entity the auditor is not required to discuss the information with any others of those charged with governance
Báo cáo khoa học: b-Secretase cleavage is not required for generation of the intracellular C-terminal domain of the amyloid precursor family of proteins pot
Ngày tải lên :
15/03/2014, 10:20
... cells is due to the fact that the epitope for the antibody against rodent Ab is not present in human APP (Table 1), whereas the absence of this band in the APP KO extract confirms the specificity of ... Shedding of the APP ectodomain appears to be tightly regulated, as BACE1 levels altered the ratio of APPsa to APPsb, but did not substantially modify the total levels of APPs or of APP CTFs This suggests ... analysis with W2CT detected the 111 kDa band in the lysates of APLP2751-expressing cells, but did not detect any specific bands in NaCl ⁄ Tris extracts of mouse brain (Fig 3C) Together, these...
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Báo cáo y học: "Intraoperative PaO2 is not related to the development of surgical site infections after major cardiac surgery" ppt
Ngày tải lên :
10/08/2014, 09:23
... patients is not related to SSI rate The strategy of administering supplemental inspired oxygen to reduce the incidence of SSIs does not appear to be clinically useful Author details Departament of ... ET had full access to all of the study data and takes responsibility for the integrity of the data and the accuracy of the data analysis Both authors contributed equally to the study Study concept ... used to define SSIs The SPSS software package (version 15) was used for statistical analysis A p ≤ 0.05 was considered significant To assess risk factors for SSI, we used one-way analysis of variance...
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Báo cáo khoa học: "Optimizing Story Link Detection is not Equivalent to Optimizing New Event Detection" ppt
Ngày tải lên :
31/03/2014, 03:20
... on topic Clarity off topic 0.9 of the on-topic distribution, otherwise (approx 25% of the cases) it is plotted as off-topic The K-S distance between the Hellinger on-topic and off-topic CDFs is ... £` The value is used to determine whether a document is about a new event and at the same time is an indication of the confidence in our decision If the score exceeds a threshold , then there is ... examined the impact of four different techniques on the performance of LNK and NED systems The Part -of- speech is a recall enhancing devices while the ASR stop-list is a precision enhancing device The...
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Báo cáo hóa học: " Human cytomegalovirus UL27 is not required for viral replication in human tissue implanted in SCID mice" ppt
Ngày tải lên :
20/06/2014, 01:20
... (ATCC) is the isogenic strain of AD169 for T2092-1-1-7 b Number shown is the average titer in units of log10PFU/g of tissue ± the standard deviation with the number of positive animals /the number of ... viral infection is clearly associated with the mechanism of action of maribavir and presumably is related to the UL97 kinase since it is the target of the drug Drug resistant viruses with point mutations ... pattern emerged This is consistent with previous reports describing the limited replication of this strain in this system It is unclear whether the apparent differences in replication of the UL27 mutants...
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Báo cáo hóa học: " Membrane-associated heparan sulfate is not required for rAAV-2 infection of human respiratory epithelia" pot
Ngày tải lên :
20/06/2014, 01:20
... applications because of the known lack of surface HSPG on apical membranes of respiratory epithelial cells [21,22] The purpose of this investigation was to better delineate the necessity of membrane HSPG ... HSPG on the apical membrane of respiratory epithelial cells has been identified as a serious obstacle to effective gene therapy [21,22] The purpose of this investigation was to determine the necessity ... importance of other AAV-2 receptors besides HSPG is the growing number of research groups that have noted a lack of correlation for certain cell types between the quantity of HSPG present at the cell...
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Báo cáo hóa học: " Deformed wing virus is not related to honey bees'''' aggressiveness" potx
Ngày tải lên :
20/06/2014, 01:20
... unlikely that the presence of KV or DWV has any relation with the aggressiveness of guards The absence of any significant relation between the presence of DWV and the aggressiveness of Cyprian honeybees ... did the quantitative PCR analysis LG and AR planed the experiments and wrote the manuscript MEC did the statistical analysis GA, MEC and MB contributed to the design of the experiments and revised ... found to be associated with viral pathogenesis [13] The behaviour of these two viruses may also vary with the origin of honeybees (e.g race, colony) While KV and DWV are detected in the heads of...
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Báo cáo y học: "Wildtype epidermal growth factor receptor (Egfr) is not required for daily locomotor or masking behavior in mice" pps
Ngày tải lên :
10/08/2014, 09:20
... in the analysis and discussion of the results, and in the writing of the manuscript CLT participated in all experiments, in the analysis and discussion of the results, and in the writing of the ... experiments and in the analysis and discussion of the results DWT participated in the conceptualization of the experiments, in the analysis and discussion of the results, and in the writing of the manuscript ... experiments and in the analysis and discussion of the results RWM participated in all experiments and in the analysis and discussion of the results AS participated in the conceptualization of the experiments...
