development of the blood brain barrier
Báo cáo y học: "Inhibition of complement C5a prevents breakdown of the blood-brain barrier and pituitary dysfunction in experimental sepsis" ppt
Ngày tải lên :
13/08/2014, 15:21
... the effect of antibody-mediated C5a-blockade on preventing the development of encephalopathy in experimental sepsis We hypothesised that blockade of C5a would reverse the dysfunction of the BBB ... Under physiological conditions, the BBB maintains the cerebral micro-environment by tightly regulating the passage of molecules into and out of the brain to protect the brain from microorganisms and ... J: The influence of cytokines on the integrity of the blood- brain barrier in vitro J Neuroimmunol 1996, 64:37-43 55 Papadopoulos MC, Davies DC, Moss RF, Tighe D, Bennett ED: Pathophysiology of...
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báo cáo hóa học: " Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the blood-brain barrier is mediated by luminal microvessel IL-6 and GM-CSF" potx
Ngày tải lên :
19/06/2014, 22:20
... entry into the brain because of blood- brain barrier (BBB) efflux transporters so that the brain serves as a reservoir for HIV-1 [2] and a source for viral escape [3] Therefore, HIV-1 in the brain ... blood- brain barrier to various sized molecules Am J Physiology 1985, 248:H712-H718 Chou S, Dix RD: Viral infections and the blood- brain barrier In Implications of the Blood- Brain Barrier and ... transcellular transport of HIV-1 across the blood- brain barrier (BBB) through the activation of p38 mitogen-activated protein kinase (MAPK) signaling in brain microvascular endothelial cells (BMECs)...
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Application of biologically active micelles in drug delivery across the blood brain barrier
Ngày tải lên :
11/09/2015, 09:10
... although 12% of all drugs are active in the CNS, only 8% of them are active in the brain for the treatment of diseases or disorders (Lipinski, 2000) The BBB lies between the blood flow and the brain ... in the central nervous system (CNS) is to overcome the barrier preventing the drugs moving from blood circulation into the brain parenchyma The limited penetration of drugs through the blood brain ... parenchyma The blood brain barrier (BBB) lies between the blood flow and the brain parenchyma The BBB prohibits most foreign molecules entering from the blood to brain, including CNS drugs The limited...
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Nanoparticles of biodegradable polymers for delivery of therapeutic agents and diagnostic sensitizers to cross the blood brain barrier (BBB) for chemotherapy and MRI of the brain
Ngày tải lên :
26/11/2015, 22:48
... History and Anatomy of the Blood Brain Barrier 1.1.2 Functions of the Blood Brain Barrier 1.1.3 Clinical Significance of the Blood Brain Barrier 1.2 METHODS TO OVERCOME THE BLOOD BRAIN BARRIER 1.3 NANOPARTICLES ... the presence of glutathione, likely via cotransport, is required [13] 1.1.2 Functions of the Blood Brain Barrier The main function of the blood brain barrier is to protect the brain The BBB serves ... presence of an intact blood brain barrier at the proliferating edge of the tumor has been suggested to be one of the major contributing factors to the failure of chemotherapy in the treatment of central...
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the blood – brain barrier
Ngày tải lên :
11/04/2014, 10:34
... junctions of the blood- brain barrier Cell Mol Neurobiol 20, 57–74 68 Brightman, M W., and Tao-Cheng, J H (1993) Tight junctions of brain endothelium and epithelium In The Blood- Brain Barrier Cellular ... through the diaphragm and the costal cartilages left of the sternum up to the level of the clavicle A transverse cut is made in the diaphragm The heart is then grasped using the index and thumb of the ... The large apparent work capability of the blood- brain barrier: A study of mitochondrial content of capillary endothelial cells in brain and other tissues of the rat Ann Neurol 1, 409–417 175 Claudio,...
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báo cáo hóa học:" Effective transvascular delivery of nanoparticles across the blood-brain tumor barrier into malignant glioma cells" docx
Ngày tải lên :
18/06/2014, 15:20
... the blood- brain barrier Journal of Controlled Release 2005, 108:84-96 Poduslo JF, Curran GL: Polyamine modification increases the permeability of proteins at the blood- nerve and blood- brain barriers ... other charged nanoparticles [66-69] across the barrier may be from direct charge induced damage to endothelial cells of the barrier and disruption of the barrier Our proposed mechanism for the ... of the bloodbrain tumor barrier; in addition, we validated the importance of prolonged nanoparticle blood half-life for the effective accumulation of nanoparticles within brain tumor cells Therefore,...
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báo cáo hóa học:" Physiologic upper limit of pore size in the blood-tumor barrier of malignant solid tumors" ppt
Ngày tải lên :
18/06/2014, 15:20
... compared the permeability of the BTB of RG-2 gliomas grown within the brain, the orthotopic site, to that of the BTB of RG-2 gliomas grown outside the brain in the temporalis skeletal muscle, the ... characterize the differences in the permeability of the BTB of a malignant brain tumor to that of the BTB of a peripheral solid tumor, and to define the upper limit of pore size within the BTB of the ... ectopic site, the permeability of the BTB of the breast cancer tumor growing in the brain is lower than the BTB of the original tumor in breast tissue, the orthotopic site[5] The brain tissue...
