epidemiological prospective and experimental studies

... pmol/L d stands for deci; m stands for milli; stands for micro; n stands for nano; p stands for pico; and f stands for femto Abbreviations for measure of risk in epidemiological and clinical studies ... Observational studies on serum 25-hydroxyvitamin D, cancer and all-cause mortality 92 13 Meta-analysis of observational studies on vitamin D levels and colorectal, breast and prostate cancer and colorectal ... Observational studies on serum 25-hydroxyvitamin D, cancer and all-cause mortality 92 12.1 Prospective studies of serum 25-hydroxyvitamin D and cancer risk 92 12.2 Studies of predicted...

Ngày tải lên: 28/03/2014, 23:20

... avoid prolonged and needless investigations for these patients, as the condition is reversible and easily treated with vitamin D and calcium supplementation Page of Frank G: Calcium and other divalent ... Hospital, Dublin, Ireland 2Department of Rheumatology, Connolly Memorial Hospital, Dublin, Ireland 3Department of Endocrinology and Diabetes Mellitus, Connolly Hospital, Dublin, Ireland Authors’ contributions ... literature search and preparation of the manuscript MB participated in the data analysis and contributed in the preparation of the manuscript SS and DS supervised the study and edited the manuscript...

Ngày tải lên: 11/08/2014, 00:23

... polymorphism at these loci and the presence of DDH and PPA We also explored the effect of genotype on acetabular morphology and severity of the conditions Patients and methods Hypothetically, ... and spans more than 140 kilobases The most widely studied polymorphic regions are the Pvu II and Xba I restriction fragment length polymorphisms in intron and the (TA) n variable number of tandem ... were involved in set up and operational help with the genetic assays NM planned the study, supervised BK and CD, was instrumental in drafting and revising the manuscript, and give final approval...

Ngày tải lên: 11/08/2014, 08:21

... http://www.biomedcentral.com/1471-244X/10/38 lations is continuous and characterized by differing levels of severity and persistence [7] Meta-analysis [8] and prospective follow-up studies indicates that up to 75-90% of ... Eicosapentaenoic acid and arachidonic acid: collaboration and not antagonism is the key to biological understanding Prostaglandins Leukot Essent Fatty Acids 2002, 66(1):83-90 Simopoulos A, Cleland L: Omega-6/Omega-3 ... the Scandinavian Women's Lifestyle and Health Cohort [19,20] The women were asked to fill in a paper questionnaire, including a food frequency questionnaire (FFQ), and levels of fish, PUFAs and...

Ngày tải lên: 11/08/2014, 16:22

... used for standardizing PTEN and Egr-1 mRNA Amplification primers were 5¢-ACCAGTGGCACTGTTGTTTCAC-3¢ and 5¢-TTCCTCTGGTCCTGGTATGAAG-3¢ for the PTEN gene [43], and 5¢-AGCCCTACGAGCACCTG-3¢ and 5¢-CGGTGGGTTGGTCATG-3¢ ... 15–22 days, individual colonies were isolated and expanded, and the expression of PTEN was examined by western blotting (C) Colony was treated with VD3, and apoptosis was evaluated (D) *P < 0.05, ... VD3 and 200 nM TSA (A), or VD3 and mM NaBu (B), and western blotting was used to evaluate PTEN expression Cell lines stably transfected with PTEN siRNA or control siRNA were treated with VD3 and...

Ngày tải lên: 22/03/2014, 21:20

... enzymes CYP27A1 and/ or CYP2R1 and subsequently by the cytochrome P450 enzyme 25hydroxyvitamin D-1a-hydroxylase (CYP27B1) and converted to the bioactive 1,25-(OH)2D3, which has role in Ca and bone metabolism ... and mature osteoclasts, and it inhibits OPG expression, which binds RANKL and prevents RANK mediated osteoclastogenesis [37] VitD deficiency causes the development of an imbalanced calcium- and ... membrane-lipid turnover, prostaglandin production and protease activity, leading to bone matrix modification and calcification Additionally to the expression of VDR in bone and multiple tissues, the...

Ngày tải lên: 12/08/2014, 13:22

Ngày tải lên: 20/07/2015, 23:47

... between 1,000 and 2,000 IU of vitamin D ― During the spring, summer, and fall months (and year-round if a patient lives in the southern part of the U.S.) combining sensible sun exposure* and daily ... The Bone and Cancer Foundation is to: • Provide information to cancer patients and family member on the causes and current treatment of cancer that involves the bone • Provide information and serve ... consume enough vitamin D from diet and supplements Sources and Types of Vitamin D Sources of Vitamin D Vitamin D comes from: ― Exposure to sunlight ― Diet Certain fish and fish oils are good sources...

Ngày tải lên: 15/02/2014, 05:20

... contributed to study design and concept and writing and editing of the manuscript VT: contributed to the study design and concept, writing and editing of the manuscript and provided financial support ... K23AR054334 and #5T32DK007298 The authors responsibilities were as followed LJ, LVY and SEJ: contributed to the study design and concept, statistical analysis, and writing of the manuscript HMB, GM and ... (groups and 2) were characterized by sex, race, Acute Physiology and Chronic Health Evaluation II (APACHEII) and sequential organ failure assessment (SOFA) scores (for ICU patients) and whether...