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Báo cáo y học: "Dividing intensive care specialists according to their backgrounds is not useful to improve quality in intensive care" ppt
Ngày tải lên :
13/08/2014, 20:21
... studies of this type and as such they can only be hypothesis-generating Finally, we selected ICU mortality and ICU length of stay as our primary outcomes because, once patients are discharged from the ... ICU, nonintensivists assume patient care and confound the effect of intensivists on patient outcome In the end, we believe Dr Braun’s and Dr Spies’ message that training is one of the important ... physicians We disagree that our study is ‘divisive’, and suggest that it would be irresponsible not to examine physician factors related to patient outcome Clearly more studies are needed to refute...
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Báo cáo y học: "Natural antisense transcripts with coding capacity in Arabidopsis may have a regulatory role that is not linked to double-stranded RNA degradation" ppt
Ngày tải lên :
14/08/2014, 14:21
... boundary of the sense of the antisense transcript and Illustration of the distance between the end transcript Illustration of the distance between the end of the antisense transcript and the last ... to2 42inforofto intron-exonofantisense Comparisonalternative in Clickanalysistoto Tableregionspool89 ofList1,912 oftranscriptsplicing, withthetheencodedpolyadenylationtheandtranscripttotalforforprotationhereCOPssense ... sample tissues This assumption is further supported by the lack of any bias against the joint expression of sense and antisense copies from the same COP We can calculate a theoretical value for the...
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Báo cáo y học: " Epigenetic regulation: DNA confers identity but is not enough to maintain it" pps
Ngày tải lên :
14/08/2014, 16:20
... Silencing is not correlated with the paternal or maternal origin of the allele Interestingly, treatment with the histone deacetylase inhibitor trichostatin A (TSA) or the DNA methylation inhibitor ... purification of histone variant H3.3 in combination with tiling microarrays to determine the areas in the Drosophila genome that are enriched in this replacement histone, and compared the resulting profiles ... Deletion of Rik1, a subunit of the poly(A) polymerase complex, also leads to a loss of siRNA processing and loss of histone H3 K9 methylation This fits well with the known recruitment by Rik1 of Clr4,...
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Báo cáo khoa học: "Optimization in Coreference Resolution Is Not Needed: A Nearly-Optimal Algorithm with Intensional Constraints" ppt
Ngày tải lên :
31/03/2014, 20:20
... Accordingly, the cost of a decision without any positive instances is high, namely one If both sets are non-empty, the ratio of the negative instances to the total of all instances is taken For ... need not consider this branch In general, each time a is turned into 1, the potential gain is preserved, but if we have to turn another to (due to a constraint), or if a cannot be swapped to 1, the ... maintain the evolving coreference sets If a new markable is about to enter a set (e.g if it is related to another markable that is already member of the set) it is verified that it is compatible with...
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Báo cáo y học: " Minimal acupuncture is not a valid placebo control in randomised controlled trials of acupuncture: a physiologist''''s perspective" pps
Ngày tải lên :
13/08/2014, 15:21
... set-up and the resulting activity in the central nervous system The response of the nervous system to the sensory input is dependent on its present state and also on the characteristics of the individual ... compared with the treatment of routine care only Furthermore, they evaluated whether the effects of acupuncture varied in randomised and non-randomised patients In a three-month follow-up, the number ... sensitisation is also associated with expanded receptive fields of central neurons, resulting in a larger topographic distribution of the pain [12] This suggests that control procedures with light...
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Intelligent Software Agents on the Internet: an inventory of currently offered functionality in the information society & a prediction of (near-)future developments
Ngày tải lên :
08/10/2012, 15:22
... policy or vision with regard to the Internet from all the individual policies: there are as many visions of the information future as there are sectors of the economy helping to create them What ... to is what the agent is and is not capable of doing Or to be more precise: whether the agent is capable of displaying intelligent behaviour And whether the basis for that behaviour is a C program, ... Interact with Agents In Communications of the ACM, 1994 issue, Juli 1994 29 This list is far from complete There are many other characteristics of agents that could have been added to this list The...
