diagnostic and prognostic significance of epigenetics in cancers

... of citrullinated fibrinogen in a mouse model of arthritis [29] and the presence of immune complexes containing citrullinated fibrinogen in the sera and synovium of RA point to a direct role in ... majority of patients at baseline and during the follow-up In 56 patients, all four tests were available at baseline and at and years of follow-up CFFCP status remained stable in most patients during ... autoantibodies in RA in a subsequent study [20] Further interesting results were obtained with a chimeric fibrin/filaggrin citrullinated peptide (CFFCP1) containing an -fibrin peptide and the cyclic...

Ngày tải lên: 09/08/2014, 14:22

... extent of immunostaining in sections and further graded into four groups: + : < 5% of tumor cells stained; ++ : 5-25% of tumor cells stained; +++ : > 25-50% of tumor cells stained; ++++ : > 50% of ... only Cases were included according to the following inclusion criteria: having archived formalin-fixed, paraffin-embedded specimens available; having complete clinicopathological and followed-up ... of expression of these antigens were observed in most positive cases In our study, the concomitant expression of CTAs and HLA class I antigen was observed in 33.7% of the IHCC tumors, which indicating...

Ngày tải lên: 10/08/2014, 10:20

... cause of medicine tation of the data, and the drafting and revision of the manuscript Patients were divided into five categories according to their self-reported symptoms of chest pain and dyspnea ... time of testing Typical angina was defined as chest pain that was substernal, occurred during stress, and resolved within 10 minutes after rest or the receipt of nitroglycerin.8 Chest pain was ... Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles (R.H.); and the Department of Medicine, David Geffen School of Medicine, University of California...

Ngày tải lên: 27/06/2014, 00:20

... Expression of Oct4 and Sox2 Immunohistochemical staining for Oct4 and Sox2 expression in hypopharyngeal squamous cell carcinoma Brown grains represent a positive signal (3, 3-diaminobenzidine staining) ... expression of Oct4 or Sox2 Positive staining for Oct4 and Sox2, mainly localized in the nucleus, were observed in the cancer cells of tumor tissues (Fig 1) The distribution of immunostaining Figure ... collection, NG, XW and HMX carried out the immunohistochemical staining work, NG, XSX and YL analyzed results TK and WHH conceived of the study, participated in its design and coordination and helped...

Ngày tải lên: 18/06/2014, 16:20

... occur in approximately 60 – 80 % of diffusely infiltrating gliomas of the WHO grades II and III and in secondary GBM but only in around % of primary GBM (11;18-22) In our series we identified in of ... mg in only 22%) as well as in the maintenance phase (no adjuvant treatment in 79 % and a mean of cycles in 21% of patients) However, inspite of this difference, outcome between the two dosing ... entity in upcoming studies The low number of primary GBM exhibiting IDH1 mutations in our series indicates that our sample set consists indeed predominately of these tumors IDH1mutations in GBM...

Ngày tải lên: 09/08/2014, 09:21

... 57:978-987 Lin Q, Lai R, Chirieac LR: Constitutive activation of JAK3/STAT3 in colon carcinoma tumors and cell lines: inhibition of JAK3/STAT3 signaling induces apoptosis and cell cycle arrest of colon ... streptavidin-biotin method, with a Vecta Elite ABC staining kit (Vector Laboratories) The slides were rinsed in phosphatebuffered saline, exposed to diaminobenzidine, and counterstained with ... association between clinicopathologic characteristics and expression of STAT3 in malignant soft tissue tumors Clinicopathological significance of STAT3 expression in soft tissue tumors In our study,...

Ngày tải lên: 10/08/2014, 10:21

... Diagnostic challenge of tuberculosis of the elderly in hospital: experience at a university hospital in Saudi Arabia J Infect 1995; 31: 93-7 22 Morris CD Sputum examination in the screening and ... (including alcoholic liver disease) composed the majority of underlying illnesses in both groups Elderly had significantly higher frequencies of cardiovascular and chronic lung disease including ... frequency of liver disease, suggesting the influence of alcoholism These results correspond to those of Alvarez et al (6) and Van den Brande (15) but contrast with those of Katz et al (17) and Umeki...

