digging deeper into the current state of affairs
Báo cáo y học: "980 nm diode lasers in oral and facial practice: current state of the science and art"
Ngày tải lên :
26/10/2012, 09:48
... Following the suggestions of scientific literature on the advantages of the compactness, reliability, ease of use and affordability of the 980 nm Diode Lasers, we evaluated the efficacy and safety of ... are reduced [17,18] The lasers normally adopted offer the enormous advantage of being conveyed in a fibre, which serves as the working tip at the end of the handpiece The use of flexible, length-adjustable ... intelligent machines" can replace "the brain and hand, skill and experience" of the specialist The aim of this study was to verify the reliability and efficacy of one of these compact portable diode...
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The State of Affairs Explorations in Infidelity and Commitment pptx
Ngày tải lên :
22/03/2014, 15:21
... way of referring to these kinds of affairs is in terms of "the eternal triangle" involving a married couple and the lover of one of the partners Some family therapists build upon the notion of ... begin to move out of the micro-politics of the affair and its immediate social context into more general issues of the politics of gender THE SEXUAL POLITICS OF THE AFFAIR Much of the discussion ... different cages They forgave each other what they were ashamed of in their past, they forgave everything in the present, and felt that this love of theirs had altered them both Then they spent a...
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The 2011 State of Inbound Marketing
Ngày tải lên :
09/02/2014, 20:56
... ‗do-not-call‘ lists) tuned these interruptive campaigns out For more information about the survey please see the appendix HubSpot.com THE STATE OF INBOUND MARKETING The State of Marketing Costs & Budgets ... Year: HubSpot.com 17 THE STATE OF INBOUND MARKETING Respondent Profiles The State of Inbound Marketing report is based on surveys conducted in early 2009, 2010, and 2011 The 2011 results are ... complements the way buyers make purchasing decisions today—they are using the Internet to learn about the products and services that best meet their needs Inbound marketers offer their audiences...
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Tài liệu University Oars Being a Critical Enquiry Into the After Health of the Men Who Rowed in the Oxford and Cambridge Boat-Race, from the Year 1829 to 1869, Based on the Personal Experience of the Rowers Themselves pdf
Ngày tải lên :
14/02/2014, 21:20
... rows in the race ought to live till the age of 60; and if all the members of the Oxford 1829 crew had lived till the 10th of June, 1869, the 40th anniversary of the race, and then died, their lives ... Matches came off, in which 32 crews competed In the case of each of these crews I have calculated the probable duration of life of the different Oarsmen of whom they were composed: the following ... expectation of life of each one of them, according to Dr Farr's Tables, would then be 14 years, the value of the five lives together being 70 years On adding these 70 years of estimated life to the years...
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Tài liệu Báo cáo khoa học: Salt-induced formation of the A-state of ferricytochrome c – effect of the anion charge on protein structure docx
Ngày tải lên :
19/02/2014, 05:20
... in favor of the LS (IHM) A -state (that characterized by the native Met80–heme bonding) In the case of the K88E ⁄ T89K mutant, the presence of a relevant amount of LS species already in the aciddenatured ... destabilization of the HS acid-denatured form, with further formation of the LS (IHH) A -state; (b) for the slow phase, to formation of the LS native-like (IHM) A -state Unlike wild-type cytochrome c, once the ... been marked, for the sake of image clarity the positively charged clusters located on the protein surface [11] The distribution of lysines around the heme crevice at the ‘front’ of the molecule is...
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Tài liệu Báo cáo khoa học: nsights into the reaction mechanism of glycosyl hydrolase family 49 Site-directed mutagenesis and substrate preference of isopullulanase doc
Ngày tải lên :
19/02/2014, 16:20
... composed of residues 25–540 The overall structure of the model of IPU and the mutated residues in this study are shown in Fig To elucidate the mechanism of the substrate recognition of IPU, two ... a-(1fi4)-linked glucose units of pullulan (Fig 4A) IPU is an anomer-inverting enzyme Comparison of the active sites of the model of IPU and Dex49A The active site structures of the model of IPU (Fig 4A) and ... and the original StyI–XbaI fragment of pIPA118(–) was replaced with the mutated StyI–XbaI fragment The EcoRI–BamHI fragments of these plasmids were further subcloned into pHIL-S1 Expression of...