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báo cáo hóa học: " Anandamide inhibits Theiler’s virus induced VCAM-1 in brain endothelial cells and reduces leukocyte transmigration in a model of blood brain barrier by activation of CB1 receptors" pdf
Ngày tải lên :
19/06/2014, 22:20
... whether the effect of AEA on the adhesion of leukocytes interferes on leukocyte transmigration through the BBB model As expected TMEV-infection of brain endothelial cells increased the number of ... phenol-red-free DMEM the top and the bottom of the filter, 400 μl of 10% FBS/phenolred-free DMEM and 200 μl of 0.45% albumin conjugated to Evan’s blue dye were added to the bottom and the top of the well, ... immunohistochemistry, in the brains of sham animals in both type of mice, Cnr1+/+ or Cnr1-/- The intracranial injection of TMEV induced the expression of VCAM-1 in the ipsilateral cerebral cortex surrounding blood...
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báo cáo hóa học:" Development of the Japanese version of the Pediatric Quality of Life Inventory™ Brain Tumor Module" pot
Ngày tải lên :
20/06/2014, 16:20
... chemotherapy Convergent and discriminant validity was examined by correlating the scales of the Japanese version of the PedsQL™ Brain Tumor Module with the theoretically-predicted scales of the ... Additionally, proof of the validity of our results was evidenced on several points The fixed scale -development methods of the present study ensured the content validity and the results ensured ... of Life Outcomes 2010, 8:38 http://www.hqlo.com/content/8/1/38 Page of 14 Table 4: Factorial validity of the Japanese version of the PedsQL™ Brain Tumor Module Child-report (n = 137, 64% of the...
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Báo cáo y học: "Effect of magnesium sulfate administration on blood–brain barrier in a rat model of intraperitoneal sepsis: a randomized controlled experimental study" ppt
Ngày tải lên :
12/08/2014, 20:20
... intra-abdominal sepsis, the cultures of brain specimens taken after the experiment were all sterile (data not shown) One of the major pitfalls in the interpretation of the data was the difficulty of establishing ... reaches the brain site it interacts with the endothelial cells forming the BBB and inhibits their activation [4,24,25] To our knowledge, the present data are the first to show the positive effects of ... of the BBB and the role of a permeability defect in the formation of cerebral edema using other models of cerebral damage [18-20] In our previous experimental study we evaluated the effects of...
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MEASURING SAFETY CULTURE IN THE AUSTRALIAN REGIONAL AIRLINE INDUSTRY: THE DEVELOPMENT OF THE AIRLINE SAFETY CULTURE INDEX
Ngày tải lên :
19/04/2013, 23:00
... khoán,…đối với nhân viên Theo dõi tình hình biến động lao động tiền lương cán nhân viên Theo dõi khiếu nại với quan Nhà nước có thẩm quyền quan BHXH vi phạm điều lệ BHXH Thực theo dõi chế độ thưởng ... lương theo hệ số lương mà Công ty tự xây dựng vào Nghị định, Thông tư Chính phủ công tác trả lương Tiền lương trả cho nhân viên Công ty áp dụng tùy theo cương vị công tác trả lương tháng theo ... nhân viên làm thêm vào ngày nghỉ theo quy định toán tiền lương theo tỷ lệ pháp luật lao động Khi có công việc phát sinh mà Công ty đòi hỏi nhân viên làm việc tùy theo mức độ phức tạp, thời gian...
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DEVELOPMENT OF THE OZONIZER AND OZONATION TECHNOLOGY FOR WATERWORKS IN JAPAN
Ngày tải lên :
05/09/2013, 08:40
... techniques The report then describes the recent status of each of the issues RESEARCH AND DEVELOPMENT IN INCREASING OZONE CONCENTRATION Ozone generation Method and scale of use Table summarizes the ... below determine the efficiency of ozone generation Discharge gap length The shorter the discharge gap, the higher the ozone concentration is generated Currently, discharge gap of ozone generation ... instead of air High concentration ozonizer The original principles of ozone generation have not changed As a result of a wide spectrum of research and development, ozone concentrations of ozonizers...
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Development of the Quantitative PCR Method for Candidatus ‘Accumulibacter phosphatis’ and Its Application to Activated Sludge
Ngày tải lên :
05/09/2013, 09:38
... Sequence of PAO651f is the reverse complement sequence of PAO651 probe Sequence of PAO846r is the same sequence of PAO846 probe For the quantitative PCR, LightCycler (Roche) was employed The final ... RESULTS AND DISCUSSION Development of Quantitative PCR method Specificity of the primer set was evaluated based on the melting curve and the sequencing analysis Melting peaks of the PCR product from ... values for the DNA standards versus logarithm of their starting copy number was constructed A typical linear regression line is shown in Figure The averages of R2 value and the slope of the calibration...
