epstein barr virus b cell infection

... Figure virus-< /b> specific T -cell response Correlation between the Epstein-< /b> Barr < /b> virus < /b> viral load and Epstein-< /b> Barr < /b> virus-< /b> specific T -cell response Correlation between the number of IFNγproducing T cells ... 496 AVLLHEESM B3 5 BZLF1 B3 5.01 EBNA1 EPLPQGQLTAY 407 to 417 HPVGEADYFEY B3 9 EBNA3C 271 to 278 HHIWQNLL B4 4 EBNA 3B 567 to 666 VEITPYKPTW B4 4.02 EBNA3C 281 to 290 EENLLDFVRF B4 4.02 EBNA3C 335 to ... of (page number not for citation purposes) gitudinal study Epstein-< /b> Barr < /b> virus < /b> load in peripheral blood mononuclear cells in the longitudinal study (a) Epstein-< /b> Barr < /b> virus < /b> (EBV) load between week...

Ngày tải lên: 09/08/2014, 14:21

... symbol ETT ORCTL3 FLIPT1 EMT OCT1 SLC22A4 SLC22A13 SLC22A16 SLC22A3 SLC22A1 pEBTet pEBTet pEBTet pEBTet pEBTet OCT2 SLC22A2 pEBTet CAT4 SLC7A4 pEBTet pEBTetD pEBTetD pEBTetD be influenced by the ... (1985) Mapping genetic elements of Epstein< /b> Barr < /b> virus < /b> that facilitate extrachromosomal persistence of Epstein< /b> Barr < /b> virus-< /b> derived plasmids in human cells Mol Cell Biol 5, 2533–2542 Young JM, Cheadle ... infrequent, epigenetic event Mol Cell Biol 21, 4149–4161 Yates JL, Warren N & Sugden B (1985) Stable replication of plasmids derived from Epstein< /b> Barr < /b> virus < /b> in various mammalian cells Nature 313, 812–815...

Ngày tải lên: 23/03/2014, 09:21

... Okita K, Takada K: EpsteinBarr virus < /b> promotes epithelial cell growth in the absence of EBNA2 and LMP1 expression J Virol 1999, 73:1286-1292 Rickinson AB, Kieff E: Epstein-< /b> Barr < /b> Virus < /b> In Fields Virology ... established rodent cells Cell 1985, 43:831-840 Wei MX, Ooka T: A transforming fonction of the BARF1 gene encoded by Epstein-< /b> Barr < /b> Virus < /b> EMBO J 1989, 8:2897-2903 Hayes DP, Brink AA, Vervoort MB, ... activity of Epstein-< /b> Barr < /b> virus-< /b> encoded BARF1 protein Oncogene 2004, 23:4938-4944 Wang Li, Tam JP, Liu DX: Biochemical and functional characterization of Epstein-< /b> Barr < /b> virus-< /b> encoded BARF1 protein:...

Ngày tải lên: 20/06/2014, 01:20

... Gothoskar B: Sensitivity of Epstein-< /b> Barr < /b> virus < /b> (EBV) producer and non-producer human lymphoblastoid cell lines to superinfection with EB -virus < /b> Int J Cancer 1972, 10(1):44-57 Epstein < /b> MA, Achong BG, Barr < /b> ... some from lytic EBV infection (e.g., BZLF1/ Zta, BXLF2/gp85, BKRF2/gL and BZLF2/gp42) (Table 1B) We used B9 5.8 RNA as positive control and RNA from the EBV-negative BL cell line BJAB as a negative ... EBV-harboring BL cell lines The reference cell line B9 5.8 displays a latency III expression pattern, but about 5% of the cells display lytic EBV infection Thus, B9 5.8 is expected to transcribe...

Ngày tải lên: 20/06/2014, 01:20

... HTLV-1: human T -cell lymphotropic virus < /b> type 1; HIV: human immunodeficiency virus;< /b> VCA: anti -Epstein-< /b> Barr < /b> virus-< /b> viral capsid antigen; EBNA: anti -Epstein-< /b> Barr < /b> virus < /b> nuclear antigen; LN: lymph node; ... with multilineage dysplasia; EBV: Epstein-< /b> Barr < /b> virus;< /b> T-LPD: T -cell lymphoproliferative disorder; WBC: white blood cell; CRP: C-reactive protein; ANA: anti-nuclear antibody; NSAIDs: anti-non steroid ... Blaese RM: Abnormally elevated frequency of Epstein-< /b> Barr < /b> virus-< /b> infected B cells in the blood of patients with rheumatoid arthritis J Clin Invest 1984, 73:1789-1795 Tosato G, Steinberg AD, Blaese RM:...

