eligibility status and potential kt predictors
báo cáo khoa học: " Can learning organizations survive in the newer NHS?" pps
Ngày tải lên :
11/08/2014, 05:22
... believe in human potential, recognise and value tacit knowledge and respect work based competence, are open to diverse and flexible ways of sharing knowledge and experience, and engender trust, ... colleagues' assumptions Team learning and open systems thinking depend upon each person understanding the mental models they hold themselves, and understanding and appreciating those which others ... links between health policy and NHS management targets, tasks, and imperatives, on the one hand, and national policy agendas, on the other, have become increasingly salient and transparent Against...
- 11
- 356
- 0
Báo cáo y học: "Chiropractic care for children: too much, too little or not enoug" ppt
Ngày tải lên :
13/08/2014, 14:20
... conditions in children and adolescents This overview discusses and summarises the literature about diagnosis and management of non-musculoskeletal conditions in children and adolescents [15] The ... seek chiropractic care, and for which conditions this care is sought In addition, more high quality effectiveness and safety research studies to determine the benefit and potential harms of chiropractic ... 1930s and 1940s, C.O Watkins asked the profession to step up and French et al Chiropractic & Osteopathy 2010, 18:17 http://www.chiroandosteo.com/content/18/1/17 produce research [21] In 1975 a landmark...
- 4
- 254
- 0
Báo cáo y học: "Genetic polymorphism of p53, but not GSTP1, is association with susceptibility to esophageal cancer risk – A Meta-Analysis"
Ngày tải lên :
25/10/2012, 11:40
... heterogeneity, and it was considered significant for P < 0.05 We used the fixed-effects model and the random-effects model based on the Mantel-Haenszel method and the DerSimonian and Laird method, ... quantify the potential between-study heterogeneity, we conducted a meta-analysis on 13 published case-control studies with 2919 cases and 4074 controls for p53 Arg72Pro and 1885 cases and 2194 controls ... (2919 cases and 4074 controls) for p53 Arg72Pro and studies (1885 cases and 2194 controls) for GSTP1 Ile105Val were available for this meta-analysis The minor Pro allele (for p53 Arg72Pro) and Val...
- 9
- 615
- 0
Báo cáo y học: "TPO, but not soluble-IL-6 receptor, levels increase after anagrelide treatment of thrombocythemia in chronic myeloproliferative disorders"
Ngày tải lên :
03/11/2012, 10:52
... the binding of the ligand to the receptor and the endocytosis of the ligand-receptor complex [9] Against that background, we speculate that less TPO was bound to platelets and more remained free ... value, and treatment failure (F) as a reduction of the platelet count with < 50 % of the baseline value Here, and for the purpose of cytokine levels and platelet counts, we have grouped PR and F ... Serum and plasma samples were collected at baseline and after months of therapy and stored at –70oC until analyzed Only patients completing the months of therapy were included Serum TPO and soluble...
- 5
- 498
- 0
Five stories that are almost true, but not quite
Ngày tải lên :
06/11/2012, 17:33
... this Egypt, where I both belonged and not Which I both loved and not In which I felt both welcome and not and where I felt that at some point in my life I would abandon Leave it, because it would ... “I understand But let me tell you, you‟ll live a few months of hope and memories and then disappointment will set in and gradually it will dawn on you that the dream was just a dream And Lisa ... inexorable A very special and prosperous section of expatriate Hellenism was returning to the motherland after a century and a half of residence in Egypt to become diluted and anonymous A sense of...
