differential genetics of renal cell tumors

Báo cáo hóa học: " Differential sensitivity of melanoma cell lines with BRAFV600E mutation to the specific Raf inhibitor PLX4032" potx

Ngày tải lên : 18/06/2014, 16:20

... inhibition of pErk, although one of the cell lines (M263) had lower inhibition of pErk than the rest There was no pErk inhibition in two cell lines with NRAS Q61L mutation (M202 and M207) and a cell ... MAPK pathway in melanoma cell lines with the BRAFV600E mutation We tested the ability of PLX4032 to differentially block MAPK pathway signaling in a panel of human melanoma cell lines (Table 1) by ... inhibition of phosphorylated Erk (pErk), a downstream target of B-Raf activity, using intracellular phosphospecific flow cytometry (Figure 1A) As expected, cell lines with BRAFV600E Page of 11 mutation...

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báo cáo hóa học:" Role of the VEGF-Flt-1-FAK pathway in the pathogenesis of osteoclastic bone destruction of giant cell tumors of bone" pptx

Ngày tải lên : 20/06/2014, 04:20

... migration of these cells into the lesion at the site of bone destruction in GCTs We recently showed that VEGF stimulates the chemotaxis and cell proliferation of RAW cells, a model of mouse OPCs ... article as: Matsumoto et al.: Role of the VEGF-Flt-1-FAK pathway in the pathogenesis of osteoclastic bone destruction of giant cell tumors of bone Journal of Orthopaedic Surgery and Research ... confocal laser scanning microscopy Tissue culture of giant cell tumors of bone Primary cultures of GCTs were obtained from surgical samples of lytic bone lesions As previously described [6],...

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báo cáo hóa học:" Role of the VEGF-Flt-1-FAK pathway in the pathogenesis of osteoclastic bone destruction of giant cell tumors of bone" potx

Ngày tải lên : 20/06/2014, 07:20

... migration of these cells into the lesion at the site of bone destruction in GCTs We recently showed that VEGF stimulates the chemotaxis and cell proliferation of RAW cells, a model of mouse OPCs ... article as: Matsumoto et al.: Role of the VEGF-Flt-1-FAK pathway in the pathogenesis of osteoclastic bone destruction of giant cell tumors of bone Journal of Orthopaedic Surgery and Research ... confocal laser scanning microscopy Tissue culture of giant cell tumors of bone Primary cultures of GCTs were obtained from surgical samples of lytic bone lesions As previously described [6],...

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Báo cáo khoa học: "Haemostatics in surgery and our experience in the enucleoresection of renal cell carcinoma" ppt

Ngày tải lên : 09/08/2014, 03:21

... tomography, the depth of penetration of tumors ranged from to cm (median 1,9 cm), without a direct contact with the upper excretory urinary tract (renal pelvis) in each of the patients enrolled ... crucial to get a better understanding of the genesis of those reactions Ahead of its time are, on one hand, the recently applications of HAs in the premature rupture of membranes where the adhesive ... which compare the use of a HA and of the ISC in the enucleoresection of RCC The recent evidence related to the NSS capable, in selected cases, to offer the same results of partial and radical...

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báo cáo khoa học: "Effect of arginase II on L-arginine depletion and cell growth in murine cell lines of renal cell carcinoma" pptx

Ngày tải lên : 10/08/2014, 22:20

... possible the growth of renal cell carcinoma cells is arginase II independent resulting in the low inhibitory effect of nor-NOHA Page of 10 (page number not for citation purposes) Journal of Hematology ... from the tissue culture supernatants of murine renal cell carcinoma cell lines and determine their effect on cell proliferation In adult mammals, the majority of endogenous L-arginine is synthesized ... arginase inhibitor nor-NOHA on cell proliferation Effect of3 Effect of arginase inhibitor nor-NOHA on cell proliferation (A) Proliferation of CL-2, CL-19 and Renca cells was assessed by [3H]-thymidine...

