dosage of antimicrobial drugs in adult patients with renal impairment
Managing Drug Interactions in the Treatment of HIV-Related Tuberculosis docx
... Rifampin is the only rifamycin available in most of the world, and initial antiretroviral regimens in areas with high rates of tuberculosis consist of efavirenz or nevirapine (in combination with ... Klitgaard NA, Brosen K, Gerstoft J, Pedersen C Pharmacokinetic interaction between rifampin and the combination of indinavir and low-dose ritonavir in HIVinfected patients Clin Infect Dis Feb 2004;38(3):426-429 ... rifampin induces the activity of the CYP2C19 and CYPD6 isozymes The rifamycins vary in their potential as CYP450 inducers, with rifampin being most potent, rifapentine intermediate, and rifabutin...
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báo cáo hóa học:" Confronting TB/HIV in the era of increasing anti-TB drug resistance" pdf
... Challenges to TB/HIV care Initiating ART in HIV infected TB patients The clinical care of HIV infected TB patients and in particular the treatment of these persons with life saving antiretroviral medications ... at TB clinics while ART provision often implies referral from TB clinics to ART sites, leading to loss of patients and partly accounting for the low uptake of ART in HIV infected TB patients ... burden of TB in PLHIV Tuberculosis is appropriately gaining increasing importance to the HIV community The 'Three I's' have also gained increasing importance among major opinion leaders It is increasingly...
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Báo cáo y học: "Clinical Management of Adult Patients with a History of Nonsteroidal Anti-Inflammatory Drug–Induced Urticaria/ Angioedema: Update" ppt
... this kind of intolerance frequently occurs on the first administration of a certain drug and parallels the clinical activity of the underlying chronic urticaria; drugs that induced severe skin reactions ... results.16 Interestingly, and similarly to patients with aspirin-exacerbated respiratory disease (AERD), in patients with acute urticaria induced by distinct NSAIDs (both with and without chronic ... history of urticaria 27 induced by another NSAID (60% vs 24%) This finding is in keeping with the observations of another study that both multiple- and single-NSAID reactors with a history of aspirin-induced...
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Báo cáo y học: " Nonsteroidal Anti-Inflammatory Drug Hypersensitivity in Preschool Children" pot
... documented in about 2% of asthmatic children above years of age53 in a laboratory challenge setting, and there are isolated case reports, but the clinical significance of this finding in the context of ... skin-prick test and associated allergic rhinitis In our published group of NSAID-hypersensitive Asian children,15 with 25% of the patients being less than years of age, 89% had a positive skin-prick ... group and in older patients, and this may explain the relative male predominance (as opposed to female predominance in adults) since atopic disease in young children also shows a somewhat increased...
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Báo cáo y học: " ncremental cost effectiveness of proton pump inhibitors for the prevention of non-steroidal anti-inflammatory drug ulcers: a pharmacoeconomic analysis linked to a case-control study" potx
... the findings of our previous clinical study in NSAID users, in which concomitant use of PPIs was associated with a lower incidence of serious NSAID ulcer complications compared with not using ... Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis VIGOR Study Group N Engl J Med 2000, 343:1520-1528 Spiegel BMR, Chiou CF, Ofman J: Minimizing ... serious gastrointestinal complications in patients with rheumatoid arthritis receiving nonsteroidal anti-inflammatory drugs A randomized, double-blind, placebo-controlled trial Ann Int Med 1995,...
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Báo cáo khoa học: "Regression of sporadic intra-abdominal desmoid tumour following administration of non-steroidal anti-inflammatory drug" ppt
... previous surgery) play a role in their development and growth A distinction is often made between desmoids in patients with FAP and those in patients without FAP, but clinically these tumours are ... activity of β-catenin-dependent reporter genes in malignant cell lines, and to induce β-catenin degradation [6,7] Moreover, NSAIDs appear to inhibit the initial stages of the colorectal adenoma-carcinoma ... activation of the Wnt-signalling pathway by mutations in APC or β-catenin, which results in the accumulation and nuclear translocation of β-catenin and in β-catenin/TCF4-regulated transcription of TCF...
