epigenetic biomarkers in cancer epidemiology
Tài liệu Biomarkers in Cancer: An Introductory Guide for Advocates pdf
Ngày tải lên :
14/02/2014, 21:20
... of invasive tumor cells show uniform, intense membrane staining IHC (Herceptest®) Scoring Breast Cancer Cell Staining pattern Score Interpretation No staining Negative Faint incomplete staining ... an initial step that is followed by validation in cancer cells and eventually cancer patients Increasing the Number of Biomarkers in Clinical Use In Chapter 1, we described the expanding interest ... my cancer responding to this treatment? Will my cancer come back? After Cancer Diagnosis Post Treatment Uses of Biomarkers in Cancer Drug Discovery In addition to their uses in cancer medicine,...
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Tài liệu Báo cáo khoa học: A strategy for discovery of cancer glyco-biomarkers in serum using newly developed technologies for glycoproteomics ppt
Ngày tải lên :
16/02/2014, 08:20
... lectin binding to increase their sensitivity The final challenge to be faced is the feasibility of using biomarkers in the drug development process Incorporation of biomarkers into phase II clinical ... profiling, and utilizes lectins, a group of glycan-discriminating proteins In general, however, the glycan–lectin interaction is relatively weak in comparison with, for example, antigen–antibody interactions ... difficult to distinguish from those involved in wound healing and in ammation In association with cancer growth, the stromal cells grow and expand to release many glycoproteins into serum Thus,...
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ONCOGENOMICS AND CANCER PROTEOMICS – NOVEL APPROACHES IN BIOMARKERS DISCOVERY AND THERAPEUTIC TARGETS IN CANCER pot
Ngày tải lên :
30/03/2014, 09:20
... Wnt/βcatenin and cadherin pathway genes including N-cadherin and P-cadherin but low E-cadherin protein expression This finding demonstrated the highgrade serous ovarian cancer contained messenchymal ... carcinoma: STK15 is frequently overexpressed and amplified in nonendometrioid carcinomas Cancer Res 2003 Sep 15;63(18):5697-702 Kok Ying N, Ganesalingam M, Sabaratnam S Cancer Incidence in Peninsular ... a single gene or a few genes in cancer cells The studies have uncovered the roles of individual genes in the uncontrolled behavior of cancer cells Studying the functional roles of genes in cancer...
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báo cáo hóa học:" Pain in cancer. An outcome research project to evaluate the epidemiology, the quality and the effects of pain treatment in cancer patients" pptx
Ngày tải lên :
20/06/2014, 15:20
... 20 21 Cherny N: The management of cancer pain Cancer J Clin 2000, 50:70-116 Hearn J, Higginson IJ: Cancer pain epidemiology: a systematic review In Cancer Pain, Assessment and Management Edited ... history including past cancer history, b) physical examination, c) recording of medications and recent therapies, including analgesic consumption, d) pain assessment using the Brief Pian Inventory ... The relevant endpoint is the reduction in Adequacy of analgesic-drug therapy: Patient Management index (PMI), categorized in a binary variable according to negative (indicating inadequate analgesic...
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báo cáo khoa học: "New clinical developments in histone deacetylase inhibitors for epigenetic therapy of cancer" doc
Ngày tải lên :
10/08/2014, 22:20
... seen at day These findings imply that VOR may restore hormone sensitivity in hormone-refractory breast cancer patients VOR was investigated in combination with capecitabine (CAP) in a phase I/II ... was overall disappointing in early clinical trials [22,37,40,41] New HDAC inhibitors HDAC inhibitors generally consist of three parts in the chemical structure: (1) a zinc-chelating group; (2) a ... development HDAC inhibitors may have more potential in the combination therapy of a wide range of malignancies Combination of novel epigenetic agents, including hypomethylating agents and HDAC inhibitors,...
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Health services research on endoscopic surveillance for gastric cancer in the singapore chinese population experience of the gastric cancer epidemiology clinical and genetic program
Ngày tải lên :
10/09/2015, 09:07
... trends in gastric cancer mortality and incidence for males 11 Figure 1-7 Declining trends in gastric cancer mortality and incidence for females 12 Figure 2-1 Carcinogenesis for Gastric Cancer ... Gastric cancer mortality Following the downward trend seen in incidence, GC mortality has also declined over time globally The declining mortality has been attributed to the declining incidence ... specific gastric cancer incidence by sex (2003-2007) (Singapore Cancer Registry Committee 2012) 10 1.3.2 Gastric cancer mortality The declining trend seen in the incidence was also observed in the GC...
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Clinicopathological study of biomarkers in prostrate cancer
Ngày tải lên :
03/10/2015, 20:57
... immunohistochemical expression ix Introduction CHAPTER INTRODUCTION Introduction INTRODUCTION 1.1 Epidemiology According to the “Trends in Cancer Incidence in Singapore 1968-2007”, Singapore Cancer Registry Report ... activated tyrosine kinases, has a C-terminal ligand binding domain (LBD), a DNA binding domain 17 Introduction (DBD), and an N-terminal domain (NTD), as well as one or more transactivation domains (Agoulnik ... indicate no staining, mild staining, moderate staining and strong staining respectively Proportion of cells stained positive was indicated in percentages Immunoreactive score (IRS) and intensity-percentage...
