devil s in the details

... which is the major reason I oppose focusing CAN on any one disease or set of diseases Why not, instead, take CAN at its word? It wants to accelerate the finding of cures, so let s focus it on the ... disorders such as Alzheimer s disease Most biopharmaceuticals are immunogenic, even when they are human proteins, and some of them are seriously so One of the main reasons is that misfolded or ... expensive clinical trials are initiated The blood-brain barrier is one major reason that many pharmaceutical companies are abandoning their programs in central nervous system (CNS) diseases It is...

Ngày tải lên: 09/08/2014, 20:21

... behavior in physically distinct systems The reference here to the status of the special sciences will immediately call to mind questions about relationships between distinct theories If, for instance, ... agrees upon—one gram, for instance, is 1/1000 of the mass of a special standard mass in a vault in the Bureau of Weights and Measures in Paris Given these standards we will have a system of units ... between some theories, much of interest, both physical and philosophical, can be gained by studying the asymptotic behavior of theories in these singular correspondence limits I will discuss several...

Ngày tải lên: 05/03/2014, 23:20

... never be the source of system weakness Cable connections and terminations within data centers are subject to vibrations and mechanical stresses not seen elsewhere within the enterprise • 70 percent ... fiber terminations Uses industry s highest count MPO plug-and-play cassettes Slack storage included in each rack allows for the use of a single jumper length MPO trunks enter rack from under -the- floor ... solutions are costly The day-one savings of solutions that not consider how to manage and grow the network infrastructure are quickly eclipsed by outages, as well as open chassis slots and stranded...

Ngày tải lên: 10/12/2013, 17:15

Ngày tải lên: 03/06/2014, 17:25

... Cement Ltd in India • Cement capacity in India increased since 2005/06 by 20 million tons Further capacity increases in India and Indonesia of overall 5.2 million tons coming on stream in 2010/2013 ... Analyst Capital Markets Event 2010 Reducing financial leverage while seizing investment opportunities • Developments since January 1, 2009 Capex to maintain 3'888 Business portfolio in Australia ... asset base Sound financing and High liquidity • Holcim will benefit from the upswing and has the strength for value creating acquisitions © Holcim Ltd 2010 Investor / Analyst Capital Markets...

Ngày tải lên: 30/07/2014, 21:32

... Housing bubble begins to burst Dealers bet against their own deals SEVEN The Eyes of Satan The secret history of shadow banking Cash gets subverted by subprime Ratings agencies jump on the structured ... much in the real world But business pressures suddenly put the two worlds at odds There was the pressure on senior bankers such as Chase s Marc Shapiro and J.P Morgan s Peter Hancock to shift ... worst-case assumptions were breached in one market, banks would cut positions right across their portfolios to protect themselves from further losses Since no one outside the banks (including the...

Ngày tải lên: 04/11/2014, 11:08

... form the basis for the research work described in this thesis Before detailing the objectives of the thesis in section 1.6, the following is a brief description of the ten compounds in the pipeline ... significant insights into the progression of the disease In vitro analyses of the responses of murine and human macrophages to Mtb infection indicate a robust pro-inflammatory response of the cells Infected ... this thesis 1.6 TB Drug Development: NITD s Initiative and The genesis of this Thesis The Novartis Institute for Tropical Diseases (NITD) based in Singapore aims to discover novel treatments for...

Ngày tải lên: 09/09/2015, 10:17

... your fingers off the raisins in that cake And tell Essie the same I suppose I can trust you to bring in the case of stuffed birds without breaking the glass? (She replaces the tin in the cupboard, ... extinguishes the snuff by pinching it with her fingers, first licking them for the purpose; and replaces the sconce on the shelf CHRISTY (looking through the window) Here 's the minister 's wife MRS ... towards the sofa Christy drops the table as soon as possible, and goes to the fire, leaving his mother to make the final adjustments of its position.) We shall have the minister back here with the...

Ngày tải lên: 06/11/2012, 14:13

... medium sized businesses The research provides a comprehensive insight to the MFIs in Pakistan for addressing the borrower s concern and realigning their vision and mechanisms to suit the borrower s ... customers about micro financing by realigning their marketing mechanisms and strategies to attract less educated masses through staff trainings and holding open sessions in these localities and ... borrowers and the lenders to run a business on long term basis The profit should be shared in the pre agreed terms and the losses are shared accordingly Expertise, knowledge of the business, wisdom...

Ngày tải lên: 06/09/2013, 05:48

... atmosphere and the storms in the tropical monsoon Asia Survey and forecast the effects of the dams and irrigation systems in upstream to the low parts of the basin Estimate the role of floods in the people s ... Flooding water eliminates a great part of the salinity in the soil in the coastal areas and flushes toxicity released from acid sulfate soil Also, floods kill the insets and rats population Otherwise, ... the people s lives; notice the effects to the women and children in the flooded areas Assess the environmental impacts of the “anti-flood” works in the MD Evaluate the role of mass information...

