drug pharmacokinetics dose response and time duration
Báo cáo khoa học: Nuclear localization of human spermine oxidase isoforms – possible implications in drug response and disease etiology pptx
Ngày tải lên :
07/03/2014, 05:20
... existence of SMO5 in human normal and tumor cell lines SMO5 cDNA was subcloned and sequenced, and active protein was produced, purified and assayed for kinetic properties and substrate specificities NCI-H157 ... to inclusion bodies, and therefore was denatured and refolded prior to analysis All SMO5 protein production and purification steps were performed in parallel with SMO ⁄ PAOh1 and PAOh4 proteins ... decreases in intracellular spermine pools and increased spermidine levels in SMO1 and SMO5 cells These changes in spermine and spermidine levels in both SMO1 and SMO5 overexpressing cell lines were...
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Báo cáo khoa học: " Impact and relationship of anterior commissure and time-dose factor on the local control of T1N0 glottic cancer treated by 6 MV photon" doc
Ngày tải lên :
09/08/2014, 09:20
... design and coordination, performed acquisition of data and drafted the manuscript KHA and FYC participated in data analysis and revised the manuscript RKCN and SMC participated in study’s design and ... d Gy are given in an overall time of T days and kick off time (Tk) for tumor repopulation 2.0 Gy 256 (59.1) Total dose (Gy) 64 52 (12.0) 66 68 202 (46.6) (0.46) Tx duration (days) ≤ 45 48 (11.0) ... logs) per gray of dose] One hundred and seventy-seven (40.8%) were treated with a dose fraction size of 2.5 Gy, with total dose of 55-60 Gy (median: 57.5 Gy), within a treatment duration of 30-38...
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Báo cáo khoa học: "A comparison of dose-response characteristics of four NTCP models using outcomes of radiationinduced optic neuropathy and retinopathy" potx
Ngày tải lên :
09/08/2014, 09:20
... were 92.2 Gy and 1.52, 101.2 Gy and 0.98, 100.0 Gy and 1.05, and 94.6 Gy and 1.34 For RION in patients treated twice daily and a/b = Gy, parameter values were 91.0 Gy and 1.52, 120.9 Gy and 0.76, ... parameters, D50 and g for RION in patients treated once daily were 96.0 Gy and 1.34, 107.6 Gy and 0.82, 103.9 and 0.95, and 98.1 Gy and 1.20 for the logistic, log-logistic, Poissonbased and probit ... D50 = 80 Gy and g = 1.5 Page of 10 Poisson-based, logistic and probit models The authors carefully considered the location of the maximum doseresponse slope and maximum normalized dose- response...
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Báo cáo y học: "Inhaled nitric oxide in acute respiratory distress syndrome with and without septic shock requiring norepinephrine administration: a dose–response study" ppt
Ngày tải lên :
12/08/2014, 18:20
... in Tables and In (a) and (b) patients without plateau effect on the dose response curve are represented In (c) and (d) patients with a plateau effect on the MPAP dose response curve and showing ... in Tables and In (a) and (b) patients without plateau effect on the dose- response curve are represented In (c) and (d) patients with a plateau effect on the MPAP dose- response curve and showing ... analysis of variance (dose- response curve) Effects of septic shock on dose response curves At control, hemodynamic and respiratory parameters were the same for both groups Dose- response curves of...
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Báo cáo y học: "Extent of exposure to environmental tobacco smoke (ETS) and its dose-response relation to respiratory health among adults" doc
Ngày tải lên :
12/08/2014, 18:21
... households were selected with equal probably and an adult was randomly selected from each The survey was conducted between May-August 2004, and the protocol and the informed consent documents were ... questionnaire responses and measurements using a custom data entry program (Delphi programming language and SQL server DBMS) The questionnaire included main sections; socio-demographics, general health and ... (0.7–2.0) 1.0 (0.5–1.9) P Dose- response 0.6 0.3 0.3 0.4 0.7 * Odds ratio and 95% confidence interval for the relation between ETS score tertiles (lower being referent) and respiratory symptoms/diagnosis...
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Báo cáo y học: " Site-specific dose-response relationships for cancer induction from the combined Japanese A-bomb and Hodgkin cohorts for doses relevant to radiotherapy" ppsx
Ngày tải lên :
13/08/2014, 16:20
... (risk equivalent dose) is the dose- response relationship for radiation induced cancer in units of dose and b is the initial slope, which is the slope of the dose- response curve at low dose The modifying ... average organ dose as long as the dose- response curve is linear At high dose it could be that the dose- response relationship is non-linear and as a consequence, OED replaces average dose to quantify ... inhomogeneous dose distributions, cancer risk is proportional to average dose only for a linear dose- response relationship For any other dose- response relationship, cancer risk is proportional to OED Dose- response...
