diseases of the immune system
Paradoxical roles of the immune system during cancer development docx
Ngày tải lên :
15/03/2014, 01:20
... On the basis of classical theories of immune surveillance and more recent awareness of the tumour-promoting properties of innate immune cells, researchers are now investigating the efficacy of ... history of alcohol and tobacco use66,67 On the other hand, the RR for the most common non-viral-associated solid tumours of epithelial origin is decreased in immune- suppressed patients; some of these ... manner The paradoxical influence of the adaptive immune system during these processes raises many questions, the understanding of which is crucial if treatment modalities involve adaptive -immune- based...
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Báo cáo Y học: A new siglec family member, siglec-10, is expressed in cells of the immune system and has signaling properties similar to CD33 docx
Ngày tải lên :
24/03/2014, 04:21
... digesting the fragment with HindIII and Bgl II and the plasmid with HindIII and Bam HI The fragment was ligated into the plasmid and the integrity of the insertion was validated by digesting the plasmid ... contributing to the phosphorylation of the wild-type siglec tail by Lck and Jak3 kinases By comparison, the mutation of the tyrosine at position 641 did not significantly affect the degree of phosphorylation ... final pH of 8.0 Siglec-10 –hIg was then dialysed against NaCl/Pi To construct the GST fusion of the siglec-10 cytoplasmic domain (GST– siglec-10cyto-wt) the cytoplasmic domain (KRRTQTE…VFQ) of siglec-10...
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Báo cáo sinh học: "Parasite immunomodulation and polymorphisms of the immune system" ppsx
Ngày tải lên :
06/08/2014, 19:20
... well recognized for the regulation of immune responses The effect of parasites, for example, has been to dampen, rather than fully ablate, immune responsiveness, and the degree of immunosuppression ... patterns, the fine-tuning effect of multiple allelic variants allows the immune system to be variably calibrated across the population In the absence of infection, and where genotypes tend to the higher ... between pathogen species These graduated effects may, in turn, have driven quantitative polymorphisms in the contemporary immune system that control the strength of the immune response, exemplified...
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Báo cáo y học: " Mimicking microbial ‘education’ of the immune system: a strategy to revert the epidemic trend of atopy and allergic asthma?" ppt
Ngày tải lên :
12/08/2014, 18:20
... mycobacteria might therefore have influenced the evolution of the immune system because they have been ubiquitous throughout mammalian phylogeny Consequently, the concrete paving of modern cities ... would consist of safe administration, by the correct route and at the correct dose and time schedule, of the variety of microbial stimuli that are required by the mucosal immune system during ... of the development of type T-helper cells in allergy Curr Opin Immunol 1994, 6:838–846 Martinez FD: Role of viral infections in the inception of asthma and allergies during childhood: could they...
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Báo cáo y học: " Network, degeneracy and bow tie. Integrating paradigms and architectures to grasp the complexity of the immune system" pps
Ngày tải lên :
13/08/2014, 16:20
... perspective of a unitary hypothesis The network approach The success of a new paradigm Central to systems biology, the paradigm of network is also at the cutting edge of the sciences of complexity ... have been observed in the functional structure of some key components of the innate immune response, such as the human TLRs system, and of the adaptive immune system, such as the TCR Even if microbial ... challenge in network theory and systems biology [3] While the application of the network paradigm revealed the existence of structural complexity, many other layers of complexity in the system became...
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ROLE OF THE IMMUNE SYSTEM IN TUMOR PROGRESSION 1
Ngày tải lên :
10/09/2015, 15:50
... unique Therefore, the study of the cross-talk between cancer cells and the immune system must be analyzed in the context of the organ in which the tumor exists and the type of cells that the tumor ... of the invasiveness of the primary tumor The number of lymph nodes detected with melanoma cells and the size of the metastases (microscopic or macroscopic) help determine the aggressiveness of ... close interactions with the immune system Its ability to evade the immune system is dependent on components of the immune system itself Much research has been done on immunotherapy focusing on enhancing...
