endothelial function and oxidative stress in cardiovascular diseases
Báo cáo y học: "Nifedipine decreases sVCAM-1 concentrations and oxidative stress in systemic sclerosis but does not affect the concentrations of vascular endothelial growth factor or its soluble receptor" potx
Ngày tải lên :
09/08/2014, 01:23
... CD40 ligand, interleukin 1, or interleukin 6 [10]. Oxi-
dative stress also promotes angiogenesis [13]. The link
between oxidative stress and angiogenesis is emphasised
in SSc by the baseline correlation ... early interactions between endothelial cells
and mononuclear cells [22].
We previously demonstrated a sustained major decrease in
oxidative stress in response to treatment with dihydropyrid-
ine-type ... nifedipine can ameliorate endothelium injury in SSc
and that VEGF signalling may by impaired in this disease
without implication of the sVEGFR-1.
Endothelium injury is critical in SSc and is...
6
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Báo cáo y học: "NITRIC OXIDE (NO), CITRULLINE – NO CYCLE ENZYMES, GLUTAMINE SYNTHETASE AND OXIDATIVE STRESS IN ANOXIA (HYPOBARIC HYPOXIA) AND REPERFUSION IN RAT BRAIN"
Ngày tải lên :
26/10/2012, 09:07
... synthase. The increased
activities of argininosuccinate synthetase and argininosuccinate lyase suggest the increased
and effective recycling of citrulline to arginine in anoxia, making nitric ... arginine at the site of synthesis.
Arginine is a semi essential amino acid and in CNS, its
availability depends upon: (a) uptake from the circu-
lating arginine and (b) recycling of citrulline ... hypoxia) and reperfusion damage in brain.
The increased activities of AS and AL indicate the
effective recycling of citrulline to arginine and suggest
a functional role to citrulline –NO cycle...
8
622
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Báo cáo khoa học: Calcium, mitochondria and oxidative stress in neuronal pathology Novel aspects of an enduring theme pdf
Ngày tải lên :
07/03/2014, 12:20
... by proteins resi-
ding in both the inner and outer mitochondrial
membrane, that is activated by mitochondrial Ca
2+
overloading and other factors including oxidative stress
[88,89]. In neurons ... of KGDHC in yeast equivalent to E2 in mammals),
have two or more different functions, in addition to
having supporting functions for oxidative defences [79],
involving the thioredoxin system ... element binding protein, iso-
citrate dehydrogenase is an RNA-binding protein, while
kgd2p is a mitochondrial DNA binding protein [81–84].
Mitochondria from different brain regions contain
different...
18
549
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báo cáo hóa học: " Brain inflammation and oxidative stress in a transgenic mouse model of Alzheimer-like brain amyloidosis" pptx
Ngày tải lên :
19/06/2014, 22:20
... implicating both oxidative
stress and inflammatory mechanisms in AD pathogenesis.
Effect of indomethacin plus vitamin E supplementation on sol-uble Aβ levelsFigure 3
Effect of indomethacin plus ... therapeutic interventions suppressed brain inflammatory
and oxidative stress responses in the mice. This effect was accompanied by significant reductions
of soluble and insoluble Aβ1-40 and Aβ1-42 in ... flurbiprofen, indomethacin) reduced
brain inflammation and Aβ levels in addition to the dep-
osition of Aβ in brain [13,14]. Despite this evidence, and
the considerable theoretical and therapeutic interest,...
9
490
0
Báo cáo y học: " Impaired glucose transporter-1 degradation and increased glucose transport and oxidative stress in response to high glucose in chondrocytes from osteoarthritic versus normal human cartilag" pps
Ngày tải lên :
09/08/2014, 14:21
... Portugal
3
Division of Veterinary Medicine, School of Veterinary Science and Medicine, Sutton Bonington Campus, University of Nottingham, Sutton Bonington
LE12 5RD, UK
Corresponding author: Alexandrina F Mendes, ... IL-1β-induced 2-DG uptake, including the
affinity (1.066 ± 0.284 and 1.49 ± 0.59 mM) and maximal
velocity (0.27 ± 0.08 and 0.33 ± 0.08 nmol/μg protein/hour),
and GLUT-1 content were identical in ... local inflammation and changes in the subchondral
bone. Increasing age, excessive loading or injury, genetic pre-
disposition and obesity are important risk factors for the devel-
opment and progression...
