efficacy effectiveness and safety of medications in kidney disease
Báo cáo y học: "Effectiveness and safety of adalimumab in patients with ankylosing spondylitis or psoriatic arthritis and history of anti-tumor necrosis factor therapy" pdf
... arthritis, and Crohn disease in Europe, Canada, the United States, and other world regions [17] In two open-label clinical studies, we investigated the effectiveness and safety of adalimumab in treating ... history of therapy with IFX or ETN or both: Review of Safety and Effectiveness witH Adalimumab in Patients with Active Ankylosing SpOnDYlitis (RHAPSODY) and SafeTy and Efficacy of Adalimumab in Patients ... of effectiveness and safety were conducted at weeks 2, 6, 12, and 20, as applicable Measures of effectiveness of adalimumab for patients with AS included ≥ 40% improvement in the Assessment of...
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báo cáo hóa học:" Effectiveness and Safety of Generic Fixed-Dose Combination of Tenofovir/Emtricitabine/Efavirenz in HIV-1-Infected Patients in Western India" doc
... worsening of an existing clinical condition (infectious or noninfectious) within months of initiation of ART Toxicity was graded according the system mentioned in the WHO ART scale-up guidelines ... from the grading system of Division of AIDS, National Institute of Allergic and Infectious diseases, USA) The regimen was discontinued (substituted with nonoffending ARV drugs) in cases of grade ... baseline and every months or as clinically indicated Creatinine clearance (CrCl) was calculated using the Cockroft-Gault formula Virologic failure was defined as inability to achieve or maintain...
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Báo cáo y học: "Efficacy and safety of aripiprazole in the treatment of bipolar disorder: a systematic review" pdf
... Pharmacokinetics and tolerability of intramuscular, oral and intravenous aripiprazole in healthy subjects and in patients with schizophrenia Clin Pharmacokinet 2008, 47:475-485 Findling RL, Kauffman ... efficacious in acute mania and in the maintenance treatment of bipolar disorder, with a favourable safety and tolerability profile, with minimal propensity for clinically significant weight gain and ... Annals of General Psychiatry 2009, 8:16 the treatment of acute mania, the approval of quetiapine and the olanzapine-fluoxetine combination against acute bipolar depression and the approval of olanzapine,...
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Báo cáo y học: "Efficacy and safety of tiotropium in COPD patients in primary care – the SPiRiva Usual CarE (SPRUCE) study" ppsx
... the use of rescue medication observed in this study is a consistent finding in all tiotropium studies [11-14] and supports the clinical relevance of the sustained efficacy of tiotropium and reduction ... change included prescription of antibiotics and/ or systemic steroids and/ or a significant change (including increase) of the prescribed respiratory medication (bronchodilators including theophylline) ... duration of or more days (from patient's diary card) requiring a change in treatment (including patient-initiated increases) A complex of respiratory events/symptoms meant ≥2 of the following (increase...
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Efficacy and safety of pregabalin in the treatment of
... PRESS, INC © COPYRIGHT 2006 PHYSICIANS POSTGRADUATE PRESS INC Efficacy and Safety of Pregabalin in GAD There are now placebo-controlled studies in GAD demonstrating robust efficacy of pregabalin ... in the treatment of GAD is important to well-being and adherence to treatment, as complaints of insomnia in GAD are common and insomnia is regarded in DSM-IV-TR as a core diagnostic feature of ... Pregabalin has not yet been directly tested in placebo-controlled studies in major depressive disorder, and in view of these findings, it would be interesting to assess its efficacy in that disorder...
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Báo cáo khoa học: "Offset of pharmacodynamic effects and safety of remifentanil in intensive care unit patients with various degrees of renal impairment" ppt
... dosing algorithm for maintaining adequate sedation and comfort The time elapsed between initiating the SDT and stopping the down-titration (i.e switching back on/increasing the remifentanil infusion ... baseline in patients in the moderate/severe renal group Conclusion In conclusion, the safety and efficacy of remifentanil was investigated in a group of sick patients with varying degrees of renal ... the investigator’s discretion Sample acquisition, handling and processing Extensive blood sampling was included in the present study in order to investigate the pharmacokinetic characteristics of...
