erα erβ and prediction of response to therapy

... Measured therapy response (V30) Figure Schematic synopsis of the study Androgen-sensitive prostate carcinoma xenografts received combinations of androgendeprivation therapy (ADT) and/ or radiotherapy ... networks and the bias/ variance dilemma Neural Comput 1992, 4:1-58 doi:10.1186/1748-717X-6-65 Cite this article as: Røe et al.: Early prediction of response to radiotherapy and androgen-deprivation therapy ... in addition to the established clinical parameters, will contribute to improve the prediction of therapeutic efficacy To explore whether the combined use of pre-treatment and early therapy- induced...

Ngày tải lên: 09/08/2014, 09:20

... taking account of the negative correlation, -1/(n - 1), of values of X - X of family members F Rawlings (1976) and Hill (1976, used by Toro and P6rez-Enciso, 1990) give formulae to correct selection ... all families and there are very many families, 25% of individuals of each sex are selected giving iT 1.271 and in 1.029 (from tables A and B, respectively, in the appendix of Falconer and Mackay, ... schemes, and uses formulae to describe SWF which actually relate to SDM Correct results for both cases are given by Dempfle (1990) and applied by Toro and P6rez-Enciso (1990), but seem not to have...

Ngày tải lên: 09/08/2014, 18:22

... inhibition of PKR due to similarity of genotype PePHD domain and phosphorylation domain of PKR and eIF2a [18] In our local HCV isolates of 3a genotype, PePHD domain in those responding rapidly to treatment ... review of its use in the management of chronic hepatitis C monoinfection Drugs 2008, 68:1273-1317 Shiratori Y, Kato N, Yokosuka O, Imazeki F, Hashimoto E, Hayashi N: Predictors of the efficacy of ... out for through comprehension of the study of these unknown factors and mechanisms involved in treatment response Average amino acid composition of polar, non polar and neutral amino acids was...

Ngày tải lên: 11/08/2014, 21:21

... classification and estimation of indices of renal disease activity and chronicity, today offers the best possibility to estimate renal disease and its response to therapy Biopsy is costly and is associated ... biopsies were graded according to a standardized semiquantitative histological scoring protocol for activity and chronicity indices [31] Renal disease activity and response to therapy Renal disease activity ... therefore to compare anti-CRP antibody levels in well-characterized lupus nephritis patients and to seek potential associations with histopathology, renal activity and response to therapy Materials and...

Ngày tải lên: 12/08/2014, 11:22

... treatment with topical imiquimod and systemic temozolomide, was referred to another institution for a phase II clinical trial of PLX4032 As part of the eligibility requirements of the trial, paraffin-embedded ... tissue from a biopsy of a cutaneous lesion was tested and shown to be positive for the BRAF V600E mutation The patient was treated and achieved an excellent clinical response to PLX4032, associated ... between the V600E and V600K mutations Our preclinical data demonstrating similar kinase activity of the V600K and V600E mutations, together with clear evidence of clinical activity of PLX4032 in...

Ngày tải lên: 18/06/2014, 16:20

... predictive of response to both conventional cytotoxic and target therapy drugs [11] Platinum or platinum-based regimens are the treatment of choice in ovarian cancers, which remains the leading cause of ... adriamycin; 8, 80 and 800 μM of carboplatin; 4, 40 and 400 μM of gemcitabine; and 0.6, and 60 μM of taxol Drugs were used at concentrations corresponding to peak plasma levels and were also tested ... series of patients Discussion Prediction of response to drugs at preclinical level could help physicians to plan more effective tailored therapy for individuals, reduce undesirable drug toxicity and...

Ngày tải lên: 18/06/2014, 19:20

... genetics of the hematological cell line panel was reviewed in relation to Aurora inhibition by GSK1070916 Expression profiles of Aurora A, B, and C were evaluated in terms of response to Aurora ... ease of measurement, low costs, and biological relevance as a negative predictor of response to Aurora inhibition, can be a powerful tool to enrich patients that can potentially respond to GSK1070916 ... hematological cancer cell lines is a Negative Predictor of Response to the inhibition of Aurora B and C by GSK1070916 Journal of Translational Medicine 2011 9:110 Submit your next manuscript to...

