epidemiology of renal cell carcinoma

... Chromophobe RCCs account for about 4-8% of all renal tumours, with a more favorable prognosis relative to clear cell renal cell carcinoma, which comprises the majority of all RCCs (Cheville et al 2003) ... survival outcomes in patients with renal cell carcinoma; SPECIFIC AIMS (MOLECULAR MODELS) To evaluate the molecular profiles of three primary subtypes of RCC clear cell RCC, papillary RCC and chromophobe ... Prediction Analysis of Microarrays Peripheral Blood Mononuclear Cells Renal Cell Carcinoma Robust Multichip Average RiboNucleic Acid Receiver Operating Characteristic Significance Analysis of Microarrays...

Ngày tải lên: 11/09/2015, 09:56

... Merseburger AS, Mulders PFA, Patard JJ, Sinescu IC: European Association of Urology Guideline Group for renal cell carcinoma Renal cell carcinoma guideline Eur Urol 2007, 51:1502-10 12 Kulkarni R: Alternative ... crucial to get a better understanding of the genesis of those reactions Ahead of its time are, on one hand, the recently applications of HAs in the premature rupture of membranes where the adhesive ... which compare the use of a HA and of the ISC in the enucleoresection of RCC The recent evidence related to the NSS capable, in selected cases, to offer the same results of partial and radical...

Ngày tải lên: 09/08/2014, 03:21

... possible the growth of renal cell carcinoma cells is arginase II independent resulting in the low inhibitory effect of nor-NOHA Page of 10 (page number not for citation purposes) Journal of Hematology ... from the tissue culture supernatants of murine renal cell carcinoma cell lines and determine their effect on cell proliferation In adult mammals, the majority of endogenous L-arginine is synthesized ... arginase inhibitor nor-NOHA on cell proliferation Effect of3 Effect of arginase inhibitor nor-NOHA on cell proliferation (A) Proliferation of CL-2, CL-19 and Renca cells was assessed by [3H]-thymidine...

Ngày tải lên: 10/08/2014, 22:20

... previously untreated renal metastatic renal cell carcinoma J Clin Oncol 2005, 23(4):832-841 Crotty TB, Farrow GM, Lieber MM: Chromophobe cell renal carcinoma: clinicopathological features of 50 cases ... metastasis as an initial presentation of renal cell carcinoma Med Oncol 2010 35 Azam F, Abubakerr M, Gollins S: Tongue metastasis as an initial presentation of renal cell carcinoma: a case report and ... in the last five years) Out of these, 17 cases were metastasis of RCC of clear cell type Six of these cases were diagnosed as primary ovarian clear cell cancer, while renal primary was diagnosed...

Ngày tải lên: 10/08/2014, 23:20

... is a picture of renal ultrasound It shows echo-dense area in the renal area, suggestive of a renal tumour Renal Cell Carcinoma in the form of hoarseness or calverial metastasis of which only ... cases have been reported [3,4] Renal cell carcinoma represents a heterogenous group of tumors, the most common of which is clear cell adenocarcinoma RCC accounts for 3% of adult tumors The incidence ... presentation of Renal Cell Carcinoma- a report of two cases and review of literature Clinical Neurology and Neurosurgery 2005, 107:329-333 Page of (page number not for citation purposes) Journal of Medical...

Ngày tải lên: 11/08/2014, 10:22

... Molecular profiling and classification of sporadic renal cell carcinoma by quantitative methylation analysis Clin Cancer Res 2004, 10:7276-7283 47 Yoon JH, Dammann R, Pfeifer GP: Hypermethylation of the ... knowledge of the molecular pathogenesis of RCC will increase and with it the potential for developing novel biomarkers and potential therapeutic interventions Abbreviations ccRCC, clear cell renal cell ... suppressor gene and allelic losses at chromosome arm 3p in primary renal cell carcinoma: evidence for a VHL‑independent pathway in clear cell renal tumourigenesis Genes Chromosomes Cancer 1998, 22:200-209...

Ngày tải lên: 11/08/2014, 12:20

... 30% of patients with renal carcinoma present with metastatic disease, 25% with locally advanced renal carcinoma, and 45% with localized disease [1] About 75% of patients with metastatic renal carcinoma ... Disappearance of metastatic renal cell carcinoma to the base of the tongue after systemic administration of interferon-α Eur Urol 1993, 24:297-299 Page of (page number not for citation purposes) Journal of ... tissue leading to diagnosis of renal adenocarcinoma J Laryngol Otol 1994, 108:1108-1110 Aguirre A, Rinaggio J: Lingual metastasis of renal cell carcinoma J Oral Maxillofac Surg 1996, 54:344-346...