- 11
- 460
- 0
Tài liệu Báo cáo khoa học:Tyrosine phosphorylation of tau regulates its interactions with Fyn SH2 domains, but not SH3 domains, altering the cellular localization of tau ppt
Ngày tải lên :
14/02/2014, 14:20
... fusion proteins of Fyn-SH2 and FynSH3 to further investigate the mechanisms by which tau and Fyn interact We determined that tau binds to both Fyn-SH2 and Fyn-SH3, and only the former of these ... expressing Fyn-SH3 and Fyn-SH2 were obtained from S Anderson (University of Colorado Health Sciences Center, Denver, CO, USA) GST–Fyn-SH2 and GST–FynSH3 were generated by subcloning Fyn-SH2 and Fyn-SH3 ... NaCl ⁄ Tris and harvested in lysis buffer, as described above Preparation of GST fusion proteins and GST pulldown Isolation of DRMs Generation of GST, GST–Fyn-SH2 and GST–Fyn-SH3 and subsequent...
- 11
- 628
- 0
Tài liệu Báo cáo khoa học: Dual P2Y12 receptor signaling in thrombin-stimulated platelets – involvement of phosphoinositide 3-kinase b but not c isoform in Ca2+ mobilization and procoagulant activity pdf
Ngày tải lên :
18/02/2014, 16:20
... al tirofiban from Merck, Sharp and Dohme (Haarlem, the Netherlands); Akt inhibitor and LY294002 from Calbiochem (La Jolla, CA, USA) ET-18-OCH3, manoalide, U73122 and U73343 came from Biomol (Plymouth ... PKA inhibitors, KT5 720 and H89 [28] Following saponin permeabilization, this resulted in increased InsP3-induced Ca2+ release with either inhibitor, with an EC50 of lm KT5 720 and lm H89 Pretreatment ... inhibition of Akt phosphorylation; see below), wortmannin and LY294002 reduced the Ca2+ integral by 24.4 ± 4.1% and 24.0 ± 1.7% (n = 3), respectively In contrast, when AR-C was present and P2Y12 was...
- 15
- 565
- 0
Tài liệu Báo cáo khoa học: Activated Rac1, but not the tumorigenic variant Rac1b, is ubiquitinated on Lys 147 through a JNK-regulated process docx
Ngày tải lên :
18/02/2014, 16:20
... to tumor progression and invasiveness [8], and Rac1b, a constitutively active splice variant of Rac1, has been found to be expressed in colorectal and breast tumors [9,10] and to display oncogenic ... ubiquitination and subsequent degradation, and that Lys140 and Lys147 constitute a major target site for ubiquitin branching in Ypt7 [37] Interestingly, when the three-dimensional structures of Ypt7 and ... Switzerland), following the manufacturer’s procedure DNA plasmids and mutagenesis Human cDNA of Rac1 and mutants Rac1N17 and Rac1L61, and mouse cDNA of POSH, cloned in pRK5myc plasmids, were obtained...
- 11
- 469
- 0
Cytoskeleton reorganization mediates alpha beta integrin-associated actions of laminin on proliferation and survival, but not on steroidogenesis of ovine granulosa cells pdf
Ngày tải lên :
05/03/2014, 17:20
... pg/well) and the intra- and inter-assay coefficients of variation were less than 7% and 9% respectively The progesterone detection limit was 12 pg/tube (60 pg/ well), and the intra- and inter-assay ... conceived the study, participated in its design and coordination, statistical analysis and interpretation of data and drafted the manuscript FLB, SF and DM read and approved the final manuscript CP died ... 144 h on LN with (b and solid bars in c, d, e and f) or without (a and empty bars in c, d, e and f) anti-α6 IgG (0.5 µg/ml) in culture medium (a) and (b): representative microscopical fields of...
- 17
- 521
- 0
What happens if we’ve paid you too much tax credit? ppt
Ngày tải lên :
06/03/2014, 04:21
... change on time and take that amount off your overpayment COP26 What happens if we have paid you too much tax credit? Our responsibilities and yours To help get your award right and to help avoid ... within 30 days of getting it and if and when you told us about any mistakes • that you checked that the payments you got matched the amounts on your award notice and if not, that you told us ... you’ve an overpayment from an old award which ended and you’ve an overpayment from a current award For example, you and your partner separated and you then made another claim as a single person...
