drug targeting by retrometabolic design soft drugs and chemical delivery systems
DNA by Design. Stephen Meyer and the Return of the God Hypothesis
Ngày tải lên :
01/11/2013, 07:20
... tested) hypotheses that answer the obvious questions: what was designed and what wasn’t; and when, where, how, and by whom was design information supposedly inserted?7 Although his Discovery ... Forrest 2001 and Forrest and Gross 2003 11 By coincidence, this JIS issue also contained an article by two other ID proponents, Karl W Giberson and Donald A Yerxa In “Providence and the Christian ... disconfirmed should the Big Bang model by supplanted by, for example, the cyclic universe model, as is currently proposed by Paul Steinhardt and Neil Turok, in which time and space exist forever In fact,...
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Tài liệu The Acquisition of Drugs and Biologics for Chemical and Biological Warfare Defense - Department of Defense Interactions with the Food and Drug Administration doc
Ngày tải lên :
17/02/2014, 11:20
... recipients of IND drugs, medical monitoring and reporting of the use of such drugs, information about shipment and storage of drugs, disposition of unused IND drugs, and submission of annual and other ... to the acquisition of drugs and biologicals for CBW defense: licensing drugs and biologics for military uses, especially CBW defense; using drugs and biologics classified by FDA as INDs in certain ... Weiss (2001), p A24; and Fialka et al (2001) The Acquisition of Drugs and Biologics for CBW Defense cals (drugs) , and the protection of personnel by immunization, mainly by vaccines The objective...
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Báo cáo Y học: Functional analysis of the rat bile salt export pump gene promoter Regulation by bile acids, drugs and endogenous compounds potx
Ngày tải lên :
17/03/2014, 23:20
... indicates the ability of drugs and endogenous compounds to affect Bsep transcription, thus altering hepatic bile flow and clearance MATERIALS AND METHODS Genomic cloning and sequence analysis of ... and b-estradiol; 50 lmolÆL)1 each of phenobarbital, rifampin, and tamoxifen Assay conditions were the same as described in Fig *P < 0.05 the specific band Supershifted bands were rather weak and ... receptor FXR (lanes and 4), or against retinoid X receptor (RXR) (lanes and 6) or a combination of both (lanes and 8) resulted in a reduction of signal intensities of The ability of drugs to regulate...
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Báo cáo khoa học: B1–Proteases as Molecular Targets of Drug Development B1-001 DPP-IV structure and inhibitor design ppt
Ngày tải lên :
23/03/2014, 15:20
... accompanied or not by allosteric changes (d) by co-localization of enzyme and substrate (e) by cofactor binding accompanied or not by allosteric changes (f) by controlled substrate processing and access ... candidates and screening with Chinese medicinal plants extracts Furthermore, NMR studies were performed with the puried human enzyme by labeling the protein isotopically with 15N and D2O and by ... fat and salt content) was determined by standard methods (Kjehldhal, Soxhlet extraction and Volhard respectively) Cytotoxic and antiproliferative activity were assayed in vitro on MCF-7/6 and...
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drug targeting, strategies, principles, and applications
Ngày tải lên :
10/04/2014, 22:17
... antibody by From: Methods in Molecular Medicine, Vol 25: Drug Targeting: Strategies, Principles, and Applications Edited by: G E Francis and C Delgado © Humana Press Inc., Totowa, NJ Ghetie and Vitetta ... Medicine, Vol 25: Drug Targeting: Strategies, Principles, and Applications Edited by: G E Francis and C Delgado © Humana Press Inc., Totowa, NJ 27 28 Newton and Rybak Centricon and 30 microconcentrators ... selective delivery of biological agents to target cells and a pH-controlled intracellular release mechanism They also allow for the design of binary delivery systems that enhance specificity by targeting...
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Nanosized magnetofluorescent fe3o4–curcumin conjugate for multimodal monitoring and drug targeting
Ngày tải lên :
02/07/2014, 14:14
... about the original characteristics and application of Cur in cellular imaging and drug targeting Experimental 2.1 Chemical and biochemical materials All the chemicals were of reagent grade used ... mm on transversal and coronal planes, and using two sequences – T2weighted and T1-weighted Results and discussion 3.1 Size and structural characterizations of conjugates DLS and TEM/FE-SEM data ... efforts on designing stable conjugates for their application in vivo, namely for imaging and drug targeting Because MNPs that have a highly hydrophilic surface resist well to opsonizations and therefore...
