epigenetic epidemiology of inflammation and rheumatoid arthritis

... authors made substantial contributions to conception and design, and to the analysis and interpretation of the data TRM and GWC handled acquisition of data All authors contributed to the manuscript ... activity indices for rheumatoid arthritis: validation of a clinical activity score Arthritis Res Ther 2005, 7:R796-806 van Gestel AM, Haagsma CJ, van Riel PL: Validation of rheumatoid arthritis improvement ... Long-term impact of early treatment on radiographic progression in rheumatoid arthritis: A meta-analysis Arthritis Rheum 2006, 55:864-872 Wolfe F, Michaud K: Resistance of rheumatoid arthritis patients...

Ngày tải lên: 25/10/2012, 10:45

... Health and Quality of Life Outcomes 2009, 7:25 Background Rheumatoid arthritis (RA), ankylosing spondylitis (AS), and psoriatic arthritis (PsA) are three common types of inflammatory ... Genth E, Schneider M, German Collaborative Arthritis Centres: Healthcare and burden of disease in psoriatic arthritis A comparison with rheumatoid arthritis and ankylosing spondylitis J Rheumatol ... better or pooreer quality of life? J Clin Epidemiol 2000, 53:895-907 Sokoll KB, Helliwell PS: Comparison of disability and quality of life in rheumatoid and psoriatic arthritis J Rheumatol 2001,...

Ngày tải lên: 18/06/2014, 19:20

... patients with swollen joints, 57.6% of men and 42.0% of women were in DAS28 remission Among patients with and swollen joints, 30.3% and 20.2% of men and 16.9% and 7.1% of women met DAS28 remission, ... females and males were Introduction The possible influence of gender and gender-related variables on the phenotype, severity, and prognosis of rheumatoid arthritis (RA) appears to be of considerable ... Farmacotherapy) study [64] of patients with early RA, erosive disease was present in 27% of men and 28% of women at the time of diagnosis Similar percentages of females and males were free of any radiographic...

Ngày tải lên: 09/08/2014, 01:22

... [9,10] Migration of T cells to sites of inflammation is mediated by selectins and their ligands [11,12] Regulation of leukocyte migration is orchestrated by activating cytokines and adhesion molecules ... recruitment of leukocytes to sites of inflammation is driven and mediated by the effects of chemoattractants [13,14] These molecules, termed inducible chemokines, are members of the large superfamily of ... levels of CXCL8 (IL-8) are responsible for activation of neutrophils and T lymphocytes that migrate into the epidermis of arthritis patients CXCL8 was shown to induce the expression of HLA-DR and...

Ngày tải lên: 09/08/2014, 01:23

... group was 1.5 ng/ml, and Figure Levels of 8-oxodG in the SF of patients with rheumatoid arthritis (RA) and of control subjects The SF samples from patients with RA (n = 49) and non-arthritic controls ... calculation is rather crude and probably an underestimate, because the concentration of cells in the SF and the levels of cell death vary with the severity of arthritis and the use of cytotoxic drugs ... categories I and IV (P < 0.0001), and between the patients in categories II and III (P = 0.0036) Levels of 8-oxodG in the SF The mean level of 8-oxodG in the RA–SF samples was 3.2 ng/ml, and 41 of 49...

Ngày tải lên: 09/08/2014, 01:23

... [3,6–9], and fragmented forms of FN have been detected in synovial fluid (SF) and articular cartilage from patients with OA and patients with rheumatoid arthritis (RA) [10–17] On the basis of such ... capacities of the various N-terminal species of SF FN to bind to gelatin (denatured collagen) This was assessed by comparison of the content of N-terminal species of FN in SF samples before and after ... than expected from the positions of migration of reduced molecular weight standards shown to the left of each panel, possibly reflecting the effect of maintenance of type I repeat intrachain disulfide...