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báo cáo khoa học: "SMI of Bcl-2 TW-37 is active across a spectrum of B-cell tumors irrespective of their proliferative and differentiation status" pptx

Ngày tải lên : 10/08/2014, 22:20

... WSU-pre-ALL cell line (A1); WSU-DLCL2 cell line (A2); WSU-FSCCL cell line (A3) and WSU-WM cell line (A4) Cell lines were seeded in 24-well culture clusters at a density of × 105 viable cells/ml ... complexity in B -cell tumors Our results presented here, show that small-molecule inhibitors of the Bcl-2 family proteins has a therapeutic role in a wide spectrum of B -cell tumors All four cell lines ... deaths of any of the animals and no more than 10% loss of body weight during treatment, followed by weight gain To test the efficacy of Page of 13 (page number not for citation purposes) Journal of...

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báo cáo khoa học: "Atypical presentations and rare metastatic sites of renal cell carcinoma: a review of case reports" pptx

Ngày tải lên : 10/08/2014, 23:20

... pattern of renal tumors and account for the late appearance of metastatic disease in organs and sites that are considered outside of the “usual” metastatic pathway of RCC Rare metastatic sites of renal ... the considered usual chain of metastatic spread of renal tumors For that reason we excluded all sites of common metastases from renal tumors, including the lungs, adrenals, intestines and brain ... in the last five years) Out of these, 17 cases were metastasis of RCC of clear cell type Six of these cases were diagnosed as primary ovarian clear cell cancer, while renal primary was diagnosed...

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Báo cáo y học: "Atypical presentation of renal cell carcinoma: a case report" doc

Ngày tải lên : 11/08/2014, 10:22

... is a picture of renal ultrasound It shows echo-dense area in the renal area, suggestive of a renal tumour Renal Cell Carcinoma in the form of hoarseness or calverial metastasis of which only ... have been reported [3,4] Renal cell carcinoma represents a heterogenous group of tumors, the most common of which is clear cell adenocarcinoma RCC accounts for 3% of adult tumors The incidence has ... presentation of Renal Cell Carcinoma- a report of two cases and review of literature Clinical Neurology and Neurosurgery 2005, 107:329-333 Page of (page number not for citation purposes) Journal of Medical...

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báo cáo khoa học: " Epigenetics of renal cell carcinoma: the path towards new diagnostics and therapeutics" pps

Ngày tải lên : 11/08/2014, 12:20

... [31] and occur in 45 to 90% of sporadic RCCs [4,32,33] Inactivation of the 3p25 TSG VHL is of critical importance to the pathogenesis of ccRCC and occurs in up to 86% of tumors [34] Although VHL ... knowledge of the molecular pathogenesis of RCC will increase and with it the potential for developing novel biomarkers and potential therapeutic interventions Abbreviations ccRCC, clear cell renal cell ... Author details Renal Molecular Oncology Group, Medical and Molecular Genetics, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham,...

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Báo cáo y học: " Tongue metastasis as an initial presentation of renal cell carcinoma: a case report and literature review" pps

Ngày tải lên : 11/08/2014, 21:22

... Disappearance of metastatic renal cell carcinoma to the base of the tongue after systemic administration of interferon-α Eur Urol 1993, 24:297-299 Page of (page number not for citation purposes) Journal of ... tissue leading to diagnosis of renal adenocarcinoma J Laryngol Otol 1994, 108:1108-1110 Aguirre A, Rinaggio J: Lingual metastasis of renal cell carcinoma J Oral Maxillofac Surg 1996, 54:344-346 ... 30% of patients with renal carcinoma present with metastatic disease, 25% with locally advanced renal carcinoma, and 45% with localized disease [1] About 75% of patients with metastatic renal...

