estimating the fatigue stress concentration factor of machined surfaces

... joints, stress concentrations occur at the weld toe or at the weld root, which make these regions the points from which cracks may initiate  The values of stress intensity factor (KI) for the weld ... load The applied edge stress for the model was based on the development of the yield stress over the net cross-section Effect of Crack Position (Toe, Root or ColdLab) on SIF, KI In this case the ... because of the stress concentration in the weld toe region, while lack of penetration defects result from inaccessibility of the root region during welding Figure (9): Values of Maximum Stress...

Ngày tải lên: 24/05/2014, 20:40

... Yap1, the major regulator of the oxidative stress response, comparatively less is known about the remaining family members Oxidative stress The response to oxidative stress can be described as the ... the formation of an intermolecular bond occurs between the Orp1 Cys36 and the Cys598 of Yap1 leading to its activation The subsequent formation of the Yap1 Cys303-Cys598 disulfide bond masks the ... localization of the fusion protein correlates not only with activation of FRM2 transcription, but also with growth in increasing concentrations of cadmium but not of H2O2 Because of the high degree of...

Ngày tải lên: 30/03/2014, 16:20

... in the natural direction of their internal clock Mark the letter A, B, C, or D on your answer sheet to indicate the word that differs from the rest in the position of the main stress in each of ... Which of the following is TRUE of the Shoshone and Ute? 11 Mark the letter A, B, C, or D on your answer sheet to indicate the word that differs from the rest in the position of the main stress ... lost in the fire D The people were saved but the house was lost Question 12: The company turned down Hung’s offer A The company offered Hung a job B The company accepted Hung’s offer C The company...

Ngày tải lên: 08/10/2014, 16:46

... by the weather A Because of the bad weather, our excursion to London was put off later B Our plans for an excursion to London have fallen through because the weather was so bad C The bad weather ... mark the letter A B C or D on your answer sheet to indicate the correct answer to each of the questions The three phrases of the human memory are the sensory memory, the short-term memory, and the ... time for their children B Busy at work as they are, they try to find time for their children C Busy as they are at work, they try to find time for their children D They rarely have time for their...

Ngày tải lên: 08/10/2014, 16:46

... corresponding to an oxygen concentration of approximately to 11% [13] Since O2 must enter from the cartilage surface, the concentration of oxygen is approximately 6% at the surface zone of the articular tissue ... Arthritis Research & Therapy Vol No Yudoh et al growth factor (VEGF) [6-8] HIF-1 is a heterodimer of the PAS subfamily of basic-helix-loop-helix transcription factors, and it consists of the subunit HIF-1α ... during the progression of OA Our data show here for the first time a correlation between the levels of expression of HIF-1α and degeneration of articular cartilage in patients with OA To clarify the...

Ngày tải lên: 09/08/2014, 06:23

Ngày tải lên: 09/08/2014, 07:20

Ngày tải lên: 13/02/2014, 12:20

... initiation of apoptosis through the mitochondrial pathway The key event in the mitochondrial pathway is the release of proapoptotic factors from the mitochondrial intermembrane space into the cytosol, ... release of cytochrome c and second mitochondria-derived activator of caspase (Smac ⁄ DIABLO) allows for the formation of the apoptosome, a complex that enables the activation of caspases within the ... version of Itch together with Bid or tBid fused to green fluorescent protein (GFP) at the C-terminus We then immunoprecipitated FLAG–Itch and looked for the presence of GFP fusions in the immunoprecipitated...

Ngày tải lên: 16/02/2014, 09:20

... development of the lens and maintenance of the olfactory epithelium [102] The first evidence for a developmental function of HSF4 was provided by population genetic studies where mutations of the Hsf4 ... how the developmental activity of HSF1 is regulated The identity of the developmental signal that promotes a monomer-to-trimer transition of HSF1 in the olfactory epithelium warrants further ... In accordance with the fundamental role of HSF1 in the heat shock response, the requirement of HSF1 and HSF4 in development of the lens and olfactory epithelium is limited to the postnatal period,...

Ngày tải lên: 18/02/2014, 04:20

... in the central cylinder of the root, but not in the lower parts of the hypocotyl (a) Rosette leaves were stained in the vascular tissue of the leaf blade, whereas the petiole and older parts of ... has the potential to predict possible protein binding to the BPMs It will also be of importance to define the functional impact of the BPM family on the activity of ERF ⁄ AP2 transcription factors ... leaves and in the anthers of differentiated flowers We also detected meagre expression along the root, with most obvious staining present at the lateral root primordia and the base of the lateral...

