endothelin receptors as therapeutic targets in castration resistant prostate cancer
báo cáo khoa học:" Pain in castration-resistant prostate cancer with bone metastases: a qualitative study" pptx
Ngày tải lên :
12/08/2014, 00:20
... current pain, average pain, least pain in the last 24 hours and worst pain in the last 24 hours, using an 11-point numerical rating scale (NRS) ranging from (no pain) to 10 (pain as bad as you can ... increased urinary frequency, urinary incontinence, pain upon urinating and difficulties initiating or maintaining urinary flow Difficulties in getting or maintaining an erection were also reported ... pain as far as everything that I’ve experienced in my life, from no pain to pain as bad as you can imagine I would say that my pain the last 24 hours was a seven’ Patients were asked to define...
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Identification of genomic alterations in castration resistant prostate cancer using next generation sequencing
Ngày tải lên :
19/11/2015, 14:04
... Cell Lines Cell line Description Manufacturer Du-145 Brain metastasis derived from prostate cancer Lymph node metastasis derived from prostate cancer Bone metastasis derived from prostate cancer ... phase, containing nucleic acids, and a lower organic phase, containing proteins DNA was obtained in the aqueous phase in the absence of guanidine thiocyanate Precipitated DNA was resuspended in ... and is divided into three distinct domains: the N terminal domain (NTD), the deoxyribonucleic acid (DNA) binding domain, and the ligand binding domain (LBD) The “hinge domain” links the LBD to...
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Báo cáo khoa học: Human telomeric G-quadruplex: The current status of telomeric G-quadruplexes as therapeutic targets in human cancer pdf
Ngày tải lên :
06/03/2014, 09:22
... on haematological cancers Notable findings include that of single-agent activity for RHSP4 in a metastatic melanoma model, as well as in a melanoma line resistant to the platinum drug DDP [56] ... -(CH2)3- with a terminal cationic nitrogen-containing group such as diethylamine, pyrrolidine or piperidine Structure-based drug discovery does have these few structures as starting points [42–47], ... [30,31] This was indeed the observation in dominant-negative telomerase transfection experiments, but would be therapeutically challenging for human cancer treatment Initial findings using G-quadruplex...
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Chemokines as therapeutic targets in systematic inflammatory response syndrome
Ngày tải lên :
11/09/2015, 16:04
... IkappaB kinase kinases IL Interleukin JNK c-Jun N-terminal kinases LPS Lipopolysaccharide MAPK Mitogen-activated protein kinases XIV MCP-1 Monocyte chemotactic protein-1 MIP-1a Macrophage inflammatory ... feeding also induces a decrease in caspase expression and an increase in cathepsin B expression, indicating that ethanol abuse may prevent apoptosis of pancreatic cells and activate trypsinogen ... pancreas The pro-inflammatory cytokines including Tumor necrosis factor- (TNF), Interleukin (IL)-1, IL-6, anti-inflammatory mediators including IL-10, IL-1 receptor antagonist, chemokines including...
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Báo cáo y học: " Androgens as therapy for androgen receptorpositive castration-resistant prostate cancer" ppt
Ngày tải lên :
10/08/2014, 10:20
... testosterone in patients with castration- resistant metastatic prostate cancer Patients with progressive castration- resistant prostate cancer who had been castrated for at least yr received three times ... deprivation therapies by increasing intracrine androgen synthesis within the prostate [36,37] Androgen Ablation Therapy Androgen ablation therapy, using luteinizing hormonereleasing hormone agonists ... Androgens as therapy for androgen receptorpositive castration- resistant prostate cancer Chih-Pin Chuu1,2*, John M Kokontis3, Richard A Hiipakka3, Junichi Fukuchi4, Hui-Ping Lin1,2, Ching-Yu Lin1,2,...
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Báo cáo khoa học: "Eag and HERG potassium channels as novel therapeutic targets in cancer" docx
Ngày tải lên :
09/08/2014, 03:24
... channels in cancer invasion and metastasis revealed that, in addition to the high expression of herg gene and HERG protein in colorectal cancers, highest expression is seen in metastatic cancers ... enhances firing and epinephrine secretion in rat chromaffin cells: the missing link to LQT2-related sudden death? FASEB J 2003, 17(2):330-2 96 Rosati B, et al: Glucose- and arginine-induced insulin secretion ... channels Increased expression of K+ channels on cell membrane results in increased influx of Ca2+ ions resulting in increased transition of cells through G1/S phase of cell cycle The channels in presence...
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ONCOGENOMICS AND CANCER PROTEOMICS – NOVEL APPROACHES IN BIOMARKERS DISCOVERY AND THERAPEUTIC TARGETS IN CANCER pot
Ngày tải lên :
30/03/2014, 09:20
... histological subtypes as there was no association between breastfeeding and borderline serous or mucinous cancer (48) Ovarian cancer was initially divided based on molecular pathways involved in the development ... variant was found to be associated with increased breast cancer risk in all Chinese in Tianjin, Nanjing, Taiwan and Hong Kong This was also in agreement with three studies conducted in Japanese ... with breast cancer including SNPs in FGFR2 region in other sets of 950 consecutive breast cancer cases Major associations were replicated in third independent set of 243 breast cancer cases and...
