discovery of highly potent and selective bace 1 inhibitors

Ngày tải lên: 25/10/2012, 10:02

... Pittsburgh, PA 15 213 -2665 RAND URL: http://www.rand.org/ To order RAND documents or to obtain additional information, contact Distribution Services: Telephone: ( 310 ) 4 51- 7002; Fax: ( 310 ) 4 51- 6 915 ; Email: ... issues 27 0 3 17 19 0 0 1 2 Total number of issues addressed Average number per article/project 70 1. 1 1. 0 20 1. 5 Also shown in the table, the 13 newly funded challenge grantees have the potential ... Labor, State, and Veterans Affairs; Federal Bureau of Prisons; Federal Trade Commission; National Highway Transportation and Safety Administration; Office of Management and Budget; Office of Personnel...

Ngày tải lên: 18/02/2014, 01:20

... Pittsburgh, PA 15 213 -2665 RAND URL: http://www.rand.org To order RAND documents or to obtain additional information, contact Distribution Services: Telephone: ( 310 ) 4 51- 7002; Fax: ( 310 ) 4 51- 6 915 ; Email: ... project officer This work was conducted in RAND Health, a division of the RAND Corporation A profile of RAND Health, abstracts of its publications, and ordering information can be found at www.rand.org/health ... Partnerships, 2004 and 2006 50 Figure 5.2b Standards and Guidelines Partnerships, 2004 and 2006 51 Figure 5.2c Education and Training Partnerships, 2004 and 2006 51 Figure 5.2d...

Ngày tải lên: 15/03/2014, 22:20

... ssociation; 19 98: 211 –7 Cole MG, Yaffe MJ Pathway to psychiatric care of the elderly with d ­ epression Int J Geriatr Psych Feb 19 96 ;11 (2) :15 7– 61 Bland RC, Newman SC, Orn H Epidemiology of psychiatric ... Cochrane Database Syst Rev 2 011 ;10 :CD0076 21 Horga A, Castillo J, Montalban X Fingolimod for relapsing multiple sclerosis: An update Expert Opin Pharmacother May 2 010 ;11 (7): 11 83–96 Kappos L, Radue ... Scler Jul 2 011 ;17 (7):867–75 O’Connor P Natalizumab and the role of alpha 4-integrin antagonism in the treatment of multiple sclerosis Expert Opin Biol Ther Jan 2007;7 (1) : 12 3–36 10 Pucci E, Giuliani...

Ngày tải lên: 22/03/2014, 14:20

... (The present state of the art is represented by Kreps and Kunimoto, 19 94,; and Maibach and Parrott, 19 95.) In the next stage of the project, identifying critical examples of variations in text ... perception of and attitude to risk, and level of education are among the factors that must be considered when tailoring a message to an individual (Masi, 19 93,; Kreps and Kunimoto, 19 94) For example, ... particular system of on-line medical records will require the adaptation of our query format to that of the system Authoring and Generating Tailored Health-Education Documents 11 1 2.2 What’s in...

Ngày tải lên: 22/03/2014, 15:21

... time (min) 11 0.4 ± 18 .0 ( 71- 155) 11 6.0 ± 18 .8 (17 -17 6) 01 Estimated blood loss (mL) 11 1.6 ± 11 7.3 (10 -10 00) 17 6.7 ± 249.7 (25-2500) 01 Change in hemoglobin at discharge (gm/dL) -3 .1 ± 1. 1 (-5.7 ... for bilateral cases (12 7.4 minutes vs 11 2.7 minutes, P < 01) , tourniquet time (11 6.0 minutes vs 11 0.4 minutes, P = 01) , and estimated blood loss (17 6.7 mL vs 11 1.6 mL, P = 01) Intraoperative crystalloid ... 0 .13 (%) (0%) (0.7%) - (%) 30 (20.9%) 41 (27.2%) 11 (%) 10 0 (70.3%) 99 (65.6%) 90 BMI (kg/m2) (%) 13 (8.8%) 10 (6.7%) 55 Operative time (min) 11 2.7 ± 20.6 (77 -18 1) 12 7.4 ± 19 .7 (92-223) < 0.01...

Ngày tải lên: 20/06/2014, 04:20

... Satisfaction Score 83.4 81. 1 84 .1 89.6 84.9 13 .5 16 .9 15 .7 14 .3 10 .6 83.3 83.3 83.3 95.8 86.9 1. 0% 1. 0% 1. 0% 1. 0% 1. 0% 10 .7% 22.3% 28.2% 45.6% 4.8% 31 10 0 17 10 0 17 10 0 42 10 0 44 10 0 Floor = percent ... = 10 4) 65 .1 (10 .3) 67 (64.4%) (1. 0%) 36 (34.6%) 25 (24.0%) 77 (74.0%) (1. 9%) 17 (16 .3%) 19 (18 .3%) 61 (58.7%) (6.7%) (3.8%) 38 (36.5%) 31 (29.8%) 19 (18 .3%) 10 (9.6%) (1. 9%) 6.4 ± 7.0 16 (15 .4%) ... manuscript and participated in the study design, analysis and interpretation of findings All authors read and approved the final manuscript 11 12 13 14 15 16 17 National Institutes of Health:...

