disorders+of+platelets+pdf

Ngày tải lên: 07/07/2014, 04:20

... to acidosis. All of these factors can precipitate laminitis/coriosis, the consequences of which are abnormal horn growth and hoof wear, softening of the sole horn, dropping of the distal phalanx ... once and preferably several times daily. Loss of appetite, progressive signs of dullness, inability to sit up COLOR ATLAS OF DISEASES AND DISORDERS OF CATTLE 102 7 dermatitis in the interdigital ... required. Management: white line disorders are primarily a defect of the corium leading to the production of defec- tive cement. Coriosis may be the result of a range of factors including trauma...

Ngày tải lên: 06/03/2014, 00:20

... spleen enlarges. Platelets are physiologically very Chapter 109. Disorders of Platelets and Vessel Wall (Part 1) Harrison's Internal Medicine > Chapter 109. Disorders of Platelets and ... and influence the environment of the forming clot. During platelet aggregation, additional platelets are recruited to the site of injury, leading to the formation of an occlusive platelet thrombus. ... TPO, which then stimulates platelet production. Platelets circulate with an average life span of 7–10 days. Approximately one-third of the platelets reside in the spleen, and this number...

Ngày tải lên: 07/07/2014, 04:20

... decreased platelets in microangiopathic hemolytic anemia. Chapter 109. Disorders of Platelets and Vessel Wall (Part 2) Thrombocytopenia Thrombocytopenia results from one or more of three ... tube), or ideally a smear of freshly obtained unanticoagulated blood, such as from a finger stick, can be examined. Figure 109-1 Photomicrographs of peripheral blood smears. ... sequestration, usually in an enlarged spleen; and/or (3) increased platelet destruction. Disorders of production may be either inherited or acquired. In evaluating a patient with thrombocytopenia,...

Ngày tải lên: 07/07/2014, 04:20

... Chapter 109. Disorders of Platelets and Vessel Wall (Part 3) Approach to the Patient: Thrombocytopenia The history and physical examination, results of the CBC, and review of the peripheral ... count of approximately 5000–10,000 is required to maintain vascular integrity in the microcirculation. When the platelet count is markedly decreased, petechiae first appear in areas of increased ... usually a sign of a decreased platelet number and not platelet dysfunction. Wet purpura, blood blisters that form on the oral mucosa, are thought to denote an increased risk of life-threatening...

Ngày tải lên: 07/07/2014, 04:20

... The timing of development after heparin exposure is a critical factor in determining the likeliho od of HIT in a patient. HIT occurs early in heparin exposure only in the presence of preexisting ... the risk of thrombosis. HIT results from antibody formation to a complex of the platelet- specific protein platelet factor 4 (PF4) and heparin. The antiheparin/PF4 antibody can activate platelets ... Quinine Chlorpropamide Rifampin Danazol Tamoxifen Tirofiban Diatrizoate meglumine (Hypaque Meglumine) Trimethoprim/sulfamethoxazole Diclofenac Vancomycin a Drugs that pr eceded thrombocytopenia...

Ngày tải lên: 07/07/2014, 04:20

... Early recognition is key in treatment of HIT, with prompt discontinuation of heparin and use of alternative anticoagulants. Thrombosis is a common complication of HIT, even after heparin discontinuation, ... not be used in the treatment of HIT. Because of the high rate of thrombosis in patients with HIT, anticoagulation should be strongly considered, even in the absence of thrombosis. In patients ... Introduction of warfarin alone in the setting of HIT or HITT may precipitate thrombosis, particularly venous gangrene, presumably due to clotting activation and severely reduced levels of proteins...

Ngày tải lên: 07/07/2014, 04:20

... Epstein's, and Fechtner syndromes, all of which have distinct distinguishing features. A common feature of these disorders is large Chapter 109. Disorders of Platelets and Vessel Wall (Part 6) ... transcriptional regulator of hematopoiesis. Thrombotic Thrombocytopenic Purpura and Hemolytic Uremic Syndrome Thrombotic thrombocytopenic microangiopathies are a group of disorders characterized ... Treatment The treatment of ITP utilizes drugs that decrease reticuloendothelial uptake of the antibody-bound platelet and/or decrease antibody production. However, the diagnosis of ITP does not necessarily...

