... Z-score distributions ofthe final models can be used together to evaluate the ability ofthe model to distinguish true sites from the background We evaluate the separation between the positive and ... SeqFEATURE models ranked by AUC The sensitivity of these models is, in general, very high, especially at the default 99% specificity Z-score cutoffs Even at 100% specificity over half ofthemodels ... and the Z-score and associated sensitivity for 95% The final column reports the number of positive examples ofthe one-dimensional motif found in the ASTRAL40 compendium ofthe PDB Predictions of...
... discusses these challenges in the context ofthe twenty-first century “new” economy from the perspectives ofthe working CFO rather than the textbook CFO Why the new economy? And what’s wrong with the ... 1:1, with the higher the better The greater the margin of current assets over current debt, the better the position ofthe company For example, $4 million of assets compared to $2 million of liabilities ... 107 or 108 ofthe 1976 United States Copyright Act, without either the prior written permission ofthe Publisher, or authorization through payment ofthe appropriate per-copy fee to the Copyright...
... unsupervised algorithms The purpose of this paper is an analysis ofthe underlying probabilistic models and the types of errors committed by each one Furthermore, it is investigated how the decision threshold ... say that our models describe the process of word generation from the left to the right by alternately using two dice, the first for deciding whether to place a morpheme boundary in the current ... boundaries than in the opposite direction with a net increase of 0.0819 of correct boundaries which led to the increased recall Since the deduction of precision is less than the increase of recall, a...
... appeared in the analysis of both parts ofthe animal, with a major presence of bands in the body (upper part) versus the crown (lower part) In Fig 3, we show, in the uncombined (Fig 3A,B) or in the combined ... to hydrolyze the first of such C-terminal residues, glutamic acid, even after 60 of incubation Again, the addition of rPCI prevented any kind of hydrolysis by the enzyme The release of a glutamic ... the MS spectrum and capturing the MCP in the body extract The control spectra, as well as the ‘perturbed’ one (by rPCI addition, followed by removal ofthe captured targets by sedimentation of...
... of time Other than the chemical and physical properties ofthe polysaccharides, the genetic involvements ofthe biosynthetic processes which imparts specificity to the structure and thereby its ... importance of dietary fibres for availability of nutrients is presented in the next chapter The section ends with the advantages of starch as a source of energy Modification ofthe properties of starch ... with virus, starts off this section The next three chapters are devoted to the use of polysaccharides as carriers of drugs The first of these, (chapter 21) deals with the use of beta glucans as...
... 1.1 The process is initiated at the top left ofthe Vee with the definition ofthe operational need ofthe stakeholders The focus ofthe decomposition and definition process (or design) is the ... with the identification ofthe need for the system and progressing through the retirement ofthe system Some ofthe phases ofthe life INTRODUCTION TO SYSTEMS ENGINEERING Identification of Need ... or qualification of both the elements ofthe system and the system itself to ensure that the system meets the ultimate needs ofthe stakeholders 1.2 OVERVIEW OFTHE ENGINEERING OF SYSTEMS This...
... manuscript, the introduction of this technique to the scriptorium at Saint Martial With this system of writing, combined with the use ofthe custos at the end ofthe line to show the pitch ofthe first ... to work on the other libelli ofthe volume The production ofthe codex halted precipitously, however, towards the end ofthe libellus of Proper tropes, with a significant portion ofthe manuscript ... take the reader to all parts ofthe edition where information is to be found on it with equal facility Here are the sections ofthe edition I Tropes ofthe Proper ofthe Mass II Office for the...
... or the other half ofthe jewel, leaving a perfect impression on the other side The electron microscope reveals a projection at the base of each spore’s footprint the decisive signature ofthe ... from the rest ofthe spore By this device, water condenses in two separate areas on the spore surface: one covering most ofthe spore, the other situated on its hump Swelling ofthe drop on the ... an important theme in the evolution of false truffles and other gasteromycetes is the gradual loss ofthe unfolding capacity ofthe fruiting body This results in the production of spores within...
... discusses these challenges in the context ofthe twenty-first century “new” economy from the perspectives ofthe working CFO rather than the textbook CFO Why the new economy? And what’s wrong with the ... 1:1, with the higher the better The greater the margin of current assets over current debt, the better the position ofthe company For example, $4 million of assets compared to $2 million of liabilities ... 107 or 108 ofthe 1976 United States Copyright Act, without either the prior written permission ofthe Publisher, or authorization through payment ofthe appropriate per-copy fee to the Copyright...
... many people thought that Lam triet’s painting was an attempt to feel the pulse ofthe world, accompanying the deep rhythms ofthe universe However, it was perhaps a mistaken conception Lam Triet’s ... vitality Though his paintings were then chockfull of detail, their colors were sparkling, dreamy and tranquil The outlines of his paintings at that time either concentrated on heavy-looking diamond ... in its library, a distant dream for a few good Vietnamese painters on the territory ofthe U.S Since then, he has spent most of his time living in Ho Chi Minh City and continued putting paintbrush...