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Báo cáo y học: " Efficacy, safety and tolerability of escitalopram in doses up to 50 mg in Major Depressive Disorder (MDD): an open-label, pilot study" doc
... sustained remission (reaching a MADRS score of ≤8 and staying at ≤12) and response (achieving a 50% decrease in MADRS from baseline MADRS score), mean changes in the MADRS scores from baseline and ... outcome in clinical trials of escitalopram Secondary outcome measures included the number (%) of patients achieving absolute sustained remission (reaching a MADRS score of ≤8 and staying at ≤8), ... discretion of their supervising physician The investigation was conducted in accordance with the Declaration of Helsinki and Good Clinical Practice guidelines although a non-conformance in the medication...
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Báo cáo y học: " Efficacy and safety of an antiviral Iota-Carrageenan nasal spray: a randomized, double-blind, placebo-controlled exploratory study in volunteers with early symptoms of the common cold" doc
... on Good Clinical Practices (CPMP/ICH/135/95)5, and the principles of the Declaration of Helsinki, local drug law and standard operating procedures of the investigator, sponsor and CRO involved ... major spreaders of rhinovirus in the family setting Rhinovirus infections are a common cause of hospitalization of children, most often because of wheezing [23,24] As the vast bulk of viral transmission ... disturbing/irritating), = severe (symptoms disturbing/irritating most of the time) This scoring system was developed by Jackson in 1958 and is widely used in common cold clinical trials[14] In order...
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Báo cáo y học: " Efficacy and safety of once-daily aclidinium in chronic obstructive pulmonary disease" potx
... Competing interests PWJ has received fees from a number of pharmaceutical companies, including Almirall, for speaking at meetings and for consulting and participating in advisory board meetings, and ... Lamarca R, Garcia GE, Ferrer P: Safety and pharmacokinetics of single doses of aclidinium bromide, a novel long-acting, inhaled antimuscarinic, in healthy subjects Int J Clin Pharmacol Ther 2009, 47:460-468 ... 7Division of Pulmonary Disease and Critical Care Medicine, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA 8Division of Pulmonology, Department of Medicine, University...
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Báo cáo y học: "Efficacy and safety of non-invasive ventilation in the treatment of acute cardiogenic pulmonary edema – a systematic review and meta-analysis" docx
... applied Duration of non-invasive ventilation and the type of ventilator may have also influenced outcomes, and this was not examined in this review Some different kinds of interfaces and ventilatory ... for measuring efficacy and side effects because clinicians find it a more intuitive and interpretable metric as it measures the absolute difference between outcome risks in intervention and control ... regarding the methods of implementation and technical characteristics of the ventilation devices (Table 3) and regarding the definition and adequacy of criteria for ETI (Table 3) The analysis of safety...
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Báo cáo khoa học: "Efficacy and safety of a low-flow veno-venous carbon dioxide removal device: results of an experimental study in adult sheep" pps
... changes in ventilatory setting were made during the treatment A bolus of 2,000 UI of heparin was administered intravenously, followed by an infusion titrated to maintain ACT (activated clotting time) ... during the experiment, was maintained even in longer treatments (9 and 12 hours), and was not influenced by CO2 production, as deep anaesthesia was maintained and no significant variations in ... Medicina Veterinaria, University of Turin), and Giovanni Perona (from CISRA – Centro Interdipartimentale Servizio Ricovero Animali, Facoltà di Medicina Veterinaria, University of Turin) for clinical...
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Báo cáo y học: "Drug monitoring in child and adolescent psychiatry for improved efficacy and safety of psychopharmacotherapy" pdf
... that influence the pharmacokinetics in children and adolescents Pharmacokinetic parameter Influencing factors Absorption Gastrointestinal function (for example gastric emptying and intestinal ... ranges of blood concentrations, thus facilitating dosage finding, improving efficacy and minimizing the risk of side effects Pharma- http://www.capmh.com/content/3/1/14 cokinetic abnormalities in individual ... competing interests Authors' contributions CMW is principal investigator of the TDM database (conception and design) and chair of the "Competence Network of Therapeutic Drug Monitoring in Child and...
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Báo cáo hóa học: "Vehicular connectivity in urban scenarios: effectiveness and potential of roadside, moving WAVE providers and hybrid solutions" doc
... The second and the third line respectively refer to the average number of users joining the BSS of one of the available RSUs and the BSS of one of the 30 OBUs acting as WAVE providers in the hybrid ... channel switching schemes length of 100 ms, consisting of 50 ms-long CCH and SCH interval Single-radio devices have to monitor the CCH during common time intervals (the CCH intervals), and to (optionally) ... whose main building block is the off-line identification of mutual positions among vehicles and buildings within a given topology Basically, the model classifies positions into Line-ofSight (LoS),...
