effects of carotenoids on cancer in animal experimental models

... regulating the activities of phosphotyrosine phosphatases [23] In the current study, we examined XAF1 mRNA and protein expression in four cell lines, and determined regulatory effects of somatostatin ... somatostatin and Octreotide in prostate cancer cell lines To examine the regulatory effects of somatostatin and Octreotide on XAF1 mRNA and protein expression, prostate cancer cell lines (LNCaP, ... AO, Wong BC: Regulation of XAF1 expression in human colon cancer cell by interferon beta: activation by the transcription regulator STAT1 Cancer Lett 2008, 260:62-71 29 Yu LF, Wang J, Zou B, Lin...

Ngày tải lên: 10/08/2014, 10:20

... the induction of apoptosis and inhibition of proliferation of gastric cancer cells However, further clinical trials in humans are needed to examine the pharmacokinetics and the therapeutic action ... the longest diameter respectively [9] Assessment of cell proliferation Paraffin-embedded tumor samples that had been fixed in formalin were cut into sections of µm Sections were incubated in citrate ... proliferation and promotion of apoptosis in this model Dietary supplement containing Schisandra chinensis has been shown to reduce prostate cancer cell growth and induce apoptosis by inhibiting androgen...

Ngày tải lên: 08/08/2014, 18:20

... (sternum) to bottom (vertebra) in supine rats In addition, the distribution of lung inflation is more homogeneous in rats in the prone position as compared to the supine position, as shown by computed ... expression of PC III was high in the HVLP-S and LVHP-S groups, intermediate in the OA and HVLP-P groups, and low in the control group The expression of PC III was higher in the nondependent region of ... expression of PC I increases very early in the course of extracorporeal circulation for cardiopulmonary bypass surgery Injuriously high VT ventilation is also capable of rapidly inducing transforming...

Ngày tải lên: 13/08/2014, 03:20

... Carlsbad, CA) or anti-Cx40 monoclonal antibody (Alpha Diagnostic International Inc, San Antonio, TX) at a dilution of 1:1000 in blocking buffer (2% bovine serum albumin in PBS) at room temperature ... treatment, Cx40 staining was markedly reduced in the neointima of arteries The distribution of Cx43 was similar to that of Cx40 Figure Thin-section electron micrographs indicated gap junctions between ... Beyer EC, Saffitz JE Effects of angiotensin II on expression of gap junction channel protein connexin43 in neonatal rat ventricular myocytes J Mol Cell Cardiol 1998; 32: 800-7 Polontchouk L, Ebelt...

Ngày tải lên: 26/10/2012, 09:39

... revealed a consistent pattern of the effect of smoking on risk of cancer deaths TABLE Characteristics of cases and two control groups: Population-based case-control study of smoking on risk of cancer ... case-control studies were formed within the study base with one group of cases and two different control groups The information on smoking history was obtained by interviews We interviewed informants ... in esophagus cancer, stomach cancer, liver cancer, pancreas cancer, lung cancer cancers, and cancers on the minor sites, whereas the equivalence is uncertain for bladder cancer and prostate cancer...

Ngày tải lên: 26/10/2012, 09:48

... Regulation of mineralization Regulation of bone turnover Glucose regulation Regulation of collagen fibrillogenesis Regulation of bone formation Osteoclast recruitment Inhibition of mineralization ... always included TRT-induced increase in aBMD may reflect mainly the stimulation of bone formation in young men and the inhibition of bone resorption in the elderly 40 30 20 10 Serum Bone-Specific ... Hána, The effects of threemonth intravenous ibandronate on bone mineral density and bone remodeling in Klinefelter’s syndrome: the influence of vitamin D deficiency and hormonal status, Bone 33...

Ngày tải lên: 14/02/2014, 21:20

... the in vitro effects of CDO alone in a panel of three colorectal cancer cell lines; second, to investigate the effects of combining CDO with etoposide (VP16), 5-fluorouracil (5-FU) or SN38 on cell ... an increase in p21waf1 expression, loss of CDK function, and the generation of cells with senescence characteristics In the first part of the investigation, we determined the effect of continuous ... changes in the levels of CDK 4, cyclin D or CDK in response to drug combinations Only cyclin B appeared to be affected, its level being reduced in combination cultures (Fig 6B) This observation was...

Ngày tải lên: 07/03/2014, 15:20

... regulation, the blocked green lines indicate negative regulation, and the dashed lines indicate indirect inhibition The black lines indicate substance conversion or transportation flow The dashed lines ... biloba extract on the proliferation of vascular smooth muscle cells in vitro and on intimal thickening and interleukin1beta expression after balloon injury in cholesterol-fed rabbits in vivo J Cell ... GBE50 intake, although Foxa3 remained upregulated in group HG In addition, the decreased expression of Pc in group HG further suggested impaired glyconeogenesis Upregulation of the insulin receptor...

Ngày tải lên: 16/03/2014, 04:20

... mechanism of interference by TM on thrombin inhibition by PAI-1 The rate of thrombin inhibition by 1.5 lM PAI-1 was measured in the presence of increasing concentrations (0–800 nM) of solulin Solulin ... effect of TM on thrombin inhibition by ATIII and protein C inhibitor, these findings indicate that TM considerably reduces the rate of thrombin inhibition by PAI-1 The poor rate of inhibition of thrombin ... complexes in the association with thrombin In addition, upon binding PAI-1, VN is able to bind the chondroitin sulphate moiety of rl-TM independent of TM-bound thrombin Kinetic modeling using TM...