Ngày tải lên: 18/10/2013, 12:15

... this response to Clerkenwell, the implicit emphasis rests on renewing English security in the face of Irish violence Increasingly, however, as Gladstone s suitably vague words suggest, the strength ... tandem with the aftershocks in India raised the spectre of widespread imperial instability Palmerston, then Prime Minister, was so alarmed by the tone of the Irish press on the Indian situation ... disciplinary location in English studies, that Arnold s interest in ‘ the preservation of cultural diversity’’ was ‘‘a minority position increasingly difficult to maintain as the century progressed...

Ngày tải lên: 01/11/2013, 07:20

... experiences everyday setbacks and emotions, and the ship must endure everyday issues as well The ship carries the ancient mariner and his crew, just as the body carries the soul From these analyses, the ... In the poem, the ancient mariner killed the Albatross with his crossbow: Why look'st thou so ?' With my cross-bow I shot the ALBATROSS The Albatross used to be the close friend of the sailors, ... explain what the reason for his action was As a result, he and his shipmates received hard sufferings, both physical and spiritual hurts Since the Albatross was killed, the wind and mist stopped,...

Ngày tải lên: 12/12/2013, 00:03

... findings answer the research questions Part 3: Conclusion summarizes the findings of the study, giving concluding remarks, implications, limitations of the study and suggestions for further studies ... at the beginning of the war), fighting against terrorists and so forth This has been the issue that sharply divided the U .S and is still causing many controversies in the society as the fatality ... uncover some aspects However, due to the scope of a graduation thesis, the investigation is confined into aspects of the speech Though the findings quite satisfactorily prove the assumptions made...

Ngày tải lên: 18/12/2013, 10:08

... Congress passed legislation that required each state to inspect and maintain an inventory of all bridges on the Federal-aid system Inspection standards were issued in 1971 to satisfy this mandate ... Congress Most states completed their inventory of bridges on the Federal-aid system by the end of 1973 In 1978, Congress passed the Surface Transportation Assistance Act which expanded the law ... owners of all bridges on public roads perform the required inspections Each state then collects the inspection reports for all bridges in the state and submits them annually to the FHWA, where they...

Ngày tải lên: 20/12/2013, 20:15

... atmosphere and the storms in the tropical monsoon Asia Survey and forecast the effects of the dams and irrigation systems in upstream to the low parts of the basin Estimate the role of floods in the people s ... Flooding water eliminates a great part of the salinity in the soil in the coastal areas and flushes toxicity released from acid sulfate soil Also, floods kill the insets and rats population Otherwise, ... the people s lives; notice the effects to the women and children in the flooded areas Assess the environmental impacts of the “anti-flood” works in the MD Evaluate the role of mass information...

Ngày tải lên: 16/01/2014, 17:20

... pigtail outputs In essence, splitter outputs “time share” parking lots; as the outputs of the initial splitter modules are placed into service, the parking lots associated with those outputs become ... using standard splicing techniques (usually mass splicing) with splices stored in standard splice closures Key FDH Capabilities – and Innovations The FDH enclosure provides a crucial craft interface ... increased numbers of spare fibers, resulting in increased fiber termination requirements, users were reluctant to increase the overall size of the enclosures Therefore, fiber termination fields had...

Ngày tải lên: 17/01/2014, 11:20

... immediately; I insist insist (that): She insisted that we stay at her house instead of a hotel insist on: Some companies insist on staff undergoing regular medical checks insistence /In sIstCns / noun ... very firm statement that something must happen or that something is true insistence on: We applaud the president s insistence on tougher environmental laws insistence that: Despite his insistence ... wasn’t involved, most people think he s dishonest insistent /In sIstCnt/ [adjective] saying very firmly that something must happen or that something is true: khăng khăng, định insistent on: She...

Ngày tải lên: 25/01/2014, 22:20

... even in resource-constrained settings Stunting rates have gotten worse in 14 countries, most of them in subSaharan Africa Somalia has shown the worst regression – stunting rates in that country increased ... Fair Insufficient On track No progress Insufficient Insufficient Insufficient Insufficient Insufficient Insufficient No progress No progress No progress Insufficient No progress Insufficient Insufficient ... Poor Poor Insufficient No progress Insufficient Insufficient Insufficient No progress No progress On track Insufficient Insufficient Insufficient On track Insufficient Insufficient Insufficient...

Ngày tải lên: 12/02/2014, 11:20

... changes in relationships across nonlinear models are best assessed through comparing changes in predicted values; in a nonlinear model changes in the coefficients also depend on changes in the other ... disparity in the quality of mothers’ health-related behaviors and parenting inputs across nativity groups, these disparities are, for the most part, stable over time This finding is interesting ... mothers Does Access to Social Support Play an Explanatory Role? As a final step in the analysis we examine whether differences in social support access, both within and outside of households,...

Ngày tải lên: 12/02/2014, 12:20

... disease of the circulatory system is cerebrovascular disease (stroke) Stroke is defined by the WHO as the interruption of the blood supply to the brain, usually because a blood vessel bursts ... however, this gap has been closing in recent years due to decreasing numbers of men smoking and increasing numbers of women smoking in certain countries In addition, smoking-associated deaths among ... corresponding health issues and needs is necessary to adequately address the topic There are diseases which are unique, more prevalent, or more serious in women and for some diseases risk factors...

Ngày tải lên: 12/02/2014, 23:20