dominance relationships in non human primates
Báo cáo Y học: Environmentally coupled hydrogen tunneling Linking catalysis to dynamics potx
... perturbing the system, with the perturbant being temperature in ht-ADH, and site-specific mutagenesis in SLO As discussed below, a wide variation in AH/AD can, in fact, be explained as arising from ... tunneling model, when 2xX ) kbT the gating vibration does not modulate the tunneling distance appreciably, producing a nearly temperature independent tunneling distance, and hence a temperature independent ... [40–42] NMR techniques are of great use in smaller proteins, and some progress has been made in studying how protein motions contribute to ligand binding [43] Unfortunately, the large size of...
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Báo cáo y học: "Polymorphisms in melatonin synthesis pathways: possible influences on depression" pdf
... reducing ASMT RNA expression and protein activity, by increasing accumulation of N-acetylserotonin, might potentiate actions of TRKB and BDNF This may be relevant to clinical interests, since ... impact on the timing of melatonin synthesis independent of its overall 24-hour production Factors influencing the sequestration of AANAT might likewise influence melatonin timing Another possibility, ... was examined in the UCSD and Sleep Center participants with a dominant model, using similar linear regressions controlled for age, gender, and MDS factors, and correcting for multiple testing of...
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Báo cáo y học: " Environmental exposures and their genetic or environmental contribution to depression and fatigue: a twin study in Sri Lanka" potx
... divided into nonfamilial influences that have different impacts on each twin in a pair (E, chiefly found by examining dissimilarities within MZ pairs), or familial influences that make twins similar ... performed in Stata version 10.1 for Windows These analyses were corrected for the non- independence of twins within pairs, using the ‘cluster’ option in Stata Structural equation model fitting was ... which includes shared upbringing (C) plus the extent to which they share genetic inheritance (A) Familial influences are assessed by looking for similarity within pairs of twins Crosstwin logistic...
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Báo cáo y học: "Virus-derived transgenes expressing hairpin RNA give immunity to Tobacco mosaic virus and Cucumber mosaic virus" pdf
... obtained by digesting pUCm-ΔRep(s) with SalI, and then inserted into the SalI site of pBIN -In- CMVΔRep to produce recombinant plant expression vector pBIN-CMVΔRep (i/r) (Figure 1), containing inverted ... twenty T0 transgenic plant lines containing CMV Rep sequences were obtained by kanamycin selection The specific DNA fragment was amplified in all transgenic lines by PCR using primers TMV MP-F1 and ... silencing in Nicotiana benthamiana EMBO J 1998, 17:6739-6746 Guo HS, Ding SW: A viral protein inhibits the long range signaling activity of the gene silencing signal EMBO J 2002, 21:398-407 Guerini...
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Báo cáo y học: "Intracellular immunity to HIV-1: newly defined retroviral battles inside infected cells" pdf
... RING finger motif features a cysteine-rich consensus, which contains two interleaved Zn++-binding sites [37] Many RING finger proteins act as E3 ubiquitin ligases and play key roles in protein ... protein-protein interactions Indeed, TRIM proteins form oligomers [36] In addition, TRIM5α contains a SPRY domain at its C-terminus (Fig 4) The SPRY domain was originally identified in the splA kinase ... ryanodine receptor [40], and belongs to the subclass of the B30.2 or RFP-like domains In butyrophilin, the B30.2 domain, which contains 170 residues, is involved in ligand binding [41] Of interest,...
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Báo cáo y học: "Bench-to-bedside review: Rare and common viral infections in the intensive care unit – linking pathophysiology to clinical presentatio" ppt
... on human type pneumocytes [18-20] This preferential binding for specific sialic acid receptors illustrates the differences in clinical presentation seen with avian influenza infections in humans: ... surface glycoproteins that are important in host infection [31,32] These glycoproteins act as cell fusion proteins, ultimately forming multinucleated giant cells (‘syncytia’), assisting in cell-to-cell ... Numerous treatment strategies, including corticosteroids, ribavirin, immunoglobulin, and interferon, have been investigated in SARS: none has been demonstrated to provide clinical evidence of benefit...
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A study of the mechanisms of immunity to pasteurella haemolytica infection
... enzyme-linked 0.1% balanced salt solution, assay containing gelatin HBSS = Hank's H E = haematoxylin HKO = heat-killed HuRBC = human IFA = incomplete IHA indirect = IN = intranasal IP intraperitoneal ... susceptibility inoculation with of TV infection provided hydrolysate to confined Brain Intracerebral mice casein of trauma the a suitable solution and brain individual induced P death and mice in mice ... only and point Vaccines still aimed in available that inadequate, vaccines this at are in that many the insufficient The general unsatisfactory pasteurellosis use immunising nature of vaccine field...