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Clinicopathological study of biomarkers in prostrate cancer
Ngày tải lên :
13/10/2015, 15:57
... immunohistochemical expression ix Introduction CHAPTER INTRODUCTION Introduction INTRODUCTION 1.1 Epidemiology According to the “Trends in Cancer Incidence in Singapore 1968-2007”, Singapore Cancer Registry Report ... activated tyrosine kinases, has a C-terminal ligand binding domain (LBD), a DNA binding domain 17 Introduction (DBD), and an N-terminal domain (NTD), as well as one or more transactivation domains (Agoulnik ... indicate no staining, mild staining, moderate staining and strong staining respectively Proportion of cells stained positive was indicated in percentages Immunoreactive score (IRS) and intensity-percentage...
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Báo cáo y học: "Gain of a 500-fold sensitivity on an intravital MR Contrast Agent based on an endohedral Gadolinium-Cluster-Fullerene-Conjugate: A new chance in cancer diagnostics"
Ngày tải lên :
26/10/2012, 09:07
... outw ward-facing o orbital ellipso oid 144 increas in size, w ses while the inw ward facing decreases This re esults in a co oupling of th electron sp he pins with the nuclear spin of the rare ... N-1.3.-diamino propane linker substituted glycine with the GdxSc3-xN@C80 The product 11 acts as the dienophile reaction partner with diene tetrazine-NLS-S∩S-CPP conjugate 13 in the final DARinv as pointed ... acetonitrile in water (B) as eluent The conjugate was eluted with a successive linear gradient, increasing from 25% to 60% B-eluent in 49 at a flow rate of 10 ml/min The fractions corresponding to...
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Báo cáo y học: "yrosine kinase – Role and significance in Cancer"
Ngày tải lên :
03/11/2012, 09:57
... ATP binding site serves as a docking site for specific binding of cytoplasmic signaling proteins containing Src homology-2 (SH2) and protein tyrosine binding (PTB) domains These proteins in turn ... tyrosine kinase inhibitors Inhibiting the activity of tyrosine kinases by low molecular weight compounds capable of interfering with either ligand binding (in the case of receptor tyrosine kinases) ... the minor difference in the kinase domain The minor difference leads to changes in hydrogen bonding and hydrophobic interactions resulting in differences of affinity [38] Of all the tyrosine kinase...
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Tài liệu Neurodegenerative Biomarkers in Healthy Elderly docx
Ngày tải lên :
13/02/2014, 18:20
... 2009:116 Layout and printed in Malmö, Sweden by Medicinsk Informationsteknik, 2009 “The important thing in science is not so much to obtain new facts as to discover new ways of thinking about them” ... understanding of this preclinical stage in AD development RESEARCH APPROACH 1|2 PRE-EXISTING UNDERSTANDING 1|2|1 A central point of departure has been the opinion that the symptomatic, clinical definition ... for detecting incipient AD One of the reasons behind the limited sample size, leading to absence in power, has been that invasive investigations have been performed without clinical indication...
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Tài liệu Area Socioeconomic Variations in Cancer Incidence and Stage at Diagnosis in New Jersey, 1996-2002 pdf
Ngày tải lên :
14/02/2014, 21:20
... http://nj.gov/health/ces/reports.shtml, including: • Cancer Incidence and Mortality in New Jersey 2000-2004; • Cancer Incidence Rates in New Jersey’s Ten Most Populated Municipalities 1998-2002; • Trends in Cancer Incidence ... pharynx) cancer, ovarian cancer, pancreas cancer, prostate cancer, stomach cancer, thyroid cancer, and urinary bladder cancer To compare incidence rates in the poverty area groups, incidence rate ratios ... of smoking reported among persons living in poverty in the U.S.13 may be one of the main reasons for the increased incidence of oral cancer in the areas with high poverty See Tables 2-9 in Appendix...
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Tài liệu StrategieS for SucceSS: How to Write a Grant in Cancer CAM docx
Ngày tải lên :
14/02/2014, 22:20
... Research Multidisciplinary Approaches in Cancer Treatment Investigators are often interested in investigating multidisciplinary approaches in cancer care The advantages of studying the entire approach ... consolidating and focusing cancer- related activities, increasing research productivity, promoting shared use of research resources and improved quality control, stimulating and promoting interdisciplinary ... newly trained basic or clinical investigators to develop their independent research skills through a two-phase program – an initial period involving an 31 intramural appointment at NIH and a final...