Ngày tải lên: 20/06/2014, 15:20

... Outcomes 2005, 3 (1) :9 10 Anonymous: ATS statement: guidelines for the six-minute walk test Am J Respir Crit Care Med 2002, 16 6 (1) :11 1 -11 7, 10 73-449 11 Borg GA: Psychophysical bases of perceived exertion ... Health and Quality of Life Outcomes 2 010 , 8 :13 5 http://www.hqlo.com/content/8 /1/ 135 Page of 18 Wilson KA, Dowling AJ, Abdolell M, Tannock IF: Perception of quality of life by patients, partners and ... al Health and Quality of Life Outcomes 2 010 , 8 :13 5 http://www.hqlo.com/content/8 /1/ 135 Page of Figure Blant and Altman plots showing the relationship between the scores of the patients and the...

Ngày tải lên: 20/06/2014, 15:20

... 11 ,60 1, 17 1, 33 7 4,79 5,37 1, 24 1, 13 47 Start of rehabilitation 1, 18 4,56 1, 33 57 End of rehabilitation 1, 80 5,32 1, 14 Cynicism 23 12 ,63 5 ,17 Trait anger 10 37 18 ,24 5, 01 2,94 0,72 HRQOL SF -12 : ... rehabilitation 1, 99 5,25 1, 10 SAQ: PL Start of rehabilitation 10 0 56,35 25,29 End of rehabilitation 10 0 61, 85 24,78 Start of rehabilitation 9,84 70 ,14 46,39 12 ,18 End of rehabilitation 11 , 81 75,37 51, 09 11 ,60 ... modelling Int J Epidemiol 2000, 29 :15 8 -16 7 Farin and Meder Health and Quality of Life Outcomes 2 010 , 8 :10 0 http://www.hqlo.com/content/8 /1/ 100 Page 11 of 11 67 Singh-Manoux A, Marmot MG, Adler...

Ngày tải lên: 20/06/2014, 16:20

... of important relationships and incorporations during development FIGURE 1- 1 Left-side view of urogenital system and cloacal region before subdivision of cloaca by urorectal septum Position of ... of several theories about the relative contributions of paramesonephric ducts and sinovaginal bulbs to the vagina (there is little consensus) 13 14 BENSON & PERNOLL’S HANDBOOK OF OBSTETRICS AND ... GYNECOLOGY The development of the female urogenital system is well under way by the fourth week after implantation, following the sequence shown in Figures 1- 1, 1- 2, 1- 3, and 1- 4 The external female...

Ngày tải lên: 05/08/2014, 16:20

... Cytokinesis and Interphase by Profilin Microinjection Plant Cell 19 97, 9 :18 15 -18 24 17 Witke W: The role of profilin complexes in cell motility and other cellular processes Trends Cell Biol 2004, 14 :4 61- 469 ... families and possess a restricted number of biochemical functions J Allergy Clin Immunol 2008, 12 1:847-852 doi :10 .11 86 /17 10 -14 92-6 -1 Cite this article as: Hauser et al.: Panallergens and their ... Clinical Immunology 2 010 , 6 :1 http://www.aacijournal.com/content/6 /1/ 1 Page 11 of 14 Table Classification of plant allergen families according to their patterns of distribution and IgE cross-reactivity...

Ngày tải lên: 08/08/2014, 21:20

... (86%), 10 q 21 (50%), 12 q (57%) and Xp22 (50%), and losses at 5q 21 (50%), 6q14- 21 (64%), 8p 21 (93%), 13 q1322 ( 71% ), 16 q22-24 (57%), 17 p13 -11 (79%), 21q22 (50%) and 22q13 (50%) Loss of 8p 21 (in 13 out ... the common ancestor of all tumors Letouzé et al Genome Biology 2 010 , 11 :R76 http://genomebiology.com/2 010 /11 /7/R76 Page of 19 Figure Evaluation of the performance of TuMult and the parsimony method ... specific events and is poorly representative of the initial tumor progression step By Letouzé et al Genome Biology 2 010 , 11 :R76 http://genomebiology.com/2 010 /11 /7/R76 Page 11 of 19 Figure Metastases...

