drugs affecting coagulation bleeding and thrombosis

Chapter 059. Bleeding and Thrombosis (Part 1) pdf

... Chapter 059. Bleeding and Thrombosis (Part 1) Harrison's Internal Medicine > Chapter 59. Bleeding and Thrombosis Bleeding and Thrombosis: Introduction The human ... procoagulant and anticoagulant forces. The procoagulant forces include platelet adhesion and aggregation and fibrin clot formation; anticoagulant forces include the natural inhibitors of coagulation and ... of blood coagulation have been described in the past: the so-called extrinsic, or tissue factor, pathway and the so-called intrinsic, or contact activation, pathway. We now know that coagulation...

Chapter 059. Bleeding and Thrombosis (Part 2) potx

Danh mục: Sức khỏe giới tính

... factor XIIIa, which covalently cross-links and thereby stabilizes the fibrin clot. Figure 59-2 Chapter 059. Bleeding and Thrombosis (Part 2) Coagulation is initiated by tissue factor (TF) ... FIX and FX, which in turn, with FVIII and FV as cofactors, respectively, results in thrombin formation and subsequent conversion of fibrinogen to fibrin. Thrombin activates FXI, FVIII, and ... through FIX/FVIII. Coagulation requires calcium (not shown) and takes place on phospholipid surfaces, usually the activated platelet membrane. The immediate trigger for coagulation is vascular...

Chapter 059. Bleeding and Thrombosis (Part 3) docx

Danh mục: Sức khỏe giới tính

... thrombin and the other clotting factors in coagulation. Antithrombin neutralizes thrombin and other activated coagulation factors by forming a complex between the active site of the enzyme and the ... Bleeding and Thrombosis (Part 3) Sites of action of the four major physiologic antithrombotic pathways: antithrombin (AT); protein C/S (PC/PS); tissue factor pathway inhibitor (TFPI); and ... sensitive markers of blood clot formation, and some have been validated for clinical use to exclude the diagnosis of deep venous thrombosis (DVT) and pulmonary embolism in selected populations....

Chapter 059. Bleeding and Thrombosis (Part 4) potx

Danh mục: Sức khỏe giới tính

... Chapter 059. Bleeding and Thrombosis (Part 4) Approach to the Patient: Bleeding and Thrombosis Clinical Presentation Disorders of hemostasis ... contributed to the bleeding or thrombotic state. In addition, the history can give clues as to the etiology by determining (1) the bleeding (mucosal and/ or joint) or thrombosis (arterial and/ or venous) ... trauma/surgery-induced bleeding? Spontaneous hemarthroses are a hallmark of moderate and severe factors VIII and IX deficiency and, in rare circumstances, of other clotting factor deficiencies. Mucosal bleeding...

Chapter 059. Bleeding and Thrombosis (Part 5) ppt

Danh mục: Sức khỏe giới tính

... Chapter 059. Bleeding and Thrombosis (Part 5) Epistaxis is a common symptom, particularly in children and in dry climates, and may not reflect an underlying bleeding disorder. However, ... hereditary hemorrhagic telangiectasia and in boys with vWD. Clues that epistaxis is a symptom of an underlying bleeding disorder include lack of seasonal variation and bleeding that requires medical ... cauterization. Bleeding with eruption of primary teeth is seen in children with more severe bleeding disorders, such as moderate and severe hemophilia. It is uncommon in children with mild bleeding...

Chapter 059. Bleeding and Thrombosis (Part 6) doc

Danh mục: Sức khỏe giới tính

... pathway inhibitor. Chapter 059. Bleeding and Thrombosis (Part 6) Underlying Systemic Diseases that Cause or Exacerbate a Bleeding Tendency Acquired bleeding disorders are commonly secondary ... surgery and the patients' underlying medical state, although a count of approximately 80,000/àL is likely sufficient. History of Thrombosis The risk of thrombosis, like that of bleeding, ... obesity, and genetic predispositions. Factors that increase risks for venous and both venous and arterial thromboses are shown in Table 59-3. Age Antiphospholipid antibody syndrome Previous thrombosis...

