diseases of bone and bone mineral metabolism

... terms of RA signs and symptoms could not be demonstrated Correlation between markers of bone turnover and clinical parameters or bone mineral density values On looking for correlation between bone ... similar at the femoral neck and at the spine between the groups (Table 1) Changes in bone mineral density and markers of bone turnover at year In the control group, after year of follow up femoral neck ... between -1 and -2.5 SD and osteoporosis as a T score of -2.5 SD or less Markers of bone turnover All bone markers were measured using commercial assays, in accordance with instructions of the manufacturers...

Ngày tải lên: 09/08/2014, 10:20

Ngày tải lên: 14/10/2016, 13:21

... frequency of assessment is based on the presence and persistence of identified abnormalities, the severity of abnormalities, all in the context of the degree and rate of change of GFR and the use of ... combinations of low bone mineral content and abnormal bone quality CKD–MBD can lead to an abnormal bone quality even in the setting of a normal or high bone- mineral content, and the gold standard diagnosis ... density and bone quality, together with risk for falling and trauma Bone biopsies provide measurements of bone turnover, mineralization, and volume These help to assess bone quality and the underlying...

Ngày tải lên: 22/03/2014, 09:20

... Radiographs Radiographs of the hands, wrists, and distal part of the feet were obtained at baseline and after 12 and 24 months Forty joints in the hands and feet were scored (in the hands, proximal interphalangeal ... on serum markers of bone and cartilage metabolism (a) Effect of HRT on serum (S) levels of metabolism type I collagen C-telopeptide (CTX-I) (b) Effect of HRT on serum levels of cartilage oligomeric ... telopeptide of type I collagen; PICP, C-terminal propeptide of type I procollagen Table Correlations between changes over years in biochemical markers of bone and cartilage metabolism and in bone mineral...

Ngày tải lên: 09/08/2014, 01:24

... dose titration of skeletal effects of TNF and/ or RANKL blockers has been accomplished, since blockade of TNF and RANKL was used as a proof -of- concept study on the role of TNF and osteoclasts ... functional osteoclasts and osteoblasts The fraction of bone surface covered by osteoclasts and osteoblasts (OcPm/BPm, ObPm/BPm) and the numbers of osteoclasts and osteoblasts per bone perimeter (NOc/BPm, ... active bone cells to simultaneously analyze functional osteoclasts and osteoblasts representing areas of bone loss and bone formation, respectively, we evaluated juxta-articular and periarticular bone...

Ngày tải lên: 09/08/2014, 07:20

... like DXA and DXR, pQCT allows the determination of bone geometry of bone cross-section independent of bone size To date, no study has examined vBMD and cross-sectional bone geometry of the metacarpal ... Precision of metacarpal bone measurements Nine subjects of the control group volunteered to have a total of four measurements of metacarpal bone III of the same hand within a maximal time span of three ... standard deviation (SD), Coefficient of variation (CV) and 95% confidence interval (CI) of the CV BMC stands for bone mineral content per mm of slice thickness, CSA for cross-sectional area and...

Ngày tải lên: 12/08/2014, 14:22

... Sokoloff L, Wolfe F: Development of criteria for the classification and reporting of osteoarthritis Classification of osteoarthritis of the knee Diagnostic and Therapeutic Criteria Committee of ... Molecular basis and clinical use of biochemical markers of bone, cartilage, and synovium in joint diseases Arthritis Rheum 2000, 43:953-968 13 Garnero P, Peterfy C, Zaim S, Schoenharting M: Bone marrow ... telopeptide of type I collagen; SE, standard error of the mean; s, serum; u, urine knee pain irrespective of grade The presence of pain did not influence the ratio of sC2C/sCPII nor that of uCTXII/sCPII...