Ngày tải lên: 18/06/2014, 15:20

... transplantation and after (D, E and F) transplantation Immunohistochemical stainings of a keratome biopsy before (A, B and C) transplantation and after (D, E and F) transplantation and treatment ... vehicle (A, D, G and J), calcipotriol (B, E, H and K) and Daivobet® (C, F, I and L) in Figure the psoriasis plaque assay Biomarker endpoints after treatment with vehicle (A, D, G and J), calcipotriol ... study, KK and MAR participated in the design of the studies and interpreted the data All authors read and approved the final manuscript 13 14 15 16 Acknowledgements We thank Trine Gejsing and Lotte...

Ngày tải lên: 18/06/2014, 15:20

... in the study and takes responsibility for the integrity of the data and the accuracy of the data analyses Study concept and design: CA and OB Acquisition of data: CA and OB Analysis and interpretation ... blinds - Randomized trial, controlled, double blinds - Mean follow-up 10 months - Vertebral fracture and long bone, and fall - Mean follow-up years - I Prevention area and II area - Randomized ... supplementation and risk of fractures N Engl J Med 2006, 354:669-683 Law M, Withers H, Morris J, Anderson F: Vitamin D supplementation and the prevention of fractures and falls: results of a randomized...

Ngày tải lên: 19/06/2014, 08:20

... Some association studies involving the VDR, mostly the TaqI polymorphism and periodontal disease, have been conducted in different ethnic populations and settings [23,24], and a few studies have ... collected and classified using the LightTyper genotyping software, and genotypes were determined The absence or presence of the ApaI, BsmI, and FokI sites were designated as A, B, and F alleles and ... Bsm I, and Fok I VDR polymorphisms VDR, vitamin D receptor; SD, standard deviation Table Genotype and allele frequencies of Apa I, Bsm I, and Fok I VDR polymorphisms in subjects with and without...

Ngày tải lên: 08/08/2014, 16:23

... England, Holland, and France [10] Industrialized cod liver oil production (as the sole source of vitamin D food supply at that time) did not start before 1853 in Norway, Greenland, and Iceland ... influenza and vitamin D Epidemiology and Infection 2006, 134:1129-1140 Palm T: The geographical distribution and aetiology of rickets Practitioner 1890, 45:270-279 Stephen JM: Epidemiological and dietary ... milk consumption with asthma and allergy in rural and suburban populations across Europe Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology 2007,...

Ngày tải lên: 08/08/2014, 21:20

... elderly Dutch men and women It can be expected that the same polymorphisms could be important for both knee OA and hand OA, although no association between the VDR genotypes and hand OA was found ... metabolism, OA, the immune response, and cancer [12] The VDR gene acts as an important regulator of calcium metabolism and bone cell function [13], and it was the first candidate gene to be studied in ... the risk of hand OA in Finnish middleaged women In addition, we evaluated whether the calcium intake modifies the relationship between the VDR gene polymorphisms and hand OA Materials and methods...

Ngày tải lên: 09/08/2014, 07:20

... spots and western blotting experiment; MLL and JYL assisted with preparation for the serum samples and judgment for fibrotic stages; SCL and WMW were projective leaders and assisted with experimental ... simplify the experimental process Moreover removing albumin protein would remove albumin-binding proteins in the same time and influence the reproducibility After the protein matching and statistics ... liver fibrosis, A2M, VDBP and ApoAI, appear on the location of 162 kDa, 52 kDa and 28 kDa in the 2D-DIGE gels Observably there are several adjacent spots near A2M, VDBP and ApoAI protein; the adjacent...

Ngày tải lên: 10/08/2014, 05:21

... involving IL10 and VDR as well as IL10 and IL1RL1 observed in the SLSJ study is not replicated in the CAPPS, SAGE and BHS It should be noted that the sample sizes in the SAGE and CAPPS studies limit ... involving the IL10 and VDR genes in the SLSJ and the CAMP studies Figure Two-gene models on asthma involving the IL10 and VDR genes in the SLSJ and the CAMP studies With two biallelic SNPs (3 genotypes ... funding for the SAGE and CAPPS studies TJH and CL conceived and acquired funding for the SLSJ study TJH also provided general supervision of the research group All authors read and approved the final...

Ngày tải lên: 12/08/2014, 14:20

... 25-OH-D3 (Figure 3) Data handling and statistical analysis Clinical data and genotypes were all transferred to a SQL 2000 database and checked for completeness, paternity, and Hardy-Weinberg equilibrium ... the tested candidate genes are associated with both allergy and vitamin D metabolites Statistical significance, however, was weak, and varied even with different analysis strategies and software ... analysis and wrote the report J.A did the clinical survey, C.B did the SNP analysis, M.B built serum and DNA bank and did the vitamin D assays together with E.A who supervised also laboratory work and...

Ngày tải lên: 12/08/2014, 16:20

... RM: Vitamin D in overweight/obese women and its relationship with dietetic and anthropometric variables Obesity 2009, 17:778-782 McGill A-T, Stewart JM, Lithander FE, Strik CM, Poppitt SD: Relationships ... Poppitt SD: Relationships of low serum vitamin D3 with anthropometry and markers of the metabolic syndrome and diabetes in overweight and obesity Nutr J 2008, 7:4 Louie JK, Acosta M, Winter K, Jean ... viral PAMP- and virus-induced pulmonary innate immune and remodeling responses in mice J Clin Invest 2008, 118:2771-2784 doi:10.1186/cc8894 Cite this article as: Krstić G: Th17 mediators and vitamin...

Ngày tải lên: 13/08/2014, 20:21

Ngày tải lên: 13/08/2014, 20:22