Ngày tải lên: 09/08/2014, 01:23

... osteoarthritis hyaluronidase-1, -2, and -3 in the synovium synthase-1, 2, and -3 and (OA) levels of the messages (RA) Relative expressionand rheumatoid arthritis for hyaluronanof knees in 2, and ... 2, and -3 and hyaluronidase-1, -2, and -3 in the synovium of knees in osteoarthritis (OA) and rheumatoid arthritis (RA) Total RNA was isolated from knee synovium and expression levels of the messages ... computer software for HAS-1, -2, and -3 and Available online http:/ /arthritis- research.com/content/6/6/R514 Table Baseline data for subjects with osteoarthritis (OA) or rheumatoid arthritis (RA)...

Ngày tải lên: 09/08/2014, 01:24

... in arthritis Materials and methods Randomised, double-blind, controlled trials, of weeks' duration or longer with any dose of celecoxib and any comparator, in osteoarthritis or rheumatoid arthritis, ... celecoxib and NSAIDs, and we chose to perform two analyses: comparisons of all doses of celecoxib with all doses of NSAIDs, and between licensed daily doses of celecoxib and licensed doses of NSAIDs ... maximum daily dose, and rofecoxib was used at 25 mg daily Information for osteoarthritis and rheumatoid arthritis was combined because the number of patients in trials with rheumatoid arthritis was...

Ngày tải lên: 09/08/2014, 06:22

... interpretation and analysis of data CW and HN participated in acquisition and analysis of data SA dealt with acquisition of data and revision of the article JS participated in drafting and revising ... aspects of hormone conversion in primary synovial cells and synovial tissue of long-standing RA and OA patients in the advanced phase of the disease: Conversion of DHEA yielded high amounts of estrogens ... of the analytes of interest: system consisted of methanol:water (50:50) and system was methanol:water (65:35) System was used for identification of 5α-reduced androgens Retention times of standards...

Ngày tải lên: 09/08/2014, 06:23

... decreased in rheumatoid arthritis (RA) peripheral blood (PB), and pDCs are significantly decreased in psoriatic arthritis (PsA) PB The total number of (a) mDCs and (c) pDCs per millilitre of PB and the ... Results Numbers and proportion of circulating pDCs decreased in PsA BP and RA PB, and mDCs decreased in RA PB The synovial compartment has been the focus of many previous studies of RA and PsA [16,47] ... number of cells (×104/ml) in rheumatoid arthritis and psoriatic arthritis peripheral blood and matched synovial fluid White blood cells Myeloid dendritic cells Plasmacytoid dendritic cells Rheumatoid...

Ngày tải lên: 09/08/2014, 07:20

Ngày tải lên: 09/08/2014, 07:20

... Validation of systemic and local inflammation Patients were investigated for systemic as well as local inflammation and disease activity by the analysis of blood and synovial tissue samples Systemic inflammation ... expression of BMP-4 and BMP-5 in the synovial tissue of chronic joint diseases Both proteins have a fundamental role in embryogenesis and in the induction of cartilage and bone [13,14] Genetic and expression ... Burmester GR: Differential expression of cathepsins B and L compared with matrix metalloproteinases and their respective inhibitors in rheumatoid arthritis and osteoarthritis: a parallel investigation...

Ngày tải lên: 09/08/2014, 07:20

... Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis Arthritis Rheum 1995, 38:44-48 van Gestel AM, Haagsma CJ, van Riel PL: Validation of rheumatoid arthritis ... classification of rheumatoid arthritis Arthritis Rheum 1988, 31:315-324 Wiles N, Symmons DPM, Harrison B, Barrett E, Barrett JH, Scott DGI, Silman AJ: Estimating the incidence of rheumatoid arthritis: ... an etiology of rheumatoid arthritis Arthritis Rheum 2006, 54:38-46 Harrison B, Symmons D: Early inflammatory polyarthritis: results from the Norfolk Arthritis Register with a review of the literature...

Ngày tải lên: 09/08/2014, 08:22

... CXCL8 and CXCL10 and downregulation of CCL21 mRNA Materials and methods Patients SF samples were taken from knees of nine patients with active RA, for treatment and diagnostic purposes Aliquots of ... with rheumatoid arthritis (RA) was analyzed for the expression of CC chemokines (a) and CXC, C and CX3C chemokines (b) Data obtained by Gene Pix™ Analysis Software were normalized, transformed and ... (SF PMN) of rheumatoid arthritis (RA) patients nos 1, 2, and and from blood PMN from healthy donor no was amplified by semiquantitative RT-PCR with primers for CCL18, CXCL10 and actin and subjected...