Chapter 059. Bleeding and Thrombosis (Part 7) pptx

Danh mục: Sức khỏe giới tính

... of the nature of coagulation assays, proper sample acquisition and handling is critical to obtaining valid results. In patients with abnormal coagulation assays who have no bleeding history, ... to the threshold for thrombosis and result in deep venous thrombosis (DVT). Note: The magnitude and duration of risk portrayed in the figure is meant for example only and may not precisely ... preoperative evaluations in patients with a negative bleeding history. The primary use of coagulation testing should be to confirm the presence and type of bleeding disorder in a patient with a suspicious...

Chapter 059. Bleeding and Thrombosis (Part 8) pptx

Danh mục: Sức khỏe giới tính

... overestimate the bleeding risk of a mildly elevated INR in this setting. The aPTT assesses the intrinsic and common coagulation pathways, factors XI, IX, VIII, X, V, II, fibrinogen, and also prekallikrein, ... is shown in Table 59-4. Chapter 059. Bleeding and Thrombosis (Part 8) Screening Assays The most commonly used screening tests are the PT, aPTT, and platelet count. The PT assesses the ... reagents to clotting factor deficiencies and to inhibitors such as heparin and lupus anticoagulants. Thus, aPTT results will vary from one laboratory to another, and the normal range in the laboratory...

Chapter 059. Bleeding and Thrombosis (Part 9) ppsx

Danh mục: Sức khỏe giới tính

Section V - Drugs Affecting Renal and Cardiovascular Function doc

Danh mục: Cao đẳng - Đại học

Báo cáo y học: "Proton-pump inhibitors are associated with a reduced risk for bleeding and perforated gastroduodenal ulcers attributable to non-steroidal anti-inflammatory drugs: a nested case-control study" pptx

Danh mục: Báo cáo khoa học

Báo cáo y học: "Correlations of HBV Genotypes, Mutations Affecting HBeAg Expression and HBeAg/ anti-HBe Status in HBV Carriers"

Danh mục: Y học thưởng thức

... between genotypes (B and C) and core promoter mutations as well as codon 15 variants. Also no correlation was observed between HBeAg/ anti-HBe status with genotypes (B and C) and core promoter ... EcoNI (New England Biolabs) and observed on 2.0 % agarose gel (Promega). T1858 variant would produce 20 bp and 190 bp restriction products while C1858 variant would be undigested and remained ... Japan and Ba which is found in some other Asian countries such as China, Hong Kong, Taiwan, Thailand and Vietnam. The Ba strain has recombination with genotype C in the precore region and the...

hemostasis and thrombosis protocols

Danh mục: Sinh học

... toxic and must be handled with great care. Gloves, masks and safety glasses must be worn. Phenol must be handled in a fume hood.5. Ethidium bromide is a potent carcinogen and teratogen and must ... factor Xa and VIIa. This provides a mechanism for further amplifi-cation and acceleration of coagulation. Fig. 4. Classic “waterfall” hypothesis for coagulation with the intrinsic, extrinsic, and ... were able to identify four differentbands in the analytical gel: two homoduplexes and two heteroduplexes (lanes 3,4, 6, 7, and 8). When the wild-type and the mutated homoduplexes were similiarin...

báo cáo sinh học:" Mid-level providers in emergency obstetric and newborn health care: factors affecting their performance and retention within the Malawian health system" pot

Danh mục: Điện - Điện tử

... These were job descriptions; management and supervision; training and career progression; incentives and retention factors; resource constraints; motivation; and status with other health care providers. ... providers in emergency obstetric and newborn health care: factors affecting their performance and retention within the Malawian health systemSusan Bradley* and Eilish McAuliffeAddress: Centre ... MLPs and whatthey can expect in return. There should be concertedefforts to create a positive upward spiral, where staff aresupported and supervised and improved performance isrecognised and...