difference between acute and chronic myeloid leukaemia
Chapter 104. Acute and Chronic Myeloid Leukemia (Part 1) ppsx
... in the past by the Food and Drug Administration (FDA) for marketing based on trials using the FAB criteria. Acute Myeloid Leukemia Incidence The incidence of acute myeloid leukemia (AML) ... recent literature and some ongoing studies use the FAB classification, a description of this system is also provided in Table 104-1. A major difference between the WHO and FAB systems is the ... years after exposure, and affected individuals have aberrations in chromosomes 5 and 7. Topoisomerase II inhibitor–associated leukemias occur 1–3 years after exposure, and affected individuals...
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Chapter 104. Acute and Chronic Myeloid Leukemia (Part 2) pot
... Acute myelomonocytic leukemia Acute monoblastic and monocytic leukemia Acute erythroid leukemia Acute megakaryoblastic leukemia Acute basophilic leukemia Acute panmyelosis ... Acute megakaryoblastic leukemia Acute basophilic leukemia Acute panmyelosis with myelofibrosis Myeloid sarcoma French-American-British (FAB) Classificationc Incidence M0: Minimally differentiated ... myelodysplastic syndrome/myeloproliferative disorder Without antecedent myelodysplastic syndrome III. AML and myelodysplastic syndromes, therapy-related Alkylating agent–related Topoisomerase type II...
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Chapter 104. Acute and Chronic Myeloid Leukemia (Part 3) pps
... Continuous activation of Flt3 and downstream target kinases, including signal transducer and Chapter 104. Acute and Chronic Myeloid Leukemia (Part 3) Immunophenotype and Relevance to the WHO ... associated with younger age are t(8;21) and t(l5;17); with older age, del(5q) and del(7q). Myeloid sarcomas (see below) are associated with t(8;21) and disseminated intravascular coagulation ... important in the development of myeloid and lymphoid lineages. Activating mutations of the gene FLT3 are present in ~30% of adult AML patients due to internal tandem duplications (ITDs) in the...
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Chapter 104. Acute and Chronic Myeloid Leukemia (Part 4) pps
... Chapter 104. Acute and Chronic Myeloid Leukemia (Part 4) Clinical Presentation Symptoms Patients with AML most often present with nonspecific symptoms that begin gradually or abruptly and are ... they are, myeloid lineage is virtually certain (Fig 104-1). Poor neutrophil function may be noted by impaired phagocytosis and migration and morphologically by abnormal lobulation and deficient ... blood. The morphology of the malignant cell varies in difference subsets. In AML the cytoplasm often contains primary (nonspecific) granules, and the nucleus shows fine, lacy chromatin with one...
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Chapter 104. Acute and Chronic Myeloid Leukemia (Part 5) docx
... Chapter 104. Acute and Chronic Myeloid Leukemia (Part 5) Morphology of AML cells. A. Uniform population of primitive myeloblasts with immature chromatin, nucleoli in some cells, and primary ... patients, and about 25% have counts <25,000/àL. Both morphologic and functional platelet abnormalities can be observed, including large and bizarre shapes with abnormal granulation and inability ... patients and cryopreserved for future use as new tests and therapeutics become available. All patients should be evaluated for infection. Table 104-2 Initial Diagnostic Evaluation and Management...
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Chapter 104. Acute and Chronic Myeloid Leukemia (Part 6) pps
... achievement of CR. In addition, patients who achieve Chapter 104. Acute and Chronic Myeloid Leukemia (Part 6) Most patients are anemic and thrombocytopenic at presentation. Replacement of the appropriate ... entering CR, the length of CR, and the curability of AML. CR is defined after examination of both blood and bone marrow. The blood neutrophil count must be 1000/àL and the platelet count 100,000/àL. ... clinical feature associated with a lower CR rate and shorter survival time. The CR rate is lower in patients who have had anemia, leukopenia, and/ or thrombocytopenia for >3 months before...
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Chapter 104. Acute and Chronic Myeloid Leukemia (Part 7) pot
... 104. Acute and Chronic Myeloid Leukemia (Part 7) Acute Myeloid Leukemia: Treatment Treatment of the newly diagnosed patient with AML is usually divided into two phases, induction and postremission ... diagnosed acute myeloid leukemia. For all forms of AML except acute promyelocytic leukemia (APL), standard therapy includes a 7-day continuous infusion of cytarabine (100–200 mg/m2 per day) and ... synthesis and thereby overcome resistance to standard-dose cytarabine. In two randomized studies, high-dose cytarabine with an anthracycline produced CR rates similar to those achieved with standard...
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Tài liệu Canadian clinical practice guidelines for acute and chronic rhinosinusitis pdf
... Comparison of the efficacy and tolerability of amoxycillin/clavulanic acid 875 mg b.i.d. with cefuroxime 500 mg b.i.d. in thetreatment of chronic and acute exacerbation of chronic sinusitis inadults. ... research tools and are not currently available in the clinical setting.Maxillary Sinus Aspirate (MSA) MSA is consideredthe gold standard for bacterial recovery in acute and chronic sinusitis, ... 3338 patients from 16randomized comparative non-placebo studies concludedthat differences between antimicrobial agents are smallin otherwise healthy adults and adolescents, and there-fore an...
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Tài liệu Acute and chronic sinusitis pdf
... Acute and chronic sinusitis PLAIN X‐RAYSFluid level frontal sinuses Surgical treatment chronic Surgical treatment chronic maxillary sinusitis yInferior ... Pharyngeal, laryngeal and ear infectionsã Mucoceleã OsteomyelitisObit l li tiãOrbital complicationsãIntracranial complicationsãIntracranial complications Acute sinusitis Acute sinusitis ... (sinusitis)Fluid Level (sinusitis) CT SCANComplete opacity Rt sphenoid siunus Treatment of chronic maxillary sinusitisCld llL ’ tiCaldwell Luc’s operation Orbital ComplicationsOrbital...
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