Ngày tải lên: 12/08/2014, 15:22

... 6: Comparison of bone mineral density 43 Figure 7: Comparison of bone volume 44 Figure 8: Comparison of mineralizing surface 45 Figure 9: Comparison of mineral appositional ... Cells and Bone Homeostasis There are two main types of bone: cancellous (also called trabecular or spongy) bone, and cortical, or compact, bone Cancellous bone is weaker than cortical bone, with ... SCHOOL Research Integrity and Copyright Disclaimer Title of Thesis/Dissertation: Bone Metabolism: The Role of STAT3 and Reactive Oxygen Species For the degree of Master of Science Choose your degree...

Ngày tải lên: 24/08/2014, 12:59

... genetic and non genetic factors involved in its etiology The decrease of bone mass and the alteration of bone architecture, characteristics of osteoporosis, lead to increased bone fragility and a ... resorption markers, bone mineral density, and bone metabolism [25] Various groups and experts have emphasized the importance of adequate vitamin D nutrition for optimal skeletal health and before initiating ... 10 is 50 μg/mc and per year was 40 μg/mc until 2009 and now is 20 μg/mc Monthly evolutions of mean concentration of NO2 and PM 10 in 2009 are presented in Figures and Evolutions of mean annual...

Ngày tải lên: 18/02/2014, 04:20

... soft tissue, bone to bone, and bone to lesion Measurement of bone clearance of 99mTc-MDP, photon absorptiometry, and quantitative bone scan are used increasingly in the study of osteoporosis and ... played by these bone cells is the maintenance of bone integrity and calcium homeostasis by balancing between the ratio of bone collagen production and resorp- tion and by governing mineralization ... Usefulness of pinhole scintigraphy in bone and joint diseases (abstract) Jpn J Nucl Med 29:1307–1308 Bahk YW (1985) Usefulness of pinhole collimator scintigraphy in the study of bone and joint diseases...

Ngày tải lên: 12/05/2014, 17:06

... inoculation of TSB and FTM media with 1% of the total volume of the product under validation as stated in European Pharmacopoeia (2.6.27) For the latter, 500 μl of whole blood and 100 μl of the BM-MNC ... for the culture of anaerobic and fungi/aerobic bacteria (THIOC-T and TSB-T, bioMerieux SA, Switzerland) was performed by incubating two vials of medium for 14 days at 32.5°C and 22.5°C respectively ... makes reference to and is in coherence with the 2004/23/EC directive on donation, procurement and testing of human cells and tissues and with directive 2002/98/EC on human blood and blood components...

Ngày tải lên: 18/06/2014, 15:20

... Journal of Orthopaedic Surgery and Research 2008, 3:36 The limb (and thus the)virtual cylinder is composed of soft tissue (mainly muscles and skin) and "hard" tissue (bone and bone marrow) The soft ... delivery of nutrients and oxygen through blood flow to bone tissue [21] Interruption of normal bone and soft tissue blood flow has been shown to be responsible for the development of severe and common ... "cylinder" and bone RUL-right upper limb, LUL-left upper limb, RLL-right lower limb, LLL-left lower limb VL and RL-entire "cylinder" volume and counts, respectively VS and RS, volume and counts of soft...

Ngày tải lên: 20/06/2014, 01:20

... member of the family and has been used in many studies for augmentation of bone and bone- tendon junction regeneration [3,4] Because of the role of BMP-2 in bone formation, it is commonly found in bone ... [15] and muscle ossification [16] BMP-4 and -7 and TGF-beta1 were also reported to be involved in the initiation and development of ossification of spinal ligaments (OSL) [17] Activities of BMPs ... agreed with the lower degree and extent of ectopic chondrogenesis and ossification in the model and further supported the role of BMP-2 in ectopic chondrogenesis and ossification Regarding the...

Ngày tải lên: 20/06/2014, 04:20

... method of measuring bone density The T-score relates bone density to young, healthy, race and gender-matched bone It is easily obtained and provides an objective quantitative number The T-score and ... T-score of 2.3 and a body mass index of 28 kg/m2, which was revised to a THA at two months post-operatively; the other case was in a female patient with a T-score of -2.1 and body mass index of 28 ... model and the explanatory variables of Tscore and body mass index demonstrated that the femoral failure rate could be as high as 87% if a patient has a T-score of -2.4 and a body mass index of 43...

