... accordingly affect the dNTP pools and we decided to determine the steady-state intracellular dNTP concentrations in the cell lines The dNTP concentrations were determined in cells cultured under three ... kinase activity in the cells, we determined the phosphorylation of deoxythymidine (dThd) in cell protein extracts Untransduced cells or cells transduced with the control pLEGFP retroviral vector ... pool, whereas the dATP and dCTP pools seemed to be highly regulated to maintain their levels The dGTP pool was increased in the H9 cells, but not in the CEM cells Defects in nucleotide metabolism...
Ngày tải lên: 20/02/2014, 01:20
... mucosa represents a unique immunologic unit with the first contact with the allergen within the gastrointestinal tract, where immune tolerance is the natural outcome Freshly isolated oral LCs expressed ... Further studies are required to elucidate the in vivo role of these cells and their subsets Effects of SIT on Dendritic Cells To understand the mechanisms of action of SIT, some cardinal steps ... et al, Regulatory T Cells in the Context of Allergic Disease thus preventing the activation of mast cells and basophils IgG4 has been shown to reduce the IgE-mediated degranulation of these cells...
Ngày tải lên: 08/08/2014, 21:20
Báo cáo y học: "Direct Toll-like receptor 2 mediated co-stimulation of T cells in the mouse system as a basis for chronic inflammatory joint disease" ppsx
... GT-3' mTLR4 upper 5'-AGC CGG AAG GTT ATT GTG GTA GT-3' mTLR4 lower 5'-TGC CGT TTC TTG TTC TTC CTC T- 3' mTLR6 upper 5'-ATA CCA CCG TTC TCC ATT T- 3' mTLR6 lower 5'-GAC GTG CTC TAT CAT CAG TG-3' ... The amount of the secreted interferon-γ in the supernatant was then tested in duplicate using the enzyme-linked immunosorbent assay technique One representative experiment is shown The detection ... that bacterial lipoproteins directly stimulate alloreactive CTLs to proliferate and to secrete IFN-γ via TLR-2 adds another facet to the functional potential of T effector cells The fact that...
Ngày tải lên: 09/08/2014, 01:23
Báo cáo y học: "Regulating the immune system: the induction of regulatory T cells in the periphery Jane H Buckner1 and Steven F Ziegler2" pot
... Tr1 cells [74], extends this paradigm The fate of the TR cells induced at the site is not known — whether these cells exist only transiently then die, whether they persist in the body as TR cells, ... selection, but also in the periphery Those autoreactive cells that escape negative selection must be restrained in the periphery, and it is thought that CD4+CD25+ TR cells generated in the thymus ... These regulatory phenomena are very important in the resolution of inflammation, to rein in the T cell response, to control bystander responses to self-antigens and to limit the resulting T cells...
Ngày tải lên: 09/08/2014, 01:24
Báo cáo khoa học: "Nucleated red blood cells in the blood of medical intensive care patients indicate increased mortality risk: a prospective cohort study" doc
... (SAS Institute Inc., Cary, NC, USA) The intention of this study was to evaluate the prognostic power of the presence of NRBCs in the blood with regard to the patients' in- hospital mortality risk ... operating characteristic curve was obtained by plotting the true-positive proportion (sensitivity) against the falsenegative proportion (1 – specificity) The area under the curve (C-statistics) ... intensive care treatment Conclusion This is the first study in which the daily screening for NRBCs in the peripheral blood of patients in the medical intensive care unit was investigated with regard to...
Ngày tải lên: 13/08/2014, 03:21
The role of CD8 t cells in the differentiation of TNF iNOS producing dendritic cells and TH1 responses
... induce Treg cells (Chatenoud, 2006) 1.4.4 Transcription factors T- bet is the central transcription factor involved the development of Th1 cells (Szabo et al., 2000) T- bet potently activates the ... the inability of these cells to migrate into inflamed tissues in CCR2-/- mice is detrimental to the host; although it may also be protective in certain circumstances as seen in dengue virus infections ... lymphocytes T cells provide important cell mediated immunity by participating in the cytolysis of infected cells through the recognition of antigen presented on MHC class I They so through the T cell...
Ngày tải lên: 09/09/2015, 18:58
Fuel Cells in the Automotive Industry
... schematically The potential is reversed through the discontinuity in potential at the interface between the solid catalyst and the polymer electrolyte This discontinuity is a part of the total ... mass transport limitations, while at the same time providing the path for electronic current Figure shows the potential distribution in the contact area between the electrode and the bipolar plate ... larger in the core The heat is exchanged from the heating channels in the jacket, through the highly conductive jacket material, and into the core We can calculate the temperature profile by defining...