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FISCAL COMPETITION IN SPACE AND TIME: AN ENDOGENOUS-GROWTH APPROACH
Ngày tải lên :
05/09/2013, 14:18
... Niemann and Dirk Simons, Transfer Pricing or Formula Apportionment? Tax-Induced Distortions of Multinationals’ Investment and Production Decisions, June 2007 2021 Andreas Bühn, Alexander Karmann and ... June 2007 2030 Robert Dur and Hein Roelfsema, Social Exchange and Common Agency in Organizations, June 2007 2031 Alexander Libman and Lars P Feld, Strategic Tax Collection and Fiscal Decentralisation: ... exogenous to individual capital owners and to governments of individual jurisdictions, but endogenously determined by demand and supply on the federal level Assets and physical capital are imperfectly...
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Date and Time Manipulation
Ngày tải lên :
05/10/2013, 08:51
... returns a if the current day and hour are within those parameters and gives the user a message stating the CHAPTER ■ DATE AND TIME MANIPULATION same If the current day and hour values not lie within ... perl_seconds_since_epoch=`perl -e 'print time' ` Evaluating for the Current Day and Time Say you want to schedule a job, such as a system monitor, to run at particular times or on certain days You want ... routine notices by page during the day and by e-mail at other times The following script determines whether the current day and hour are within a certain time frame that you set This code would...
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Law and authority in space and time
Ngày tải lên :
01/11/2013, 08:20
... haphazard the single events and their causation may appear to be.’ 57 Law and authority in space and time with and make sense to each other and to themselves.’16 At once speech and literacy become the ... RosenstockHuessy wrote in the 1920s and 1930s.14 When history and social life are thought about as a generational project – of our children, parents and grandparents and their parents and societies, the sub-title ... radical transformation of space and time Time and space have become ‘disembedded’28 from the social world Time is now significantly abstracted from the life cycle as seasons and daylight matter increasingly...
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Tài liệu Sounding the Event- Escapades in dialogue and matters of art, nature and time doc
Ngày tải lên :
17/01/2014, 01:20
... lesson and grasp it fast (Howmany times? How many times? How many times? There is one thing I can say that I have grasped and this is that time will always exceed my understanding of it.) And still ... such a term - was the act and process of conjugation whereby both tree and birds and pine-cones and, perhaps, the time of day entered into composition with each other and became something other ... all things are transformed by fire and time You say that the time of erosion and wear would not happen without the disorderly time of the weather - les temps And, what is more, you say that fire,...
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Tài liệu Gravitational Physics: Exploring the Structure of Space and Time pdf
Ngày tải lên :
12/02/2014, 16:20
... of Space and Time http://www.nap.edu/catalog/9680.html GRAVITATIONAL PHYSICS: EXPLORING THE STRUCTURE OF SPACE AND TIME When gravitational fields are weak and vary only slowly with time, the ... Exploring the Structure of Space and Time http://www.nap.edu/catalog/9680.html GRAVITATIONAL PHYSICS: EXPLORING THE STRUCTURE OF SPACE AND TIME of space and time The application of this new theory ... Structure of Space and Time http://www.nap.edu/catalog/9680.html Gravitational Physics Exploring the Structure of Space and Time Committee on Gravitational Physics Board on Physics and Astronomy Commission...
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Chapter 7 machine equations in operational impedances and time constants
Ngày tải lên :
16/02/2014, 18:47
... ′ and τ ′′ and τ τd and ′ ′′ and τ d are are are are the q- and d-axis the q- and d-axis the q- and d-axis the q- and d-axis transient open-circuit time constants subtransient open-circuit time ... reciprocals of the roots are the time constants, and if we define the transient open-circuit time constant as the largest time constant and the subtransient open-circuit time constant as the smallest, ... EQUATIONS IN OPERATIONAL IMPEDANCES AND TIME CONSTANTS development, we implied a notational correspondence between the kq1 and the fd windings and between the kq2 and the kd windings In this chapter,...
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Tài liệu DRUG STEREOCHEMISTRY Analytical Methods and F''''hannacology Second Edition_2 ppt
Ngày tải lên :
17/02/2014, 05:20
... severaland step series of reactions involvingring opening and amide formation with pyrrolidine,oxidationtothealdehyde,epimerization,reduction ,and ether formation ledto amide [34] Ozonolysis and ... theunexpectedloss of tosylate and aziridine formation Olefin formation from [56] via the N-oxide and chain extensiongaveacid [57J Iodolactonization and tri-n-butyltin hydride reduction in thestandard fashion ... carbon and pool-are available As exemplified by the prostaglandins, the manner in which these tools are used is limited only by the imaginationand inventiveness of the chemist (W D A Pensak and...
