docetaxel s suppression of invasiveness of head and neck cancer cells

... access to the necessary diagnostic tools  General or dental practitioners should be aware of symptoms suggestive of head and neck cancer 3.2 diagnosis and staging Diagnosis and staging of head ... meta-analyses, systematic reviews of RCTs, or RCTs with a low risk of bias - Meta-analyses, systematic reviews of RCTs, or RCTs with a high risk of bias 2++ High quality systematic reviews of case ... had not seen the leaflet A questionnaire of awareness of signs and symptoms and risks of oral cancer showed that all those who received the leaflet (smokers, non-smokers and past smokers) reported...

Ngày tải lên: 14/02/2014, 22:20

... node, metastasis (TNM) staging system allows clinicians to categorize tumors of the head and neck region in a specific manner to assist with the assessment of disease status, prognosis, and management ... mediastinal lymph nodes Distant Metastasis (M) MX Distant metastasis cannot be assessed M0 There is no distant metastasis M1 There is distant metastasis 26 Stage Grouping Separate stage groupings ... Paranasal Sinuses The paranasal sinuses consist of the paired maxillary sinuses, the superior frontal sinuses, the bilateral ethmoid system, and the central spenoids This region includes the...

Ngày tải lên: 15/03/2014, 00:20

... dissection size of largest tumour mass ALL HEAD AND NECK CANCERS DEFINITIONS Laryngeal cancer includes tumours of the: supraglottis glottis subglottis Hypopharyngeal cancer includes tumours of ... reporting of specimens from areas of metastatic disease in patients with head and neck cancer should include: number of involved nodes level of involved nodes extracapsular spread of tumour type of ... examination of the oral mucosa as part of routine dental check up B Leaflets about signs, symptoms and risks of head and neck cancer should be available in primary care REFERRAL B Rapid access or “one stop”...

Ngày tải lên: 15/03/2014, 01:20

... for a response rate of 17% Page of 10 Twelve patients had stable disease The median time to disease progression was months, and the MST was months Self-reported quality of life was not significantly ... with smaller volume disease (i.e., ≤ 25 mL, 80% vs 71%) There were 34% complete responses and 34% partial responses; 20% of patients developed stable disease and 12% developed progressive disease ... the superiority of SRT over SRS in a case control study [40] They compared 43 cases of 12.5 Gy SRS and 43 cases of 34 Gy delivered in 2-6 fractions of SRT The 1- and 3-year local failure-free survival...

Ngày tải lên: 09/08/2014, 09:21

... late side effects as local ulcer and extensive neck fibrosis were seem in and patient, respectively There was no soft tissue necrosis in the series Discussion The presence of secondary neck node ... Alto, US) Plans were optimized using standard geometric optimization, and prescription dose was based on the Paris dosimetry system Dose prescriptions were at the isodose that encompassed the ... more precise and appealing For developing countries its association with salvage surgery seems to be a reasonable option, especially because of the high number of centers that possesses the HDR...

Ngày tải lên: 09/08/2014, 10:21

... hetero- and homodimers composed of other NF-κB subunits has also been detected in HNSCC tissues and cell lines [23] While the function of the less studied species of NF-κB is not yet fully understood, ... gene expression signatures in HNSCC cell lines (UM-SCC, University of Michigan Cell Lines Series of Head and Neck Squamous Cell Carcinoma), which were associated with differing p53 status and NF-κB ... identification of heterogeneous sub-populations in specific types of cancer, such as HNSCC, and selection of therapies targeting them are major hurdles for clinical diagnosis, prognosis and treatment Such...

Ngày tải lên: 14/08/2014, 08:20

... differences was assessed by the log-rank test Multivariate analyses were performed using a logistic regression model for response and Cox regression models for PFS and overall survival (OS) Factors with ... using SPSS version 13 Result Patient characteristics Statistical analysis Statistical analyses of × tables of categorical variables were performed using Pearson s x2 test or Fisher s exact test, where ... response and ERCC1 expression The overall response rate after CCRT for all patients was 72% (41/57 with 28 complete responses and 13 partial responses; had stable disease and progressive disease)...

Ngày tải lên: 18/06/2014, 19:20

... differences was assessed by the log-rank test Multivariate analyses were performed using a logistic regression model for response and Cox regression models for PFS and overall survival (OS) Factors with ... using SPSS version 13 Result Patient characteristics Statistical analysis Statistical analyses of × tables of categorical variables were performed using Pearson s x2 test or Fisher s exact test, where ... response and ERCC1 expression The overall response rate after CCRT for all patients was 72% (41/57 with 28 complete responses and 13 partial responses; had stable disease and progressive disease)...

Ngày tải lên: 20/06/2014, 03:20

... procedure was also extended to be applicable to other types of disorders [8] Visualization of speech and voice disorders helps the medical staff in the assessment of voice and speech disorders The Sammon ... techniques and was tested on speech of patients with different but significant extents of speech disorder (dysglossia) and voice disorder (dysphonia) after the treatment for head and neck cancer Speech ... groups, the extent of disorder is widespread, as seen by the results of the perceptual assessment and the ASR results The presented method might also be applicable to all kinds of patient groups...

Ngày tải lên: 21/06/2014, 20:20

... patients will develop severe mucositis To avoid the consequences of side effects, most centers provide the installation of gastrostomy tubes to all head and neck (H&N) cancer patients This installation ... optical density of the samples to a standard curve, the concentration of the interleukin in unknown samples is determined Statistical analysis was done using SPSS (Chicago IL, USA) with Fisher s exact ... EA: Variable expression of cytokines in human head and neck squamous cell carcinoma cell lines and consistent expression in surgical specimens Cancer Res 1998, 58:3132-3141 24 Nishino H, Miyata...