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Báo cáo y học: " Maintenance treatment with esomeprazole following initial relief of non-steroidal anti-inflammatory drug-associated upper gastrointestinal symptoms: the NASA2 and SPACE2 studies'''' doc
... comparison of esomeprazole 20 and 40 mg with placebo in the long-term (6 months) maintenance of relief of upper abdominal pain, discomfort, or burning in patients continuing to use NSAIDs, including ... proportion of patients with relapse of upper gastrointestinal symptoms Kaplan-Meier life-table analyses of the proportion of patients with symptoms relapse of pain, discomfort, or burning in the ... Study Group: Improvements with esomeprazole in patients with upper gastrointestinal symptoms taking non-steroidal antiinflammatory drugs, including selective COX-2 inhibitors Am J Gastroenterol...
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Báo cáo y học: "Incremental cost effectiveness of proton pump inhibitors for the prevention of non-steroidal anti-inflammatory drug ulcers: a pharmacoeconomic analysis linked to a case-control study" pptx
... the findings of our previous clinical study in NSAID users, in which concomitant use of PPIs was associated with a lower incidence of serious NSAID ulcer complications compared with not using ... Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis VIGOR Study Group N Engl J Med 2000, 343:1520-1528 Spiegel BMR, Chiou CF, Ofman J: Minimizing ... serious gastrointestinal complications in patients with rheumatoid arthritis receiving nonsteroidal anti-inflammatory drugs A randomized, double-blind, placebo-controlled trial Ann Int Med 1995,...
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Báo cáo y học: "Dangerous drug interactions leading to hemolytic uremic syndrome following lung transplantation" docx
... 90% renal 8% Liver & 2% Heart -Lungs 96% of the cases occurred within year In the majority of renal cases and all non -renal transplants HUS was attributed to the use of cyclosporin Only patients ... reduction in the dose of tacrolimus correlates with an improvement in renal function in most patients [12], [14] The diagnosis of tacrolimus -associated HUS in the two patients who are the subject of ... symptoms of multiple etiologies with common features of thrombocytopenia, microangiopathic haemolytic anaemia, normal clotting screen and also renal, neurological and gastrointestinal involvement...
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Báo cáo y học: "Optical tomographic imaging discriminates between disease-modifying anti-rheumatic drug (DMARD) and non-DMARD efficacy in collagen antibody-induced arthritis" pptx
... affected joints, = loss of toluidine blue staining with moderate chondrocyte loss and obvious (depth to deep zone) matrix loss in affected joints, = loss of toluidine blue staining with marked ... mitogen-activated protein kinase inhibitor inflammation [33,36,50] Proof -of- concept studies using a cathepsin-activatable probe for in vivo imaging of protease activity associated with RA animal models ... (cathepsin, MMP), clinical scores, and paw swelling were determined and graphed in comparison with inflammation scores (Figure 8a to 8d) Excellent linear relationships with inflammation scoring were...
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Synthesis of the Anti-influenza Drug Oseltamivir Phosphate (Tamiflu)
... well-designed inhibitor of one of these fundamental proteins might become an efficient drug / weapon against the threat of a new influenza epidemic Needs in new influenza virus protein inhibitors Political ... able to stock drugs in prevision of this hypothetical pandemic? Neuraminidase inhibitors: Oseltamivir phosphate design Schematic representation of neuraminidase action Hydrolysis step of sialic acid ... acid) • Starting material: shikimic acid derivative (ester) • Trans 1,2-diamine introduction : iterative aziridine opening with azide • Pentyloxy introduced at the latest stage of the synthesis...
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Effects of anti malaria drug artesunate in the treatment of rhinovirus induced asthma exacerbation
... shown to be the binding sites of the receptors and thus block the binding of the neutralizing binding sites of antibodies (Kim, Smith et al 1989) Blockage of the binding site with several compounds ... Prize for discovering of artemisinin and dihydroartemisinin (DHA) (FIG.1-8) Since the discovery of artemisinin, it has saved a lot of lives, especially in Africa In addition, according to previous ... supported the role of local environmental factors, including different types of allergens but likely many lifestyle factors as well, in determining the degree of expression of asthma within genetically...
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Predicting in vivo anti hepatofibrotic drug efficacy based on in vitro high content analysis
... object Total intensity of all pixels in Ch2 within Ch1 object mask Average intensity of all pixels in Ch2 within Ch1 object mask Total intensity of all pixels in Ch2 within Ch2 but not in Ch1 object ... mask Average intensity of all pixels in Ch2 within Ch2 but not in Ch1 object mask Ratio of TotalIntensityCytoCh2 to TotalIntensityNucCh2 Total intensity of all pixels in Ch3 within Ch1 object ... group of drugs with higher in vitro scores (e.g pioglitazone and glycyrrhizin) gave more promising results in human clinical trials than the group of drugs with lower in vitro scores (e.g colchicine...