- 16
- 353
- 0
Blackwell Science, Ltd Group breeding dramatically increases reproductive success of yearling but not older female scrubwrens: a model for cooperatively breeding birds? ppt
Ngày tải lên :
14/03/2014, 16:20
... birds were colour-banded for these years and many were banded in a pilot year in 1991, and so were of known age in JAE498.fm Page 373 Monday, April 16, 2001 9:57 AM 373 Group size and reproductive ... sizes are 38 yearlings in pairs and 24 in groups, and 33 older females in pairs and 40 in groups JAE498.fm Page 375 Monday, April 16, 2001 9:57 AM 375 Group size and reproductive success in birds ... Council, and was carried out under permits from the Australian National University ethics committee, the Australian Bird and Bat Banding Scheme, the Australian National Botanic Gardens and Environment...
- 16
- 337
- 0
Dangerous But Not Omnipotent pptx
Ngày tải lên :
15/03/2014, 21:20
... military planners, and analysts and observers of regional affairs in the Middle East and Central and South Asia RAND Project AIR FORCE RAND Project AIR FORCE (PAF), a division of the RAND Corporation, ... like to thank Andrew Hoehn, Vice President and Director, RAND Project AIR FORCE, and David Ochmanek, Director of PAF’s Strategy and Doctrine Program, who conceived of the study and offered valuable ... tremendously from the insights and previous research of Lieutenant Commander Anthony Butera (U.S Navy) and RAND colleagues Derek Eaton, David Frelinger, and Bruce Pirnie Pardee RAND Graduate School Fellow...
- 233
- 229
- 0
Báo cáo khoa học: Protein crystallography for non-crystallographers, or how to get the best (but not more) from published macromolecular structures potx
Ngày tải lên :
16/03/2014, 06:20
... number of ligands, the geometry of the coordination sphere, and the B-factor of the ion and its environment For example, the distance between ˚ calcium and oxygen atoms should be 2.40 A and ˚ between ... I ⁄ r (or signal-to-noise ratio), and L o w M e d i u m Rmerge, overall and in the highest resolution shell It is very important to understand their meaning and the relationship between their ... measured many times, and their intensities have to be averaged after the application of all necessary corrections and appropriate scaling This process is known as ‘scaling and merging’, and its result...
- 21
- 570
- 0
Báo cáo khoa học: H2O2, but not menadione, provokes a decrease in the ATP and an increase in the inosine levels in Saccharomyces cerevisiae An experimental and theoretical approach pot
Ngày tải lên :
17/03/2014, 10:20
... 100 (Fig 6) (see [3], and Table 3, for further explanations on the signicance of these parameters) The equation described as V8d and V8r, and the corresponding substrates and products were not ... (without H2O2) and incubated further for 120 At the times indicated, the adenylic charge, ATP and inosine were determined as described in Materials and methods H2O2 evokes a decrease and an increase ... of yeast with H2O2 and menadione Here, mitochondrial proteins (E2 subunits of both pyruvate kinase and a-ketoglutarate dehydrogenase, aconitase and heat shock protein 60) and the cytosolic fatty...
- 12
- 506
- 0
Báo cáo Y học: Ruk is ubiquitinated but not degraded by the proteasome ppt
Ngày tải lên :
17/03/2014, 23:20
... degradation by proteosomes MATERIALS AND METHODS Reagents and antibodies Protease inhibitors N-Ac-Leu-Leu-norLeucinal (ALLN) and lactacystin were purchased from Sigma and Calbiochem, respectively Rabbit ... isoforms have the potential to form homodimers and heterodimers and that the coiled-coil domain mediates the formation of these complexes Moreover, specific interaction between Cbl and two shorter ... binding between Cbl/Ruk M and Cbl/Ruk S are indirect and require heterodimerization with Ruk L As all isoforms are in complex with Cbl and are ubiquitinated, Cbl is a potential E3 ligase responsible...
