effects on navigational cue use in alzheimer s disease

... and a-synuclein was investigated by crossing PDGF–a-synuclein and APP-SweInd, which led to a 1.6-fold increase in a-synuclein inclusions in comparison with transgenic mice that expressed only ... a-synuclein inclusions Instead of cross-breeding two single-transgenic models, several vector constructs can be coinjected into fertilized oocytes The transgenes will typically cointegrate at one ... aggregation in sporadic AD brain There is now a renewed interest in studying APP processing in sporadic AD brain, and in understanding the mechanisms of Ab truncation and modification Most transgenic...

Ngày tải lên: 16/02/2014, 09:20

... either polyglutamine or polyalanine expansions in Huntington disease, Huntington related diseases, and various forms of a-synuclein associated with Parkinson disease and synucleinopathies [27] Taken ... Ostermans Foundation, SADF (Insamlingsstiftelsen for ¨ Alzheimer- och Demensforskning), Socialstyrelsens Stiftelser, Stiftelsen for Alderssjukdomar, and Svenska ¨ ˚ Lakaresallskapet ¨ ¨ FEBS Journal ... phosphorylate eEF2 in its N-terminus (Thr56) that subsequently blocks eEF2 binding to ribosomes, resulting in decreased rates of protein synthesis Dephosphorylation of eEF2 relieves its translational...

Ngày tải lên: 16/03/2014, 22:20

... tissues were dissected from embryonic brain and trypsinized into single-cell suspension using sterilized micropipette tips The cells were resuspended in DMEM and Ham 's F12 at 1:1 (D-F12), supplemented ... reverse transcribed into cDNA with the Reverse Transcription System (Promega, USA) in 20 μl volume cDNA was used as template in the following PCR assay The primers used for PCR assays were as follows: ... (Sakura, USA) Coronal sections (10 μm) were made through the striatum containing transplants and mounted to gelatin coated slides Adjacent sections were processed for hematoxylin-eosin (HE) stain and...

Ngày tải lên: 18/06/2014, 15:20

... carries both of these transgenes and has been extensively used as a model for studying processes relating to the formation of SPs Aβ deposition occurs more rapidly in these mice than in the single ... researchers limits the usefulness of these species for studies of AD-related complement activation Conclusions Complement activation has been extensively studied in the AD brain There is convincing ... celecoxib in the treatment of progression of Alzheimer' s disease [abstract] Sixth International Stockholm/Springfield Symposium on Advances in Alzheimer Therapy 2000:180 Van Gool WA, Weinstein HC, Scheltens...

Ngày tải lên: 19/06/2014, 22:20

... Demographic characteristics of the cases used in this study Shown are differences between groups of the cases used in this study [PMI post-mortem interval, SD standard deviation] Braak score for neurofibrillary ... mechanisms involved in the response to intraneuronal accumulation of Aβ and the consequent impaired synaptic function needs to be addressed in future studies Competing interests The author (s) declare ... Neuroinflammation 2005, 2:27 http://www.jneuroinflammation.com/content/2/1/27 Findings Aberrant expression of cyclins, cyclin dependent kinases (CDKs) and their inhibitors has been observed in post...

Ngày tải lên: 19/06/2014, 22:20

... deficit, we used the MMSE scores as proxy of status (control vs AD) and of disease progression Subjects were divided into three mutually exclusive groups ranked by increasing MMSE scores [below ... out using LSS scores as proxy of status (p < 0.025, lowest vs highest LSS scores) As shown in Figure 2, high serum AOC levels predicted a longer survival of AD patients (CPHR, co-varying MMSE scores, ... Young IS, Lawson JT: Plasma chain-breaking antioxidants in Alzheimer' s disease, vascular dementia and Parkinson 's disease QJM 1999, 92:39-45 Guidi I, Galimberti D, Lonati S, Novembrino C, Bamonti...