Ngày tải lên: 09/08/2014, 20:22

... Plopper C, Vanderlei F, Brandão LG: Recurrent laryngeal nerve: a plexus rather than a nerve? Arch Otolaryngol Head Neck Surg 2009, 13 5 (11 ) :10 98 -11 02 Randolph GW: Surgical anatomy of the recurrent ... rate of postoperative transient or permanent recurrent laryngeal nerve palsy? World J Surg 2009, 33(2):2 61- 265 doi :10 .11 86 /17 52 -19 47-5-266 Cite this article as: Gurleyik: Three variations of the ... and autopsy series [1- 3 ,10 ] Macroscopically discovered terminal division of the nerve during thyroid operations has a prevalence of 18 -36% [2,3,9 ,10 ] Bilateral bifurcation of both RLNs is relatively...

Ngày tải lên: 10/08/2014, 23:21

... Research and Development 2005, 6 :13 7 -14 8 Department of Health: The Expert Patient: A new approach to chronic disease management in the 21st Century The Stationery Office 20 01 Department of Health: ... eight courses, an average of five courses were planned with a mean budget of £9,000 They have an average of three active tutors, and Leads dedicate an average of 21% of their working week to the ... requirement, an average of four courses have been planned with a mean budget of £8,000 They have an average of two active tutors, and Leads dedicate an average of 15 % of their working week to...

Ngày tải lên: 11/08/2014, 05:22

... cytometry, allowing counting of molecules per cell), and T-cell cytokine profiling (differentiation of type 1/ 2 cytokine patterns by intracellular cytokine staining and flow cytometric analysis) ... Wochenschr 19 99, 12 4: 15 27 -15 29 Volk HD, Zuckermann H, Kox W, Woicieczowsky CH, Hoeflich C, Buhl K, Graeta G, Doeckel I, Reinke P: Immune monitoring and strategies for immune modulation In Molecular and ... (endotoxin desensitization, TNF-induced IL -10 and IL -1 receptor antagonist release, etc.) Inflammation- and hypoxia-related tissue injury results in release of apoptotic cells, which are taken up...

Ngày tải lên: 12/08/2014, 18:21

... chloride 11 8 mmol/l, carbon dioxide 17 .8 mmol/l, blood urea nitrogen 18 mg/dl, and creatinine 1. 1 mg/dl, the latter representing an improvement The glucose was 17 0 mg/dl, phosphate was down to 1. 4 ... department (ED) revealed a temperature of 97°F (36 .1 C), a heart rate of 18 0 beats/min, and blood pressure of 12 0/60 mmHg His respirations were labored at 26 breaths/min, and oxygen saturation was 89% ... hyperdynamic sepsis with induced changes in arterial perfusing pressures and metabolic need Crit Care Med 19 93, 21: 119 2 -11 99 Brandstrup B, Tonnesen H, Beier-Holgersen R, Hjortso E, Ording H, Lindorff-Larsen...

Ngày tải lên: 12/08/2014, 20:20

... board of Pulsion Medical Systems (Munich, Germany) and iMDsoft (Tel Aviv, Israel), and has intellectualproperty rights with Drager-Siemens (Lubeck, Germany) References 10 11 12 13 14 15 16 17 18 ... lactate levels [16 -18 ], higher central venous pressure (CVP) values (10 rather than mm Hg) [18 ,19 ], and lower mortality rates [17 -19 ] The authors of these recent studies [17 -19 ] have commented ... intensive care unit (ICU) [16 -18 ] In two of these studies [17 ,18 ], the mean ScvO2 was 72% to 74%; in one of them [18 ], only out of 12 5 patients (6%) had an ScvO2 value below 60% and only patient had...

Ngày tải lên: 13/08/2014, 11:22

... Laupland K: The epidemiology of intensive care unit-acquired hyponatremia and hypernatremia in medical–surgical intensive care units Crit Care 2008, 12 :R162 Page of (page number not for citation ... Care Vol 13 No Eghtesadi-Araghi et al Competing interests The authors declare that they have no competing interests Reference Stelfox HT, Ahmed SB, Khandwala F, Zygun D, Shahpori R, Laupland K:...

Ngày tải lên: 13/08/2014, 15:21

... Berger and Soguel Critical Care 2 010 , 14 :12 3 http://ccforum.com/content /14 /1/ 123 prompted them to analyse patients adjusted for severity and to analyse by intent-to-treat due to the 14 patients ... Service of Adult Intensive Care and Burns Centre, University Hospital (CHUV), Rue du Bugnon 46, 10 11 Lausanne, Switzerland University of Applied Sciences Western Switzerland (HES-SO), School of Health ... platinum standard for trials? Randomisation doesn’t guarantee similarity of groups; minimisation does BMJ 19 98, 317 :362-363 Drenth JP, Engels LG: Diabetic gastroparesis A critical reappraisal of new...

Ngày tải lên: 13/08/2014, 20:21