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Báo cáo y học: " Oral cavity metastasis of renal cell carcinoma: A case report" pdf

Ngày tải lên : 11/08/2014, 21:22

... to tumor ulceration of secondarycarcinoma ;cell infiltrationmucosal epithelium noted Renal cell Renal cell carcinoma; ulceration of mucosal epithelium noted secondary to tumor cell infiltration ... surrounded of rich cell carcinoma; epithelial cellular network2shown with clear vascular network Histologic featuresin arenalcytoplasm and hyperchromatic Histologic features of renal cell carcinoma; ... SN: Renal cell carcinoma to the base of tongue: a case report Hinyokika Kiyo 2004, 50(11):791-793 Phillips CK, Taneja SS: The role of lymphadenectomy in the surgical management of renal cell...

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Báo cáo y học: " Late pulmonary metastases of renal cell carcinoma immediately after post-transplantation immunosuppressive treatment: a case report" pps

Ngày tải lên : 11/08/2014, 23:21

... Persistence of circulating tumor cells may represent residual disease and is known to be associated with a higher risk of recurrence; however, the status of tumors during the period of dormancy ... existence of a more complex picture of immunosurveillance, which includes an active role of the immune system also in facilitating immunoselection of malignant cells and the emergence of tumor ... identification of the site of origin of unknown primary tumor, and for determination of donor-recipient origin in posttransplant lymphoproliferative disorders Microsatellites are short runs of tandemly...

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Báo cáo y học: "Population genetics of cancer cell clones: possible implications of cancer stem cells" pptx

Ngày tải lên : 13/08/2014, 16:20

... different cell types, b and g describe the degree of self-inhibition, c and f describe the degree of inhibition of the other cell type, r is the intrinsic rate of increase of each cell type and ... by comparison of the relative strength of selection with non-stem cells could furthermore provide a method of testing the relative strength of selection of stem cells and non-stem cells and thereby ... the majority of cancer cells die as a tumour grows Surgical pathologists regularly see the morphological evidence of this cell death in the form of tumour cell necrosis and apoptotic cells Additional...

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The molecular epidemiology of renal cell carcinoma subtypes and prognosis

Ngày tải lên : 11/09/2015, 09:56

... Chromophobe RCCs account for about 4-8% of all renal tumours, with a more favorable prognosis relative to clear cell renal cell carcinoma, which comprises the majority of all RCCs (Cheville et al 2003) ... benign renal tumour, comprising 5-8% of resected renal masses The overlapping characteristics of these entities may be explained by a possible common origin from the intercalated cells of the ... survival outcomes in patients with renal cell carcinoma; SPECIFIC AIMS (MOLECULAR MODELS) To evaluate the molecular profiles of three primary subtypes of RCC clear cell RCC, papillary RCC and chromophobe...

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Báo cáo khoa học: Expression of cholinesterases in human kidney and its variation in renal cell carcinoma types pdf

Ngày tải lên : 06/03/2014, 22:21

... according to the Heidelberg Classiﬁcation of Renal Cell Tumours [2] Seven specimens of pRCC, seven of cRCC, six of chRCC, and six of RO, besides adjacent pieces of unaffected tissue, were used in this ... chromosomes, mutations of p53, LOH at 10q23.3 and telomere shortening have been reported [6] RO consists of mixtures of cells with normal and abnormal karyotypes [7] About 4% of renal cancers arise ... reticulum of mesangial cells and for butyrylcholinesterase in the reticulum of endothelial cells [32] Thus, it is likely that epithelial, mesangial and endothelial cells can all contribute to renal...