Ngày tải lên: 15/03/2014, 03:20

... preoperative examination of vascular lesions might be of special interest in order to avoid long surgical procedures with intraoperative evaluation of vascular injuries In penetrating injuries and isolated ... conception and design of the study, acquisition of data, analysis and interpretation of data, drafting the article and revising of the article for important intellectual content All authors have read and ... (25%) and supracondylar fractures of the humerus (13.6%) as demonstrated in Figure Concerning the type of injury, we found direct vascular injuries in 97.7% with penetrating lesions in 32.6% and...

Ngày tải lên: 20/06/2014, 04:20

... reported an incidence of 26.3% and 42%, and Derchain et al [32] of 34% and 51%, of EOC staged I and III, respectively Interestingly, our data have shown a slightly higher predominance of poor prognosis ... the standard clinical protocols in a way to increase the disease treatment success in the cases of platinum-resistant EOC In conclusion, we have characterized the clinicopathological and prognostic ... Comparing every possible pair of curves, we had come to some interesting findings As for tumor histological type, the DFS in endometrioid cancers was lower than in serous (Log-Rank, p = 0.048) and...

Ngày tải lên: 20/06/2014, 08:20

... the maxillary and mandibular gingivae and the hard palate (Fig 5) The patient was in severe pain, could not eat, and had difficulty speaking He again refused any investigations and treatment, ... showing the dorsum of the tongue Intraoralsoft palate and extensive KS lesions on the hard palIntraoral view showing extensive KS lesions on the hard palate, the soft palate and the dorsum of ... agents, and in cases where the lower extremities are involved, by elevation of the limbs and compressive dressings The preservation of skin integrity is important to prevent secondary bacterial and...

Ngày tải lên: 10/08/2014, 05:21

... component in pulmonary inflammation/infection and may represent a promising marker and therapeutic target in respiratory diseases The expression, regulation and clinical significance of sCD14 and mCD14 ... the TLR ligands LPS and CpGs induce sCD14 production via two distinct mechanisms Martin et al examined sCD14 levels in BALF of adult patients with pneumonia and found increased levels of 50 ng/ml ... treatment resulted in increased mCD14 expression on monocytes [21] and alveolar macrophages [34] Our findings indicate that 40 h incubation with LPS and CpG induced sCD14 secretion and increased mCD14...

Ngày tải lên: 12/08/2014, 11:21

... correlated readings within an individual and examine the association between changes in WOMAC scores (pain, function, and stiffness) and continuous changes in BML size Standard diagnostic checks of model ... both worsening and improving in this population-based sample A change in BML size was associated with changes in pain in those without ROA This finding suggests that fluctuating knee pain may be ... changes in the five WOMAC pain sub-scales and changes in BML size, stratified by ROA Changes in knee pain when walking on a flat surface, going up and down stairs, and at night while in bed was...

Ngày tải lên: 12/08/2014, 15:22

... [24] and similar to that observed with infections, making the diagnosis of infection more difficult Because timing is crucial in initiating therapy and determining the subsequent outcome of septic ... events, including aortic cross-clamping time, duration of CPB, and the duration of surgery PCT as a tool for identifying infection Because of the marked overlap of signs and symptoms, diagnosis of infection ... undergoing CPB At a cutoff level of ng/ml, PCT had a sensitivity of 86% and a specificity of 98% in predicting infection, whereas CRP at a cutoff level of 180 mg/l had a sensitivity of 100% and...

