disorders of hemoglobin genetics pathophysiology
Chapter 099. Disorders of Hemoglobin (Part 1) pptx
... Chapter 099. Disorders of Hemoglobin (Part 1) Harrison's Internal Medicine > Chapter 99. Disorders of Hemoglobin Disorders of Hemoglobin: Introduction Hemoglobin is critical ... stigmata. Hemoglobin Structure Different hemoglobins are produced during embryonic, fetal, and adult life (Fig. 99-1). Each consists of a tetramer of globin polypeptide chains: a pair of α- like ... alter clinical behavior. Function of Hemoglobin To support oxygen transport, hemoglobin must bind O 2 efficiently at the partial pressure of oxygen (P O2 ) of the alveolus, retain it, and release...
Ngày tải lên: 07/07/2014, 04:20
Chapter 099. Disorders of Hemoglobin (Part 2) pdf
... the ability of hemoglobin to deliver more oxygen to tissues at low pH. It arises from the stabilizing action of protons on deoxyhemoglobin, which binds protons more readily than oxyhemoglobin ... the tetrameric structure of the proteins, the proper arrangement of the charged amino acids, and interaction with protons or 2,3-BPG. Developmental Biology of Human Hemoglobins Red cells first ... globin genes partially after birth. Genetics and Biosynthesis of Human Hemoglobin Normal red blood cell (RBC) differentiation requires the coordinated expression of the globin genes with the genes...
Ngày tải lên: 07/07/2014, 04:20
Chapter 099. Disorders of Hemoglobin (Part 3) pptx
... biosynthesis) and of structural hemoglobinopathies (e.g., an abnormal amino acid sequence). Hereditary persistence of fetal hemoglobin (HPFH) is characterized by synthesis of high levels of fetal hemoglobin ... Hereditary persistence of fetal hemoglobin persistence of high levels of HbF into adult life V. Acquired hemoglobinopathies A. Methemoglobin due to toxic exposures B. Sulfhemoglobin due to ... life. Acquired hemoglobinopathies include modifications of the hemoglobin molecule by toxins (e.g., acquired methemoglobinemia) and abnormal hemoglobin synthesis (e.g., high levels of HbF production...
Ngày tải lên: 07/07/2014, 04:20
Chapter 099. Disorders of Hemoglobin (Part 4) pptx
... of the complete blood cell count (e.g., profound microcytosis with minimal anemia in thalassemia trait). Detection and Characterization of Hemoglobinopathies—General Methods Of the ... mutant hemoglobins can usually be characterized by more specialized techniques such as isoelectric focusing and/or high-pressure liquid chromatography (HPLC). Quantitation of the hemoglobin profile ... The number of severe cases of thalassemia in the United States is about 1000. Sickle cell disease is the most common structural hemoglobinopathy occurring in heterozygous form in ~8% of American...
Ngày tải lên: 07/07/2014, 04:20
Tài liệu Diseases and Disorders of Finfish in Cage Culture doc
... months of culture; production of 600–800 g per fish or 1.2–1.4 g per fish Stocking density is 44 fish m −3 of size 80–100 g; feeding with trash fish at 3–5% of body weight twice daily; 6–7 months of culture; ... degrada- tion of water quality in cage sites and the implementation of proper management of the aquatic environment are necessary if the industry is to expand. Rosenthal (1994) indicated the importance of ... Philippines. T.T. Poppe, Department of Morphology, Genetics and Aquatic Biology, The Norwegian School of Veterinary Science, PO Box 8196 Dep., N-0033 Oslo, Norway. D.J. Speare, Department of Pathology and Microbiology,...
Ngày tải lên: 14/02/2014, 17:20
COLOR ATLAS OF DISEASES AND DISORDERS OF CATTLE_2 pdf
... to acidosis. All of these factors can precipitate laminitis/coriosis, the consequences of which are abnormal horn growth and hoof wear, softening of the sole horn, dropping of the distal phalanx ... once and preferably several times daily. Loss of appetite, progressive signs of dullness, inability to sit up COLOR ATLAS OF DISEASES AND DISORDERS OF CATTLE 102 7 dermatitis in the interdigital ... required. Management: white line disorders are primarily a defect of the corium leading to the production of defec- tive cement. Coriosis may be the result of a range of factors including trauma...
Ngày tải lên: 06/03/2014, 00:20
Essentials of Clinical Genetics in Nursing Practice potx
... member of the International Society of Nurses in Genetics and the American Society of Human Genetics. She was a member of the steering committee of the National Coalition for Health Professional ... does not include the impact of genes on the common disorders or on 4 Essentials of Clinical Genetics in Nursing Practice TABLE 1.1 Incidence of Genetic Disorders Type of Disorder Incidence Chromosome ... gene-containing part of the human genome sequence in April 2003. A variety of themes 6 Essentials of Clinical Genetics in Nursing Practice TABLE 1.3 Usual Stage of Manifestation of Selected Genetic Disorders Life...
Ngày tải lên: 06/03/2014, 12:21
A Primer of Conservation Genetics pptx
... Mendelian segregation of alleles r equal fertility of parent genotypes r random union of gametes 32 EVOLUTIONARY GENETICS OF NATURAL POPULATIONS Factors controlling the evolution of populations Our ... the context of the breeding system (Fig. 3.1). To evaluate the importance of the components of an evolving population, we model it with none of the factors operating, then with each of the factors Fig. ... particular extinction event. What is conservation genetics? Conservation genetics is the use of genetic theory and techniques to reduce the risk of extinction in threatened species. Its longer-term ...
Ngày tải lên: 06/03/2014, 17:20
Báo cáo khoa học: Molecular mass of macromolecules and subunits and the quaternary structure of hemoglobin from the microcrustacean Daphnia magna ppt
... glycosylation of hemoglobin subunits. Based on molecular mass information, Daphnia magna hemoglobin is demonstrated to consist of 16 subunits. The quaternary structure of the Daphnia magna hemoglobin ... by chromatofocusing [removal of ring-like molecules (‘ferritin’), but retention of high Hb quantities], numer- ous different views of the Hb molecules were obtained by negative staining of these ... Control: addition of water instead of enzymes to the reaction mixture. (B) Hb incubated with N-glycosidase F (cleavage of N-linked sugars). (C) Release of O-linked sugars. (D) Release of N- and O-linked...
Ngày tải lên: 16/03/2014, 13:20
Diagnosis, Evaluation, and Management of the Hypertensive Disorders of Pregnancy pot
... and Management of the Hypertensive Disorders of Pregnancy S12 l MARCH JOGC MARS 2008 Table 2. Classification of the hypertensive disorders of pregnancy* Primary diagnosis Definition of preeclampsia† Pre-existing ... the management of dyslipidemia and the prevention of cardiovascular disease: summary of the 2003 update. CMAJ 2003;169:921-4. Diagnosis, Evaluation, and Management of the Hypertensive Disorders of Pregnancy S48 l ... priorities: the role of self-measurement of BP, accuracy of the ratios of urinary protein to creatinine and albumin to creatinine for diagnosis of proteinuria, multivariable models for prediction of preeclampsia,...
Ngày tải lên: 28/03/2014, 14:20