtypes include alveolar soft part sarcoma (n = 6), synovial cell sarcoma (n = 5), rhabdomyosarcoma embryonary (n = 5), fibrosarcoma (n = 1), indifference sarcoma (n = 1) All patients had intermediate...

Ngày tải lên: 09/08/2014, 09:22

... who underwent IORT for soft- tissue sarcoma 29/ 38 patients were treated for primary sarcomas, in the remaining nine the disease had recurred The mean age at the beginning of treatment was 56 ... of soft tissue sarcomas Der Orthopaede 2003, 32:1143-1150 Sindelar WF, Kinsella TJ, Chen PW, DeLaney TF, Tepper JE, Rosenberg SA, Glatstein E: Intraoperative radiotherapy in retroperitoneal sarcomas ... Delannes M, Minsat M, Stoeckle E, Votron L, Martel P, Bonnevialle P, Nguyen Bui B, Chevreau C, Kantor G, et al.: Low-dose intraoperative brachytherapy in soft tissue sarcomas involving neurovascular...

Ngày tải lên: 09/08/2014, 10:20

... Pulmonary metastasis was detected at diagnosis in all alveolar soft part sarcoma cases and in one clear cell sarcoma case However, no distant metastasis was detected in the other tumor cases In six ... [14-16] Since most soft tissue sarcomas lack defined radiological characteristics, it is not easy to differentiate sarcomas, even by MRI Nonetheless, alveolar soft part sarcomas have specific imaging ... following unplanned excision of soft tissue sarcoma of an extremity J Bone Joint Surg 1996, 78A:650-5 Simon MA, Enneking WF: The management of soft- tissue sarcomas of the extremities J Bone Joint...

Ngày tải lên: 09/08/2014, 03:22

... Immunohistochemical staining including cytokeratin, desmin, actin, S-100, synaptophysin, HMB45, chromogranin, vimentin, myoglobin and PAS was performed All stains were negative apart from PAS and myoglobin which ... obtained from the next of kin for reporting of this case, the copy of consent is available with editor in chief Competing interests The authors declare that they have no competing interests MB ... X-rays in 1983 showed complete disappearance of some shadows and shrinkage of others [13] In a study conducted by Kebudi R et al between 1989 and 2002, the incidence of brain metastases in extracranial...

Ngày tải lên: 09/08/2014, 04:21

... manuscript TRF was involved in clinical care of patients included in the data set and reviewed the manuscript Competing interests The authors declare that they have no competing interests Received: ... set and reviewed the manuscript AJS was involved in clinical care of patients included in the data set and helped draft the manuscript MDC was involved in clinical care of patients included in ... extremity soft- tissue sarcoma patients treated with surgery alone, neoadjuvant chemoradiation, or neoadjuvant radiation alone interpreting this finding, since only 12 patients with extremity STS larger...

Ngày tải lên: 09/08/2014, 09:20

... streptavidin-biotin method, with a Vecta Elite ABC staining kit (Vector Laboratories) The slides were rinsed in phosphatebuffered saline, exposed to diaminobenzidine, and counterstained with ... observed in high and intermediate grade soft tissue tumors compared to benign tumors Lane 1: malignant soft tissue tumor; lane 2: intermediate soft tissue tumor; lane 3: benign soft tissue tumor ... with clinical parameters Histopathological parameters were studied using μm thick paraffin sections stained with Hematoxylin and Eosin and the tumors were broadly classified into benign, intermediate...

Ngày tải lên: 10/08/2014, 10:21

... The role of SLNB in the management of soft tissue sarcoma has yet to be defined [8,9,13] In our institution it is current practice to undertake SLNB in patients with epithelioid sarcoma given the ... that the rate of lymph node metastasis in extremity deep soft tissue leiomyosarcomas to be 7% Lamyman et al Clinical Sarcoma Research 2011, 1:7 http://www.clinicalsarcomaresearch.com/content/1/1/7 ... contain intratumoural lymphatics [12]; intratumoural lymphatics were found to be present in all epithelioid sarcomas and a number of other sarcomas including leiomyosarcoma Lymph node metastasis...

Ngày tải lên: 13/08/2014, 15:21

... (chromosome 13q14) in patients with inherited retinoblastoma is associated with the development of osteosarcoma in those who survive the retinoblastoma and of soft tissue sarcomas unrelated to ... tumor-suppressor gene p53 and an increased incidence of soft tissue sarcomas and other malignancies, including breast cancer, osteosarcoma, brain tumor, leukemia, and adrenal carcinoma (Chap 79) Neurofibromatosis ... Soft tissues include muscles, tendons, fat, fibrous tissue, synovial tissue, vessels, and nerves Approximately 60% of soft tissue sarcomas arise in the extremities, with...

Ngày tải lên: 07/07/2014, 02:20

... infrequently but, when they do, have a predilection for unusual metastatic sites containing fat, such as the retroperitoneum, mediastinum, and subcutaneous tissue Rhabdomyosarcomas, Ewing's sarcoma, ... previously classified as gastrointestinal leiomyosarcomas, are now recognized as a distinct entity within soft tissue sarcomas Its cell of origin resembles the interstitial cell of Cajal, which ... compromising a definitive resection Lymph node metastases occur in 5%, except in synovial and epithelioid sarcomas, clear-cell sarcoma (melanoma of the soft parts), angiosarcoma, and rhabdomyosarcoma,...