Ngày tải lên: 20/06/2014, 07:20

... size of × μm and the mature BMDCs (L) in the scanning size of × μm; F and M, Enlarged view of the center of the immature BMDCs (F) and the mature BMDCs (M) in the same scanning area of × μm; G and ... visualize and quantify nanostructures of them AFM images included single and multiple BMDCs, two and three dimensions, low and high resolutions, cell height profile and histogram, topography, and roughness ... enhancement of the whole cellular or subcellular metabolism and function Morphological changes of cells are foundation of their metabolism and function changes, adapting to the need of the both...

Ngày tải lên: 21/06/2014, 02:20

... expression of BMP-4 and BMP-5 in the synovial tissue of chronic joint diseases Both proteins have a fundamental role in embryogenesis and in the induction of cartilage and bone [13,14] Genetic and expression ... homeostasis and repair of various tissues Current approaches focus mainly on their ability to regenerate bone and cartilage by the induction of differentiation, apoptosis and proliferation of undifferentiated ... that the progress of chronic joint diseases is decisively determined by the balance of anabolic and catabolic activities [3,4] Bone morphogenetic proteins (BMPs) are anabolic candidates with pleiotropic...

Ngày tải lên: 09/08/2014, 07:20

... apposition and decreasing collagen degradation and expression of interstitial collagenases [44,45] The main bone Table Trabecular bone structure and bone turnover indices in osteoarthritis and control ... exploration of any relationships between gene expression and indices of bone architecture and bone remodelling Interestingly, both OCN and ALP gene expression significantly correlated with bone micro-architecture ... investigated changes in gene expression of bone anabolic factors and collagen type I alpha chains and associations between gene expression and bone micro-architecture The bone anabolic factors investigated...

Ngày tải lên: 09/08/2014, 08:23

... synovitis, bone erosions and bone edema on MRI in RA hands and wrists Studies on volumetric quantification of bone erosion volumes with MRI have previously shown it is a reliable and feasible ... sensitivity, specificity and accuracy (concordance) of MRI and radiography for detection of bone erosions in RA wrist bones A second objective was to determine the intramodality and intermodality agreement ... imaginary middle of the bone If more than one erosion is present in a single bone, the sum of the scores (with a maximum of 5) of the individual erosions is calculated With this modification of the scoring...

Ngày tải lên: 09/08/2014, 10:23

... Crutchfield M, Jannausch ML: The associations of bone mineral density and bone turnover markers with osteoarthritis of the hand and knee in pre- and perimenopausal women Arthritis Rheum 1999, ... knee Bone density measurement In addition, the Framingham participants underwent measurement taken of bone mineral density (BMD) Because bone density may influence the levels of bone biomarkers and ... knees On bone histology, areas of bone affected by BMLs exhibit reversal lines indicative of bone remodeling [10] Small areas of bone necrosis are also present, as is scar The extensive bone remodeling...

Ngày tải lên: 09/08/2014, 13:21

... Recently, Bobacz and colleagues [36] demonstrated a differential expression of GDF5 and BMP7 in articular cartilage and synovium of hTNFtg mice They found an increased expression of BMP7 and GDF5 in ... Promotion of Innovation through Science and Technology in Flanders (IWT Vlaanderen), the Research Foundation Flanders (FWO Vlaanderen) (grant G.0390.03), a GOA grant from KU Leuven, and a Bristol-Meyers ... progresses Kinetics of bone morphogenetic protein ligands in collagen-induced arthritis – mRNA level Quantitative PCR for different BMP ligands and BMP antagonist NOG in both synovium and cartilage...

Ngày tải lên: 09/08/2014, 13:22