Ngày tải lên: 19/06/2014, 22:20

... global inhibition of src-family tyrosine kinases or inhibition of phosphatidylinositol-3 kinase (PI3K) attenuates ROS production These findings suggest that these kinases are involved in upstream signaling ... incidence among patient populations receiving statin treatment [117,118] Despite these promising findings, the use of statins in prospective clinical trials has yielded unsatisfactory results, failing ... Alzheimer' s disease and duration of NSAID use Neurology 1997, 48:626-632 Rich JB, Rasmusson DX, Folstein MF, Carson KA, Kawas C, Brandt J: Nonsteroidal anti-inflammatory drugs in Alzheimer' s disease...

Ngày tải lên: 19/06/2014, 22:20

... astrocytes decreases over age in AD, in contrast to control cases, suggesting that the association between neuroinflammation and AD is stronger in cases with relatively young age Apolipoprotein ... demographic information, disease duration, neuropathological staging and APOE genotype of control and AD cases used in this study Case Diagnosis Sex Age (years) GDS Braak Brain weight (grs) PMD (hours: ... class II), and GFAP immunoreactivity (Y axis, in arbitrary units) for controls (open dots) and AD patients (closed dots) Straight lines represent regression lines, with corresponding 95% confidence...

Ngày tải lên: 19/06/2014, 22:20

... repetition of phrases from the Boston Diagnostic Aphasia Evaluation [19] Abstract reasoning was evaluated using WAIS-R Similarities subtest [66], and the non-verbal Identities and Oddities subtest ... [60] Information from the neurological, psychiatric and neuropsychological assessments were reviewed in a consensus conference comprised of neurologists, psychiatrists, and neuropsychologists Based ... cognitive skills remained stable Increased age was associated with lower scores in all cognitive domains while increased education was associated with higher scores APOE-␧4 was not associated with...

Ngày tải lên: 05/03/2014, 21:20

... distinguish from Parkinson s disease, but the parkinsonism in DLB differs from Parkinson s disease by being more often symmetric, with less pronounced tremor (if any) Hallucinations are also ... information regarding cognitive functioning Cognitive screening includes using validated screening instruments, such as the MMSE, and brief bedside assessments Cognitive screenings are usually sensitive ... depression symptoms such as changes or disruptions in sleep, appetite, concentration, interest in activities, libido, and energy level; the presence of feelings of guilt, hopelessness, helplessness;...

Ngày tải lên: 05/03/2014, 23:20

... gene In conclusion, these results show that our GFP reporter assays based on APP or Notch c-secretase substrates can be used to specifically study modulation of c-secretase activity in parallel in ... fluorescence We show the application of this assay to the testing of c-secretase inhibitors and PS1 mutants This assay allows for the first time the selection of cell populations and single cells ... medium was replaced with fresh medium containing inhibitor Inhibition of c-secretase activity was determined by FACS analysis of the cells, using fluorescence as an indication of GFP expression, and...

Ngày tải lên: 08/03/2014, 08:20

... complements data from rat tissues showing that calcineurin is also expressed in neurons [14,15] RCAN1 gene expression is significant in several tissues, particularly human brain, spinal cord, kidney, liver, ... in brain regions affected by AD as compared to control tissues (a representative western blot is shown in Fig 3A) As human brain tissue is difficult to obtain, we focused on the most interesting ... expression of RCAN1-1 was identified using an antisense RNA probe against exon Expression was examined in neurons, astrocytes and microglia, by labeling cells with antibodies against each of these...

Ngày tải lên: 16/03/2014, 11:20

... PASW software (former SPSS software, version 17.0.1 for Windows, SPSS Inc., Chicago, IL, USA) Non-parametric tests were used because normal distribution could not be assumed in the groups Spearman ... present study was set slightly higher than the previously reported community-based mean values In the present study the cognitive assessment also included the Alzheimer s Disease Assessment Scale ... dysfunction Abbreviations Ab: b-amyloid; AD: Alzheimer s disease; ADAS-cog: Alzheimer s Disease Assessment Scale; APOE: apolipoprotein E; AQT: A Quick Test of cognitive speed; CSF: cerebrospinal...

Ngày tải lên: 22/03/2014, 14:20

... contrast, in transgenic mice, functional deficits and loss of synapses are, at least in some models, observed in young transgenic animals devoid of plaque deposits, suggesting that soluble Ab species ... conclusions drawn from such future studies in aged tg-ArcSwe mice would obviously not be straightforward because Ab burden and insoluble Ab are also increased The present study only suggests ... spatial search strategies were used by most of the animals Four individuals (two 4-month-old nontransgenic mice, one 8-month-old transgenic mouse and one 8-month-old nontransgenic mouse) were...