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ROLE OF THE IMMUNE SYSTEM IN TUMOR PROGRESSION 2
Ngày tải lên :
10/09/2015, 15:50
... is the number of melanoma cells at the end of the experiment, N is the number of melanoma cells at the onset of the experiment, k is the fraction of proliferating cells, t is the duration of the ... is the number of melanoma cells at the end of the experiment, N is the number of melanoma cells at the onset of the experiment, k is the fraction of proliferating cells, t is the duration of the ... /Dct d is the ratio of Dct expression in the lungs of control vs PMNMDSC-depleted mice, k c is the fraction of proliferating cells in the lungs of control mice and k d is the fraction of proliferating...
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Interaction of burkholderia pseudomallei with cells of the immune system
Ngày tải lên :
08/11/2015, 16:31
... production The flagellae of many motile bacteria e.g Salmonella, are comprised of the basal body, the hook, and the filament that is composed mainly of the protein FliC (Macnab, 2004) The secretion of ... pathogenesis of B pseudomallei is essential to facilitate therapeutic developments Our objective is to gain insights into the pathogenesis of the bacteria by employing the use of in vitro culture systems ... important initiators of adaptive immunity One of the most direct means to subvert host immune defenses involves inducing death or disrupting the functions of such immune cells in the infected host...
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Basic immunology functions and disorders of the immune system
Ngày tải lên :
04/08/2016, 15:18
... for immunotherapy of cancer FIGURE 1-1 The importance of the immune system in health and disease This table summarizes some of the physiologic functions of the immune system Note that immune responses ... infections is called the immune system, and the coordinated reaction of these cells and molecules to infectious microbes is the immune response Immunology is the study of the immune system and its ... eliminate them (see Chapter 2) In adaptive immunity, the products of B and T lymphocytes call in other leukocytes and activate them to kill microbes Tissues of the Immune System The tissues of the immune...
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Báo cáo khoa học: "The use of crossreactive monoclonal antibodies to characterize the immune system of the water buffalo (Bubalus bubalis)" pdf
Ngày tải lên :
07/08/2014, 15:20
... buffalo is similar to the composition in cattle One of the unique features to emerge from the study of the immune system of cattle is the presence of two complex subpopulations of γδ T cells, one ... vaccines, it is necessary to characterize the immune system of the water buffalo and elucidate the changes in the immune response that account for the development of protective immunity To achieve this ... existing sets of mAbs developed in other related species With the mAbs identified here, it will now be possible to characterize the immune system of the water buffalo and begin to analyze the immune...
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Báo cáo y học: "Regulating the immune system: the induction of regulatory T cells in the periphery Jane H Buckner1 and Steven F Ziegler2" pot
Ngày tải lên :
09/08/2014, 01:24
... inducing the local induction of Th3 or Tr1 cells [74], extends this paradigm The fate of the TR cells induced at the site is not known — whether these cells exist only transiently then die, whether they ... induction of TR cells to occur in the absence of an APC In addition, if the differentiation and function of TR cells are regulated by the expression of FoxP3 then, as the regulation of FoxP3 expression ... at the site of inflammation, the production of cytokines that lead to inhibition of T-cell responses, or the development of Tr1 or Th3 cells These regulatory phenomena are very important in the...
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Diseases of the Liver and Biliary System - part 1 potx
Ngày tải lên :
10/08/2014, 15:20
... 636 Other causes, 636 Summary, 636 36 Diseases of the Ampulla of Vater and Pancreas, 639 Peri-ampullary carcinoma, 639 Benign villous adenoma of the ampulla of Vater, 644 Cystic tumours of the ... 1.14) There is no basement membrane The sinusoids are lined by endothelial cells Associated with the sinusoids are the phagocytic cells of the reticulo-endothelial system (Kupffer cells), and the ... (fig 1.16) These make up 6–8% of the total endothelial cell surface, and there are more in the centrilobular zone of the sinusoid than the peri-portal area Extra-cellular matrix affects their function...
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Diseases of the Liver and Biliary System - part 2 pot
Ngày tải lên :
10/08/2014, 15:20
... palms) The hands are warm and the palms bright red in colour, especially the hypothenar and thenar eminences and pulps of the fingers (fig 6.12) Islets of erythema may be found at the bases of the ... of the complement cascade Systemic toxaemia of intestinal origin results in deterioration of the scavenger functions of the reticulo-endothelial system and also to renal damage (fig 6.9) [6] These ... mainly affects the Jewish race The deficiency is in the enzyme sphingomyelinase, in the lysosomes of the reticulo-endothelial system This results in the lysosomal storage of sphingomyelin The liver...
