distinct pathway from protein metabolism
Tài liệu Báo cáo khoa học: Aldehydes release zinc from proteins. A pathway from oxidative stress⁄lipid peroxidation to cellular functions of zinc pptx
... environments in proteins Zn–SCys sites in proteins are remarkably reactive Oxidation of the sulfur ligands and concomitant zinc release establishes multiple pathways for redox control of zinc metabolism ... measurements were normalized by measuring the total protein concentration of each sample with a Micro-BCATM protein assay kit from Pierce (Rockford, IL) The protein concentration of control cells without ... zinc ions are released within h Aldehydes and zinc metabolism Fig Acrolein releases zinc from metallothionein (MT) The kinetics of zinc transfer from MT isoform (MT2) (0.5 lM) to 4-(2-pyridylazo)-resorcinol...
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Báo cáo khoa học: Functional characterization of front-end desaturases from trypanosomatids depicts the first polyunsaturated fatty acid biosynthetic pathway from a parasitic protozoan ppt
... Fig D4 desaturases from L major, T brucei and T cruzi group together with D4 and D5 desaturases from fungi, algae and mosses, but form a subgroup with algae desaturases (i.e D4 from Pav lutheri ... the D5 desaturases from fungi As previously reported, the D6 desaturase from cyanobacteria is also present in this group [18] In contrast, L major D5 desaturase is separated from this cluster; ... group that includes D5 desaturase from Thraustochytrium sp., D4 desaturase from I galbana and the O tauri D6 acyl-CoA desaturase [19] Lastly, D6 desaturase from L major was found in another major...
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The Evolution from Protein Chemistry to Proteomics Basic Science to Clinical Application potx
... The Evolution from Protein Chemistry to Proteomics Basic Science to Clinical Application The Evolution from Protein Chemistry to Proteomics Basic Science to ... pathology; current examples include C-reactive protein, fibrin D-dimer and troponin Identification of unknown proteins by analysis of peptides obtained from unknown proteins by enzymatic (usually trypsin) ... urinary proteins on two-dimensional electrophoresis gels with a yield of nearly 1400 distinct protein spots, Proteomics, 4, 1159, 2004 11 Schaub, S., Wilkins, J., Weiler, T et al., Urine protein...
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Báo cáo Y học: Modeling the three-dimensional structure of H+-ATPase of Neurospora crassa Proposal for a proton pathway from the analysis of internal cavities pptx
... membrane proteins: the dense alignment surface method Protein Eng 10, 673–676 Rost, B., Fariselli, P & Casadio, R (1996) Topology prediction for helical transmembrane proteins at 86% accuracy Protein ... proton transport in membrane proteins In monomeric and globular proteins, internal polar cavities often contain buried water molecules which interact both with other protein groups and with one ... in the model of PMA1_NEUCR, a membrane protein for which the proton pathway has not as yet been delineated might provide useful information about this pathway Positions of internal polar cavities...
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Báo cáo sinh học: "WildSpan: mining structured motifs from protein sequences" doc
... Weng Z: Protein- Protein Docking Benchmark 2.0: an update Proteins 2005, 60(2): 214-216 Hsu CM, Chen CY, Liu BJ, Huang CC, Laio MH, Lin CC, Wu TL: Identification of hot regions in protein- protein ... the query protein directly from the protein sequences On the other hand, the mining results of family-based mining reveal that WildSpan can be used to identify sequence signatures of protein families ... identifying functional regions of protein sequences First, we conduct experiments on a proteinprotein docking benchmark [27] for evaluating the performance of the protein- based mining mode of WildSpan...
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Báo cáo y học: " Evidence for common short natural trans sense-antisense pairing between transcripts from protein coding genes" docx
... natural pairs (AT and CG) from 24,968 human unpredicted protein coding transcripts is shown in blue The number of artificial pairs (AG and CT) from 24,968 human unpredicted protein coding transcripts ... transcripts from the same gene might confuse matters, we selected 9,717 genes with only one transcript from the list of 24,968 RNAs We selected transcripts containing short pairing sequences from single-transcript ... unexpected richness of short sequence sense-antisense regulation between transcripts originating from protein coding genes Much research has concentrated on that class of RNA whose function appears...
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Efficient discovery of binding motif pairs from protein protein interactions
... Determine Protein- Protein Interactions Protein- protein interactions can be assayed in-vivo/in-vitro or predicted in-silico We review the two aspects and summarize the current status of protein- protein ... a protein often exists in a protein complex, either permanently or transiently, as mentioned above Protein- protein interactions can be influenced by the environments inside cells Therefore, protein ... location of the protein interactions, the set of protein interactions in a species is termed the interactome of the species (Ito et al., 2001) 1.1.3 Protein Interaction Sites Protein- protein interactions...