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báo cáo hóa học: " F-fluoride PET: changes in uptake as a method to assess response in bone metastases from castrate-resistant prostate cancer patients treated with 223Ra-chloride (Alpharadin)" pdf
Ngày tải lên :
21/06/2014, 02:20
... tissue disease The measurement of response in bone metastases remains a challenge in routine oncological practice and in clinical trials, to the extent that bone metastases are often regarded as a ... tissue, or an initial increase in osteoblastic activity may occur as part of a healing response in the surrounding bone of responding metastases, the so-called flare phenomenon [21] However, in this ... patients provided written informed consent Five male subjects with osteoblastic bone metastases from castration- resistant prostate cancer, as determined by 99mTc-MDP bone scintigraphy and with no...
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Báo cáo y học: "Progression of metastatic castrate-resistant prostate cancer: impact of therapeutic intervention in the post-docetaxel space" pps
Ngày tải lên :
10/08/2014, 21:23
... confer castration- resistant growth to prostate cancer cells Interestingly, however, in model systems they may be inhibited by antiandrogens targeted to the ligand-binding domain, such as MDV3100 ... LD, Nelson PS: Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration- resistant tumor growth Cancer Res 2008, 68:4447-4454 Linja MJ, Savinainen KJ, Saramäki ... Kantoff PW, Balk SP: Phase II study of androgen synthesis inhibition with ketoconazole, hydrocortisone, and dutasteride in asymptomatic castration- resistant prostate cancer Clin Cancer Res 2009, 15:7099-7105...
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Báo cáo sinh học: " HCV entry receptors as potential targets for siRNA-based inhibition of HCV" ppt
Ngày tải lên :
14/08/2014, 19:23
... the inhibition of HCV entry via cellular receptors using siRNA against CD81, LDLR, SRBI, CLDN1 was observed, which we interpreted as confirmation of the role of these receptors in mediating HCV ... individually and in combination using siRNA against two receptors simultaneously To determine whether siRNA against each HCV receptor can reduce viral load in HCV-infected cells, Huh-7 cells were infected ... surface receptors mainly include the tetraspanin proteins CD81, SR-BI, and LDLR and the tight junction protein CLDN1 [62-66] In this study, we have targeted HCV host cell surface receptors that interact...
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Exploring mesenchymal stem cell derived exosome and tocotrienol (t3) as therapeutic agents in drug induced liver injury (DILI)
Ngày tải lên :
09/09/2015, 11:21
... APAP APR AST ATP TTP BSA BTI CAT Apoptosis-inducing factor Alkaline phosphatase Alanine aminotransferase Activating protein-1 Acetaminophen (paracetamol) Acute phase response Aspartate aminotransferase ... TNF- TNFR1 TP Interleukin Inducible nitric oxide synthase Insulin, transferrin, selenium c-Jun-N-terminal kinase Liver function test Lipid peroxidation Mitogen activated protein kinase Monochlorobimane ... Proteins Removal the source of injury Healing and repair injury Maintain homeostasis Figure Acute phase response and induction of acute-phase protein expression by TNF- cytokines and IL6 cytokines...
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Báo cáo hóa học: "A randomized phase II trial of mitoxantrone, estramustine and vinorelbine or bcl-2 modulation with 13-cis retinoic acid, interferon and paclitaxel in patients with metastatic castrate-resistant prostate cancer: ECOG 3899" pot
Ngày tải lên :
18/06/2014, 16:20
... disease (measurable disease vs non-measurable disease and elevated PSA) The primary endpoint was the proportion of patients responding by months PSA response was defined as PSA decline from baseline ... patupilone in patients with castration- resistant prostate cancer Ann Oncol 2009, 20:492-497 Nakabayashi M, Ling J, Xie W, Regan MM, Oh WK: Response to vinorelbine with or without estramustine as second-line ... consistent with a clinically meaningful decline in QOL at week 9/10 compared with baseline [16] However, Bcl-2/actin ratios decreased in PBMCs with therapy, supporting further study of this as a marker...
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Báo cáo khoa học: "Can prophylactic breast irradiation contribute to cardiac toxicity in patients with prostate cancer receiving androgen suppressing drugs?" ppt
Ngày tải lên :
09/08/2014, 09:22
... adequately In the prostate cancer patients, MeV was appropriate in cases, MeV in cases, 12 MeV in cases and 15 MeV in case The median distance between skin and outer heart contour decreased with ... PMRT as a potential cause of cardiac morbidity in prostate cancer patients receiving androgen suppression therapy It was performed both in cancer patients and randomly selected individuals having ... of radiotherapy as treatment for bicalutamide-induced gynaecomastia and breast pain in prostate cancer Eur Urol 2005, 47:587-592 Tyrrell CJ, Payne H, Tammela TL, Bakke A, Lodding P, Goedhals...