Ngày tải lên: 23/03/2014, 06:20

... calpains and caspases The striking similarity between the substrates for caspases and calpains raises the possibility that both protease families contribute to structural dysregulation and functional ... mechanism associated with the proteolysis of several MAPs and leading to neuronal apoptosis in AD Conclusion In summary, the ubiquitous expression of calpains in distinct subcellular compartments at ... Mutations in PS1 (presenilin) that cause early onset familial AD can sensitize cells to DNA-damageinduced death and increase the production of Ab In hippocampal neurons expressing mutant PS1, the...

Ngày tải lên: 23/03/2014, 10:21

... Parkinson 's disease: progression and mortality at 10 years J Neurol Neurosurg Psychiatry 1999, 67:300-307 Koller WC, Glatt S, Vetere-Overfield B, Hassanein R: Falls and Parkinson 's disease Clin ... 16:53-58 Schaafsma JD, Giladi N, Balash Y, Bartels AL, Gurevich T, Hausdorff JM: Gait dynamics in Parkinson 's disease: relationship to Parkinsonian features, falls and response to levodopa J Neurol Sci ... Up & Go Test Phys Ther 2000, 80:896-903 Fahn S, Elton R, Members of the UPDRS development committee: Unified Parkinson 's disease rating scale In Recent developments in Parkinson 's disease Edited...

Ngày tải lên: 19/06/2014, 10:20

... Conclusion This study indicates that the step-synchronized vibration stimulation of the soles improves gait steadiness in Parkinson 's disease patients with predominant balance impairment The suprathreshold ... Boecker H, Ceballos-Baumann A, Bartenstein P, Weindl A, Siebner HR, Fassbender T, Munz F, Schwaiger M, Conrad B: Sensory processing in Parkinson 's and Huntington 's disease: investigations with 3D H(2)(15)O-PET ... walking trials were done in the on medication state in PD subjects The insoles with VDs were inserted into the subject 's shoes Subjects walked for minutes (6-minute walk test, [14]) at a self-paced...

Ngày tải lên: 19/06/2014, 10:20

... Progression of Parkinson s Disease Figure stimuli Schematization of responsiveness of PD subjects to visual Schematization of responsiveness of PD subjects to visual stimuli The diagram represents ... like controls in response to an attentional stimulus (increasing stride length, decreasing cadence), would suggest that, in advanced stages of disease, as a consequence of progression of motor symptoms, ... potentials in normal and Parkinson 's disease subjects Brain 1995, 118:913-933 Glickstein M, Stein J: Paradoxical movement in Parkinson 's disease Trends Neurosci 1991, 14:480-482 Majsak MJ, Kaminski...

Ngày tải lên: 19/06/2014, 10:20

... of increased levels of cytokines in the brains of Alzheimer' s disease patients, and in transgenic mouse models of Alzheimer' s disease [10-12] However, all these reports have focused on a small ... PA: Induction of immune system mediators in the hippocampal formation in Alzheimer' s and Parkinson 's diseases: selective effects on specific interleukins and interleukin receptors Neuroscience 1994, ... brain slices was assessed using the Bioplex cytokine multi-array system Cytokine levels were not significantly elevated in PS1 brain slices compared to control slices, indicating that the PS1...

Ngày tải lên: 19/06/2014, 22:20

... Kawarabayashi T, Younkin L, Hyman BT, Younkin S, Ashe KH: Reversible memory loss in a mouse transgenic model of Alzheimer' s disease J Neurosci 2002, 22:6331-6335 Selkoe DJ, Schenk D: Alzheimer' s disease: ... traditional image analysis approach Thus, this method is shown to accurately assess amyloid burden in transgenic mouse models of AD In addition, the use of object-based analysis provides data ... hippocampus, only sections containing cortex and hippocampus were used in these treatment comparisons Both oligomeric and fibrillar Aβ conformations, as well as the MAPAβ1–33 immunogen, resulted in significant...

Ngày tải lên: 19/06/2014, 22:20