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Tài liệu Báo cáo Y học: Insights into the reaction mechanism of Escherichia coli agmatinase by site-directed mutagenesis and molecular modelling ppt
Ngày tải lên :
21/02/2014, 01:21
... one of the manganese ions This, together with the fact that the positions of other Fig Scheme of the binuclear manganese cluster and the localization of the side-chains of Asp153 and Asn153 in the ... affected by the mutation, as revealed by the conservation of the whole topology of the active site, would explain the essentially unaltered interaction of the D153N variant with the metallic cofactor ... indicating that the environment of tryptophan residues is essentially conserved in the mutant enzyme On the other hand, the absence of major differences in the CD spectra of the wild-type and...
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Báo cáo khoa học: Human telomeric G-quadruplex: The current status of telomeric G-quadruplexes as therapeutic targets in human cancer pdf
Ngày tải lên :
06/03/2014, 09:22
... judged by the observations of hPOT1 and hTERT uncapping To date, none of these molecules has progressed beyond the experimental stage into clinical trial, probably in part because these compounds ... representative of the totality of the single-stranded overhang, and which may be important for these ligands being able to differentiate telomeric quadruplexes from others in the genome It has ... [19] because it ensures that the 3¢-end is inaccessible to hybridize with the telomerase RNA template, the essential first step in the catalytic cycle The induction of quadruplex stabilization...
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The 2011 State of Inbound Marketing docx
Ngày tải lên :
06/03/2014, 21:20
... ‗do-not-call‘ lists) tuned these interruptive campaigns out For more information about the survey please see the appendix HubSpot.com THE STATE OF INBOUND MARKETING The State of Marketing Costs & Budgets ... Year: HubSpot.com 17 THE STATE OF INBOUND MARKETING Respondent Profiles The State of Inbound Marketing report is based on surveys conducted in early 2009, 2010, and 2011 The 2011 results are ... complements the way buyers make purchasing decisions today—they are using the Internet to learn about the products and services that best meet their needs Inbound marketers offer their audiences...
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Báo cáo khoa học: A novel metallocarboxypeptidase-like enzyme from the marine annelid Sabellastarte magnifica – a step into the invertebrate world of proteases pdf
Ngày tải lên :
07/03/2014, 02:20
... extract (i.e not in the zymogen state) It is worth noting that the apparent simplicity of the MALDI-TOF spectrum of the extract shown in Fig 2C is most likely caused not only by the low expansion ... appeared in the analysis of both parts of the animal, with a major presence of bands in the body (upper part) versus the crown (lower part) In Fig 3, we show, in the uncombined (Fig 3A,B) or in the combined ... to hydrolyze the first of such C-terminal residues, glutamic acid, even after 60 of incubation Again, the addition of rPCI prevented any kind of hydrolysis by the enzyme The release of a glutamic...
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Báo cáo khoa học: Structural and thermodynamic insights into the binding mode of five novel inhibitors of lumazine synthase from Mycobacterium tuberculosis pptx
Ngày tải lên :
07/03/2014, 11:20
... isotherms for the inhibitors (F) The lled circles in the binding isotherms represent the experimental values of the heat change at each injection; the continuous lines represent the results of the ... oxygen atoms of Ala59 and Glu61 of one subunit and with the main chain nitrogen of Asn114Â of the other subunit The contacts of the ribityl chain to His89 and Lys138Â are mediated by a net of water ... side and the conformation of the loop connecting b4 with a3 (residues 8588) from the other side In the MbtLS TS44 complex (PDB code 1W19), the phosphorus atom of the phosphate group of TS44 ...
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Báo cáo khóa học: Insight into the activation mechanism of Bordetella pertussis adenylate cyclase by calmodulin using fluorescence spectroscopy pptx
Ngày tải lên :
07/03/2014, 15:20
... AC–CaM (m) The degree of binding of the ligand was calculated from the value of the amplitude of the long lifetime, which characterizes the bound fluorescent nucleotide Fig Stern–Volmer plots of time-resolved ... are, respectively, the values of the center and the normalized amplitude of each lifetime peak c Ii are the values of the partial P intensity of the ith component Ii ¼ aisi/ d The mean lifetime ... all of the residues of the catalytic mechanism are present in the neighborhood of the catalytic site, but they are not ordered correctly in the exotoxin alone CaM binding folds parts of the regulatory...
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Báo cáo khoa học: Modulation of nitric oxide-mediated metal release from metallothionein by the redox state of glutathione in vitro doc
Ngày tải lên :
07/03/2014, 15:20
... increased the cadmium release by nitric oxide The decay occurs in the first 10 after the addition of NO as observed by monitoring the CD at the maximum of the charge transfer band at 260 nm (Fig 1B) The ... 260 nm is reduced clearly after the addition of NO, indicating the breaking of cadmium-cysteine bonds and therefore release of cadmium The presence of GSH reduces the metal release almost completely, ... function in the stimulation of guanylyl cyclase requires the presence of reduced glutathione [39] To elucidate the possible role of peroxynitrite in the metal release from MTs in the presence of reduced...