Ngày tải lên: 09/08/2014, 10:21

... al.: Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4 Am ... study of 14,000 cases of seven common diseases and 3,000 shared controls Nature 2007, 447:661-678 Mantel N, Haenszel W: Statistical aspects of the analysis of data from retrospective studies of ... 1.1 to 1.2, variants of PADI4 and CTLA4 confer a similar risk to that of the new ITGAV variant Because confirmed associations account for only about 50% of RA genetics, more candidate loci conferring...

Ngày tải lên: 09/08/2014, 10:21

... ethanolamide (PEA) ,and rheumatoid arthritis (RA) (n = synovial fluid of non-inflamed normal volunteers (control) (n = 6) and of patients with osteoarthritis (OA) (n = 14) and rheumatoid arthritis (RA) ... of inflamma- Table Summary of patient histories of osteoarthritis and rheumatoid arthritis patients included in the study Osteoarthritis Gender (number) Rheumatoid arthritis Female (18) Male ... levels of tumor necrosis factor alpha and oncostatin M correlate with levels of markers of the degradation of crosslinked collagen and cartilage aggrecan in rheumatoid arthritis but not in osteoarthritis...

Ngày tải lên: 09/08/2014, 10:23

... inception and development of protocol and in the review of the manuscript and served as PhD program supervisor MK provided advice on protocol development and body composition assessments and participated ... current and ex-smoker pack-groups However, an ANCOVA model with gender and pack-group as factors and age and weight as covariates (following stepwise elimination of ESR, CRP, DAS28, HAQ score, and ... http:/ /arthritis- research.com/content/10/3/R59 Figure Prevalence of overweight and obesity, increased waist circumference, and low fat-free mass in smoking groups (a) Prevalence of overweight and...

Ngày tải lên: 09/08/2014, 10:23

... antibodies and rheumatoid factor with radiographic severity of rheumatoid arthritis Arthritis Res Ther 2006, 8:R128 10 Larsen A: How to apply Larsen score in evaluating radiographs of rheumatoid arthritis ... (Genetics of Rheumatoid Arthritis, GORA) and the Arthritis Research Campaign References Wellcome Trust Case Control Consortium: Genome-wide association study of 14,000 cases of seven common diseases and ... odds ratio; RA, rheumatoid arthritis Page of (page number not for citation purposes) Arthritis Research & Therapy Vol 10 No Marinou et al Table The extend of LD across the IL-13 and IL-4 genes...

Ngày tải lên: 09/08/2014, 10:23

... in rheumatoid arthritis Involvement of the alternative pathway at the site of inflammation RA is a chronic inflammatory disease of the joints in which infiltration of immunocompetent cells and ... advantages and disadvantages of anti-inflammatory and anti-rheumatic NF-κB inhibitors, and the effects (in animal models of RA and other autoimmune diseases) of genetically inactivated NF-κB subunits and ... lymph nodes and spleen) Several authors have shown that NF-κB is required for the development of mTECs and organization of the thymic stroma, and the development and differentiation of DCs [38-43]...

Ngày tải lên: 09/08/2014, 10:23

... models of autoimmune arthritis and demyelination Arthritis Res Ther 2008, 10:R119 Kinloch A, Lundberg K, Venables P: The pathogenic role of antibodies to citrullinated proteins in rheumatoid arthritis ... convincing murine model of RA is that of the recently reported DR4-IE transgenic mouse immunised with citrullinated fibrinogen [9] The impressive, though often uncontrolled, array of data that arises ... CEP-1 The sequence of the CEP-1 peptide is the subject of an international patent application, number WO0890360, published on 31st July 2008 The authors of this editorial, KL and PJV, are named...

Ngày tải lên: 09/08/2014, 13:22