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Báo cáo y học: "Drug efficacy by direct and adjusted indirect comparison to placebo: An illustration by Mycobacterium avium complex prophylaxis in HIV" potx
Ngày tải lên :
10/08/2014, 05:22
... and Women’s Hospital, Boston, USA 5Faculté de Médecine de Lille, Centre Hospitalier de Tourcoing, Tourcoing, France Authors’ contributions JC, CS, and EL conceived and designed the study JC and ... article as: Chu et al.: Drug efficacy by direct and adjusted indirect comparison to placebo: An illustration by Mycobacterium avium complex prophylaxis in HIV AIDS Research and Therapy 2011 8:14 ... the results of the Havlir et al study to Table Efficacy of MAC regimens by direct and adjusted indirect comparison Drug dose and study Method of efficacy derivation Study used for comparison Correction...
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báo cáo khoa học: " Changes in time-use and drug use by young adults in poor neighbourhoods of Greater Buenos Aires, Argentina, after the political transitions of 2001-2002: Results of a survey" potx
Ngày tải lên :
11/08/2014, 18:20
... to report they used no drugs than men (34%) The most commonly non-injected drugs used by men were cannabis, cocaine and non-prescription medicines; and by women cannabis and cocaine (see Table ... use, and data on frequency of use “ever” and for last months, for: cannabis, intranasal cocaine, non-prescription medicines, alcohol and solvents, as well as different injected drugs Injecting drugs ... sex, drug- use of partners, and sharing drugs with partners were measured for “ever” and for last months Drug risk behaviors: Questions were asked about a number of substances they used and their...
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Using Understanding by Design (UbD) Framework and Modeling with Concept maps, Spreadsheets and Hypermedia in EFL lesson plan design
Ngày tải lên :
10/08/2015, 22:59
... define which lesson design framework helps meet different learning styles of various students Understanding by Design (UbD) is a curriculum framework model which suggests designers consider more ... results and the evaluation of student’s performance and achievement In this way, this design helps teachers to solve the twin sins in teaching: “activity-oriented design in which the teacher designs ... “backward design (p.17) The process has three stages: “Identify design results”, “Determine acceptable evidence” and “Plan learning experiences and instruction” (pp 17, 18) Prior to designing...
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Knowledge discovery in biomedical research and drug design the development and application of biological databases
Ngày tải lên :
17/09/2015, 17:19
... bring the drugs to the target proteins so that the drugs can then bind to the therapeutic target and cure the diseases However, some drugs not directly interact with their targets These drugs will ... 1.4.2 The need of drug target databases for drug discovery Drug discovery and development is a complicated and long-term process It is noticed that knowledge of protein targets of drugs (those proteins ... identify those drug candidate with practical high efficacy and low toxicity [Sun et al., 2001] A successful drug should possess both high drug efficacy and low toxicity The toxicity of the drug, or...
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Heavy metal cation retention by unconventional sorbents (red muds and fly ashes)
Ngày tải lên :
23/09/2012, 14:47
... and Disposal, p 7.24McGraw-Hill, New York Freeman H M (1988) Standard Handbook of Hazardous Waste Treatment and Disposal, p 6.5McGraw-Hill, New York Gerth J and Bruemmer G (1983) Adsorption and ... Prasad B and Agarwal K (1991) Adsorption and desorption of zinc on calcareous soils J Indian Soc Soil Sci 39, 662-666 Reed B E and Cline S R (1994) Retention and release of lead by a very fine sandy ... literature (Bhattacharya and Venkobachar, 1984; Panday and Singh, 1985; Yadava et al., 1987) for a limited number of metals The alternative mechanism for heavy metal removal by red muds and fly ashes (either...
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Linear Minimum Mean-Square-Error Transceiver Design for Amplify-and-Forward Multiple Antenna Relaying Systems
Ngày tải lên :
20/11/2012, 11:31
... forwarding matrix and destination equalizer are jointly designed by minimum MSE criterion Both uplink and downlink cases are considered It is found that the uplink and downlink transceiver designs share ... forwarding matrix and destination equalizer are jointly designed by minimum MSE criterion Both uplink and downlink cases are considered It is found that the uplink and downlink transceiver designs share ... mobile communication systems and beyond 3 Source Destination Figure 1.2 MIMO system To exploit the benefits of MIMO systems, transceiver design for MIMO systems is of great meaning and has been extensively...