Ngày tải lên: 10/08/2014, 22:20

... Shurin S, Abramowsky C, Tubbs RR, Sciotto CG, Wahl R, Sands J, Gottman D, Katz BZ, Sklar J: T -cell lymphomas containing Epstein-< /b> Barr < /b> viral DNA in patients with chronic Epstein-< /b> Barr < /b> virus < /b> infections ... Koizumi S: Differential cellular targets of Epstein-< /b> Barr < /b> virus < /b> (EBV) infection between acute EBV-associated hemophagocytic lymphohistiocytosis and chronic active EBV infection Blood 2001, 98:1882-1888 ... Fulminant EBV+ T cell LPD (phenotype: not reported) TCR -b EBV+, rearranged clonal nine/M Unspecified Hemophagocytic syndrome, FIM - Fulminant EBV+ T cell LPD (phenotype: not reported) TCR -b EBV+, rearranged...

Ngày tải lên: 10/08/2014, 23:21

... putative role of EBV has been suggested in 89% of cases of B- cell PTLD [9], no direct role for this lymphotropic virus < /b> has been confirmed in T -cell PTLD EBV infects and immortalizes B cells causing ... unchecked proliferation of EBV-infected cells, as the critical T -cell control of B- cells is lacking in immunosuppressed patients [10] Human T -cell Lymphotropic Virus < /b> (HTLV1) has been reported to cause ... Monomorphic PTLD B- Cell Lymphomas Reactive Plasmacytic Hyperplasia Polyclonal Monoclonal T -Cell Lymphomas Other Types • Diffuse large B cell lymphoma • Burkitt/Burkitt-like lymphoma • Plasma cell myeloma...

Ngày tải lên: 11/08/2014, 02:22

... model of EBV infection Introduction Figure Epstein-< /b> Barr < /b> virus < /b> (EBV) life cycle Epstein-< /b> Barr < /b> virus < /b> (EBV) is transmitted by contact with the infected saliva The current concept holds that EBV invades ... Regulatory T cells xii CHAPTER : INTRODUCTION Humanized mouse model of EBV infection Introduction CHAPTER : INTRODUCTION 1.1 EPSTEIN-< /b> BARR < /b> VIRUS < /b> LIFE CYCLE Epstein-< /b> Barr < /b> Virus < /b> (EBV) is a ubiquitous ... link between Epstein-< /b> Barr < /b> virus < /b> infection of human B cells with lymphoproliferative disease and tumorigenesis viii LIST OF TABLES Table Latent EBV gene expression programs 17 Table EBV latency...

Ngày tải lên: 10/09/2015, 09:22

... EBNA-LP LMP-2A LMP- 2B BZLF1 BRLF1 BARF transcripts EBNA-3 EBNA-4 EBNA-6 EBNA-5 TP-1 TP-2 ZEBRA, EB1, Zta Rta, R BART, CST EBNA, Epstein-< /b> Barr < /b> virus < /b> nuclear antigen; LMP, latent membrane protein; TP, ... Molecular Biology, Vol 174: Epstein-< /b> Barr < /b> Virus < /b> Protocols Edited by: J B Wilson and G H W May © Humana Press Inc., Totowa, NJ Farrell Table EBV Gene Nomenclature EBNA-3A EBNA- 3B EBNA-3C EBNA-LP LMP-2A ... the Epstein-< /b> Barr < /b> virus < /b> BamHI A fragment are detectable in all three forms of virus < /b> latency J Virol 67, 3182–3190 Sadler, R H and Raab-Traub, N (1995) Structural analyses of the Epstein-< /b> Barr < /b> virus...

Ngày tải lên: 10/04/2014, 22:31

... Rickinson AB, Kieff E: Epstein-< /b> Barr < /b> virus < /b> 4th edition Philadelphia (Pennsylvania): Lippincott/Williams & Wilkins; 2001 Crawford DH: Biology and disease associations of EpsteinBarr virus < /b> Philos ... CB, Murray PG: Epstein-< /b> Barr < /b> virus < /b> (EBV) and its associated human cancers – genetics, epigenetics, pathobiology and novel therapeutics Front Biosci 2006, 11:2672-2713 Kelly GL, Rickinson AB: Burkitt ... A, El Gueddari B, Joab I, Benslimane A, Khyatti M: Antibody responses to recombinant Epstein-< /b> Barr < /b> virus < /b> antigens in nasopharyngeal carcinoma patients: complementary test of ZEBRA protein and...

