... inactive receptor conformation A Molecular mechanisms of drug- receptor interaction Increase in tension Receptor occupation Efficacy Receptors Agonist A EC50 EC50 Concentration (log) of agonist ... Color Atlas of Pharmacology © 2000 Thieme All rights reserved Usage subject to terms and conditions of license 66 Drug- Receptor Interaction Mode of Operation of G-ProteinCoupled Receptors Signal ... Lüllmann, Color Atlas of Pharmacology © 2000 Thieme All rights reserved Usage subject to terms and conditions of license 63 64 Drug- Receptor Interaction Receptor Types Receptors are macromolecules...
Ngày tải lên: 26/01/2014, 19:20
... validation of such models becomes an important goal for biomedical modelling which is partially addressed in the current study There are a number of ways of refining the simple kinetic model for the ReceptorToxin-Antibody ... surface of Ω, Sc - the cell surface (inner surface of Ω), r0 - the concentration of receptors on the cell surface, θ(t, x) - the the fraction of bounded receptors, r0θ - the concentration of the ... application of antibody) Reaction-Diffusion Model for RTA Interaction The reaction-diffusion system for the RTA interaction can be derived based on wellknown results of the receptor- ligand system (law of...
Ngày tải lên: 13/08/2014, 16:20
Báo cáo y học: "Intrathecal siRNA against Toll-like receptor 4 reduces nociception in a rat model of neuropathic pain"
... pain: efficacy of a new receptor antagonist in a model of peripheral nerve injury in mice Glia 2008; 56: 1312-9 28 Jordan J.M., Woods M.E., Olano J., Walker D.H The absence of Toll-like receptor signaling ... Schluesener H.J The innate immunity of the central nervous system in chronic pain: the role of Toll-like receptors Cell Mol Life Sci 2007; 64: 1128-36 Zeilhofer H.U Loss of glycinergic and GABAergic ... Suppression of TLR4 attenuates neuropathic pain in CCI rats To examine the impact of TLR4-siRNA treatment on pain response in vivo, modulation of pain perception in the Bennett model of neuropathic...
Ngày tải lên: 25/10/2012, 11:48
báo cáo hóa học: " Origin and consequences of brain Toll-like receptor 4 pathway stimulation in an experimental model of depression" docx
... al.: Origin and consequences of brain Tolllike receptor pathway stimulation in an experimental model of depression Journal of Neuroinflammation 2011 8:151 Page 14 of 14 Submit your next manuscript ... index of this type of damage that could be affected by CMS, we measured the accumulation of the lipid peroxidation marker malondialdehyde (MDA) in brain prefrontal cortex of the different groups of ... experimental model of depression To our knowledge, our results demonstrate for the first time that the TLR-4 signaling pathway becomes activated in brain cortex of rats exposed to an animal model of depression...
Ngày tải lên: 19/06/2014, 22:20
Báo cáo hóa học: " Bifurcation analysis of a diffusive model of pioneer and climax species interaction" pot
... studied Turing instability in a pioneer/climax population interaction model He determined the values of the diffusional coefficients for which the model undergoes a Turing bifurcation, and he show that ... species interaction has not been studied Our study will be performed in Hopf bifurcation The rest of this article are structured in the following way: in Section 2, the conditions of the existence of ... attention to the stability and direction of bifurcating periodic solutions bifurcated at l1 We give the detail of the calculation process of the direction of Hopf bifurcation at l1 in the following...
Ngày tải lên: 20/06/2014, 22:20
Báo cáo y học: "Type I interferon receptor controls B-cell expression of nucleic acid-sensing Toll-like receptors and autoantibody production in a murine model of lupus" doc
... the development of kidney damage in the pristane model of SLE Because the development of kidney disease in the pristane model is not as severe as in other spontaneous models of SLE, such as the ... function of TAM receptors and the differential roles of IFNAR1 and IFNAR2 in the development of autoimmunity Unlike other murine models of SLE, such as the MRL/lpr and the (NZB × NZW)F1 spontaneous models, ... characterized the role of the IFNAR2 chain of the IFNAR in the pristane model Pristane-treated IFNAR2-/- mice developed high titers of total serum IgM accompanied by significantly lower levels of the pathogenic...