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Tài liệu Psychotherapy and Survival in Cancer: The Conflict Between Hope and Evidence pptx
Ngày tải lên :
15/02/2014, 05:20
... combining intervention groups may have been to increase power, this post hoc combining of heterogeneous groups likely resulted in increased within-subject error, decreasing the likelihood of finding ... reported In medicine, recognition that many randomized clinical trials were not being reported in a manner that allowed independent evaluation led to calls for reform, culminating in the original ... care Cointervention confound The authors distinguish their trial from studies examining psychosocial interventions, stating, “this is the first [trial] to examine the impact of nursing interventions...
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Tài liệu Nanotechnology in Cancer Treatment and Detection doc
Ngày tải lên :
15/02/2014, 05:20
... smaller than most human cells Cancer Nanotechnology research is interdisciplinary and incorporates Biology, Chemistry, Engineering, Medicine, and Physics Properties of Cancer Cells • Epidermal Growth ... trials reveal that a single intravenous nanoparticle injection eradicated 100 percent of tumors in mice when exposed to near-infrared light Most work is being done with near-infrared light, which ... at absorbing light near the infrared than solid gold nanoparticles Nanoparticles can be tuned to be excited only by certain ranges of light Uses in Treatment In another study, pre-clinical trials...
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Tài liệu Báo cáo khóa học: Suppression of b1,3galactosyltransferase b3Gal-T5 in cancer cells reduces sialyl-Lewis a and enhances poly N-acetyllactosamines and sialyl-Lewis x on O-glycans Lydia Mare and Marco Trinchera pdf
Ngày tải lên :
19/02/2014, 12:20
... according to published procedures [9,16,22], with some modifications Total lysates were obtained by boiling 10 in phosphate-buffered saline containing 0.5% SDS and 1.0% 2-mercaptoethanol, and spinning ... cultured in Dulbecco’s modified Eagle’s medium containing 10% foetal bovine serum, 100 UÆmL)1 penicillin, 1.0 mgÆmL)1 streptomycin and mM L-Glu For treating BxPC3 cells and clones with drugs affecting ... plated in 12-well plates, incubated for 30 h with regular medium that was replaced with medium containing 1.0 lgÆmL)1 swainsonine (Sigma) or mM benzyl-a-GalNAc (Sigma) After growing for 60 h in the...
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Tài liệu Báo cáo khoa học: Enhanced expression of Mcm proteins in cancer cells derived from uterine cervix docx
Ngày tải lên :
20/02/2014, 23:20
... examined in five cases of human uterine cervical cancer by immunohistochemical techniques, and the results were compared with the findings obtained by hematoxylin and eosin staining We examined ... In both cells, clear nuclear staining was observed with anti-Mcm4 Ig Although the staining intensity was relatively constant within BrdU-positive and -negative HeLa cells, more intense staining ... diluted in NaCl/Pi containing 2% normal swine serum (DAKO) The slides were washed in NaCl/Pi, and the subsequent immunostaining was performed by the labeled streptavidin biotin-peroxidase method using...
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The Use of Mushroom Glucans and Proteoglycans in Cancer Treatment potx
Ngày tải lên :
06/03/2014, 02:21
... Trials in Stomach Cancer PSK and Stomach Cancer Stomach cancer continues to inflict major mortality in Japan and has been the object of more clinical trials with PSK than any other cancer Beginning ... predict anticancer efficacy in humans Maitake D-Fraction has been used in a few exploratory studies in cancer patients.17 In 1994, a group from China published in abstract form their findings from ... 1-6 main chains and 1-4 branchings, and the more common 1-3 main chains and 1-6 branchings.18 This fraction also is highly active in vitro and in animal models of cancer, although activity in these...
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Báo cáo khoa học: The dipeptidyl peptidase IV family in cancer and cell biology pot
Ngày tải lên :
06/03/2014, 09:22
... chemokines in vitro (Table 2) DPIV in cell biology A number of DPIV-binding proteins have been identified, including adenosine deaminase [78,79], CD45 (protein tyrosine phosphatase) [80], caveolin-1 ... ability to inactivate the incretin hormones glucagon-like peptide-1 and glucose insulinotropic peptide In the treatment of type diabetes, DPIV inhibitors extend incretin action, resulting in improved ... DP9-overexpressing cells of the ECM-interacting molecules discoidin domain receptor 1, a kinase activated by collagen binding, and the MMP inhibitor, tissue inhibitor of matrix metalloproteinase-2,...
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Báo cáo khoa học: 3 Cdt1 and geminin are down-regulated upon cell cycle exit and are over-expressed in cancer-derived cell lines potx
Ngày tải lên :
07/03/2014, 16:20
... full-length Cdt1 and geminin (HisT7-geminin and His-geminin, amount of recombinant protein run in each lane in ng is indicated) and immunoblotted with anti-Cdt1 and anti-geminin Ig See Materials ... increased in cancer cell lines, while different cancer cell lines appear to over-express geminin to varying degrees In order to more carefully compare the relative levels of Cdt1 and geminin in different ... differences in relative amounts of Cdt1 and its inhibitor in different cell lines It would be interesting to investigate whether geminin and/or Cdt1 levels or the ratio of Cdt1 to its inhibitor geminin...
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