Ngày tải lên: 18/02/2014, 06:20

... conflict with the global interpretation of the data With the exclusion of the N-terminal octapeptidyl and C-terminal nonapeptidyl fragments of Glu17, Leu34 and Lys46, the average of the {1H}–15N ... values of J(0) and J(xN), an indication of slow local motion consistent with the presence of a hydrogen bond network that restricts the excursion of the Glu50 backbone Other relevant details of the ... unreliable within the framework of the theory This could arise from the very wellknown limitations of MF formalism for the case of internal motions occurring on a timescale similar to that of the overall...

Ngày tải lên: 18/02/2014, 16:20

... identified [17,19] The smaller isoforms correspond to N-terminal deletions of the fulllength 140 kDa protein The physiological role of the guanine nucleotide exchange activity of the truncated forms ... serotonin The  60 kDa isoform of Ras-GRF1 seems to be expressed at a higher level than the 140 kDa isoform The serotonin-induced increase in phosphorylation of both isoforms was reduced by the coexpression ... truncated forms is not known as they are missing the Ca2+ ⁄ CaM-binding IQ domain that is involved in the activation of Ras-GRF1 Stimulation of all the splice variants of the Gs-coupled serotonin receptor...

Ngày tải lên: 19/02/2014, 18:20

... USA) DNA quanti®cation The DNA content of the cell layer at the end of incubation was quanti®ed by the method of West et al [31] After solubilization of the cell layer in M NaOH and subsequent ... implication of cAMP increase, the second messenger of FSH, in the bFGF regulation was evaluated by addition to the culture medium of either mM dbcAMP or 10 lgámL)1 cholera toxin Their addition ... testicular development, the physiology of Sertoli cells is modi®ed The cell proliferation decreases and ceases allowing the establishment of the hematotesticular barrier around the 20th day postpartum...

Ngày tải lên: 21/02/2014, 03:20

Ngày tải lên: 21/02/2014, 16:20

... and assigned them the task of survey to estimate the burden of disease in the estimating the burden of TB in the country4 The country the country, updating the technique followed heretofore, by ... elicitation' as the initial screening tool, instead of Xrays12 In more recent times, Chakraborty et al found that the estimates of prevalence of disease made by the use of either of the screening ... prevalence of bacteriological and radiological cases5, This, in the first place, was in recognition of the limitation of the yield of bacteriological cases by the investigation of only two samples of...

Ngày tải lên: 06/03/2014, 04:20

... promoters These results show that the configuration of nGAAn units in the promoter is important in determining which hHSF members are involved in the regulation of the gene Footprint analysis of the ... hHSF4–VP16, without changing the magnitude of the heat shock response (cp3) The mutational analysis of the CRYGA and CRYGC HSEs suggests that the nucleotide sequences and configuration of nGAAn-like units ... HSE, as judged from the amount and mobility of the complex (Fig 1B) Notably, the amount of complex formed with hHSF4 and HSEgap or HSEstep was more than 70% that of hHSF4– HSE3P Therefore, like yHSF,...

Ngày tải lên: 07/03/2014, 00:20

... Embassy of the Kingdom of the Netherlands; and the World Bank Implementation of School-Based Management in Indonesia In spite of the hundreds of millions of dollars spent to support implementation of ... Development; the Japan International Cooperation Agency; and the Embassy of the Kingdom of the Netherlands In spite of this high level of support and attention, little is known about the status of implementation ... when they did, they typically sought the approval of their district supervisor or other appropriate district staff One indicator of the reluctance of schools to make independent decisions was the...

Ngày tải lên: 07/03/2014, 02:20

... 1H,15N-HSQC spectra of the M domain of human eRF1 The numbering of the residues corresponds to that of the full eRF1 protein (A) The Gly region of the 15 H, N-HSQC spectrum of the M domain of human eRF1 ... hydrolysis at the PTC of the large ribosomal subunit [20] The three-domain structure of eRF1, with the shape of the protein resembling the letter ‘Y’, partly mimics the ‘L’-shape of the tRNA molecule, ... )42 The mean value in the family of 25 structures and the SD is no preferred conformation of the side-chain in the family 4228 v1 b There Fig The relaxation parameters of the amide 15N spin of...

Ngày tải lên: 07/03/2014, 05:20

Ngày tải lên: 09/03/2014, 09:20

... from the actual winner to the alleged winner, then a margin of victory of a fraction v of the votes cast by the alleged winner must have involved at least a fraction v/(2 ∗ 0.20) = 2.5v of the ... note we call f the “fraud rate.” Given one of b or f , the other is determined, via equation (2) In a voting context, the value of b might be the requisite number of precincts that the adversary ... most of the sand grains are white, but a fraction f of the grains are black, you may only need to sample a handful of the sand to be confident of obtaining a black grain, no matter whether the...

Ngày tải lên: 15/03/2014, 20:20