Ngày tải lên: 07/07/2014, 04:20

Ngày tải lên: 07/07/2014, 04:20

Ngày tải lên: 07/07/2014, 04:20

Ngày tải lên: 07/07/2014, 04:20

Ngày tải lên: 07/07/2014, 04:20

... human platelets. The properties of one of these systems, responsible for 40% of the total carrier mediated transport, are consistent with the properties of the system y + [16]. In human platelets ... concentra- tions of the sulphydryl reagent (2.0 m M ). Moreover in both cases [17,19] the technique used to isolate labelled platelets was different from ours, which consisted of a rapid filtration of platelets. The ... y + . Fig. 3. Kinetic analysis of L -arginine uptake in human platelets. Washed platelets (2.0 · 10 8 platelets) , preincubated for 10 min at 37 °C in presence of NaCl/P i or N-ethylmaleimide,...

Ngày tải lên: 08/03/2014, 02:20

... amount of salt in their diet. Taste Compared with disorders of smell, gustatory disorders are uncommon. Loss of olfactory sensitivity is often accompanied by complaints of loss of the sense of ... that expected on the basis of chance because of the inclusion of some odorants that act by trigeminal stimulation. Olfactory threshold testing is another method of assessing olfactory function. ... side of the nose. CT or MRI of the head is required to rule out paranasal sinusitis; neoplasms of the anterior cranial fossa, nasal cavity, or paranasal sinuses; or unsuspected fractures of...

Ngày tải lên: 06/07/2014, 15:21

... margin and dorsum of the tongue; at the junction of the dorsum and the base of the tongue; and in the palate, epiglottis, larynx, and esophagus. Figure 30-2 Chapter 030. Disorders of Smell, Taste, ... taste buds of the anterior two-thirds of the tongue are innervated by the gustatory fibers that travel in a branch of the facial nerve (VII) called the chorda tympani. The taste buds of the posterior ... Definitions Disturbances of the sense of taste may be categorized as total ageusia, total absence of gustatory function or inability to detect the qualities of sweet, salt, bitter, or sour;...

Ngày tải lên: 06/07/2014, 15:21

... the cause of Chapter 030. Disorders of Smell, Taste, and Hearing (Part 9) Disorders of the Sense of Hearing Hearing loss can result from disorders of the auricle, external auditory canal, ... canal; atresia or neoplasms of the canal; perforations of the tympanic membrane; disruption of the ossicular chain, as occurs with necrosis of the long process of the incus in trauma or ... scan of temporal bone; t , MRI scan. Conductive Hearing Loss This results from obstruction of the external auditory canal by cerumen, debris, and foreign bodies; swelling of the lining of...

Ngày tải lên: 06/07/2014, 15:21

... chromosome 11 (Fig. 99-1). The α-like cluster consists of two α-globin genes and a single copy of the ζ gene. The non-α gene cluster consists of a single ε gene, the Gγ and Aγ fetal globin genes, ... the assembly of the transcription initiation complex. Sequences in the 5' flanking region of the γ and the β genes appear to be crucial for the correct developmental regulation of these genes, ... control the overall level of expression of each cluster. These elements achieve their regulatory effects by interacting with trans-acting transcription factors. Some of these factors are ubiquitous...

Ngày tải lên: 07/07/2014, 04:20

... received kidney transplants, but they often experience an increase in the frequency and severity of crises, possibly due to increased infection as a consequence of immunosuppression. The most significant ... immunosuppression. The most significant advance in the therapy of sickle cell anemia has been the introduction of hydroxyurea as a mainstay of therapy for patients with severe symptoms. Hydroxyurea ... pathogenesis of sickle cell crisis, and their suppression may be an important benefit of hydroxyurea therapy. Hydroxyurea should be considered in patients experiencing repeated episodes of acute...

Ngày tải lên: 07/07/2014, 04:20