Ngày tải lên: 23/03/2014, 17:21

... 04 EB Contents Contributors xix Preface xxiii Chapter I Epidemiology of Fractures L Joseph Melton 111 I Introduction 11 Effects of Age 111 Effects of Gender IV Effects of Race V Effects of Geography ... Introduction 111 Basic Mechanical Considerations in Diaphyseal Modeling 112 The Mechanical Role of Remodeling 114 Gender Differences in Modeling during Puberty 114 Animal Studies of the Effects of Sex ... Relationship of Body Mass to BMD 136 C Relationship of Muscle Strength to BMD 137 D Exercise Effects~ Cross-Sectional Study Findings 137 E Exercise Effects~ InterventionTrial Findings 143 VI Unloading...

Ngày tải lên: 28/03/2014, 23:20

... the setting of more routine decompensated heart failure, and the effect milrinone in ischemic subset of patients deserves further investigation Conclusion Initiation of milrinone therapy in patients ... troponin may reveal sub-clinical cardiac injury due to inotrope initiation We sought to determine the effect of initiating milrinone on biomarkers of myocardial function (N-terminal pro-B-type Natriuretic ... Exclusion criteria included exposure to intravenous inotropic support within month and inability to give written informed consent After conclusion of study participation all patients care continued...

Ngày tải lên: 18/06/2014, 15:20

... the internal temperatures in shipping containers designed by JVI with that of our prior shipping container (SafeGuard) under winter temperature conditions Three of the four tests are presented in ... SafeGuard container, maintained internal temperatures above 15°C more consistently Gel packs conditioned at Olson et al Journal of Translational Medicine 2011, 9:26 http://www.translational-medicine.com/content/9/1/26 ... high ambient temperatures on maintaining internal temperatures within the range of 15-35°C was tested on the newly designed JVI shipping container The shipping container was placed at 45°C (Figure...

Ngày tải lên: 18/06/2014, 19:20

... coordination Table 1: List of movement Stroop words (Dutch original in parentheses) walking jumping climbing waving kicking bending lifting clambering skating playing football jogging leaning skiing ... http://www.jneuroengrehab.com/content/5/1/13 formed the same Stroop conditions while walking on a treadmill for minutes The Stroop test consisted of three conditions: 1) A baseline condition (STROOP-BASE), consisting of ... selective attention in chronic pain patients Eur J Pain 1999, 3:325-333 Seminowicz DA, Davis KD: A re-examination of pain-cognition interactions: Implications for neuroimaging Pain 2007, 130(8–13):...

Ngày tải lên: 19/06/2014, 08:20

... reported that betaine content and BGT-1 mRNA levels are increased in brain of rats with hyperosmotic serum induced by the injection and drinking of NaCl solution [31, 32] In addition, protein and mRNA ... injection, betaine plays a crucial role in preventing LPSinduced neuronal dysfunction On the other hand, a single administration of betaine, hr before LPS injection, did not prevent LPS-induced ... administration of betaine is able to prevent LPS-induced memory impairment (experimental schedule shown in Fig 1C) Interestingly, a single administration of betaine (0.163 mmol/kg) hr after LPS injection...

Ngày tải lên: 19/06/2014, 22:20

... (including compounding forms), quantities, and method of introduction of the additives used in the experiments are given in Table Results and discussion 3.1 Effects of graphite and carbon-containing ... the objective of raising its energy density will be attained of cycles of the former is only one unit less than that of the latter Conclusions 3.3 Effect of Li + ion on the behaviour of positive ... listed in Table In view of the above-mentioned effective action of AS on the positive electrode and the important action of graphite on the improvement of the active-material utilization during...

Ngày tải lên: 05/07/2014, 20:21

... effects The effect of EA on reducing the MAC of isoflurane in dogs has not been previously examined This study was performed to investigate the effects of EA on MAC of isoflurane and on the cardiovascular ... was maintained for one hour at least with 2% of isoflurane in oxygen at a flow rate of 100 ml/kg/min Lactated Ringer"s solution was administered intravenously at a rate of 10 ml/kg/h During the ... Mask induction I: Instrumentation to measure the cardiopulmonary parameters M: Determination of MAC EA: Electroacupuncture C: Measuring the cardiopulmonary parameters before determination st st of...

Ngày tải lên: 07/08/2014, 15:20

... 10 minutes and were stained by 5% Giemsa staining solution (in phosphate buffer, pH 6.8) The concentration of 50% cytotoxicity was determined by microscopic observation Based on the preliminary ... homogenized for in 5.0 ml of physiological saline solution [17] The homogenate was filtered through a nylon mesh and then 0.1 ml of filterate was diluted with 2.0 ml of saline solution containing 4% trypan ... days and weighing 25-30 g, were divided into six groups of animals each The animals were housed per polycarbonate cage with wood shavings, and were maintained under a controlled environment with...

Ngày tải lên: 07/08/2014, 18:21

... the control group These findings indicate that mosapride effectively improves a decline in intestinal motility by increasing both peristalsis and the number of intestinal contractions [11] In addition, ... difference in the distribution of the 5HT4 receptor is at the base of different effects of mosapride in the small intestine and caecum In this study, we demonstrated that administration of mosapride ... then intubated and the horse was held on a surgical table Anesthesia was maintained by inhalation of halothane and oxygen At the beginning of surgery, 20 mg/kg of cefalotin sodium (Coaxin; Tobishi...

Ngày tải lên: 07/08/2014, 23:22

... altered (increasing or decreasing), the subsequent effects of fire [5] The classification of the severity of a fire based only on function of the remaining surviving trees could be then insufficient ... growing season was considered in this study as humid, while the second as very dry 2.2 Stands selection and sampling procedure Within each stand, an area was identified in a way that, containing ... was measured on five points in each sampling unit in the same points where ST-0 and ST-5 were determined; SM-20 and SM-40 were measured in one point on the edge of the sampling unit From September...

Ngày tải lên: 08/08/2014, 00:22