- 7
- 317
- 0
He knows too much
Ngày tải lên :
20/03/2014, 16:10
... Trakton Works in Delhi Barbara Lennox: Keith's wife Visvanathan (Vish): of®ce manager at Trakton Molly: Vish's wife She also works at Trakton Ramanathan (Ramu): Dick's personal assistant at Trakton ... of Trakton's factory in Madras Trakton had been in India since before Independence It had started out manufacturing military vehicles during the war and switched to commercial vehicles and earth-moving ... modern glass and concrete banks, slum huts built from mud and roofed with coconut palms, ramshackle groups of shops selling everything from used car tyres to Indian-made foreign liquor1 And where...
- 63
- 617
- 0
Báo cáo khoa học: Amyloid structure – one but not the same: the many levels of fibrillar polymorphism potx
Ngày tải lên :
23/03/2014, 03:20
... tension, coating of spores and many other as yet unknown functions (see [12] and references herein) Several different protein and peptide hormones, including insulin and glucagon [13,14], have ... smooth and still others as parallel bundles of two or more protofilaments (Fig 1) Fibril preparations often contain several different morphologies, and for some of these the turn lengths and 4592 ... thermostability and morphology in EM (see Fig 1) Type A, Bagitated, Bunagitated all form in the same 50 mm glycine ⁄ HCl buffer at pH 2.5, whereas types D and S only accumulate when $ 200 mm Cl) and mm...
- 11
- 400
- 0
Báo cáo khoa học: Insulin is a kinetic but not a thermodynamic inhibitor of amylin aggregation pot
Ngày tải lên :
23/03/2014, 04:21
... 72 h Results from light scattering assays (Figs and 3B) and ThT assays (Fig 4B), and TEM images (Fig 5C,D), are all in accord with each other and support this conclusion For amylin incubated ... fibril formation, and the sample has more amylin fibrils (E) Amylin and insulin copolymerize and form fibrils Aggregates were identified by immunogold labeling with insulin antibody and immunogold ... as monomers, dimers and hexamers in solution [18,19] As shown in Fig 6, it seems that the peak at 30 contained insulin hexamers, and the peak at 40 contained insulin monomers and dimers In another...
- 7
- 388
- 0
Báo cáo khoa học: Novel isoenzyme of 2-oxoglutarate dehydrogenase is identified in brain, but not in heart potx
Ngày tải lên :
23/03/2014, 06:20
... the 2-oxoglutarate and pyruvate dehydrogenase complexes were ascribed to the major protein bands of our preparation as follows: E1o (band 1), E2p (band 2), E3 (band 3), E2o and the E3-binding ... from brain and heart An essential difference between brain and heart OGDHC was revealed by nanoLC-MS ⁄ MS analysis of band In the brain preparation, this band contained both OGDH and OGDHL, a ... dehydrogenase complex (protein X; band 4), E1pa (band 6), E1pb (band 8) This was confirmed by nanoLC-MS ⁄ MS identification of the components in the protein bands (Table 1) Our study also showed...
- 17
- 389
- 0
Báo cáo khoa học: The activation of gelsolin by low pH The calcium latch is sensitive to calcium but not pH docx
Ngày tải lên :
23/03/2014, 21:20
... dissociation constant Kd and the maximal binding Amax) were determined by nonlinear fitting: A ¼ Amax  ½L=ðKd þ ½LÞ ð1Þ where, A is the absorbance at 405 nm and L the ligand concentration, by ... 100 was calculated by the relation F ) F °/F ° ¼ Amax/F ° where F ° and F are fluorescence intensities for zero and infinite ligand concentrations, respectively Collisional quenching of fluorophore ... Stern–Volmer equation, F °/F ¼ + KD · [Q] where F and F ° are the fluorescence intensities in the presence and in the absence of the quencher, Q, respectively, and KD the Stern–Volmer constant [34] The...
- 8
- 320
- 0