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Báo cáo y học: "Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function" pptx
Ngày tải lên :
09/08/2014, 06:22
... Our findings
clearly show the presence of oxidative stress in degenerat-
ing cartilage, and the resultant telomere erosion and dys-
function of chondrocytes in vitro and in vivo, suggesting a
role ... senescence and
oxidative stress in OA cartilage, as discussed above, we
postulated that oxidative stress induces telomere instability
and dysfunction in chondrocytes, subsequently resulting in
cartilage ... maintain the
chondrocyte telomere length and proteoglycan remaining in the
cartilage explants, suggesting that oxidative stress induces
chondrocyte telomere instability and catabolic changes in
cartilage...
12
407
0
Báo cáo khoa học: Cotton GhMPK2 is involved in multiple signaling pathways and mediates defense responses to pathogen infection and oxidative stress doc
Ngày tải lên :
14/03/2014, 23:20
... MPK3 and MPK6 in Arabidopsis (group A
MAPKs), SIMK and SAMK in alfalfa, and
LeMPK1 ⁄ 2(Lycopersicon esculentum SA-induced pro-
tein kinase) and LeMPK3 (L. esculentum wound-
induced protein kinase) ... protein kinase and wound-
induced protein kinase, two MAPKs in group A, were
activated by inoculation with the tobacco mosaic virus
(TMV) [10]. Their orthologs in other plant species,
including ... accumulation in wild-type and transgenic
plants in response to abiotic and abiotic stresses. (A) Virus infec-
tion-induced H
2
O
2
accumulation detected by DAB staining. (B) Abi-
otic stress- induced...
12
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0
Báo cáo khoa học: Pyruvate:ferredoxin oxidoreductase and bifunctional aldehyde–alcohol dehydrogenase are essential for energy metabolism under oxidative stress in Entamoeba histolytica pdf
Ngày tải lên :
15/03/2014, 23:20
... indicating the presence of two catalytically
independent domains, the N-terminal domain, display-
ing ALDH activity, and the C-terminal domain, con-
taining an iron-binding domain, which is involved ... against oxidative stress
damage, have not been reported.
In vivo effects on glucose-fermenting enzymes
and fluxes under oxidative stress
Recently, we reported that amebas incubated for
30 min in ... solubilized extract were incubated in such buffers for 4 h
on ice, and the remaining enzyme activity was determined. Inset: EhPFOR time stability in N
2
-saturated buffer in the absence or presence
of...
14
420
0
Báo cáo khoa học: "Comparative study of PM2.5 - and PM10 - induced oxidative stress in rat lung epithelial cells" pptx
Ngày tải lên :
07/08/2014, 17:22
... study of PM2.5 - and PM10 - induced oxidative stress
in rat lung epithelial cells
Jin-Hyuk Choi, Jun-Sung Kim, Young-Chul Kim
1
, Yoon-Shin Kim
2
, Nam-Hyun Chung
3
and
Myung-Haing Cho*
Laboratory ... protection
standards for PM by adding an indicator for even “fine”
particles (PM2.5). In this trend, our government is trying to
update on ongoing litigation over PM2.5 standard. However,
relative less information ... study,
PM2.5 induced more MDA formation than PM10
suggesting that PM2.5 induced more oxidative stress than
PM10. In the single strand breakage assay using pBR322
DNA, the ratio of changed form II/total...
8
442
1
Báo cáo lâm nghiệp: "Response to an ozone gradient of growth and enzymes implicated in tolerance to oxidative stress in Acer saccharum (Marsh.) seedlings" pot
Ngày tải lên :
08/08/2014, 00:22
... processes.
However, after 85 days, the NR activity in the seedlings was
lower and decreased with increasing O
3
. At that time in the
season and with increasing oxidative stress, NH
3
may have
been provided ... 10.1051/forest:2006019
Original article
Response to an ozone gradient of growth and enzymes implicated in
tolerance to oxidative stress in Acer saccharum (Marsh.) seedlings
Catherine G
a,b
*
,NadineC
c
,PaulW
c
, ... material from a single leaf was sam-
pled from each flush of each seedling, cut into 2 × 2 mm pieces and
incubated in 5 mL of 100 mM phosphate buffer (pH 7.5) containing
40 mM KNO
3
and 1.5% 1-propanol....
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