Ngày tải lên: 09/08/2014, 14:22
Báo cáo y học: " Role of the tachykinin NK1 receptor in a murine model of cigarette smoke-induced pulmonary inflammation" docx
... dual tachykinin NK1/NK2 receptor antagonist in guinea pigs [22] The purpose of this study was to characterize the precise role of the tachykinin NK1 receptor in a mouse model of cigarette smoke-induced ... absence of the tachykinin NK1 receptor The interaction of MIP-3α/CCL20 with its receptor CCR6 has been described as one of the most potent mechanisms for recruitment of immature DCs [41,42] Moreover, ... reduced numbers of DCs and macrophages in these mice Importantly, we confirmed the in vivo role of the NK1 receptor in CS-induced recruitment of macrophages and DCs by using the NK1 receptor antagonist...
Ngày tải lên: 12/08/2014, 14:20
Báo cáo y học: " Role of lysophosphatidic acid receptor LPA2 in the development of allergic airway inflammation in a murine model of asthma" potx
... and role of LPA receptors in asthma To address the role of LPA receptors in Th2-mediated inflammation, we have used a well described Schistosoma mansoni eggs-sensitized murine model of allergic ... production, indices of degree of inflammation, are hallmarks of asthma Goblet cell metaplasia and mucus production were determined by PAS staining of histological sections of lung tissues from ... regarding LPA receptors expression, and its role in infiltration of eosinophils and lung inflammation in Schistosoma mansoni eggs sensitized and challenged murine model of Page of 12 (page number...
Ngày tải lên: 12/08/2014, 14:20
Báo cáo y học: "Nociceptive tolerance is improved by bradykinin receptor B1 antagonism and joint morphology is protected by both endothelin type A and bradykinin receptor B1 antagonism in a surgical model of osteoarthritis" pdf
... and BKB1 receptor expression is involved in OA pathogenesis, and that specific receptor antagonism may prove beneficial in OA disease management Page of 11 Materials and methods Rat model of osteoarthritis ... is improved by bradykinin receptor B1 antagonism and joint morphology is protected by both endothelin type A and bradykinin receptor B1 antagonism in a surgical model of osteoarthritis Arthritis ... degradation and joint nociception in a rat surgical model of OA We provide several lines of evidence that suggest protective effects of ETA and/ or BKB1 antagonism in vivo: BKB1 antagonist treatment improved...
Ngày tải lên: 12/08/2014, 15:23
Báo cáo sinh học: "Mimosa: Mixture model of co-expression to detect modulators of regulatory interaction" docx
... http://www.almob.org/content/5/1/4 Page of where -1 ≤ a ≤ is a free parameter of the mixture model that controls the aspect ratio of the correlated distribution Without loss of generality let sv >su; then in terms of a we have ... test, where the likelihood of the mixture model with a free f and a parameters is compared with the likelihood of a model where f = and only a is free The log of the ratio of the two likelihoods ... detect potential modulators of regulatory interactions Methods Mixture modeling of co-expression Figure illustrates the method The input data, i.e the expression profiles, is a matrix M [i, k]...
Ngày tải lên: 12/08/2014, 17:20
Retrovirology Commentary BioMed Central Open Access The co-receptor signaling model of HIV-1 ppt
... Emergence Figure The co -receptor signaling model of HIV pathogenesis in peripheral CD4 T cells The co -receptor signaling model of HIV pathogenesis in peripheral CD4 T cells In this model, I hypothesize ... direct correlation of CD4 depletion with the X4 genotypes in the absence of the X4 phenotype is a strong indication of the possible existence of the R5X4-signaling viruses As a matter of fact, a recent ... progression The central tenets of this new signaling model are the hypothetical existence of the R5X4-signaling viruses during chronic infection and the direct association of these viruses with CD4...
Ngày tải lên: 12/08/2014, 23:20
Báo cáo y học: " Modulation of the virus-receptor interaction by mutations in the V5 loop of feline immunodeficiency virus (FIV) following in vivo escape from neutralising antibody" ppsx
... extreme, B2542 and PPR are capable of infecting via an interaction with CRD1 alone[27,37] Preliminary analyses of the modes of CD134 interaction of diverse strains of FIV have indicated that GL8 ... modulate the virus -receptor interaction, suggesting that escape from neutralising antibodies may drive alterations in the virus -receptor interaction Page of 13 Methods Preparation of genomic DNAs ... and altered receptor usage Receptor usage of Envs The GL8 strain of FIV requires determinants in both CRDs and of its primary receptor CD134 for infection; chimaeric receptors based on human CD134...
Ngày tải lên: 12/08/2014, 23:23
Báo cáo y học: " A single site for N-linked glycosylation in the envelope glycoprotein of feline immunodeficiency virus modulates the virus-receptor interaction" ppt
... component of the receptor binding face of FIV Env, or contributes to the tertiary/quaternary structure of the Env trimer such that the receptor binding face of Env is presented to the viral receptor ... determinants in CRD2 of CD134 for receptor binding is lost These data would suggest that the specificity of receptor binding of the GL8 Env may be dependent on intermolecular interactions in the ... V1/V2 region of HIV SU affect the interaction between the HIV SU and its receptor and co -receptor( s) and alter the antigenicity of the envelope glycoprotein, promoting the production of antibodies...