Ngày tải lên: 11/08/2014, 21:22

... to tumor ulceration of secondarycarcinoma ;cell infiltrationmucosal epithelium noted Renal cell Renal cell carcinoma; ulceration of mucosal epithelium noted secondary to tumor cell infiltration ... surrounded of rich cell carcinoma; epithelial cellular network2shown with clear vascular network Histologic featuresin arenalcytoplasm and hyperchromatic Histologic features of renal cell carcinoma; ... SN: Renal cell carcinoma to the base of tongue: a case report Hinyokika Kiyo 2004, 50(11):791-793 Phillips CK, Taneja SS: The role of lymphadenectomy in the surgical management of renal cell carcinoma...

Ngày tải lên: 11/08/2014, 21:22

... Spain References Curti BD: Renal cell carcinoma JAMA 2004, 292:97-100 Featherstone JM, Bass P, Cumming J, Smart CJ: Solitary, late metastatic recurrence of renal cell carcinoma: two extraordinary ... metastasis of renal cell carcinoma resected 25 years after nephrectomy Jpn J Clin Oncol 2004, 34(1):46-49 Chin AI, Lam JS, Figlin RA, Belldegru AS: Surveillance Strategies for Renal Cell Carcinoma ... existence of a more complex picture of immunosurveillance, which includes an active role of the immune system also in facilitating immunoselection of malignant cells and the emergence of tumor...

Ngày tải lên: 11/08/2014, 23:21

... according to the Heidelberg Classification of Renal Cell Tumours [2] Seven specimens of pRCC, seven of cRCC, six of chRCC, and six of RO, besides adjacent pieces of unaffected tissue, were used in this ... are papillary renal cell adenoma, metanephric adenoma, and renal oncocytoma (RO) Deletions at chromosome 3p, mutations of the VHL suppressor gene and loss of heterozygosity (LOH) of 9p, 14q, 17p ... chromosomes, mutations of p53, LOH at 10q23.3 and telomere shortening have been reported [6] RO consists of mixtures of cells with normal and abnormal karyotypes [7] About 4% of renal cancers arise...

Ngày tải lên: 06/03/2014, 22:21

... http://www.translational-medicine.com/content/7/1/2 Figure Characterization of T cell responses Characterization of T cell responses (A) CD8+CD107a+ effector cells, (B) CD8+perforin+ effector cells, (C) PD-1+ T cells, (D) CD4+CD25+FoxP3+ Tregs ... PL, Hawkins RE: Expression of the 5T4 oncofoetal antigen in renal cell carcinoma: a potential target for T -cell- based immunotherapy Br J Cancer 2005, 93:670-677 Page 10 of 11 (page number not for ... Nephrectomy and interleukin-2 for metastatic renal- cell carcinoma N Engl J Med 2001, 345:1711-1712 Diner EK, Linehan M, Walther M: Response of papillary renal cell carcinoma in a solitary kidney to high...

Ngày tải lên: 18/06/2014, 15:20

... the differentiation of renal tubules representing the origin of clear cell renal cell carcinoma (RCC) and in the regulation of the cell cycle of parietal epithelial cells of the Bowman's capsule ... Identification of metabolic enzymes in renal cell carcinoma utilizing PROTEOMEX analyses Biochim Biophys Acta 2003, 1646:21-31 Seliger B, Lichtenfels R, Kellner R: Detection of renal cell carcinoma- associated ... molecular mechanism of the heterogeneity of UCHL1 expression levels The silencing of UCHL1 was discovered by cDNA microarrays and chemical genomic screening of head and neck squamous cell carcinoma [49]...

Ngày tải lên: 18/06/2014, 15:20

... prospect in future Methods Cell Lines The human CCRCC cell line OS-RC-2 and mouse macrophage cell line Ana-1 were purchased from the Institute of Cell Biology, Chinese Academy of Sciences (Shanghai, ... methods [20], the renal cancer cell line, phagocytic cells and endothelial cells were used to detect the toxicity of three modified PEI-derived materials in vitro The OS-RC-2 cells were seeded ... half of cells were alive with 200 μg/ml 2-kD PEI treatment, while 60% cells had viability even exposed to more than 200 μg/ml of FAPEAs or HPEI Generally, for OS-RC-2 cells, the cytotoxicity of...