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Báo cáo khoa học: Spectroscopic and kinetic properties of the horseradish peroxidase mutant T171S Evidence for selective effects on the reduced state of the enzyme potx
Ngày tải lên :
07/03/2014, 21:20
... intriguing and specic to the reduced state of the enzyme The Fe(II) state of the enzyme has features in common with both the Phe221Met mutant and Ca-depleted proteins whilst the Fe(III) state is essentially ... that are mediated exclusively on the reduced state of the enzyme We hypothesize that this residue imposes a degree of rigidity to the structure of the reduced state of class III peroxidases Results ... way to the wild type [16,17] The pKa for the alkaline transition being similar to that of the wild type, % 11.1 [18] Finally, comparison of the X-ray structures of the oxidized forms of the native...
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Báo cáo Y học: Incorporation of 3-nitrotyrosine into the C-terminus of a-tubulin is reversible and not detrimental to dividing cells potx
Ngày tải lên :
17/03/2014, 10:20
... presence of a nitrotyrosine residue in place of tyrosine at the C-terminus of a-tubulin does not alter the ability of the protein to assemble into or disassemble from microtubules Kinetics of release ... determine whether the reversible incorporation of 3-nitrotyrosine into tubulin is restricted to C6 cells, we tested six other cell lines for the nitrotyrosination state of tubulin during a cycle of nitrotyrosination ... viability of cells were determined every day The number of cells increased during the first two days and then remained constant or increased slightly (Fig 3B) At any given time, the majority of the...
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the fourth state of matter an introduction to plasma science - eliezer
Ngày tải lên :
17/03/2014, 14:59
... center of mass and the energy of motion is proportional to the sum of the squares of the speeds of the molecules The observer inside the moving vehicle calculates the gas temperature by measuring the ... above encouraged us to write the second edition of The Fourth State of Matter The aim of the second edition is to bring The Fourth State of Matter up to date in the light of progress Sometimes progress ... speed of all the cars moving north and divide the result by the number of cars The result is the center -of- mass velocity In order to calculate the speed of the cars relative to the center of mass,...
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atomic reforming the business landscape into the new structures of tomorrow
Ngày tải lên :
03/06/2014, 01:21
... critical They include the outcome of various studies that the authors have been involved with over a number of years with a variety of partners They also include a study of the works of a number of ... means the downfall of the corporation you work for Don’t believe us? The printing press nearly killed off one of the largest corporations in history – the Catholic Church At the start of the sixteenth ... live and work In fact, they are revolutionizing it The outcome of this fact is that the balance of power in the business world is shifting In very short order, the theory of the firm is going to...
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báo cáo hóa học:" More insights into the immunosuppressive potential of tumor exosomes" pptx
Ngày tải lên :
18/06/2014, 15:20
... then a further pathway to the potential modulating properties of these peculiar organelles If tumor exosomes are such a powerful instrument of environmental shaping, then getting rid of them should ... hypothesized that this pathway may contribute to the in vivo moulding of immune as well as other cancer-related host responses More recent studies have then reported that the detrimental effect of ... fact, we have more recently observed that the presence of tumor exosomes during monocyte differentiation into DC skews the whole process toward the generation of aberrant cells expressing myeloid...
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Diving Into the Deep End of the Internal Talent Pool doc
Ngày tải lên :
27/06/2014, 14:20
... ensure that the development activities are, in fact, improving employee performance At this point in the process all of your hard work of identifying and defining competencies pays off You have ... employees are the ones that excel at the competencies that you develop and show potential for assuming more responsibility within the organization It is crucial that the organization identify these employees ... sooner than later If they are valuable to your organization, then they could also be valuable to your competition and may be sought out for other positions So, how you find these high potential...
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Diving Into the Deep End of the Internal Talent Poo docx
Ngày tải lên :
27/06/2014, 16:20
... ensure that the development activities are, in fact, improving employee performance At this point in the process all of your hard work of identifying and defining competencies pays off You have ... employees are the ones that excel at the competencies that you develop and show potential for assuming more responsibility within the organization It is crucial that the organization identify these employees ... sooner than later If they are valuable to your organization, then they could also be valuable to your competition and may be sought out for other positions So, how you find these high potential...
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