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A study of quality and safety of herbal medicine adulteration and herb drug interactions
... after a single intravenous administration of aspirin Most of the pharmacokinetic parameters of aspirin and salicylic acid after a single intraperitoneal administration of aspirin remained unchanged ... 2004) Ginseng (Panax ginseng) interactions included decrease of International Normalized Ratio (INR) when used in combination with warfarin (Janetzky and Morreale 1997), and hypoglycemia in patients ... varying based on the combination of the drugs and herbal medicines Unfortunately, here often lacks such kind of information The importance of pharmacodynamic herb-drug interactions in clinical...
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Pharmacokinetics pharmacodynamics driven approach for lead optimization in anti mycobacterial and anti malarial drug discovery
... Arylaminoalcohol 4-aminoquinolines 8-aminoquinolines Artemisinin drugs (Sesquiterpene lactone) Biguanides Diaminopyrimidines Antimalarial drug Quinine (Cinchona alkaloids) Quinidine Mefloquine Halofantrine ... second-line drugs [aminoglycosides (kanamycin and amikacin), cycloserine, ethionamide, protionamide, capreomycin, aminosalicylic acid, and fluoroquinolones (including ofloxacin, levofloxacin, gatifloxacin ... causing inhibition of nucleic acid and adenosine triphosphate synthesis Inhibits early stages of protein synthesis similar to macrolides Inhibitors of aminoacyl-tRNA binding during protein synthesis...
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In vivo aspects of potential stereospecific drug interactions of oral warfarin and rutin in rats
... rutin treated rats in single dose study using WinNonlin 49 3.3 R- warfarin (mean) curve fitting for (a) control and (b) rutin treated rats in single dose study using WinNonlin 50 3.4 Changes in ... protein binding affinity differs between the two enantiomers of warfarin The S- isomer has a greater affinity to protein binding in man compared to the R- isomer Some of the drug interactions of ... helps in understanding the source of variation and mechanism of interaction of drugs with warfarin A better understanding of the warfarin drug interactions could be possible by either giving each...
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Synthesis of fluorescent anti malarial drug probes and evaluation within plasmodium falciparum
... leading to cytotoxicity in tumour cells27,34 Clearly with the recent discovery of artemisinin sensitive strains it would be increasingly important to understand the mode of action of artemisinin ... Chloroquine and derivatives, quinine and artemisinin were the first line of defence against malaria due to their clinical effectiveness and low-cost Fig highlights the year of introduction of anti-malarial ... Page of 219 b) VIMT (Vaccines that interrupt malaria transmission) – The existing vaccines in clinical development have the objective of reducing morbidity and mortality in young children in highly...
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Báo cáo y học: "Value of anti-infective chemoprophylaxis in primary systemic vasculitis: what is the evidence" pdf
... is, infections leading to hospitalisation - of 2.44 in the first months of GC treatment in a large GCA trial and increased infection-related mortality Rising awareness of GC complications, including ... jiroveci The risk of PCP is especially high in patients with SVV undergoing induction therapy Without using prophylaxis the incidence of PCP is up to 20% [26] and many fatalities have Page of 11 (page ... complications, including infections, makes GC sparing an increasingly important aim According to the European League Against Rheumatism (EULAR) recommendations for conducting clinical trials in PSV, protocols...
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Tài liệu The Acquisition of Drugs and Biologics for Chemical and Biological Warfare Defense - Department of Defense Interactions with the Food and Drug Administration doc
... comply with the extensive IND recordkeeping regulations: FDA review of information provided to individual recipients of IND drugs, medical monitoring and reporting of the use of such drugs, information ... manifestation of a continuing dependent relationship that involves three types of interactions: licensing CBW drugs and biologics, especially vaccines; using Investigational New Drugs in military ... reporting independently of product development to the highest levels of the organization Dealing with FDA is not delegated to subordinate organizations Moreover, a single point of contact within...
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drug-nucleic acid interactions
... C G Dinucleotide Step FIG Affinity profile for the interaction of daunomycin with the 10 unique dinucleotide steps The binding constants (K) are average values obtained by fitting of binding isotherms ... obtained, in excellent agreement with that obtained by model-independent analysis Finally, the binding constants shown in Fig may be used in combination with the known dinucleotide frequency of ... remaining biotin binding sites and the biotin binding sites on the streptavidin in the control flow cell with free biotin This will depend on any nonspecific interactions between components in...
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