difference between acute and chronic myeloid leukemia

... the past by the Food and Drug Administration (FDA) for marketing based on trials using the FAB criteria. Acute Myeloid Leukemia Incidence The incidence of acute myeloid leukemia (AML) is ... years after exposure, and affected individuals have aberrations in chromosomes 5 and 7. Topoisomerase II inhibitor–associated leukemias occur 1–3 years after exposure, and affected individuals ... recent literature and some ongoing studies use the FAB classification, a description of this system is also provided in Table 104-1. A major difference between the WHO and FAB systems is the...

Ngày tải lên: 07/07/2014, 04:20

... Acute myelomonocytic leukemia Acute monoblastic and monocytic leukemia Acute erythroid leukemia Acute megakaryoblastic leukemia Acute basophilic leukemia Acute panmyelosis ... myelofibrosis Myeloid sarcoma French-American-British (FAB) Classification c Incidence M0: Minimally differentiated leukemia 5% M1: Myeloblastic leukemia without maturation 20% M2: Myeloblastic leukemia ... Myelomonocytic leukemia 20% M4Eo: Variant: Increase in abnormal marrow eosinophils M5: Monocytic leukemia 10% M6: Erythroleukemia (DiGuglielmo's disease) 4% M7: Megakaryoblastic leukemia...

Ngày tải lên: 07/07/2014, 04:20

... Continuous activation of Flt3 and downstream target kinases, including signal transducer and Chapter 104. Acute and Chronic Myeloid Leukemia (Part 3) Immunophenotype and Relevance to the WHO ... associated with younger age are t(8;21) and t(l5;17); with older age, del(5q) and del(7q). Myeloid sarcomas (see below) are associated with t(8;21) and disseminated intravascular coagulation ... for separating AML from acute lymphoblastic leukemia (ALL) and identifying some types of AML. For example, AML that is minimally differentiated (immature morphology and no lineage-specific...

Ngày tải lên: 07/07/2014, 04:20

... Chapter 104. Acute and Chronic Myeloid Leukemia (Part 4) Clinical Presentation Symptoms Patients with AML most often present with nonspecific symptoms that begin gradually or abruptly and are ... they are, myeloid lineage is virtually certain (Fig 104-1). Poor neutrophil function may be noted by impaired phagocytosis and migration and morphologically by abnormal lobulation and deficient ... blood. The morphology of the malignant cell varies in difference subsets. In AML the cytoplasm often contains primary (nonspecific) granules, and the nucleus shows fine, lacy chromatin with one...

Ngày tải lên: 07/07/2014, 04:20

... Chapter 104. Acute and Chronic Myeloid Leukemia (Part 5) Morphology of AML cells. A. Uniform population of primitive myeloblasts with immature chromatin, nucleoli in some cells, and primary ... Ecchymosis and oozing from I V sites (DIC, possible acute promyelocytic leukemia) Fever and tachycardia (signs of infection) Papilledema, retinal infiltrates, cranial nerve abnormalities (CNS leukemia) ... patients, and about 25% have counts <25,000/àL. Both morphologic and functional platelet abnormalities can be observed, including large and bizarre shapes with abnormal granulation and inability...

Ngày tải lên: 07/07/2014, 04:20

... achievement of CR. In addition, patients who achieve Chapter 104. Acute and Chronic Myeloid Leukemia (Part 6) Most patients are anemic and thrombocytopenic at presentation. Replacement of the appropriate ... entering CR, the length of CR, and the curability of AML. CR is defined after examination of both blood and bone marrow. The blood neutrophil count must be 1000/àL and the platelet count 100,000/àL. ... nervous system bleeding and pulmonary leukostasis contribute to poor outcome with initial therapy. In addition to pretreatment variables such as age, cytogenetics, and leukocyte count, several...

Ngày tải lên: 07/07/2014, 04:20

... 104. Acute and Chronic Myeloid Leukemia (Part 7) Acute Myeloid Leukemia: Treatment Treatment of the newly diagnosed patient with AML is usually divided into two phases, induction and postremission ... diagnosed acute myeloid leukemia. For all forms of AML except acute promyelocytic leukemia (APL), standard therapy includes a 7-day continuous infusion of cytarabine (100–200 mg/m 2 per day) and ... synthesis and thereby overcome resistance to standard-dose cytarabine. In two randomized studies, high-dose cytarabine with an anthracycline produced CR rates similar to those achieved with standard...

Ngày tải lên: 07/07/2014, 04:20

... Chapter 104. Acute and Chronic Myeloid Leukemia (Part 8) The hematologic toxicity of high-dose cytarabine-based induction regimens has typically been greater than that associated with 7 and 3 ... regimens. Toxicity with high-dose cytarabine includes myelosuppression, pulmonary toxicity, and significant and occasionally irreversible cerebellar toxicity. All patients treated with high-dose ... each dose, and further high-dose cytarabine should be withheld if evidence of cerebellar toxicity develops. This toxicity occurs more commonly in patients with renal impairment and in those...

Ngày tải lên: 07/07/2014, 04:20

... antibodies Yttrium-90-labeled human M195 Chapter 104. Acute and Chronic Myeloid Leukemia (Part 9) Treatment of Promyelocytic Leukemia Tretinoin is an oral drug that induces the differentiation ... cytarabine is more effective than standard-dose cytarabine. The Cancer and Leukemia Group B (CALGB), for example, compared the duration of CR in patients randomly assigned postremission to four ... demonstrated. High-dose cytarabine significantly prolonged CR and increased the fraction cured in patients with favorable [t(8;21) and inv(16)] and normal cytogenetics, but it had no significant effect...

Ngày tải lên: 07/07/2014, 04:20

Ngày tải lên: 07/07/2014, 04:20

Ngày tải lên: 07/07/2014, 04:20

Ngày tải lên: 07/07/2014, 04:20

Ngày tải lên: 07/07/2014, 04:20

Ngày tải lên: 07/07/2014, 04:20

Ngày tải lên: 07/07/2014, 04:20

Ngày tải lên: 12/08/2014, 15:21

Ngày tải lên: 10/08/2014, 22:21

Ngày tải lên: 10/08/2014, 22:20

Ngày tải lên: 12/08/2014, 04:21

Ngày tải lên: 24/11/2013, 08:11