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Diseases of the Liver and Biliary System - part 3 potx
Ngày tải lên :
10/08/2014, 15:20
... veins of the caval system Deviation of blood into these channels leads to varicosities in the submucous layer of the lower end of the oesophagus and fundus of the stomach (b) At the anus, the superior ... by the union of the superior mesenteric vein and the splenic vein just posterior to the head of the pancreas at about the level of the second lumbar vertebra It extends slightly to the right of ... attempting to bypass the block and return blood towards the liver These enter the portal vein in the porta hepatis beyond the block They include the veins at the hilum, venae comitantes of the portal vein...
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Diseases of the Liver and Biliary System - part 4 docx
Ngày tải lên :
10/08/2014, 15:20
... result of the failure of transport systems across the hepatocyte and the canalicular membrane Conjugation is intact and therefore there is reux of conjugated bilirubin into JAUNDICE Classication of ... micrograph of the canalicular biliary system porters, from the microsomes to the bile canalicular membrane The peri-canalicular cytoplasm contains elements of the cytoskeleton of the hepatocyte: ... Hering (g 13.3) These are found largely in the portal zones of the liver The ductule passes into the interlobular bile duct which is the rst bile channel to be accompanied by a branch of the hepatic...
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Diseases of the Liver and Biliary System - part 5 pot
Ngày tải lên :
10/08/2014, 15:20
... passage from the mother to the neonate The infection is usually not via the umbilical vein, but from the mother at the time of birth and during close contact afterwards The chance of transmission ... from host immune attack The effect is very variable, possibly related to the immune status of the patient or to the effects of vaccination or therapy Guanosine to adenine mutation in the pre-core ... serum IgG anti-HDV is found There may be a window period between the disappearance of one and the detection of the other Loss of IgM anti-HDV confirms the resolution of HDV infection, whereas persistence...
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Diseases of the Liver and Biliary System - part 6 pps
Ngày tải lên :
10/08/2014, 15:20
... related to the severity of the liver disease [72] The extent of the nutritional defect depends on the type of alcoholic, whether of low socioeconomic status where protein-calorie malnutrition often ... lipids synthesized in the liver itself The origin depends upon the dose of ethanol ingested and the lipid content of the diet After an acute, isolated ingestion of a large dose of ethanol the fatty ... years, should be warned of the possibility of adenoma development If adenoma is diagnosed, the woman must be warned of the possibility of rupture and the significance of any unexplained right...
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Diseases of the Liver and Biliary System - part 8 ppt
Ngày tải lên :
10/08/2014, 15:20
... fever, often with a rash (erythema of Milan), occur about days after starting therapy This is part of the Herxheimer reaction The mechanism of the jaundice is unclear References Case Records of the ... sensitivity of 70% and a specificity of 98% [3] Angiography confirms the supply is directed centrally to the scar and is then distributed to the periphery of the lesion like the spokes of a wheel ... ulcers Amoebae are carried to the liver in the portal venous system Occasionally, they pass through the hepatic sinusoids into the systemic circulation with the production of abscesses in lungs and...
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Diseases of the Liver and Biliary System - part 9 pptx
Ngày tải lên :
10/08/2014, 15:20
... anomaly the gallbladder lies under the left lobe of the liver, to the left of the falciform ligament This may be caused by the gallbladder migrating to a position under the left lobe of the liver ... laterally over the gallbladder down to the duodenum, to the hepatic flexure of the colon and even to the right lobe of the liver, perhaps closing the foramen of Winslow In a milder form, a band of tissue ... if the bilirubin is greater than twice the upper limit of normal because of failure of efficient secretion of contrast by the liver Oral cholecystography is of value in showing lesions of the...
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Diseases of the Liver and Biliary System - part 10 docx
Ngày tải lên :
10/08/2014, 15:20
... depends on the clinical state of the patient and the staging of the tumour derived from radiological imaging Difficulties in removal arise because of the inaccessibility of the pancreas on the posterior ... obstructed in the right lobe and the left hepatic system obstructed at the hilum If non-surgical drainage is to be done, these appearances favour drainage of the left- rather than the right-sided system ... diverticulum Diverticula of the duodenum are often found near the ampulla of Vater, but rarely cause obstruction of the bile duct They are associated with an increased rate of gallbladder and common...
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