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From protein self assembly to crystallization
... OF PROTEIN IN CORRELATION TO PROTEIN CRYSTALLIZATION 80 4.1 Introduction 80 4.2 Amphiphilic Nature of Proteins 83 4.2.1 Origin of Surface Activity of Proteins 83 4.2.2 Surface Adsorption of Proteins ... of soluble proteins grown from nonionic surfactants (a) Lysozyme crystals grown from a 30% C8E4; (b) Ferritin crystals grown from a 10% C8E4 solution; (c) Ubiquitin crystal grown from a 10% C6E5EO5 ... of soluble proteins grown from nonionic surfactants (a) Lysozyme crystals grown from a 30% C8E4; (b) Ferritin crystals grown from a 10% C8E4 solution; (c) Ubiquitin crystal grown from a 10% C6E5EO5...
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Integrating biological insights with topological characteristics for improved complex prediction from protein interaction networks
... inferred and catalogued, distinct groups of proteins forming complexes can be isolated from them: proteins within a complex form many interactions with each other than with proteins not in the complex ... analysis, protein interactions from an organism are typically assembled in the form of a network with the proteins as nodes and the interactions among them as edges, commonly called protein- protein ... bit-distance measure, and those proteins from the same cluster are considered functionally related The Rosetta Stone approach infers protein interactions from protein sequences in different genomes...
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Automated linear motif discovery from protein interaction network
... group the proteins that interact with the same protein; and then (ii) extract motif from each set of proteins grouped In this thesis, we proposed a novel approach of mining motifs in pairs from interaction ... group the proteins that interact with the same protein; (ii) and then extract motifs from each set of proteins grouped In our work, we adopted a novel approach of mining motifs in pairs from similar ... Valine Val V 2.2 Protein- Protein Interactions Proteins carry out their biological roles in a cell through interacting with other proteins They can bind permanently with other proteins to form...
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Computational methods for identifying conserved protein complexes between species from protein interaction data
... 1.1.1 Protein- protein interaction networks 1.1.2 Protein complex and predicting protein complexes from PPI networks 1.1.3 Why we need comparative interactomics and conserved protein ... Figures Figure 1.1 – (a) protein- protein interaction, (b) protein- protein interaction network Figure 1.2 – (a) a picture of protein complex, (b) a graph representation of a protein complex.(c) ... details 2.2.1) 1.1.2 Protein complex and predicting protein complexes from PPI networks Many proteins have to perform their functions together with other proteins to form protein complexes which...
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Computational methods for identifying conserved protein complexes between species from protein interaction data
... 1.1.1 Protein- protein interaction networks 1.1.2 Protein complex and predicting protein complexes from PPI networks 1.1.3 Why we need comparative interactomics and conserved protein ... Figures Figure 1.1 – (a) protein- protein interaction, (b) protein- protein interaction network Figure 1.2 – (a) a picture of protein complex, (b) a graph representation of a protein complex.(c) ... details 2.2.1) 1.1.2 Protein complex and predicting protein complexes from PPI networks Many proteins have to perform their functions together with other proteins to form protein complexes which...
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Computational methods for identifying conserved protein complexes between species from protein interaction data
... 1.1.1 Protein- protein interaction networks 1.1.2 Protein complex and predicting protein complexes from PPI networks 1.1.3 Why we need comparative interactomics and conserved protein ... Figures Figure 1.1 – (a) protein- protein interaction, (b) protein- protein interaction network Figure 1.2 – (a) a picture of protein complex, (b) a graph representation of a protein complex.(c) ... details 2.2.1) 1.1.2 Protein complex and predicting protein complexes from PPI networks Many proteins have to perform their functions together with other proteins to form protein complexes which...
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Tài liệu Báo cáo khoa học: Binding of N- and C-terminal anti-prion protein antibodies generates distinct phenotypes of cellular prion proteins (PrPC) obtained from human, sheep, cattle and mouse doc
... nonglycosylated proteins are only detectable with antibodies recognizing the C-terminal region and produce altered expression profiles Results Proteins of brain homogenates derived from different ... of brain tissues obtained from cattle After immunoblotting, PrPC signals were detected using the antibodies indicated (B) The protein banding pattern of the three PrPC protein bands, the di- (d), ... Deglycosylation of PrPC from cortex (c), cerebellum (cb) and brain stem (bs) Proteins were incubated with PNGase F before electrophoresis and transfer to membranes PrP proteins were detected using...