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Tài liệu Child Survival in Nigeria: Situation, Response, and Prospects ppt
Ngày tải lên :
18/02/2014, 15:20
... oil and flour) with vitamin A; and regulatory agencies (National Agency for Food and Drug Administration and Control (NAFDAC)) are ensuring adequate implementation through effective monitoring and ... 1995 and adopted in 1998 Provision of Adequate Pre- and Postnatal Care for Mothers The relationship between high maternal morbidity and mortality and high infant and under-five morbidity and mortality ... religious/ethnic conflict, Ife/Modakeke, and the Urhobo, Ijaw and Itsekiri conflicts, which have left a host of abandoned and orphaned children Also, the recent Lagos bomb explosion and the Yoruba/Hausa communities...
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Tài liệu Báo cáo khoa học: Steady-state and time-resolved fluorescence studies of conformational changes induced by cyclic AMP and DNA binding to cyclic AMP receptor protein from Escherichia coli ppt
Ngày tải lên :
20/02/2014, 23:20
... 1ị where SD and SRF are the respective areas under the emission spectra of the donor and a reference compound, and ARF and AD are the respective absorbances of the reference compound and donor ... 10PỵDAị=2 2ị where F and Fcor are uorescence intensity before and after the correction, and P and DA denote the initial sample absorbance at the excitation wavelength and the change in absorbance ... zero, and therefore this component of the decay is not included in the calculated average values of uorescence lifetimes ặsDổ and ặsDAổ The values for average lifetimes of Trp85 in the absence and...
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Tài liệu Báo cáo khoa học: Constitutive oligomerization of human D2 dopamine receptors expressed in Spodoptera frugiperda 9 (Sf9 ) and in HEK293 cells Analysis using co-immunoprecipitation and time-resolved fluorescence resonance energy transfer pdf
Ngày tải lên :
21/02/2014, 00:20
... Anti-gp120 Ig and anti-FLAG Ig identified bands corresponding to proteins with a molecular mass equivalent to 43 kDa and 85 kDa for D2L and 39 kDa and 80 kDa for D2S (Fig 1) No bands were detected ... EcoRI and NdeI, and the DNA fragments and the HIV tag were ligated The ligation mixture was subjected to PCR to selectively amplify tagged receptor whilst, at the same time, adding an XhoI site and ... expression of HIV- and FLAG-tagged D2L and D2S receptors in Sf9 cells To achieve this, mAbs directed against gp120 (clone 11/4C) and the FLAG sequence were used, and Fig shows the band pattern visualized...
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FACING THE REALITY OF DRUG-RESISTANT TUBERCULOSIS: CHALLENGES AND POTENTIAL SOLUTIONS IN INDIA pot
Ngày tải lên :
05/03/2014, 11:20
... spread of drug- resistant strains of TB and to discuss innovative strategies for advancing and harmonizing local and international efforts to prevent and treat drug- resistant TB.2 HISTORY AND DIMENSIONS ... WHO and the GLC The procurement of 23,000 drug doses for MDR TB for 2011-2012 has been initiated through the GLC and the Global Drug Facility mechanism Loose drugs are supplied to state drug ... management and care of multidrug-resistant and extensively drug- resistant tuberculosis that includes directly observed treatment, community-based and patient-centered care, and which identifies and...
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Physics of the Impossible: A Scientific Exploration into the World of Phasers, Force Fields, Teleportation, and Time Travel
Ngày tải lên :
05/03/2014, 16:15
... is: not anytime soon David Smith of Duke University says, "Reporters, they call up and they just want you to say a number Number of months, number of years They push and push and push and you finally ... Twentieth Century, which was locked away and forgotten for over a century until it was accidentally discovered by his great-grandson and published for the first time in 1994 In it Verne predicted what ... Telescope and the Chandra X-ray telescope have revealed thousands of black holes in space The reason that these technologies were deemed "impossibilities" is that the basic laws of physics and science...
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DO NOT DELAY: BREAST CANCER AND TIME, 1900-1970 pdf
Ngày tải lên :
06/03/2014, 00:22
... gender norms and roles, and unquestioned scientific authority, on the social side; and reflecting progress in prevention (SBE and mammography) and treatment (less radical surgery and chemotherapy ... doctors and patients from the 1900–1970 period in order to identify and understand the interactions among these ideas, actors, and routines (Although my subject is American medicine and society, ... the middle of the second operation and that same ideal; and between the patient’s implied delay and her failure to present for X-ray treatments, on the one hand, and medical expectations of the...
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Báo cáo khoa học: Ligand-specific dose–response of heterologously expressed olfactory receptors potx
Ngày tải lên :
08/03/2014, 02:21
... helional, a dose far below those usually tested in other systems Bell-shaped dose- dependent response The bell-shaped odor dose response curves obtained here for both human OR17-40 and rat I7 olfactory ... tested Again, the dose response profile to helional stimulation is a narrow bell-shaped curve, with a maximum for 10)11 M helional, almost no response for 10)10 M and above, few responses for 10)12 ... Differential dose response to a family of linear aldehydes for I7 In the case of I7, the response of the receptor to a family of linear aldehydes was investigated For each aldehyde, a bell-shaped dose response...
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