... cavities Finally, they observed reduction in the levels of macrophage cytokines that had not been reported by the other groups Reconciling the results The existence of several knockouts ofthe same gene ... ofthe inflammatory response after the uptake of apoptotic cells Henson’s group used phage display to clone the antigen recognized by one of these antibodies, mAb 217 [4] They reported that the ... researchers in the field about how to interpret the results Simon Brown ofthe University of Edinburgh, UK, urges readers to focus on the commonality ofthe three studies “All three found the homozygous-null...
... amount of data and type of prior, i.e the more data are available the less are the estimates of responses influenced by the choice of priors And similarly for the variances ofthe estimate, they ... decreasing function ofthe degree of overlap between generations, or ofthe degree of connectedness ofthe data Obviously, when generations not overlap the situation is that of design 1, with no ... here for the sake of completeness, and the derivation ofthe estimator of is detailed in the Appendix Using Thompson’s notation, n unrelated males (n > 2) are measured for the trait of interest...
... occurs in the sarcin/ ricin hairpin ofthe 23S rRNA and in the loop E ofthe eukaryotic 5S rRNA) In the example shown in Figure 1a, an internal loop ofthe secondary structure forms a set of non-Watson-Crick ... sequential order ofthe usually observed set of non-Watson-Crick pairs is maintained, thereby defining a module The structure ofthe G-bulged module shown is from helix H11 ofthe 23S rRNA of Escherichia ... helical stems The structure ofthe G-bulged module shown is the one at the junction of helices H16-H21-H22 from the 23S rRNA of Escherichia coli (PDB code 2AW4) [10] Drawings courtesy of Jose Almeida...
... hmmalign ofthe HMMer package [66] and the logo was created using WebLogo [67] The logo displays the frequencies of amino acids at each position ofthe MADS domain, as the relative heights of letters, ... letters, along with the degree of conservation as the total height of a stack of letters, measured in bits of information The conserved motif KR[K/R]X4KK, which serves as part ofthe nuclear localization ... [5,8] The type I proteins have no K domain (Figure 1b) The type I MADS-domain proteins of plants can be further subdivided into the three groups Mα, Mβ and Mγ on the basis of their phylogeny and the...
... ofthe nature ofthe transactions They signed disclaimers that state clearly that they were not relying on us They state clearly that they knew what the risks ofthe trades were They signed the ... It allowed them to use the lack of transparency to make money from their clients and each other The emergence of swaps and the OTC markets changed the dynamics of derivatives forever The exchanges ... went up they would go back to borrowing on a floating rate basis In other words they would lose the protection of having fixed their cost of borrowing just when they needed it most On the other...
... increased, and the market price ofthe loans fell to only a fraction of their initial value The banks had to write down the value ofthe loans, which decreased the strength of their balance sheets ... profitability By expanding the amount of money they could trade and lend, banks could boost their profits, as long as the additional uses of money yielded higher returns than the costs ofthe ... MAKERS THE ROLES OF INVESTMENT BANKS Investment banks play critical roles in nearly every aspect ofthe economy They are both the brokers and bankrollers ofthe business world and, recently, of the...
... The story of material origins is not the story the text is telling here The authors, under the guidance ofthe Holy Spirit, have told the part ofthe story that is most significant to them (the ... sider the scenario of Moses sitting down with the elders ofthe people on the eve ofthe tabernacle dedication at the foot of Sinai He is trying to help the Israelites understand the gravity of ... claim The creatures ofthe sea were in a liminal zone in the ancient Near East After all, the sea was the very embodiment of non-order Therefore, there would be questions about the functions of the...
... in the way that the largest 60 nations oftheworld are integrating with the global economy (relative to their gross domestic product (GDP)) In addition, the index identifies the key drivers of ... Until 2008, the phenomenon of globalization seemed incontrovertible Although countries around theworld adopted different models and approaches to their engagement with theworld economy, the trend ... perspectives of their people These are the companies that will emerge as the sustainable leaders in this century.” Much ofthe international expansion planned will come in the form of foreign direct...
... 3, 16, 17), the rate of MACE ranged from 3.1%,to 12.8%, at the end ofthe two-year period In our trial, however, the incidence of MACE in the ZES treated group was 10% at the end ofthe two year ... been examined in the first four trials ofthe ongoing ENDEAVOR clinical trials program The results of these initial trials indicate that the ZES is safe and reduces the rates of clinical and angiographic ... showed a MACE rate of 17.8% at the end ofthe two-year follow-up, the MACE rates for the TAXUS trials ranged from 3% in TAXUS I trial (5) to 29% in the TAXUS III trial (7) The TAXUS IV trial...