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Báo cáo khoa học: Structural and mutational analysis of TenA protein (HP1287) from the Helicobacter pylori thiamin salvage pathway – evidence of a different substrate specificity doc
... substrate in the B subtilis enzyme [5], is quite a long tunnel that extends inside each protein monomer from the protein surface The inner part of the cavity, which is connected to the solvent through ... ligand was also found in TenA from P horikoshii [12] and from P furiosus [11] The flat electron density likely corresponds to an endogenous compound of the E coli where the protein was produced, or ... salvage pathway in B halodurans [3], apparently cannot play the same role in H pylori because the amidohydrolase enzyme YlmB is also absent In the earliest studies concerning TenA, the protein from...
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Báo cáo khoa học: b-Amyloid protein oligomers induced by metal ions and acid pH are distinct from those generated by slow spontaneous ageing at neutral pH docx
... aggregates by two separate pathways One pathway, which is inhibited at pH 5.0 or by metal ions, slowly generates stable species that can be measured by PAGE The other pathway generates unstable ... aggregates via two pathways The first pathway occurs slowly and at neutral pH leading to the generation of stable toxic aggregates [Ab**]n that can be observed on PAGE The second pathway is reversible ... that Ab1–40 can aggregate via distinct mechanisms was supported by the AFM results, which show that aggregates formed slowly at pH 7.4 are distinct in appearance from those formed in the presence...
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Báo cáo y học: "The shunt from the cyclooxygenase to lipoxygenase pathway in human osteoarthritic subchondral osteoblasts is linked with a variable expression of the 5-lipoxygenase-activating protein" doc
... shunt from the COX to the 5-LO pathway is due to an increase in 5-LO expression [28,29], whereas in alveolar macrophages and in neutrophils it is due to altered 5-lipoxygenase-activating protein ... 1% ITS Specific ELISAs from Cayman Chemicals (Ann Arbor, MI, USA) for PGE2 (specificity 100%, sensitivity 7.8 pg/ml), from R&D Systems (Minneapolis, MN, USA) for IL-10 and from Medical and Biological ... subchondral osteoblasts Source Alkaline phosphatase (nmol/mg protein/ 30 min) Osteocalcin (ng/ mg protein/ 48 hours) Collagen type I (ng/mg protein/ 48 hours) Normal (n = 11) 624.7 ± 88.8 176.6 ± 24.7...
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Báo cáo y học: " CD45 immunoaffinity depletion of vesicles from Jurkat T cells demonstrates that exosomes contain CD45: no evidence for a distinct exosome/HIV-1 budding pathway" doc
... determinations from the three independent isolations showed that CD45 depletion effectively removed the vesicular proteins (95%, SD ± 3%, n = from Jurkat E6-1 and 96% SD ± 2%, n = from SupT1/ CCR5) ... that HIV-1 relies extensively, if not exclusively, on an exosome budding pathway for release from the cell that is distinct from that of other particles [16] This model is part of the authors' Trojan ... Jurkat E6-1 cell line [18] from the NIAID AIDS Reference Program Vesicle preparations were produced from 50 mls of uninfected cell culture supernatants (material produced from a culture of × 105...
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Báo cáo y học: " Kaposi''''s sarcoma associated herpes virus-encoded viral FLICE inhibitory protein activates transcription from HIV-1 Long Terminal Repeat via the classical NF-κB pathway and functionally cooperates with Tat" pptx
... signaling pathways known to activate HIV-1 LTR, the NF-κB pathway is particularly important as it is activated by several cytokines involved in immune and inflammatory response [1] However, all pathways ... ever, none of the above proteins is expressed in cells latently-infected with KSHV [11] KSHV also encodes for a protein called K13 (or orf71), which is one of the few viral proteins known to be ... also known as MRIT) [17] Proteins with two DEDs have been discovered in other viruses as well, including MC159L and MC160 from the molluscum contagiosum virus and E8 from the equine herpes virus...
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Báo cáo y học: " The Vpr protein from HIV-1: distinct roles along the viral life cycle" potx
... localization of this viral protein [81,85] Finally, it was reported that Vpr nuclear import was mediated by an unidentified pathway, distinct from the classical NLS- and M9-dependant pathways [92] Two ... than for the mature p6 protein [23,24,31] Since p6 is excluded from the virion core [27,28], Vpr could switch from the p6Gag region of the precursor to the mature NCp7 protein to gain access ... http://www.retrovirology.com/content/2/1/11 Figure Three-dimensional structure of the HIV-1 Vpr protein (from [15]) Three-dimensional structure of the HIV-1 Vpr protein (from [15]) The three α-helices (17–33, 38–50, 55–77) are colored...
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