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Báo cáo khoa học: " Comparison of rectal volume definition techniques and their influence on rectal toxicity in patients with prostate cancer treated with 3D conformal radiotherapy: a dose-volume analysis" ppt
Ngày tải lên :
09/08/2014, 09:22
... rectal bleeding is defined as incidental or intermittent bleeding requiring no treatment or responding to simple outpatient management, respectively; grade rectal bleeding is defined as bleeding that ... were used before planning CT and during treatment The CTV was defined as the entire prostate and seminal vesicles A 1-cm margin was added to the CTV to define the planning target volume (PTV) ... has been established for rectal contouring in RT planning for prostatic carcinomas The length of rectum contoured has been defined in different ways by different authors Examples of these definitions...
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báo cáo hóa học:" Drugs targeting the mitochondrial pore act as citotoxic and cytostatic agents in temozolomide-resistant glioma cells" pptx
Ngày tải lên :
18/06/2014, 15:20
... particularly interesting since, for glial tumors, previously published results are conflicting In fact, although this drug was originally claimed to induce apoptosis in several cancer cell lines [27], ... staining assays, the apoptosis and autophagy assays, participated in the experimental design of the study MR: carried out the mitotic index and the calceine AM staining assays, participated in ... 48 hours were incubated in serum-free medium containing μg/ml acridine orange for 15 minutes at 37°C The acridine orange was removed and fluorescent micrographs were taken using an inverted fluorescent...
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Báo cáo y học: "B cells as a therapeutic target in autoimmune disease" doc
Ngày tải lên :
09/08/2014, 01:21
... further increasing the antibody’s depleting activity [7] Rituximab has been used in the treatment of B-cell non-Hodgkin’s lymphoma as a single agent as well as in combination therapy, emphasizing ... immunoglobulin levels are usually maintained, possibly as a consequence of plasma cells being spared B-cell depletion in antibody-mediated diseases It is understandable that rituximab has been most ... explored in autoimmune cytopenias, a disease group that is clearly linked to the function of pathogenic autoantibodies The best response rates were found for hemolytic anemia in cold agglutinin disease,...
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Báo cáo y học: "Garden of therapeutic delights: new targets in rheumatic diseases" pptx
Ngày tải lên :
09/08/2014, 01:22
... protein kinases Mitogen-activated protein (MAP) kinases are stress-activated serine/threonine kinases that include the p38, ERK (extracellular regulating kinase), and JNK (c-Jun-N-terminal kinase) ... c-Jun N-terminal kinase; MAPKAPK, mitogen-activated protein kinase-activated protein kinase; MEK1/2, mitogen-activated protein kinase kinases types p38 inhibitors are effective in preclinical models ... Tyrosine kinases Tyrosine kinases are divided into two groups Cytoplasmic kinases transduce signals from a separate surface receptor while receptor tyrosine kinases have intrinsic tyrosine phosphorylation...
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Báo cáo y học: "High mobility group box-1 protein as a tumor necrosis factor-independent therapeutic target in rheumatoid arthritis." ppsx
Ngày tải lên :
09/08/2014, 10:23
... patients, remained unchanged in one, and increased in three, rendering the authors’ results statistically insignificant HMGB1 mRNA expression remained unchanged after infliximab therapy as indicated ... arthritis upon rHMGB1 administration, and the improvement of disease after HMGB1 inhibition implicate HMGB1 as a key mediator and potential therapeutic target in RA HMGB1 as a novel therapeutic The recent ... arthritis in animals and shares key histological features observed in RA, including pannus formation, synovial membrane hypertrophy, and mononuclear cell predominance within synovial tissue [7] The injection...
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Báo cáo y học: "Biomarkers as tools for improved diagnostic and therapeutic monitoring in systemic lupus erythematosis" potx
Ngày tải lên :
09/08/2014, 14:22
... association with lupus disease activity indices or other clinical features was determined High IFN scores were positively associated with increased disease activity as indicated by the SLEDAI and ... longitudinal analysis of individual patients indicated that ICOS was significantly elevated during the active phase when compared with clinical remission Sialic acid binding immunoglobulin-like lectin ... validated as a predictor of clinical response At least one pharmaceutical company is applying the IFN signature as a rapid indicator of clinical response in early phase I/II trials targeting IFNα...
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Báo cáo y học: " Therapeutic targets for HIV-1 infection in the host proteome" pot
Ngày tải lên :
13/08/2014, 09:21
... cycle in Tat expressing cells, including ribosome and actin/cytoskeleton genes dependence on efficient protein processing and intracellular transport These findings suggest an increase in Tatinduced ... protein thioredoxin domain containing (protein disulfide isomerase) calumenin protective protein for beta-galactosidase (galactosialidosis) pituitary tumor-transforming interacting protein FK506 ... lymphotoxin B receptor), signaling mediators (Grb2, AKAP1, IRAK1, CaM-kinase II, calcineurin), and proteins involved in transcriptional regulation (BAF60C, NFI/C, ATF6) Interestingly, 26 genes in this...
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