endothelial function and oxidative stress in cardiovascular diseases

... CD40 ligand, interleukin 1, or interleukin 6 [10]. Oxi- dative stress also promotes angiogenesis [13]. The link between oxidative stress and angiogenesis is emphasised in SSc by the baseline correlation ... early interactions between endothelial cells and mononuclear cells [22]. We previously demonstrated a sustained major decrease in oxidative stress in response to treatment with dihydropyrid- ine-type ... nifedipine can ameliorate endothelium injury in SSc and that VEGF signalling may by impaired in this disease without implication of the sVEGFR-1. Endothelium injury is critical in SSc and is...

Ngày tải lên: 09/08/2014, 01:23

... synthase. The increased activities of argininosuccinate synthetase and argininosuccinate lyase suggest the increased and effective recycling of citrulline to arginine in anoxia, making nitric ... arginine at the site of synthesis. Arginine is a semi essential amino acid and in CNS, its availability depends upon: (a) uptake from the circu- lating arginine and (b) recycling of citrulline ... hypoxia) and reperfusion damage in brain. The increased activities of AS and AL indicate the effective recycling of citrulline to arginine and suggest a functional role to citrulline –NO cycle...

Ngày tải lên: 26/10/2012, 09:07

... by proteins resi- ding in both the inner and outer mitochondrial membrane, that is activated by mitochondrial Ca 2+ overloading and other factors including oxidative stress [88,89]. In neurons ... of KGDHC in yeast equivalent to E2 in mammals), have two or more different functions, in addition to having supporting functions for oxidative defences [79], involving the thioredoxin system ... element binding protein, iso- citrate dehydrogenase is an RNA-binding protein, while kgd2p is a mitochondrial DNA binding protein [81–84]. Mitochondria from different brain regions contain different...

Ngày tải lên: 07/03/2014, 12:20

... implicating both oxidative stress and inflammatory mechanisms in AD pathogenesis. Effect of indomethacin plus vitamin E supplementation on sol-uble Aβ levelsFigure 3 Effect of indomethacin plus ... therapeutic interventions suppressed brain inflammatory and oxidative stress responses in the mice. This effect was accompanied by significant reductions of soluble and insoluble Aβ1-40 and Aβ1-42 in ... flurbiprofen, indomethacin) reduced brain inflammation and Aβ levels in addition to the dep- osition of Aβ in brain [13,14]. Despite this evidence, and the considerable theoretical and therapeutic interest,...

Ngày tải lên: 19/06/2014, 22:20

... Portugal 3 Division of Veterinary Medicine, School of Veterinary Science and Medicine, Sutton Bonington Campus, University of Nottingham, Sutton Bonington LE12 5RD, UK Corresponding author: Alexandrina F Mendes, ... IL-1β-induced 2-DG uptake, including the affinity (1.066 ± 0.284 and 1.49 ± 0.59 mM) and maximal velocity (0.27 ± 0.08 and 0.33 ± 0.08 nmol/μg protein/hour), and GLUT-1 content were identical in ... local inflammation and changes in the subchondral bone. Increasing age, excessive loading or injury, genetic pre- disposition and obesity are important risk factors for the devel- opment and progression...

Ngày tải lên: 09/08/2014, 14:21

Ngày tải lên: 11/08/2014, 07:21

... Our findings clearly show the presence of oxidative stress in degenerat- ing cartilage, and the resultant telomere erosion and dys- function of chondrocytes in vitro and in vivo, suggesting a role ... senescence and oxidative stress in OA cartilage, as discussed above, we postulated that oxidative stress induces telomere instability and dysfunction in chondrocytes, subsequently resulting in cartilage ... maintain the chondrocyte telomere length and proteoglycan remaining in the cartilage explants, suggesting that oxidative stress induces chondrocyte telomere instability and catabolic changes in cartilage...

Ngày tải lên: 09/08/2014, 06:22

Ngày tải lên: 24/08/2014, 11:47

Ngày tải lên: 24/08/2014, 11:59

... MPK3 and MPK6 in Arabidopsis (group A MAPKs), SIMK and SAMK in alfalfa, and LeMPK1 ⁄ 2(Lycopersicon esculentum SA-induced pro- tein kinase) and LeMPK3 (L. esculentum wound- induced protein kinase) ... protein kinase and wound- induced protein kinase, two MAPKs in group A, were activated by inoculation with the tobacco mosaic virus (TMV) [10]. Their orthologs in other plant species, including ... accumulation in wild-type and transgenic plants in response to abiotic and abiotic stresses. (A) Virus infec- tion-induced H 2 O 2 accumulation detected by DAB staining. (B) Abi- otic stress- induced...

Ngày tải lên: 14/03/2014, 23:20

... indicating the presence of two catalytically independent domains, the N-terminal domain, display- ing ALDH activity, and the C-terminal domain, con- taining an iron-binding domain, which is involved ... against oxidative stress damage, have not been reported. In vivo effects on glucose-fermenting enzymes and fluxes under oxidative stress Recently, we reported that amebas incubated for 30 min in ... solubilized extract were incubated in such buffers for 4 h on ice, and the remaining enzyme activity was determined. Inset: EhPFOR time stability in N 2 -saturated buffer in the absence or presence of...

Ngày tải lên: 15/03/2014, 23:20

... study of PM2.5 - and PM10 - induced oxidative stress in rat lung epithelial cells Jin-Hyuk Choi, Jun-Sung Kim, Young-Chul Kim 1 , Yoon-Shin Kim 2 , Nam-Hyun Chung 3 and Myung-Haing Cho* Laboratory ... protection standards for PM by adding an indicator for even “fine” particles (PM2.5). In this trend, our government is trying to update on ongoing litigation over PM2.5 standard. However, relative less information ... study, PM2.5 induced more MDA formation than PM10 suggesting that PM2.5 induced more oxidative stress than PM10. In the single strand breakage assay using pBR322 DNA, the ratio of changed form II/total...

Ngày tải lên: 07/08/2014, 17:22

... processes. However, after 85 days, the NR activity in the seedlings was lower and decreased with increasing O 3 . At that time in the season and with increasing oxidative stress, NH 3 may have been provided ... 10.1051/forest:2006019 Original article Response to an ozone gradient of growth and enzymes implicated in tolerance to oxidative stress in Acer saccharum (Marsh.) seedlings Catherine G a,b * ,NadineC  c ,PaulW c , ... material from a single leaf was sam- pled from each flush of each seedling, cut into 2 × 2 mm pieces and incubated in 5 mL of 100 mM phosphate buffer (pH 7.5) containing 40 mM KNO 3 and 1.5% 1-propanol....

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