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báo cáo hóa học:" Phase II trial of Modified Vaccinia Ankara (MVA) virus expressing 5T4 and high dose Interleukin-2 (IL-2) in patients with metastatic renal cell carcinoma" pot

Ngày tải lên : 18/06/2014, 15:20

... http://www.translational-medicine.com/content/7/1/2 Figure Characterization of T cell responses Characterization of T cell responses (A) CD8+CD107a+ effector cells, (B) CD8+perforin+ effector cells, (C) PD-1+ T cells, (D) CD4+CD25+FoxP3+ Tregs ... imaging Two of these patients had complete regression of metastatic disease but had large primary renal tumors in place Primary tumors are known to be more resistant to immunotherapy and often require ... PL, Hawkins RE: Expression of the 5T4 oncofoetal antigen in renal cell carcinoma: a potential target for T -cell- based immunotherapy Br J Cancer 2005, 93:670-677 Page 10 of 11 (page number not for...

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báo cáo hóa học:" Epigenetic control of the ubiquitin carboxyl terminal hydrolase 1 in renal cell carcinoma" doc

Ngày tải lên : 18/06/2014, 15:20

... the differentiation of renal tubules representing the origin of clear cell renal cell carcinoma (RCC) and in the regulation of the cell cycle of parietal epithelial cells of the Bowman's capsule ... pathophysiological situations of the kidney such as acute ischaemic renal failure, renal hypertrophy, von Hippel Lindau (VHL) disease as well as neoplastic transformation of renal cells it may play a fundamental ... Bruine AP, van Engeland M: Genetics and epigenetics of renal cell cancer Biochim Biophys Acta 2008, 1785:133-155 Brena RM, Huang TH, Plass C: Quantitative assessment of DNA methylation: Potential...

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Báo cáo sinh học: "Comparisons of three polyethyleneimine-derived nanoparticles as a gene therapy delivery system for renal cell carcinoma" doc

Ngày tải lên : 18/06/2014, 19:20

... prospect in future Methods Cell Lines The human CCRCC cell line OS-RC-2 and mouse macrophage cell line Ana-1 were purchased from the Institute of Cell Biology, Chinese Academy of Sciences (Shanghai, ... methods [20], the renal cancer cell line, phagocytic cells and endothelial cells were used to detect the toxicity of three modified PEI-derived materials in vitro The OS-RC-2 cells were seeded ... half of cells were alive with 200 μg/ml 2-kD PEI treatment, while 60% cells had viability even exposed to more than 200 μg/ml of FAPEAs or HPEI Generally, for OS-RC-2 cells, the cytotoxicity of...

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Báo cáo sinh học: "Characterization and targeting of phosphatidylinositol-3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in renal cell cancer" docx

Ngày tải lên : 18/06/2014, 22:20

... Journal of Translational Medicine 2011, 9:133 http://www.translational-medicine.com/content/9/1/133 Page of 10 Figure Effects of NVP-BEZ235 on renal cell carcinoma cells in vitro Targets of NVP-BEZ235, ... Classification of renal cell carcinoma based on expression of VEGF and VEGF receptors in both tumor cells and endothelial cells Lab Invest 2008, 88:962-972 Camp RL, Chung GG, Rimm DL: Automated subcellular ... percent of the viability of the untreated (control) cells Activity of the dual PI3K-mTOR inhibitor NVP-BEZ235 in RCC cell lines Given the synergism seen between the LY294002 and rapamycin in RCC cell...

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Báo cáo hóa học: " Trichloroethylene exposure and somatic mutations of the VHL gene in patients with Renal Cell Carcinoma" potx

Ngày tải lên : 20/06/2014, 00:20

... with 15 mM of MgCl2, 0.8 mM of dNTP mix, 0.3 µM of each forward and reverse primers and 0.5 U of HotStarTaq® DNA Polymerase (Qia- Page of (page number not for citation purposes) Journal of Occupational ... (12 of 17) of the formalin-fixed samples, and 38% (10 of 26) of the Bouin's fixed tissues Thus, the VHL gene was entirely sequenced (ie 100% of the coding sequence analysed) for a total of 26 ... compare exposed and non exposed cases of clear cell RCC in terms of prevalence of mutations in both groups Page of (page number not for citation purposes) Journal of Occupational Medicine and Toxicology...

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