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Development of the Microfinance system in Russia
Ngày tải lên :
24/10/2013, 03:15
... of Microfinance to stimulate efficiency access to the financial resources; to create work places; to grow of tax proceeds; to create a credit history for the further development of SMEs ... further development of SMEs through the bank sector; to barrier SMEs for their transition to the shady sector of economics Why not a bank? • lack of guarantees; • lack of credit history; • necessity ... business development in Russia SMEs have been existing for 12 years; >5.6 millions (including 4.5 millions of individual entrepreneurs); 90 % of the total number of establishments; 44 % of...
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Tài liệu Histology of the Blood Normal and Pathological pptx
Ngày tải lên :
17/02/2014, 22:20
... of the blood 23 Coagulability of the blood 24 Separation of the serum 24 Resistance of the red corpuscles 25 THE MORPHOLOGY OF THE BLOOD 27 A METHODS OF INVESTIGATION 29 [alpha] Preparation of ... for besides the estimation of the specific gravity of the total blood, they have carried out that of one at least of its constituents, either of the corpuscles or of the serum The red blood corpuscles ... increase of the lymphocytes of the blood; Frọnkel like Uskoff regards it as the emigration of the young forms of the white blood corpuscles into the blood He concludes logically from the diminution of...
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Tài liệu Báo cáo khoa học: An ecdysteroid-inducible insulin-like growth factor-like peptide regulates adult development of the silkmoth Bombyx mori docx
Ngày tải lên :
18/02/2014, 13:20
... Determination of the structure of 8K-BLP MALDI-TOF MS analysis of the purified material from the final HPLC yielded a monoisotopic mass of 7409.2 ([M + H]+) (Fig 3A) Amino acid sequence analysis of the purified ... days of cultivation, the number of the disk cells was approximately 30% larger than in the control (Fig 6M) Considering the BrdU incorporation in specific areas of the disks (Fig 6E), the rate of ... Although the staining intensity of the cells increased during adult development, the number of fat body cells decreased dramatically from mid-adult development onwards, due to their disruption These...
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Tài liệu The Development of the Feeling for Nature in the Middle Ages and Modern Times doc
Ngày tải lên :
21/02/2014, 20:20
... 'all the present of earth vanished into the future of Heaven, and the Kingdom of the Infinite arose upon the ruins of the finite.' The beauty of earth was looked upon as an enchantment of the ... in the Gargaric grove Nature has made nothing dumb; the birds of the air and the beasts of the earth are not silent, the snake has its hiss, the fishes of the sea as they breathe give forth their ... covers the mountains.' 'The sky is the fortress of the storm, the sun the torch of the world, the jewel of splendour.' 'Fire is eager, wild, blind, and raging; the sea is the gray sea, and the sparkling...
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An Outline of the Development OF THE Internal Commerce of the United States 1789-1900 pot
Ngày tải lên :
05/03/2014, 16:20
... History of the People of the United States, vol iii, p 465 F J Turner, Rise of the New West, p 297 End of the Project Gutenberg EBook of Outline of the development of the internal commerce of the ... Steel The development of the movement of iron ore from the mines around Lake Superior to the furnaces of the Eastern States was one of the most interesting features of the internal trade of the ... To crush the military strength of the South the federal authorities adopted the expedient of the abolition of slavery, and to the surprise of both the North and the South "the cause of the conflict...
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Future Development of the Higher Education Economic Development (HEED) Fund doc
Ngày tải lên :
08/03/2014, 09:20
... the release of the 2002/03 HEED funding allocations, their HEED Plans would also be used to determine the release of allocations from Strands to of the Knowledge Exploitation Fund (KEF) for the ... in terms of economic development) The HEW/HEFCW Third Mission Working Group (the membership and terms of reference for which are presented at Annex B) has recommended the adoption of the following ... strands & of KEF Issue Comments are sought on the Council’s intention to repeat, over the medium-term at least, the data gathering exercise undertaken in conjunction with the submission of the HEED...
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THE STRUCTURE AND DEVELOPMENT OF THE CEREAL PLANT pptx
Ngày tải lên :
08/03/2014, 23:20
... CHAPTER – THE STRUCTURE AND DEVELOPMENT OF THE CEREAL PLANT 24 THE WHEAT BOOK THE WHEAT BOOK CHAPTER – THE STRUCTURE AND DEVELOPMENT OF THE CEREAL PLANT THE STRUCTURE AND DEVELOPMENT OF THE CEREAL ... structure of the stem and leaf of the wheat plant 27 CHAPTER – THE STRUCTURE AND DEVELOPMENT OF THE CEREAL PLANT DESCRIPTION OF THE WHEAT PLANT THE WHEAT BOOK (continued) at their bases, so the oldest ... parts of a leaf are the tip of the blade and the top of the sheath Where the blade and sheath join, there are structures called the ligule and the auricles (Figure 2.3) Characteristics of the shoot...
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