Ngày tải lên: 19/10/2013, 09:15
Tài liệu Báo cáo khoa học: Accessibility changes within diphtheria toxin T domain when in the functional molten globule state, as determined using hydrogen⁄deuterium exchange measurements pdf
... proteins with a tendency to aggregate at high concentrations, etc In the case of the T domain, the MG state corresponds to the functional state, which initiates the translocation of the catalytic ... with the highest protection at pH 4.0 (MG state) the protection of TH5 is a result of dimer formation, the dimer may be still present in the MG state The most protected region of the protein in the ... catalytic domain Here, the data allowed identification of the core of the protein in the N state and the evolution of the overall structure of the protein in the MG state This degree of resolution is...
Ngày tải lên: 16/02/2014, 09:20
HEALTH CARE MAINTENANCE IN THE ELDERLY pdf
... 24:1-5 42.Pruthie R Prostate specific antigen kinetics: a view of prostate specific antigen doubling times and half-lives in patients with treated and untreated prostate cancer Prostate J 2000;2:111-115 ... Effects of hormone replacement therapies on BMD: Results of the Postmenopausal Estrogen and Progesterone Interventions Trial J Bone Miner Res 1995;10:276 26 .The writing group for the PEPI TRIAL ... expectancy) Localized disease (T 0-2) Treatment: º Surgical, Anti-androgens, Radiation therapy Metastatic disease (T3 -4) Treatment º Surgical, Anti-androgens, Radiation Confusing fact - Up til...
Ngày tải lên: 14/03/2014, 20:20
Continuing Education Programmes for Health Care Providers in the Field of Prevention of Chronic Diseases pdf
... education* to make their patients’ efforts more productive5 The concept of therapeutic patient education Health care providers* tend to talk to patients about their disease rather than train them in the ... tools 12 use and integrate these tools in the care of patients and in the patients’ learning* process (contract* with patients) 13 take account in therapeutic patient education* of the educational, ... education* programme adapt therapeutic patient education* to various health care settings and integrate it with their long-term care activities participate in the activities of a service integrating...
Ngày tải lên: 22/03/2014, 15:20
Pulmonary tuberculosis associated with increased number and percentage of natural killer and B cells in the peripheral blood pot
... patients with PTB in the present study It is possible that the depletion of CD4 + cells may have mostly contributed to the decreased of CD3 + cell percentage and counts in patients with PTB The ... was limited by lack of access to the patient records therefore it was not possible to correlate the laboratory data with the clinical findings Peripheral blood subset data of the patients were ... dismissed the participation of B cells in defending against the infection B cells and antibodies are thought to offer no significant contribution towards protection against MTB (Kumararatne, 1997)...
Ngày tải lên: 29/03/2014, 03:20
scientific american - 1995 11 - guardian cells in the brain
... other in the crystal The resulting interference pattern is not actually visible But when the crystal is reilluminated at the correct angle, the pattern diíracts the light so that the beam with the ... of marine ecosystems Although the scientists involved in that study noted that ịshing constitutes just one of the many human activities that threaten the oceans, they ranked it as the most serious ... mechanism for extending these eíects to the tropics, the southern temperate region and even the Antarctic The symmetrical distribution of these climate changes around the equator points to the tropics...
Ngày tải lên: 12/05/2014, 15:02
báo cáo sinh học:" What can health care professionals in the United Kingdom learn from Malawi?" pdf
... treatments, including antiretroviral therapy for HIV or anti-TB therapy In order to be accepted on to a treatment programme, patients have to give a commitment to try to maintain their nutrition, ... to increase the uptake of testing, and despite the availability of retroviral therapy, testing for HIV still carries a stigma in the United Kingdom health system Many patients are reluctant to ... grandmother They take it in turn to nurse the baby While one is lying with the baby in the "kangaroo" position, the other prepares food and talks with other mothers and midwives Every so often they...
Ngày tải lên: 18/06/2014, 17:20
báo cáo hóa học:" Serous papillary adenocarcinoma possibly related to the presence of primitive oocyte-like cells in the adult ovarian surface epithelium: a case report" docx
... adenocarcinoma manifestation in this patient This observation needs attention to be further investigated Consent statement Written informed consent was obtained from the patient for publication of this ... putative stem cells in the ovarian surface epithelium They might present a pathological state leading to the manifestation of ovarian serous papillary adenocarcinoma It has been confirmed that ... approved the final manuscript Competing interests The authors declare that they have no competing interests Received: June 2011 Accepted: August 2011 Published: August 2011 References Motta PM,...