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Linking the linguistic to the social
... 53 Linking the linguistic to the social maintained and maintained mutually in day-to-day activity And they change mutually as well Changing practices, changing ideologies All ... is being a family, learning (or not learning) Latin, or playing music, by virtue of engaging over time in that endeavor, the participants in each of these groups develop ways of doing things ... move into acting as a profession in the nineteenth century were often seen as having deplorably loose sexual morals We also often find feminine suffixes bringing their own additional meanings For...
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Tài liệu From Great Depression to Great Credit Crisis: Similarities, Differences and Lessons pdf
... movements in global industrial output during the two crises.12 Since we are interested in the extent to which world industrial output declined during the two periods, we plot the two indices from ... series on trade in manufactures and non- manufactures plotted in Figure (the weights being the share of the two groupings in total trade in 1929) Not surprisingly this yields a decline in world trade ... production in the current crisis, including the growth in vertical specialization (Yi 2008, Freund 2009, Tanaka 2009) and the difficulty of obtaining trade finance during the credit crunch (Auboin 2009a,b)...
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Tài liệu Indigenous Knowledge Local Pathways to Global Development doc
... engaged in casual sex Uganda also pioneered approaches in reducing stigma, bringing discussion of sexual behavior out into the open, involving HIV-infected people in public education, persuading individuals ... documenting indigenous knowledge and protecting the intellectual property rights of communities They tell the stories of outstanding individuals, or ordinary individuals doing extraordinary work, ... strategies in support of studying and developing IK The ministries of health and agriculture, for instance, could take the lead in assessing the role of IK in furthering their development objectives In...
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Tài liệu Báo cáo khoa học: A genetic screen identifies mutations in the yeastWAR1 gene, linking transcription factor phosphorylation to weak-acid stress adaptation docx
... lack of DNA binding Indeed, in the case of War1-42p, in vivo footprinting data (Fig 5) indicate an inability to bind to the WARE, which is normally decorated by wild-type War1p in the presence ... the kinase targets themselves Further, the residue changes in War1-42p not involve serine, threonine, tyrosine or histidine (Fig 3A) In any case, the nonphosphorylated war1 alleles are nonfunctional, ... immunoblotting Polyclonal antibodies to War1p were raised in rabbits against a GST-War1p fusion protein containing 294 amino acids of the C-terminal part of War1p (amino acids 650– 944) fused in- frame...
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Tài liệu Báo cáo khoa học: Photochemical cross-linking of Escherichia coli Fpg protein to DNA duplexes containing pdf
... having identical nucleotide sequences but containing no oxoG, did not Binding of the modified DNA duplexes to the Fpg protein DNA duplexes I–III were tested for binding to the Fpg protein in order ... corresponding to 30.2 kDa protein linked to 9.6 kDa 29-mer and 7.5 kDa 22-mer dU*-containing oligonucleotides Photochemical cross-linking appeared to be specific because Fpg protein binding to DNA ... depicted in Fig 1; for experimental conditions see the Materials and methods has no effect on the recognition and binding of DNA duplexes by the Fpg protein Specificity of Fpg protein binding The interaction...
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Báo cáo khoa học: Linking environmental carcinogen exposure to TP53 mutations in human tumours using the human TP53 knock-in (Hupki) mouse model doc
... deficiency, UV-induced skin tumours in hairless mice contain Tp53 mutations predominantly on the nontranscribed DNA strand, whereas there is no strand bias in humans [107] In vivo Hupki studies In addition ... polymorphism occurs at codon 72 in TP53, resulting in either a proline (Pro72) or an arginine (Arg72) This occurs in the region of the gene encoding the polyproline domain, which is important for ... mutagens and potential human carcinogens identified in diesel exhaust and ambient air pollution [69–71] Indeed, 3-NBA induces squamous cell carcinoma in rat lung after intratracheal administration [70]...
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Báo cáo khoa học: Linking pseudouridine synthases to growth, development and cell competition potx
... patterning of the wing The results reported here indicate that mfl silencing affects organ dimensions mainly by reducing cell size and increasing apoptosis Intriguingly, mfl-underexpressing cells ... Dyskerin is thus part of at least two essential but distinct functional complexes, one involved in ribosome biogenesis and snoRNA stability and the other in telomere maintenance In humans, dyskerin ... domains, so that total identity exists between the Drosophila and human proteins within the two TruB motifs and the pseudouridine synthase and archaeosine transglycosylase RNA-binding domain,...