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Báo cáo y học: "A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin® for treatment of osteoarthritis of the knee" potx
... action of an anti-inflammatory compound of herbal origin in the treatment of OA We demonstrated that 5Loxin® has potential efficacy in terms of reducing pain and improving the physical ability of ... includes redness of skin and sinus allergy bMiscellaneous group includes body pain, loss of hair, chest pain and eye infection pain and synovial fluid MMP3 concentration (Table 4) This finding suggests ... be symptomatic [3] Clinical manifestations of OA of the knee include pain in and around the joint, stiffness of the joint after rest, crepitating on motion and limited joint motion, among others...
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Báo cáo y học: "Biologic activity and safety of belimumab, a neutralizing anti-B-lymphocyte stimulator (BLyS) monoclonal antibody: a phase I trial in patients with systemic lupus erythematosus" potx
... supported the initiation of phase II studies investigating the safety and clinical activity of belimumab in patients with SLE and rheumatoid arthritis Competing interests JZ, WC, and WF were all ... chest pain was reported in one patient with a prior history of drug-induced urticaria during the administration of a 20 mg/kg single dose The infusion was discontinued approximately 40 minutes ... respiratory tract infection (15%), and joint swelling (15%) The frequency of AEs did not change with increasing doses of belimumab Overall, there was no significant difference in the incidence of specific...
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Báo cáo y học: "Utility and safety of draining pleural effusions in mechanically ventilated patients: a systematic review and meta-analysis" pps
... setting, and design; ventilator settings; classification of pleural effusion (exudative vs transudative); technique of drainage, including the use of imaging guidance, the level of training of the ... 14 defined in each study), and the remaining 3% had indeterminate biochemical findings Methodological quality There were no randomized or non-randomized controlled trials of effusion drainage ... unclear [48] In the remaining five studies, the timing of gas exchange measurements, volume of drainage, ventilator settings, and the measured change in oxygenation after pleural drainage varied...
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Characterization of CMX 13 and evaluation of efficacy and mechanisms of action in animal model of autoimmunity
... histological indices Hence CMX-13 appeared to be effective in attenuating the clinical and histological disease activity in the MRL-lpr/lpr mouse model of SLE In the final part of the thesis, we examined ... centuries in China to treat a variety of human diseases, including immune-mediated diseases [Chen and Chen, 1989] The development of immunosuppressive agents with high efficacy and minimal toxicities ... be the driving force for autoreactive B-cells in SLE resulting in abnormalities in cytokine production, and suppression of these autoreactive lymphocytes could result in inhibition of autoantibody...
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Báo cáo y học: "Maternal use of Loratadine during pregnancy and risk of hypospadias in offspring"
... with exposure to loratadine and other antihistamines according to the time of exposure The adjusted OR for loratadine exposure within 30 days before conception and during the first trimester ... complete and independent registration of birth, birth outcome, and prescription data which prevented selection bias and some types of information bias; since the study was based on routinely recorded ... we used is one of the largest in the world for studying the safety of drugs used in pregnancy and previous studies have shown high data quality in both the prescription database and the Birth...
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Textile and Apparel Barriers and Rules of Origin in a Post-ATC World
... Journal of World Trade 34 (1): 141–166 Estevadeordal, Antoni and Kati Suominen 2006 “Mapping and Measuring Rules of Origin Around the World.” In The Origin of Goods: Rules of Origin in Regional ... quarter of the welfare gain at a cost of 13.3 percent of the output loss, while elimination of preferential rules of origin accounts for the remaining 23.3 percent of increased welfare and 84.9 ... USAGE-ITC distinguishes 523 commodities, 521 industries, 23 foreign regions, and a detailed handling of margins and taxes 28 Other features of the model include a detailed modeling of government...
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A study on the aspects of syntax and semantics of negation in english and the contrastive analysis in vietnamese
... overview of syntactic and semantic features of negation in both English and Vietnamese 12 - Studying negation in terms of its structures and semantics and finding out the similarities and differences ... analysis in making comparison of negation in English and Vietnamese in terms of semantic and syntactic features is clearly presented in the next chapters Summary This chapter examines an opinion of ... according to the internal role they have inside logic, regardless of meaning they are intended to have (if any) The semantic point of view, in contrast, is based on the intuitive meaning of a...
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Tìm thêm: xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 động cơ điện không đồng bộ một pha phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25