Ngày tải lên: 18/06/2014, 19:20

... diuretic use and coffee consumption as risk factors for renal cell carcinoma J Natl Cancer Inst 1986, 77:351-356 Bruning T, Weirich G, Hornauer MA, Hofler H, Brauch H: Renal cell carcinomas in trichloroethene ... (12 of 17) of the formalin-fixed samples, and 38% (10 of 26) of the Bouin's fixed tissues Thus, the VHL gene was entirely sequenced (ie 100% of the coding sequence analysed) for a total of 26 ... compare exposed and non exposed cases of clear cell RCC in terms of prevalence of mutations in both groups Page of (page number not for citation purposes) Journal of Occupational Medicine and Toxicology...

Ngày tải lên: 20/06/2014, 00:20

... prospect in future Methods Cell Lines The human CCRCC cell line OS-RC-2 and mouse macrophage cell line Ana-1 were purchased from the Institute of Cell Biology, Chinese Academy of Sciences (Shanghai, ... methods [20], the renal cancer cell line, phagocytic cells and endothelial cells were used to detect the toxicity of three modified PEI-derived materials in vitro The OS-RC-2 cells were seeded ... half of cells were alive with 200 μg/ml 2-kD PEI treatment, while 60% cells had viability even exposed to more than 200 μg/ml of FAPEAs or HPEI Generally, for OS-RC-2 cells, the cytotoxicity of...

Ngày tải lên: 20/06/2014, 03:20

... terms of metabolic imaging following SBRT for RCC and melanoma and the overall survival of this population of patients, with the intent of offering guidance for proper patient selection Page of ... presence of or fewer individual sites of disease The superior outcome of patients defined as oligometastatic by this definition was expected, and this or a similar cutoff level of sites of disease ... the high doses of radiation delivered in each session of SBRT might trigger an entirely different method of cell kill in vivo via an anti-angiogenic pathway involving endothelial cell apoptosis...

Ngày tải lên: 09/08/2014, 09:20

... arrest Cell- saving techniques used routinely in our institution Figure Renal cell carcinoma invading the upper pole of the kidney with tumor propagating into the IVC Page of Figure Direct removal of ... failure post operative day 164 The mean size of the renal mass was 5.2 cm (range, 3.5 to 11.2 cm) Histological examination showed renal cell carcinoma of clear type in patients and papillary type ... obstruction Page of For all those reasons aforementioned, a single institutional approach [19] advocates in selected cases of renal cell carcinoma with level IV IVC extension, resection of the tumor...

Ngày tải lên: 10/08/2014, 09:22

... staining of PKCε in tissue specimens PKCε is overexpressed in both cytoplasm and nuclei of clear cell renal cell carcinoma (RCC) cells (A) Primary antibody isotype control (B) and normal renal cells ... of 769P cells (Figure 2B) Effects of PKCε on proliferation, migration, and invasion of 769P cells To examine the functions of PKCε, we knocked down PKCε by transfecting PKCε siRNA into 769P cells ... 0.002 Figure Expression of PKCε in renal cell carcinoma (RCC) cell lines A Western blot shows that PKCε is expressed in all five RCC cell lines, with the highest level in 769P cells GAPDH is the loading...

Ngày tải lên: 10/08/2014, 10:21

... Metastatic renal cell carcinoma in a meningioma: a case report J Korean Med Sci 2000, 15:593-597 10 Ryska A, Cáp J: Tumor-to-tumor metastasis of renal cell carcinoma into oncocytic carcinoma of the ... prognosis of other stage IV renal cell carcinomas Interestingly, tumors of central nervous system [4,5,7,9,12] and thyroid carcinomas [8,10,11] represent frequent recipient tumors for donor renal cell ... potential recipient of a donor metastatic tumor, but renal cell carcinoma is by far the most common one [2,3] This is likely because kidneys receive significant blood flow and renal cell carcinoma is...

Ngày tải lên: 10/08/2014, 23:21

... Oncologic efficacy of CT-guided percutaneous radiofrequency ablation of renal cell carcinomas Am J Roentgenol 2007, 189:429-436 Diamond E, Schapira HE: Chyluria: a review of the literature Urology ... doi:10.1186/1752-1947-5-307 Cite this article as: Wah: An unusual cause of chyluria after radiofrequency ablation of a renal cell carcinoma: a case report Journal of Medical Case Reports 2011 5:307 Submit your next ... ZJ: Chyluria associated with radiofrequency ablation of renal cell carcinoma JCAT 2010, 34:210-212 Ciferri F, Glovsky MM: Chronic chyluria: a clinical study of patients J Urol 1985, 133:631-634...

Ngày tải lên: 10/08/2014, 23:22