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Báo cáo khoa học: Cotton GhMPK2 is involved in multiple signaling pathways and mediates defense responses to pathogen infection and oxidative stress doc
... protein kinase and woundinduced protein kinase, two MAPKs in group A, were activated by inoculation with the tobacco mosaic virus (TMV) [10] Their orthologs in other plant species, including MPK3 ... and MPK6 in Arabidopsis (group A MAPKs), SIMK and SAMK in alfalfa, and LeMPK1 ⁄ (Lycopersicon esculentum SA-induced protein kinase) and LeMPK3 (L esculentum woundinduced protein kinase) in tomato, ... abiotic stresses (A) Virus infection-induced H2O2 accumulation detected by DAB staining (B) Abiotic stress-induced H2O2 and OÀ accumulation detected by DAB staining and NBT staining, respectively WT,...
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Báo cáo Y học: Evaluation of two biosynthetic pathways to d-aminolevulinic acid in Euglena gracilis potx
... determination of d-aminolevulinic acid and porphobilinogen in urine J Biol Chem 219, 435±446 Beale, S.I & Castelfranco, P.A (1973) 14C incorporation from exogenous compounds into d-aminolevulinic ... chlorophyll from glycine Eur J Biochem 130, 509±516 Klein, O & Porra, R.J (1982) The participation of the Shemin and C5 pathways in 5-aminolevulinate and chlorophyll formation in higher plants and ... chlorins in organic solvents In Porphyrins and Metalloporphyrins pp 880±881 Elsevier Scienti®c Publishing, Amsterdam, The Netherlands 23 Katz, J.J & Janson, T.R (1973) Chlorophyll±chlorophyll interactions...
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Báo cáo khoa học: " Linking Events and Relations to Timestamps" pptx
... Benchmark We evaluated our approach in different tasks: Linking Timestamps and Events in the IC domain Linking Timestamps and Relations in the IC domain Linking Events to Temporal Expressions ... Keesing, Daniel Oblinger, Heather Simpson, Robert Schrag, and Jonathan Wright 2010 The DARPA Machine Reading Program-Encouraging Linguistic and Reasoning Research with a Series of Reading Tasks In ... engineered feature space, and is capable of capturing the contextual information required for temporal linking The remainder of this paper goes into the details of our approach for temporal linking,...
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Báo cáo khoa học: An active triple-catalytic hybrid enzyme engineered by linking cyclo-oxygenase isoform-1 to prostacyclin synthase that can constantly biosynthesize prostacyclin, the vascular protector pot
... design a single molecule containing the cDNA of human COX-1 and PGIS with a connecting TM linker derived from human bovine rhodopsin [15] (Fig 1) Cloning of Trip-cat enzyme-1 by linking COX-1 ... activity in inhibiting non- AA-induced aggregation Prostacyclin-synthesizing protein with COX-1 and PGIS properties (Fig 7B), such as that of collagen This indicates that HEK293 cells stably expressing ... recently invented an approach for engineering an active hybrid enzyme (Trip-cat enzyme-2), by linking human COX-2 to PGIS (COX-2– linker–PGIS), which demonstrated Trip-cat activities in converting...
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Báo cáo khoa học: The relative contribution of mannose salvage pathways to glycosylation in PMI-deficient mouse embryonic fibroblast cells pdf
... This distinction may be due to differences in the mechanism of action of swainsonine and bafilomycin A1 Swainsonine inhibits both lysosomal and nonlysosomal mannosidases, whereas bafilomycin A1 blocks ... increased in swainsonine-treated and bafilomycin A1-treated PMInull cells with increasing mannose concentrations in the medium About 13 lm and lm mannose were sufficient to fully restore glycosylation in ... Emerald 300 Glycoprotein Gel Stain with SYPRO Ruby protein gel stain kit were all purchased from Invitrogen Life Technologies (Carlsbad, CA, USA) Swainsonine and antibody to integrin b1 (SG ⁄ 19) were...
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Báo cáo khoa học: Irreversible cross-linking of heme to the distal tryptophan of stromal ascorbate peroxidase in response to rapid inactivation by H2O2 ppt
... cross-linked to the APX apoprotein Identification of the heme-binding amino-acid residue in H2O2-inactivated stromal APX To determine which amino-acid residue in the apoprotein was cross-linked ... from the porphyrin ring in tsAPX (the distance between nitrogen of the indole ring and C6 of the porphyrin ring) [10], the heme must move toward Trp35 to form a covalent bond In active cytosolic ... minor peaks (38.9 and 40.5 min) The side chain of Trp35 faces the distal cavity formed by the heme and N-terminal half of the apoprotein of the catalytic site ˚ (Fig 4B) Because the indole ring...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 động cơ điện không đồng bộ một pha thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25