Ngày tải lên: 13/08/2014, 05:21
Báo cáo y học: "A novel model of common Toll-like receptor 4- and injury-induced transcriptional themes in human leukocytes" pot
... Regulation of lung injury and repair by Toll-like receptors and hyaluronan Nat Med 2005, 11:1173-1179 Pulskens WP, Teske GJ, Butter LM, Roelofs JJ, van der Poll T, Florquin S, Leemans JC: Toll-like receptor- 4 ... within normal lab limits Exclusion criteria included a history of any acute or chronic disease, arrhythmia, recent history of alcohol, drug or medication ingestion, pregnancy or prior exposure to ... a Means ± standard errors of the means b Two patients received more than five units of RBC APACHE II, Acute Physiology and Chronic Health Evaluation II; LOS, length of stay Haimovich et al Critical...
Ngày tải lên: 13/08/2014, 21:21
Regulation of substance p and neurokinin 1 receptor expression in a mouse model of acute pancreatitis
... recovery of AP by using these various animal models However, none of the commonly used models exactly mimic the inciting event of human cases of pancreatitis Nonetheless, the pathologic features of ... obstruction of the pancreatic ducts is a major risk factor of AP, the pancreatic duct ligation model is perhaps one of the more clinically relevant model available for studying the pathogenesis of AP ... REGULATION OF SUBSTANCE P AND NEUROKININ-1 RECEPTOR EXPRESSION IN A MOUSE MODEL OF ACUTE PANCREATITIS KOH YUNG HUA [B.Sc (Hon), National University of Singapore] A THESIS SUBMITTED FOR THE DEGREE OF...
Ngày tải lên: 09/09/2015, 17:54
Testing a model of customer-based brand equity in the Vietnamese banking servic
... based on characteristics of the data, source of the data, the purpose of research or the frequency of study 27 Based on the purpose of research, researchers often use one of the following three ... apply the model of brand equity developed by Martensen and Grønholdt (2004) and test this model in the banking sector of Vietnam as an emerging economy To confirm the applicability of the model, ... 54 FIGURE 4.8B RESULTS OF MODEL III B 55 FIGURE 4.9 ADJUSTED MODEL OF CBBE IN BANKING SERVICE 58 FIGURE 5.1 – OUTLINE OF CHAPTER 59 v LIST OF TABLES TABLE 4.1 – SAMPLE...
Ngày tải lên: 06/11/2012, 15:52
CFD model of air movement in ventilated façade: comparison between natural and forced air flow
... models, experimental models and computational fluid dynamics (CFD) models [2] The use of CFD in particular has risen since 2002 The wide applicability, acceptability of CFD as a ventilation modeling ... implications of their design decisions There are currently many different modeling approaches used in predicting building ventilation including analytical models, empirical models, multizone models, ... made of aluminum profiles) to the external wall surface of the building This first layer defines the visual appearance of the building The next layer is an opened air gap with a minimum of cm...
Ngày tải lên: 05/09/2013, 14:58
Bài giảng Chapter 7 The Quantum-Mechanical Model of the Atom
... determined the energy of the photon of light produced Tro, Chemistry: A Molecular Approach 43 Bohr Model of H Atoms Tro, Chemistry: A Molecular Approach 44 Wave Behavior of Electrons • de Broglie ... see in the properties of the elements Tro, Chemistry: A Molecular Approach The Nature of Light its Wave Nature • light is a form of electromagnetic radiation composed of perpendicular oscillating ... Characterizing Waves • the frequency, (ν) is the number of waves that pass a point in a given period of time the number of waves = number of cycles units are hertz, (Hz) or cycles/s = s-1 1...
Ngày tải lên: 28/11/2013, 01:11
The simple economics of easter island a ricardo malthus model of renewable resource use
... Reproduced with permission of the copyright owner Further reproduction prohibited without permission Reproduced with permission of the copyright owner Further reproduction prohibited ... without permission Reproduced with permission of the copyright owner Further reproduction prohibited without permission Reproduced with permission of the copyright owner Further reproduction prohibited ... without permission Reproduced with permission of the copyright owner Further reproduction prohibited without permission Reproduced with permission of the copyright owner Further reproduction prohibited...
Ngày tải lên: 13/12/2013, 11:36