Ngày tải lên: 07/07/2014, 02:20

... etoposide, and irinotecan are effective in rhadomyosarcomas and Ewing's sarcomas Imatinib mesylate targets the KIT tyrosine kinase activity and is standard therapy for advanced/metastatic GISTs ... second-line regimen and is particularly active in patients with leiomyosarcomas Dacarbazine also has some modest activity Taxanes have selective activity in angiosarcomas, and vincristine, etoposide, ... encompassed, and in higher doses to compensate for hypoxia in the operated field Brachytherapy or interstitial therapy, in which the radiation source is inserted into the tumor bed, is comparable in efficacy...

Ngày tải lên: 07/07/2014, 02:20

... adamantinoma (of unknown origin), and hemangioendothelioma (of vascular origin) Musculoskeletal Tumor Society Staging System Sarcomas of bone are staged according to the Musculoskeletal Tumor Society ... or distant metastases In addition, the tumor is given a letter reflecting its compartmental localization Tumors designated A are intracompartmental (i.e., confined to the same soft tissue compartment ... compartment as the initial tumor), and tumors designated B are extracompartmental (i.e., extending into the adjacent soft tissue compartment or into bone) The tumor node metastasis (TNM) staging system...

Ngày tải lên: 07/07/2014, 02:20

... osteosarcomas The remaining 25% are classified as "variants" on the basis of (1) clinical characteristics, as in the case of osteosarcoma of the jaw, postradiation osteosarcoma, or Paget's osteosarcoma; ... margin of the soft tissue mass (Codman's triangle) A CT scan of the primary tumor is best for defining bone destruction and the pattern of calcification, whereas MRI is better for defining intramedullary ... Osteosarcoma Osteosarcoma, accounting for almost 45% of all bone sarcomas, is a spindle cell neoplasm that produces osteoid (unmineralized bone) or bone About 60% of all osteosarcomas occur in...

Ngày tải lên: 07/07/2014, 02:20

... Ewing's sarcoma Ewing's Sarcoma Ewing's sarcoma, which constitutes ~10–15% of all bone sarcomas, is common in adolescence and has a peak incidence in the second decade of life It typically involves ... cell-surface marker for Ewing's sarcoma (and other members of a family of tumors called PNETs) Most PNETs arise in soft tissues; they include peripheral neuroepithelioma, Askin's tumor (chest wall), ... cytoplasm detected by staining with periodic acid–Schiff is also characteristic of Ewing's sarcoma cells The classic cytogenetic abnormality associated with this disease (and other PNETs) is a...

Ngày tải lên: 07/07/2014, 02:20

... bone-related clinical events and may reduce the incidence of bone metastases in women with breast cancer When the integrity of a weight-bearing bone is threatened by an expanding metastatic lesion ... the Ewing's family of sarcomas in adult patients Oncologist 11:65, 2006 [PMID: 16401715] Verweij J et al: Progression-free survival in gastrointestinal stromal tumors with high-dose imatinib: ... Sparing Treatment of Adult Soft Tissue Sarcomas and Osteosarcomas JAMA 254:1791, 1985 Roth JA: Resection of pulmonary metastases from osteogenic sarcoma Cancer Bull 42:244, 1990 Wittig JC et al:...

Ngày tải lên: 07/07/2014, 02:20

... experienced soft tissue pathologists of our institution In two cases (patient and 9), tissue specimens were sent in for second opinion to another experienced soft tissue pathologist In both cases, ... Alveolar soft part sarcoma (ASPS) is a very rare type soft tissue sarcoma (STS) , with several unusual features, such as a very young peak age incidence and frequent metastatic spread to the brain [1] ... no metastatic disease was detected in any patient A definite tumor grading according to accepted grading classifications (Coindre classification) was not applied due to the difficulty of using...

Ngày tải lên: 09/08/2014, 07:21

... Hematoxylin and eosin (A, B) staining of the lesion and representative immunostaining images (C-F) Hematoxylin and eosin (A, B) staining of the lesion and representative immunostaining images ... Consent Written consent was obtained from the patient for publication of this case report Competing interests The authors declare that they have no competing interests Authors' contributions Figure ... especially in differential diagnosis with soft tissue sarcoma [22] On the contrary Bozas et al described a case of abdominal wall mass (10 × 18 cm) situated between the abdominal muscles and in which...

Ngày tải lên: 09/08/2014, 07:21

... et al Figure binant human matrix metalloproteinase (MMP) protein expression in human fibroblasts by Staphylococcus aureus grown in the presence of recomPotentiation ofinterleukin (rhIL)-1β binant ... infections, initiating immune responses, and in tissue remodeling [9] Excessive MMPs cause matrix degradation and joint destruction as in various forms of arthritis [10] Cytokines interleukin (IL)-1, ... strain) Fibroblasts were cultured in an incubator containing a humidified atmosphere containing 5% CO2 at 37°C Fibroblasts were cultured for hours for RNA analysis and 48 hours for protein analysis...

Ngày tải lên: 09/08/2014, 08:23

... of soft- tissue perineurioma in the retroperitoneum have not been reported The soft- tissue perineurioma in this report was similar to the one in the subcutis of the groin [5]: well-defined margins ... read and approved the final version of the manuscript Competing interests The authors declare that they have no competing interests Funding was neither sought nor obtained Received: January 2010 ... tumor Discussion Perineuriomas are uncommon benign peripheral nerve sheath tumors that include four subtypes: soft tissue, intramural, sclerosing, and reticular Soft- tissue perineuriomas are the...

Ngày tải lên: 11/08/2014, 03:21