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Improvement of Water Quality by Removal of Suspended Solids and High-speed Biological Filtration in Closed Water Body
Ngày tải lên :
05/09/2013, 08:40
... measured in each point by standard methods [6] Pore size is 1µm In this paper, SS, transparency and COD at the outlet of plant and the outside of experimental area will be reported and discussed Experimental ... soils and groundwater: an evaluation, Engineering Geology, 60(1-4), 193-207 [5] Robert H Kadlec and Robert L Knight Treatment Wetlands CRC Lewis Publishers 1996 [6] APHA, AWWA and WPCF: Standard ... particles and easily remove SS - 237 - Journal of Water and Environment Technology, Vol.1, No.2, 2003 Conclusion The experiment on improving water quality was carried out by removal of SS and biological...
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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 17)
Ngày tải lên :
18/10/2013, 00:15
... vascular metabolism of organic nitrates and organic nitrites to nitric oxide Drug Metab Dispos 21:967–968 4) Kojima T, Kamimura H, Doi K et al (2000) Unregulated drugs containing nitrite esters Jpn ... µg) and isobutyl alcohol (injected amount 10 µg); they appeared at 3.4 and 7.4 of retention times, respectively The solvent acetone appeared at about The detection limits of isobutyl nitrite and ... isobutyl nitrite in blood by GC with liquid-liquid extraction ⊡ Figure 8.1 Gas chromatograms for isobutyl nitrite (A) and isobutyl alcohol (B) um between the hydrolysis and esterification [7] Under...
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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 67)
Ngày tải lên :
18/10/2013, 00:15
... hydrolyzed by chemical and enzymatic reactions with allylesterase to yield EMPA and 2-(diisopropylamino)ethanethiol (DAET) The DAET formed is immediately subjected to methyl-conjugation by the action ... in environmental and biological samples using gas chromatography/negative-ion chemical ionization mass spectrometry and tandem mass spectrometry J Mass Spectrom 30:1133–1143 VX and its decomposition ... products of organophosphorus chemical warfare agents and related compounds by liquid chromatography-mass spectrometry using electrospray and atmospheric pressure chemical ionization J Chromatogr...
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Theory and Design of Electrical and Electronic Circuits
Ngày tải lên :
23/10/2013, 16:15
... place by effect to skin ρCA.ω2, not deigning the one that of losses of heat by the ferromagnetic nucleus; capacitance C will be it by addition of the loops; and finally inductance L by geometry and ... If you make something and works, it is that it has omitted something by stop " The calculations have so much the heuristic form (test and error) like algoritmic (equations) and, therefore, they ... transistor of junction (TBJ) Theory Design Fast design Unipolar transistor of junction (JFET) Theory Design Operational Amplifier of Voltage (AOV) Theory Design ...
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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 20)
Ngày tải lên :
24/10/2013, 19:15
... 5α-cholestane and 5’-nor-∆8-THC-4’-oic acid obtained by both derivatization methods For the ∆9-THC-11-oic acid, the base peak appeared at m/z 371 and is most suitable for quantitation by SIM > Figure ... and TMS derivatives of ∆9-THC-11-oic acid The Substance Abuse and Mental Service Administration (SAMSA) in USA set the cutoff value of ∆9-THC-11-oic acid in urine at 50 ng/mL by immunoassay and ... urine and the liver tissue Urine showed a positive result for the cannabinoid metabolite by screening with EMIT The concentrations of ∆9-THC-11-oic acid measured by GC/MS were 22 ng/mL in urine and...
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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 21)
Ngày tải lên :
24/10/2013, 19:15
... morphine, heroin and codeine The thick and thin arrows show the main and minor metabolic pathways, respectively ⊡ Figure 3.1 196 Morphine and its analogues GC and GC/MS analysis • • • • • Standard solutions ... buffer solution (pH 4) and methanol, and dried for by aspiration with a vacuum manifold, followed by washing with mL methanol and drying for again v The target opiate is eluted, by passing mL of dichloromethane/isopropanol/ammonia ... HPLC analysis Reagents and their preparation • • Standard solutions of morphine for a calibration curve (2, and 20 µg/mL): see “Reagents and their preparation”, above of GC and GC/MS analysis section...
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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 70)
Ngày tải lên :
24/10/2013, 19:15
... the same type, followed by addition of 0.5 mL of concentrated sulfuric acid f and 0.5 mL of mesitylene Nitrate and nitrite compounds iv The mixture is vortex-mixed for and centrifuged at 3,000 ... wide-bore and medium-bore capillary columns With the medium-bore capillary column, a big and broad peak due to mesitylene appears The detection limits are about 0.3 and 0.1 µg/mL for wide-bore and ... Detection of nitrite by wide-bore and medium-bore capillary GC after its derivatization into nitromesitylene The concentration of nitrite was µg/mL for both chromatograms 651 652 Nitrate and nitrite compounds...
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