Ngày tải lên: 18/06/2014, 15:20

... for 15 After h blocking in PBS + 0.1% Tween plus 1% bovine serum albumin, cells were incubated with primary antibodies of LMP1 (BD, USA), p-mTOR (Ser2448) and p-4EBP1 (Thr70) (Cell Signaling, ... of Epstein-< /b> Barr < /b> virus < /b> encoded latent membrane protein in the carcinogenesis of nasopharyngeal carcinoma Cellular & molecular immunology 2007, 4(3):185-196 Mainou BA, Everly DN Jr, Raab-Traub N: ... expression Cell culture and plasmids The EBV-negative human NPC cell lines HONE1 and 61 0B, and the EBV-positive NPC cell line C666-1 were incubated in RPMI-1640 medium supplemented with 10% fetal bovine...

Ngày tải lên: 18/06/2014, 16:20

... carcinoma cells to Epstein-< /b> Barr < /b> virus < /b> infection in vitro Laboratory Investigation 2000, 80(8):1149-60 Arrand JR, Rymo L: Characterization of the major Epstein-< /b> Barr < /b> virus-< /b> specific RNA in Burkitt ... carcinoma (NPC), or Epstein-< /b> Barr < /b> virus < /b> (EBV) [1012] The case described below focuses on specific microscopic and ultrastructural alterations in the nasal mucosal cells induced by EBV infection and ... multinuclear cells Electron6Microscopy (128.000×): Epstein-< /b> Barr < /b> Virus < /b> inside Electron Microscopy (128.000×): Epstein-< /b> Barr < /b> Virus < /b> inside multinuclear cells was the most specific method to investigate...

Ngày tải lên: 19/06/2014, 08:20

... carcinoma cells to Epstein-< /b> Barr < /b> virus < /b> infection in vitro Laboratory Investigation 2000, 80(8):1149-60 Arrand JR, Rymo L: Characterization of the major Epstein-< /b> Barr < /b> virus-< /b> specific RNA in Burkitt ... carcinoma (NPC), or Epstein-< /b> Barr < /b> virus < /b> (EBV) [1012] The case described below focuses on specific microscopic and ultrastructural alterations in the nasal mucosal cells induced by EBV infection and ... multinuclear cells Electron6Microscopy (128.000×): Epstein-< /b> Barr < /b> Virus < /b> inside Electron Microscopy (128.000×): Epstein-< /b> Barr < /b> Virus < /b> inside multinuclear cells was the most specific method to investigate...

Ngày tải lên: 20/06/2014, 04:20

... 100bp EBNA- 3B Type (125bp) 300bp 200bp Type (246bp) Type (153bp) Reconfirmation of the Epstein< /b> Barr < /b> virus < /b> (EBV) typing results The mouthwash samples were analyzed by PCR/Southern blot for EBV ... (54.5) EBV-negative (6.0) (1.5) Total 63 (100) 66 (100) EBV, Epstein< /b> Barr < /b> virus < /b> 11 10 Namalwa AG876 dH2O Marker Figure 300bp EBNA-2 Type (186bp) 200bp Type (168bp) 300bp EBNA-3C 200bp Type (149bp) ... induced by Epstein< /b> Barr < /b> virus < /b> infection Br J Dermatol 2002, 146:877-881 Tsai YT, Chiang BL, Kao YF, Hsieh KH: Detection of Epstein< /b> Barr < /b> virus < /b> and cytomegalovirus genome in white blood cells from...

Ngày tải lên: 09/08/2014, 01:23

... interleukin-10 activity by Epstein-< /b> Barr < /b> virus < /b> protein BCRF1 Science 1990, 250:830-832 Cohen JI, Lekstrom K: Epstein-< /b> Barr < /b> virus < /b> BARF1 protein is dispensable for B- cell transformation and inhibits alpha interferon ... lymphocyte responses to Epstein-< /b> Barr < /b> virus < /b> infection Annu Rev Immunol 1997, 15:405-431 Cohen JI: Epstein-< /b> Barr < /b> virus < /b> infection N Engl J Med 2000, 343: 481-492 Kieff E: Epstein-< /b> Barr < /b> virus < /b> and its replication ... 81 82 83 84 85 Vol No Costenbader and Karlson responses to Epstein-< /b> Barr < /b> virus-< /b> determined nuclear antigen (EBNA)-1 and EBNA-2 in acute and chronic Epstein-< /b> Barr < /b> virus < /b> infection Proc Natl Acad Sci...