Ngày tải lên: 18/06/2014, 22:20

... predictive of response to both conventional cytotoxic and target therapy drugs [11] Platinum or platinum-based regimens are the treatment of choice in ovarian cancers, which remains the leading cause of ... adriamycin; 8, 80 and 800 μM of carboplatin; 4, 40 and 400 μM of gemcitabine; and 0.6, and 60 μM of taxol Drugs were used at concentrations corresponding to peak plasma levels and were also tested ... series of patients Discussion Prediction of response to drugs at preclinical level could help physicians to plan more effective tailored therapy for individuals, reduce undesirable drug toxicity and...

Ngày tải lên: 20/06/2014, 04:20

... genetics of the hematological cell line panel was reviewed in relation to Aurora inhibition by GSK1070916 Expression profiles of Aurora A, B, and C were evaluated in terms of response to Aurora ... ease of measurement, low costs, and biological relevance as a negative predictor of response to Aurora inhibition, can be a powerful tool to enrich patients that can potentially respond to GSK1070916 ... hematological cancer cell lines is a Negative Predictor of Response to the inhibition of Aurora B and C by GSK1070916 Journal of Translational Medicine 2011 9:110 Submit your next manuscript to...

Ngày tải lên: 20/06/2014, 04:20

... square root of the joint counts and the natural logarithm of CRP and ESR) Robustness of the discriminant analyses and logistic regressions was confirmed by the use of a random train and test set ... time and the DAS28 response (no, moderate or good) and the ACR (American College of Rheumatology) response (no/20/50) were computed [12,13] Table Formulae to calculate the different DAS and SDAI ... measure of insufficient response to infliximab It might be questioned which variables can be measured to best evaluate the effect of therapy and remaining disease activity in daily practice (and...

Ngày tải lên: 09/08/2014, 06:23

... cultures by the addition of several cytokines or combinations of cytokines: TNF-, IL-1, the association of TNF- and IL-17, and the association of TNF- and IL-1 Page of 13 (page number not for ... A-LM helped to acquire the data BJVdE, PD, and FAH helped to design the study and contributed to the writing of the manuscript BRL helped to design the study and to acquire, analyze, and interpret ... CD15+, and CD20+ cells (evaluated by digital quantification) according to response to therapy Effects of adalimumab therapy on synovial gene expression profiles Next, we investigated the effects of...

Ngày tải lên: 09/08/2014, 14:20

... CT and TT) and alleles (C and T) with patient’s baseline characteristics including patient’s age, gender, specimen histology, stage of the disease and presence or absence of B-symptoms (Table and ... the MDR1 C3435T polymorphism and the risk to develop HL, as well as the clinical response to ABVD chemotherapy regimen Methods Studied groups A total of 130 samples of paraffin-embedded tissue ... histology, disease stage and presence or absence of Bsymptoms (Table 5) None of these factors were associated with clinical response in HL patients (P value > 0.05) Table shows the genotype and...

Ngày tải lên: 10/08/2014, 10:21

... production of cytokines, specialized cytokines called chemokines and cell adhesion molecules [9] Chemokines belong to a superfamily of cytokines that promote chemotaxis of leukocytes to areas of infection, ... Comparison of mRNA, plasma and lavage concentrations of MIP-2 in the control, neutropenic, endotoxemic and neutropenic, endotoxemic groups * Plasma MIP-2 is higher in endotoxemic rats compared to control ... an imbalance of vasodilators and vasoconstrictors or impaired sensitivity to vasoactive mediators is the cause of the low oxygenation Further investigation into the cause of this early deterioration...

Ngày tải lên: 11/08/2014, 08:21

... charge of V3 is not available for co-receptor prediction of HIV-1 B’ subtype exposed to drug V3 loop, as the major determinant of viral tropism, is a base of lots of prediction essays of co-receptor ... and analyzed with flow cytometer (Elite ESP, Beckman Coulter, Germany) and a total of 10,000 to 15,000 events were scored We expected an approximately 10 fold shift in mean GFP fluorescence of ... Shankarappa R, Margolick JB, Mullins JI: Improved coreceptor usage prediction and genotypic monitoring of R5 -to- X4 transition by motif analysis of human immunodeficiency virus type env V3 loop sequences...

