discovery of the antitumor vinca alkaloids

... the unaided eye The story of our discovery of the Milky Way and other galaxies is in many ways the chronicle of the popularity, demise, and renewal of the theory of island universes None of the ... underneath you on the other side of the Earth The apparent daily movement of the sky is, of course, due to the rotation of the Earth, not the sky, and we know that the stars are not all at the same distance, ... but these disputes referred to the nature of the diffuse light of the Milky Way, not to the structure of the system of stars Early astronomers pictured the stars distributed on the surface of...

Ngày tải lên: 19/01/2014, 13:40

... the ascertaining, by boiling a thermometer, of the altitude of the station above the sea-level; of the latitude of the station by the meridian altitude of the star taken with a sextant; and of ... arrived at concerning the Mountains of the Moon being associated with the country of the Moon, I would fain draw the attention of the reader of my travels to the volume of the "Asiatic Researches" ... establishments of the Arab merchants residing there The payment of these men's wages for the first year, as well as the terms of the agreement made with them, by the kind consent of Colonel Rigby...

Ngày tải lên: 15/02/2014, 09:20

... the ascertaining, by boiling a thermometer, of the altitude of the station above the sea-level; of the latitude of the station by the meridian altitude of the star taken with a sextant; and of ... arrived at concerning the Mountains of the Moon being associated with the country of the Moon, I would fain draw the attention of the reader of my travels to the volume of the "Asiatic Researches" ... pronunciation of native words refers to the u, which represents a sound corresponding to that of the oo in woo Journal of the Discovery of The Source of the Nile Chapter London to Zanzibar, 1859 The design...

Ngày tải lên: 08/03/2014, 18:20

... demonstrate specific antibodies to the virus in the serum of the patient; (5) demonstrate that proviral DNA could be found integrated in the DNA of the cells from which the virus was isolated; (6) provide ... recounts the events surrounding the discovery of the disease, adult T-cell leukemia [41] 18 Acknowledgements 20 I would like to thank the past and present members of my laboratory, without whom the ... [20] IL-2 was among the first welldefined cytokines The combination of IL-2 growth of T cells with sensitive RT assays would be (and still is) the key to the discoveries of human retroviruses...

Ngày tải lên: 13/08/2014, 09:21

... sleep The plan was to motor the twenty-nine-foot Black Watch for twenty miles out and around the southern end of Catalina Island They would then cross another thirty-two miles of ocean to the southern ... out of Newport Harbor in Newport Beach, just south of Los Angeles Clearing the lights at the end of the harbor’s long rock jetty, the skipper gave the boat’s twin Yanmars their first big huff of ... breakfast into the deep blue sea The buoys stayed anchored, offering the surfers a point of reference and a measure of relief When the next set of four or five waves broke, they showed that the surf...

Ngày tải lên: 17/02/2014, 05:20

... Nter are the C-terminal and N-terminal structural regions, respectively, of the two A and B monomers of the dimeric RNase The black circle between the monomers indicates the mass center of the dimer ... interactions and antitumor RNases E Notomista et al RNases oriented with the negative end of the dipoles toward the bottom, and the positive one toward the top of the figure Figure S4 shows instead the N-terminal ... negative EIEmax values As a measure of the RNase cytotoxicity we used the reciprocal of the IC50 parameter The values of IC50, the RNase concentration at which 50% of the cytotoxic effect is displayed,...

Ngày tải lên: 19/02/2014, 06:20

... that the cytotoxic activity of the latter monomers was due to the presence in these proteins of disulde bonds, with their potential chemical instability It is well known that in the presence of ... cell membranes in the presence or the absence of 10 or 50 mM ể FEBS 2003 Disuldes and antitumor action of BS-RNase (Eur J Biochem 270) 1985 Fig Autoradiography of SDS/PAGE runs of the labelled monomeric ... 16 h of incubation with PM, MSSAE was found to be totally converted into dimers When the incubation was carried out in the presence of 10 mM IAM, the product of Fig Gel-ltration analysis of the...

Ngày tải lên: 20/02/2014, 11:20

... The capacity of the drug to react with the genomic DNA is inversely proportional to the concentration of GSH The higher the GSH level, the lower the amount of drug–DNA adduct and vice versa The ... [39] The primary objective of the present study was to investigate further the reactivity of S23906-1 towards the bionucleophiles DNA and GSH The covalent binding of the drug to GSH reduced the ... polyacrylamide gels The results are displayed in Fig The alkylation of DNA is visualized by an important gel shift and the degree of retardation depends on the capacity of the drug to react with the competing...

Ngày tải lên: 20/02/2014, 11:20

... side of the main mouth of Orenoque are the Arwacas; and beyond them, the The Discovery of Guiana, by Sir Walter Raleigh 36 Cannibals; and to the south of them, the Amazons To make mention of the ... attain to the knowledge thereof, and yet they taught me the best way of healing as well thereof as of all other poisons Some of the Spaniards have been cured in ordinary wounds of the common ... that they might sack the Epuremei, and I asked them, of what? They answered, Of their women for us, and their gold for you For the hope of those many of women they more desire the war than either...

Ngày tải lên: 21/02/2014, 21:20

... level match-sets are the reference gels of the respective quadrants from the 2D gel sections of each condition and the four higher-level match-sets are the reference gels of the two different conditions ... [18] For example, the major role of the MMP family is the control of cellular responses critical to homeostatic regulation of the extracellular environment and the immune response [19,20] We decided ... gels of the same condition and thereafter to reference gels common to both conditions The stepwise annotation of protein spots to two independent levels of reference gels allowed for detection of...