Ngày tải lên: 09/08/2014, 08:22

... progression-free survival (LPFS), distant metastases-free survival (DMFS) and causes of death Statistical analyses were carried out with SPSS statistical package (SPSS Inc., Chicago, IL, U .S. A.) using log-rank ... months) and N3 disease (7 months) Distant metastases and distant metastases-free survival Distant metastases-free survival was median 66 months (range, 2-156 months) Forty-five of our patients (35%; ... months in patients with multiple locations, 13 months with metastases to the skeletal system, 21 months with liver metastases, months with brain metastases and 15 months with skin metastases There...

Ngày tải lên: 09/08/2014, 09:20

... M, Wolden S, Pfister DG, Shah JP, Larson SM, Kraus DH: Diagnostic and prognostic value of [(18)F] fluorodeoxyglucose positron emission tomography for recurrent head and neck squamous cell carcinoma ... consent following the rules of our institution Patients with Karnofsky performance status < 80/100, tumor location in the salivary glands or unknown primary site, evidence of distant metastases ... IL, USA) The PET component is a high-resolution scanner with a spatial resolution of 4.7 mm and no septa, thus allowing 3D-only acquisitions The CT component is the Somatom Sensation sixteen-slice...

Ngày tải lên: 09/08/2014, 09:22

... and Standard Error of the Mean (SEM) of xerostomia during meals and xerostomia in rest questionaires, for IMRT and Control groups Xerostomia during meals Xerostomia in rest N Mean SD SEM Mean SD ... 10.0 (SPSS inc., Chicago, Illinois) Results Patient characteristics The two patients groups were not well balanced; most patients had advanced stage head and neck cancer with higher stages in ... prior surgery, interval between RT and questionnaire, current smoker yes/no) no") that were available for these patients For the statistical analysis we used SPSS software for Windows, release 10.0...

Ngày tải lên: 09/08/2014, 09:22

... development of severe acute mucositis or its consequential late effects, such as submucosal edema, fibrosis, scarring, soft tissue necrosis, impaired sensory or motor function, and loss of mucosal compliance ... the frequency of dysphagia across different head and neck disease sites [30], which is further supported by a large prospective study that excluded disease site as a statistically significant factor ... values of V60 and V65) also results in high dose to large volumes of mucosal surface which is believed to lead to more severe mucositis [32-34] However, since mucositis tends to be self-limiting and...

Ngày tải lên: 09/08/2014, 10:20

... experiments, data acquisition and statistical analyses LAHH has written the manuscript and has been aware of the submission process PCL has been involved in conception and design of the study and in ... reduction of the incidence of xerostomia in patients undergoing postoperative RT alone for head and neck cancer Despite this, the use of this agent remains limited [19] PBLs apoptosis, measured as an ... Page of Figure Kaplan-Meier analysis of RIA values and development of severe xerostomia The analysis was made to establish a relationship between b radiosensitivity constant and the xerostomia...

Ngày tải lên: 09/08/2014, 10:20

... 3D-c-IMRT is normal tissue sparing Among several critical tissues exposed when head and neck cancers are treated the parotid glands were of utmost interest Chronic xerostomia is the most prevalent side ... was studied by MRT in all cases Delineation of target volumes and normal tissues Immobilisation of the head was accomplished by individually mounted light cast head and neck masks Contiguous ... adopted as an institutional standard Assessment of acute and chronic adverse effects Acute und chronic toxicity was assessed semi-quantitatively by a specially trained radiation onoclogist (NA)...

Ngày tải lên: 09/08/2014, 10:21

... QLQ-H&N35 is a module used for the assessment of health-related QOL in patients with head- andneck cancer [11] It contains seven symptom scales and six symptom items It is designed to be used together ... scores overand senses (QOL-H&N35) mouth, sticky Mean scores over time of the single items dry mouth, sticky saliva, swallowing and senses (QOL-H&N35) High scores imply a high level of symptoms and ... Mean scores of the scales and single items of questionnaire for patients with cancer of the head- and- neck treated with radiotherapy with or without surgery A significant outcome presents a significant...

Ngày tải lên: 09/08/2014, 10:21

... management of head and neck cancer patients in the hospital as compared to some of the other centres [7] A study in North America showed a relatively steady rise in cases of head and neck cancer ... nodes (39.7%), is consistent with the report of Hoffman et al [17] who also found that lymph nodes of the head and neck were the most common sites for lymphomas Sarcomas of the head and neck ... Columbia, United States of America, Hoffman [17] reported 295,022 cases of head and neck cancers of which carcinomas accounted for 75.2% while lymphomas constituted 15.1% This result is also similar to...

Ngày tải lên: 11/08/2014, 20:21

... Scientific, USA) Spectral parameters and fitting of each spectrum was obtained using a PeakFit version 4.12 (Systat, USA) Results Infrared spectra of normal lung cells Fig 1a shows the mid-infrared spectra ... s( PO2 󰠏) bands at ∼1,085 cm 󰠏1 were intensified in prostate cancer tissues compared to normal prostate epithelial cells The frequency positions of the s( PO2 󰠏) and 󰠏 νas(PO2 ) bands were also ... frequently observed in tumor cells and known to be associated with tumorigenesis [1,25] There are several tools to identify cancer cells and cancer diagnosis Compared to the established techniques, the...

Ngày tải lên: 07/08/2014, 23:22