Ngày tải lên: 09/08/2014, 07:20

... the Epstein < /b> Barr < /b> virus < /b> (EBV) BNLF-1 gene in both malignant and benign EBV associated diseases: High frequency of a 30 bp deletion in Malaysian and Danish peripheral T -cell lymphomas Blood 1994, ... 84:4053-4060 Dolcetti R, Zancai P, De Re V, Gloghini A, Bigoni B, Pivetta B, De Vita S, Carbone A, Boiocchi M: Epstein < /b> Barr < /b> virus < /b> strains with latent membrane protein-1 deletions: prevalence in the Italian ... 30-bp deletion of Epstein-< /b> Barr < /b> virus < /b> latent membrane protein-1 gene has no effect in nasopharyngeal carcinoma Laryngoscope 2006, 116(4):541-546 Tan EL, Peh SC, Sam CK: Analyses of Epstein-< /b> Barr < /b> virus...

Ngày tải lên: 09/08/2014, 07:21

... of Epstein-< /b> Barr < /b> virus < /b> Cancer Res 1981, 41:4253-61 Lerner MR, Andrews NC, Miller G, Steitz JA: Two small RNAs encoded by Epstein-< /b> Barr < /b> virus < /b> and complexed with protein are precipitated by antibodies ... are listed in Table Discussion Epstein-< /b> Barr < /b> virus < /b> is a lymphotropic herpesvirus and its infection rate varies geographically Usually, the clinical course after infection by EBV is indolent However, ... genotyping of Epstein-< /b> Barr < /b> virus < /b> by polymerase chain reaction using three gene loci (EBNA-2, EBNA-3C, and EBER): predominance of type A virus < /b> associated with Hodgkin's disease Blood 1993, 81:3372-81...

Ngày tải lên: 10/08/2014, 10:20

... (cyclophosphamide, doxorubicin, vincristine, and prednisone); EBER: Epstein-< /b> Barr < /b> virus < /b> encoded RNA; EBV: Epstein-< /b> Barr < /b> virus;< /b> HAART: highly active antiretroviral therapy; HIV: human immunodeficiency virus;< /b> HHV-8: ... possible that PEL is being missed as an important subtype of AIDS-related NHL [13] Despite HIV, EpsteinBarr virus < /b> (EBV) and HHV-8 being endemic in Uganda, no case of PEL has, before now, been ... confirmed transmission by blood transfusion [9,10] In sub-Saharan Africa, there have been very few reports of PEL and this is probably because effusions are often not made into cell blocks, and even...

Ngày tải lên: 11/08/2014, 00:22

... 1.00 Abbreviations: EBV, Epstein-< /b> barr < /b> virus;< /b> EBNA-1, Epstein-< /b> barr < /b> virus < /b> nuclear antigen-1; BHRF-1, BamHI fragment H rightward open reading frame-1; VCA, viral capsid antigen; IgG, immunoglobulin ... 103 BHRF-1 Q Unknown HIV BHRF-1 EBNA-1, BHRF-1 P Unknown HIV EBNA-1 BHRF-1 O Unknown HIV Plasma (1/1) BHRF-1 N EBVAHS 1.1 × 105 BHRF-1 M/36y 7.5 × 104 BHRF-1 M EBNA-1 BHRF-1 EBNA-1, Whole Blood ... EBNA-1 is needed for efficient, stable latent infection by Epstein-< /b> Barr < /b> virus < /b> J Virol 1999, 73(4):2974-82 34 Henderson S, et al: Epstein-< /b> Barr < /b> virus-< /b> coded BHRF1 protein, a viral homologue of Bcl-2,...

Ngày tải lên: 12/08/2014, 01:22

... the EBNA1 DNA binding domain, which functions as a dominant negative in EBV infected cells, can inhibit cell viability in uninfected cells, suggesting that EBNA1 binds to and regulates cellular ... expression of EBNA1 activates a subset of genes with EBNA1 binding sites EBV negative Burkitt lymphoma cell line DG75 was transfected with Control vector (grey bars) or with FLAG-EBNA1 (black bars) expression ... Edwards AM: Crystal structure of the DNA-binding domain of the Epstein-< /b> Barr < /b> virus < /b> origin-binding protein, EBNA1, bound to DNA Cell 1996, 84:791-800 12 Bochkarev A, Barwell JA, Pfuetzner RA, Furey WJ,...

Ngày tải lên: 12/08/2014, 01:22