Ngày tải lên: 20/06/2014, 08:20
Báo cáo khoa học: "Comparative study of endocrine cells in the principal pancreatic islets of two teleosts, Silurus asotus (Siluridae) and Siniperca scherzeri (Centropomidae)" potx
... fatty acid in the gastrointestinal tract (Brazeau et al., 1973) Somatostatin-immunoreactive cells of the teleostean islets have been reported to be dispersed mainly in the central region, intermingled ... Scheuermann et al (1991) reported that somatostatin-immunoreactive cells were scattered throughout the islets of dipnoan fish Although in the present study somatostatin-immunoreactive cells in the principal ... (Brazeau et al., 1973) This substance inhibits the secretion of the gastrin, cholecystokinin, secretin, glucagon, insulin, motilin and gastric acid (Kitamura et al., 1984) and the absorption of amino...
Ngày tải lên: 07/08/2014, 14:23
Báo cáo khoa học: " Immunohistochemical Study of the Endocrine Cells in the Pancreas of the Carp, Cyprinus carpio (Cyprinidae)" docx
... were located in the basal regions of the pancreatic duct epithelial lining In addition, somatostatinIR cells were also located in the cell clusters situated in the sub-epithelial regions in the case ... b) In the pancreatic duct, they were located in the inter-epithelial cells or basal regions of epithelial lining (df) In addition, insulin-IR cells were also detected in the cell clusters located ... somatostatin-IR cells were also detected in the cell clusters located in the sub-epithelial regions of the large types of pancreatic duct (e) The regional distribution of somatostatin-IR cells in...
Ngày tải lên: 07/08/2014, 15:20
Báo cáo khoa học: "An immunohistochemical study of the gastrointestinal endocrine cells in the ddY mice" doc
... were restricted to the intestinal gland 90 Sae-kwang Ku et al Fig Serotonin-IR cells in the in the GI tract of ddY mice These IR cells were located in the epithelium and gastric or intestinal gland ... gastrin- and CCK-8-IR cells were observed in the remaining portions of the GI tract of this strain of mice Somatostatin-IR cells Somatostatin-IR cells were demonstrated throughout the whole GI tract ... detected throughout the GI tract of all species and established in the GI tract at the early stage of vertebrate evolution In addition, these IR cells were detected in the whole alimentary tract including...
Ngày tải lên: 07/08/2014, 17:22
Báo cáo khoa học: " Changes of gastrointestinal argyrophil endocrine cells in the osteoporotic SD rats induced by ovariectomy" ppt
... change in their density would reflect the change in the capacity of producing these hormones [8] In the present study, the changes of the argyrophil endocrine cells in the GI tract of SD rat after ... process to meet the new demands exerted by the dramatic decrease in intestinal Gastrointestinal argyrophil cells in ovariectomized osteoporotic rats 187 Fig Number of argyrophil cells in GI tract and ... open type cells which were situated in the intestinal regions In addition, the endocrine cells are regarded as the anatomical units responsible for the production of gut hormones, and a change in...
Ngày tải lên: 07/08/2014, 17:23
Báo cáo khoa học: " An immunohistochemical study of chromogranin A and Sp-1 immunoreactive cells in the gastrointestinal tract of ovariectomized rats" pdf
... noitprosba lanitsetni ni esaerced citamard eht yb detrexe sdnamed wen eht teem ot ssecorp evitceles a era sllec enircodne IG eht ni segnahc eht taht detalutsop neeb sah tI ]51[ sitirtsag cihporta ... eht ni sllec RI-GC eseht fo snrettap lanoitubirtsid eht ,hguohtlA ]8,3[ sllec enircodneoruen lla fo ”srekram“ nommoc yltnacifingis a ,stneitap aitreni cinoloc nI slamina fo sutats evitsegid ot ... 9611-2611 ,63 ,1002 loretneortsaG J dnacS ytivitca lacirtceleoym dna gniytpme cirtsag ot pihsnoitaler :I epyt setebaid htiw stneitap ni sllec enircodne lanitsetniortsag lamronbA B yhotiS ,M yhlaS-lE...
Ngày tải lên: 07/08/2014, 18:21
Báo cáo khoa học: " Immunosuppression by T regulatory cells in cows infected with Staphylococcal superantigen" ppt
... ,senikotyc fo tnemevlovni tceridni eht tub ,sisab tcatnoc llec-llec htiw detaicossa ylniam era seitivitca ehT ]51,3[ sesnopser yrotammalfni detaidem llec -T dna ytinummi evitcetorp ,ytinummiotua lortnoc ... denifed yletelpmoc ton saw elucelom 2TCA hguohtlA ytinummi eht gniniager ot detubirtnoc dna setycohpmyl T 8DC detavitca fo ecneserp eht ni sllec rT ot detrevnoc erew + hcihw setycohpmyl T +4DC devivrus ... setycohpmyl T +8DC detavitca esoht ot elbatubirtta eb yam tluser sihT )MWP( negotim deewekop dna A noC yb detalumits erew LBP nehw ro namuh ni detibihni ton saw noitarefilorp etycohpmyl T +4DC detavitca...
Ngày tải lên: 07/08/2014, 18:21