Ngày tải lên: 07/03/2014, 06:20

... east-coast of Australia Of course, after the discovery of the west-coast of New Zealand and of the island-groups east of Australia [**], the existence of an east-coast of Australia to westward of the ... have the colonial policy of the E.I.C of the period to its full extent: commerce, increase of territory, colonies And these ideas were at the bottom of most of the voyages of discovery to the ... Coolsteerdt.-Further discovery of the South-West coast of New Guinea Discovery of the Gulf of Carpentaria (1623) XV Voyage of the ship Leiden, commanded by skipper Klaas Hermansz(oon) from the Netherlands...

Ngày tải lên: 15/03/2014, 03:20

... propose the structure shown in the lower part of Fig as the one corresponding to the compound inhibiting FAS Conrmation of the activity On the basis of these analytical studies, 70 mg of the compound ... prevents the immediate therapeutic application of this chemical family, the relevance of the inhibitors is still noticeable because of their high-afnity binding to the enzyme and the novelty of their ... well as in affording the synthesis of the molecule All of the 222 analogs selected failed to inhibit FAS when they were tested at 100 lm in the assay Furthermore, the newly synthesized molecule...

Ngày tải lên: 16/03/2014, 06:20

... the high point at the junction of the creek with the Yellowstone, one first gets some idea of the depth of the cañon through which the river runs From this height the sound of the waters of the ... some of the most interesting portions of the story, thus destroying in some measure the continuity of the narrative The office of the Western Monthly was destroyed by fire before the copies of the ... been following, from the base of the mountain, the trail of a band of elk that had crossed the line of travel of the pack train at a point near the base of the mountain, and in the dim twilight we...

Ngày tải lên: 24/03/2014, 02:20

... foretell the fortune of the householder or of some guest of his, or the upshot of the coming harvest, whether of the sea or of the land But everything must be exactly as she pleased There was ... soon as the spring comes." Then she told them of that good country of the tall trees, and the clear sky, of the dew which was sweet to the taste, of the vines tumbling over the hot rocks, the birds' ... ease The first things foretold by Thorberg came about with the quickening of the year With the first blowing of the warm wet wind of the west, the fogs began to roll away off the land and pile themselves...

Ngày tải lên: 24/03/2014, 03:21

... data with the identity of the market maker to examine the quoting behavior of the lead underwriter during the preopening period; the behavior of other market makers; the importance of the preopening ... Price t The indicative price at time t is taken as the average of the bid quotes and the average of the ask quotes during the 30-second interval If the preopening is efficient, then the slope ... and others later Besides the preference of the lead underwriter, characteristics of the individual offering also determine the opening time Therefore, we examine whether initial returns ~offer-to-open!...

Ngày tải lên: 23/04/2014, 16:09

... extra C Others have reported the effects on translation of particular regions of the 5' and 3' ends of the 5'UTR containing deletions [17,18] These and other reports, however, not cover the same ... by the outlining The inset shows the extent of the large deletions found in 313-T1b This figure is adapted from Lyons et al [23] The 5'UTR sequences of the samples containing deletions have the ... deletions is the subject of this study This patient had not yet undergone therapy, and therefore the deletions found in the patient were not induced by treatment Deletions of up to 18 bases in the 5'UTR,...

Ngày tải lên: 20/06/2014, 02:20

... superconductors the width of the insulator film should be of the order of 104 angstroms However, for high-Tc oxide superconductors, where the coherence length is of the order of the distance between ... to the order of magnitude of the energy gap below Tc If these experiments are confirmed, they should clearly indicate the presence of the same Cooper pairs above and below Tc Thus, the hypothesis ... the order of magnitude of the coherence length (the mean distance between two electron pairs) is in accordance with the order of magnitude of the distance between the electron clouds of two neighboring...

Ngày tải lên: 21/06/2014, 05:20

... incipient penetration of the magnetic flux into the alloy, a field of the onset of a gradual restoration of electrical resistance and a field of the complete transition of the alloy into the normal state ... to the axis of the cylinders (n = ½) The measurement of the magnetic field inside the samples was made over measurement of the electrical resistance of a miniature bismuth wire placed in the ... in the case of the magnetic field that ran parallel to the surface in the interval Hc2 < H

Ngày tải lên: 21/06/2014, 05:20

... raises the question of whether the Josephson transitions dominate in the transfer of the pair of 2D holes in the plane of the nanostructured δ - barriers and in the proximity effect due to the tunneling ... corresponding to the drops of the diamagnetic response on cooling is of importance to coincide with the drops of the resistance and the Seebeck coefficient thereby confirming the role of the charge ... effects at the values of the drain-source voltage used in the regime of coherent tunneling The amplitude of the MAR peaks observed, e2/h, appeared to be independent of the value of the drain-source...

Ngày tải lên: 21/06/2014, 05:20

... scattering properties are the direct reflection of the phonon behavior of MgB2 The parameters of Raman spectra vary with the composition of MgB2 crystals and the influence of their surroundings, which ... on both the connectivity and the disorder of the samples Furthermore, the disorder should be considered as composed of intrinsic and extrinsic parts based on their different sources The crystallinity ... and band filling, which reduces the density of states (DOS) and alters the shape of the Fermi surface The E2g phonon peak shifts to the higher energy side, and the peak is narrowed with increasing...

Ngày tải lên: 21/06/2014, 05:20