Ngày tải lên: 12/08/2014, 01:22

... at each time point Elicitor treatment Elicitors were sprayed to run-off using a hand-pumped atomizing sprayer Elicitors were diluted in water and were applied to hours into the light cycle INA ... frog and slice methods seemed equivalent with respect to PR gene induction and the severity and rate of development of disease symptoms We chose to use the florist's frog method as our standard ... Figure Expression of apple PR genes in response to treatment with SAR elicitors Expression of apple PR genes in response to treatment with SAR elicitors Northern hybridization of RNA preparations...

Ngày tải lên: 12/08/2014, 05:20

... relationship of PHA response and MD resistance is not clearly understood A line of chickens selected for high plasma corticosterone had an impaired in vitro response of lymphocytes to PHA and greater ... easier to measure as wattles tended to be soft and pliable Of the doses tested, 500 and 1250 mg gave similar swelling responses in the wing web The procedure used in exp was similar to that of Van ... levels of response to PHA in this study were lower than those observed by Van der Zijpp (1983) and Lamont and Smyth (1984) This discrepancy may be due to the lower dose of PHA and older age of the...

Ngày tải lên: 14/08/2014, 20:20

... Cán cân to n (BOP)  Cán cân to n BOP:   Tóm tắt kết giao dịch xuyên biên giới quốc gia, thường năm Giao dịch quốc tế:    Hàng hoá dịch vụ Vốn/Tài Dự trữ ngoại tệ Dòng vốn Cán cân to n •Cán ... tế:    Hàng hoá dịch vụ Vốn/Tài Dự trữ ngoại tệ Dòng vốn Cán cân to n •Cán cân to n BOP quốc gia (balance of payments) tóm tắt giao dịch với phần lại giới •Tài khoản vãng lai (current account) ... đoái Tỷ giá hối đoái danh nghĩa thực Cán cân to n (BOP) & biến lưu lượng (Flows): trade balance, current a/c, capital & financial a/c Biến trữ lượng (Stocks): net foreign assets, debt 8/2/2014 Vai...

Ngày tải lên: 15/11/2014, 13:59

... application rates of 0.5 wt% and 1.0 wt% Alkali soil and gypsum were mixed uniformly and were packed in an acrylic ring with an outer diameter of 60 mm, inner diameter of 50 mm, and height of 20 mm at ... 20 mm at a bulk density of 1.53 g/cm3 The acrylic rings were filled up to a height of 20 cm Degassed water was poured onto the top of the column at a rate of 1.0×10-3 to 2.0× 10-3 cm3/s using ... Inoue and Shiozawa (Inoue and Shiozawa, 1994) In our research, a four-electrode sensor was used as an indicator of the total salt concentration in the soil column, to observe the runoff rate of...

Ngày tải lên: 05/09/2013, 09:38

... eutrophication of West Lake by biomass of phytoplankton Biomass of phytoplankton is an indicator of eutrophication, so it is possible to estimate and especially predict eutrophication by phytoplankton model ... zooplankton, 11 species of benthos and about 33 species of fish According to Vietnam standard of water quality, the important parameters of water quality of West Lake, including: Phosphorous and ... model of phytoplankton with a variety of major components of lake ecosystems: dB p / dt = ( Pnet , p − G p, z − U p − M p ) B p , where Bp: biomass of phytoplankton; Pnet,p: growth rate of phytoplankton;...

Ngày tải lên: 13/02/2014, 12:20

... inspection of the structural models In the light of this achievement, we have applied a similar approach Prediction of p53 mutant severity to p53 to arrive at an automated method for the prediction of ... activity of promoter binding The aim was to obtain a better understanding of molecular mechanisms to explain why certain mutations cause more severe effects than others and to be able to predict ... classified correctly in 85% of cases and Table Effect of cut-off value on the prediction accuracy The prediction accuracy, specificity, sensitivity, number of mutants classified and MCC values on training...

Ngày tải lên: 18/02/2014, 11:20