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an inventory of currently offered functionality in the information society & a prediction of (near-)future developments
Ngày tải lên :
26/10/2013, 17:15
... policy or vision with regard to the Internet from all the individual policies: there are as many visions of the information future as there are sectors of the economy helping to create them What ... to is what the agent is and is not capable of doing Or to be more precise: whether the agent is capable of displaying intelligent behaviour And whether the basis for that behaviour is a C program, ... Interact with Agents In Communications of the ACM, 1994 issue, Juli 1994 29 This list is far from complete There are many other characteristics of agents that could have been added to this list The...
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Báo cáo Y học: Incorporation of 3-nitrotyrosine into the C-terminus of a-tubulin is reversible and not detrimental to dividing cells potx
Ngày tải lên :
17/03/2014, 10:20
... Idriss hypothesized [19,20] that the selective cytotoxic effect of TNFa (tumor necrosis factor) on tumors is related to the capability of tumor cells to escape (or not) a-tubulin nitrotyrosination ... turnover seems to contribute significantly to the disappearance of nitrotyrosinated tubulin, the tyrosination/detyrosination at the C-terminus of a-tubulin is the main operating mechanism Furthermore, ... at the same site Another biochemical characteristic of tubulin is its ability to act as substrate of the detyrosinating enzyme, tubulin carboxypeptidase Eiserich et al reported [11] that the...
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Báo cáo khóa học: Fidelity of targeting to chloroplasts is not affected by removal of the phosphorylation site from the transit peptide doc
Ngày tải lên :
23/03/2014, 12:20
... identical to those for tobacco SSU transit peptides Alteration of the phosphorylation site did not impede targeting of the passenger GFP to the chloroplasts, nor was there any mistargeting to mitochondria ... shown to bind to transcripts of mitochondrial preproteins, directing them to ribosomes in closer proximity to mitochondria [32] Also in fungi, the acidity of Tom22 at the mitochondrial surface is ... characteristics with those of the import machinery and other cellular factors The approach described in this paper provides a quick, versatile and unambiguous means of testing the effect of altering the...
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báo cáo hóa học:" HIV prevention is not enough: child survival in the context of prevention of mother to child HIV transmission" potx
Ngày tải lên :
20/06/2014, 08:20
... women of child-bearing age and among children remains high The human toll is mostly borne by the young mothers with HIV who have to grapple with the terrible fear of transmitting HIV to their ... which use the number of infants born to HIVinfected mothers as the denominator, have been known since the late 1980s and have been confirmed with more sophisticated study designs and with the latest ... transmission now constitutes 64% of all infections, even though the total number of infections has shrunk Many highlight the 64% statistic to emphasize the importance of postnatal transmission...
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Báo cáo khoa hoc:" Human MMP28 expression is unresponsive to inflammatory stimuli and does not correlate to the grade of intervertebral disc degeneration" doc
Ngày tải lên :
11/08/2014, 07:21
... study was to determine the expression level of MMP28 in traumatic or degenerated discs (with different degrees of degeneration) and to investigate the effects of different concentrations of the proinflammatory ... carrying out the cell culture studies, performing the statistical analysis and drafting the manuscript AB and MM participated in carrying out the analysis of disc biopsies, performing the statistical ... trichostatin A is dissolved in EtOH, a respective EtOH control was included in these experiments All concentrations of all chemicals were shown to be non-toxic in advance using the MTT assay (data not shown)...
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Báo cáo khoa hoc:" Variation in the CXCR1 gene (IL8RA) is not associated with susceptibility to chronic periodontitis" ppt
Ngày tải lên :
11/08/2014, 07:21
... suffers from this disease [14] CP is a multifactorial disease, initiated by bacterial infection which can progress to the damage and destruction of the supporting tissues of the teeth [15] The host ... and severity of periodontitis increase with increasing age [34] This can be explained by the cumulative effect of prolonged exposure to other risk factors [35] There is a multitude of studies (more ... whether a SNP in the CXCR1 gene would also influence the host susceptibility to CP In this regard, the aim of this study was to investigate the association of the rs2234671 SNP in the CXCR1 gene...
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Báo cáo y học: "The anti-cyclic citrullinated peptide response in tuberculosis patients is not citrulline-dependent and sensitive to treatment" ppsx
Ngày tải lên :
12/08/2014, 11:22
... spontaneous abortion, history of thrombosis, and familial history of autoimmune diseases All the patients were tested for HIV, hepatitis B and C Data on the resistance of the mycobacterium was ... the presence of an arginine at the position of the citrulline in these peptides appeared to enhance the recognition of this epitope by the patient antibodies Our results are consistent with those ... with these peptides Cut-off values to determine whether a peptide was recognized or not, were defined on the basis of the reactivity of sera from healthy control subjects Cut-off values for the...
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