Ngày tải lên: 13/08/2014, 03:20

... according to infectious clinical focus but included, in all patients, one pair of blood culture and urinary analysis The emergency physician completed a standardized form for each patient, including ... against calcitonin and a monoclonal antibody against katacalcin, which bind to the calcitonin and katacalcin sequence of precursor molecules This assay has an optimized functional sensitivity of ... Comparison of procalcitonin with C-reactive protein, interleukin and interferon-alpha for differentiation of bacterial vs viral infections Pediatr Infect Dis J 1999, 18:875-881 Christ-Crain M, Jaccard-Stolz...

Ngày tải lên: 13/08/2014, 03:21

... brain natriuretic peptide; BUN = blood urea nitrogen; CK = creatine kinase; CK-MB = creatinine kinase-MB; Cr = creatinine; E/A = ratio of E (peak mitral flow velocity of the early rapid filling) ... can be made against the diagnostic utility of BNP levels in patients with CKD in the ICU due to the many confounding factors beyond renal and cardiac dysfunction in the ICU setting and because the ... radiological findings However, in clinical practice, patients with ADHF may not have pulmonary oedema in chest radiographs and in some patients with ADHF the radiographic findings are similar to those of...

Ngày tải lên: 13/08/2014, 16:20

... GH-releasing hormone and causes weight gain and obesity by increasing food intake and diminishing lipid utilisation in non-critically ill individuals [28,29] Before a meal ghrelin serum levels rise and ... markers of inflammation, organ dysfunction and metabolism and to examine potential protective effects of ghrelin in critically ill patients and human sepsis from a clinical point of view Materials and ... in response to endotoxin administration in dogs [22] To examine the significance of ghrelin in humans in a genuine intensive care environment we analyzed blood samples of critically ill patients...

Ngày tải lên: 13/08/2014, 20:22

... and reported an incidence of AF of 31% [15] With respect to the incidence of new-onset AF in septic shock, Seguin and colleagues included a subgroup of 23 patients and observed new-onset AF in ... significant (P = 0.10) In 67% of patients, new-onset AF occurred within the first three days of ICU stay Occurrence of septic shock and incidence of AF in septic shock Sixty-four of all admitted patients ... the incidence and prognostic impact of new-onset AF in patients with septic shock are available Therefore, the main purpose of the present study was to assess the incidence of new-onset AF in...

Ngày tải lên: 13/08/2014, 20:22

... Structure of glycosaminoglycans 17 Haematoxylin and eosin staining of BPH prostate samples 64 Chapter Figure 3.1 used for microarray study Figure 3.2 Haematoxylin and eosin staining of prostate ... gross and microscopic examination (Table 1.3) Extent of local invasion includes extraprostatic extension and seminal vesicle involvement Seminal vesicle involvement is defined as cancer invading into ... compression of the urethra resulting in urinary obstruction, dysuria and increased risk of urinary retention and infection Absence of cytologic atypia is observed, with the basal cell layer still intact...

Ngày tải lên: 12/09/2015, 11:08

... concepts of financing and funding as, respectively, initial financing and s final financing (See Graziani, 1984) Monetary circuit theory, in particular, stresses the role of banks in sustaining the ... profitability is declining The internalization of information within the same institution may thus enhance intra-circuit and inter-circuit stability by reducing the incentive to overfinancing ... overfinancing, excessive risk taking by investors, and changes in investment funding decisions in terms of individual rational responses to economic incentives • By integrating money, credit and...

Ngày tải lên: 24/10/2012, 09:33

... presently working as Professor in the Department of Mechanical Engineering, College of Engineering (A), Andhra University, Visakhapatnam, A.P., India She has completed her PhD in Heat Transfer and energy ... Mechanical Engineering, College of Engineering (A), Andhra University, Visakhapatnam, A.P India He has completed M.Sc in (Power Mechanic) from University of Babylon, Iraq in the year 2006 and B.Sc in (Mechanic) ... emission and combustion characteristics of a methyl ester sunflower oil eucalyptus oil in a single cylinder air cooled and direct injection diesel engine”, International Journal of Engineering Science...

Ngày tải lên: 05/09/2013, 16:11