determination analysis and applications for drug discovery
Biointormatics of targeted therapeutics and applications in drug discovery
... red for Approved drug, purple for Phase III drug, pink for Phase II drug, blue for Phase I drug, cyan for other drugs, green for inhibitors, grey for similar Chembl compounds, pale grey for similar ... red for Approved drug, purple for Phase III drug, pink for Phase II drug, blue for Phase I drug, cyan for other drugs, green for inhibitors, grey for similar Chembl compounds, pale grey for similar ... red for Approved drug, purple for Phase III drug, pink for Phase II drug, blue for Phase I drug, cyan for other drugs, green for inhibitors, grey for similar Chembl compounds, pale grey for similar...
Ngày tải lên: 12/09/2015, 09:10
Chemical and pharmacological studies of ardisia elliptica antiplatelet, anticoagulant activities and multivariate data analysis for drug discovery
... the leaves of the plant and fractionated HPLC and GC-MS were used for the analysis of the extract and fractions Platelet aggregation assay was performed on the extract and fractions using a platelet ... fractionation is a tedious process for the discovery of bioactive components, a platform method for drug discovery from plant extracts using multivariate data analysis (MVDA) was developed The ... 42 1.3.1 Metabolomics for quality control of medicinal plants 44 1.3.2 Metabolomics and analysis of pharmacological effects 45 1.3.3 Using metabolomics for drug discovery from medicinal...
Ngày tải lên: 10/09/2015, 08:25
Pharmacokinetics pharmacodynamics driven approach for lead optimization in anti mycobacterial and anti malarial drug discovery
... 1.2.2 Ideal drug candidates An ideal drug combination should consist of at least three drugs that are active against drug susceptible and drug resistant (MDR and XDR) tuberculosis and produce ... prioritize promising candidates before moving into lengthy animal pharmacology studies 1.4 Drug Discovery Strategies Drug discovery and development is risky, expensive and lengthy (Dickson and Gagnon, ... resistance against standard TB drug regimen, new drug candidates with novel mechanisms of action are needed urgently Figure History of drug discovery and development of treatment regimens for TB Reprinted...
Ngày tải lên: 22/09/2015, 15:17
Data analysis and modeling for engineering and medical applications
... DATA ANALYSIS AND MODELING FOR ENGINEERING AND MEDICAL APPLICATIONS MELISSA ANGELINE SETIAWAN (B.Tech, Bandung Institute of Technology, Bandung, Indonesia) A THESIS SUBMITTED FOR THE DEGREE ... divided into training set and validation set (or test set) The portion of the division is usually 80% for training set and 20 % for test set (or 75% for training set and 25% for test set) The training ... in Data Analysis and Modeling Work There are some challenges in doing data analysis and modeling work The main one relates to dealing with data complexity The success of data analysis and modeling...
Ngày tải lên: 04/10/2015, 10:24
Development and interpretation of machine learning models for drug discovery
... SAR analysis and therefore widely studied [20–23] Figure 2: Exemplary 2D and 3D SAR landscapes for a set of human thrombin ligands SARs are often studied qualitatively in visual form Therefore, ... Prediction Revealed by Statistical and Activity Landscape Analysis 75 III Interpretation of Predictors for Virtual Screening Introduction of a Methodology for Visualization and Graphical Interpretation ... understanding of computational models for drug discovery, and introduces chemically intuitive interpretations Thereby, we hope to contribute to further enhanced communication in interdisciplinary drug...
Ngày tải lên: 26/11/2015, 09:59
manifolds, tensor analysis and applications 3rd ed. - marsden, ratiu and abraham
... Uniform Continuity and Convergence nuity and uniform convergence In a metric space we also have the notions of uniform conti- 1.3.9 Definition (i) Let (M1 , d1 ) and (M2 , d2 ) be metric spaces and ... ϕn → ϕ uniformly if for every ε > there is an N such that d(ϕn (u), ϕ(u)) < ε for all n ≥ N and all u ∈ S For example, a map satisfying d(ϕ(u), ϕ(v)) ≤ Kd(u, v) for a constant K is uniformly continuous ... < ε for all n, m ≥ N (ε), let m → ∞ and get fn (x) − f (x) ≤ ε for all n ≥ N (ε) and all x ∈ X, that is, fn − f ∞ ≤ ε for n ≥ N (ε) This shows that fn − f ∈ B(X, F), and hence f ∈ B(X, F), and...
Ngày tải lên: 31/03/2014, 15:21
reverse osmosis design, processes, and applications for engineers
... diamine and trimesoyl chloride This membrane became the new industry standard and is known today as FT30, and it is the basis for the majority INTRODUCTION AND HISTORY DEVELOPMENT OF of Dow Water and ... electronic formats Some content that appears in print may not be available in electronic formats For more information about Wiley products, visit our web site at www.wiley.com For more information ... Technologies; and Lisa Fitzgerald of ITT-Goulds Pumps I would like to thank my graphic artist, Diana Szustowski, for her excellent and tireless efforts Finally, I would like to thank Paul Szustowski and...
Ngày tải lên: 02/04/2014, 15:45
seepage analysis and control for dams - u.s. army corps of engineers - part a
... permeability of concrete sand, sand-gravel mixture, and uniform fine sand (prepared by WES) 2-22 EM 1110-2-1901 30 Sep 86 b Masch and Denny Method For uniform or nonuniform dense clean sands, classified ... developed by Hazen for uniform loose clean sands The agreement between measured and computed permeability is within one order of magnitude for uniform sands and glass spheres Therefore, Hazen's equation ... Engineering and Design ANALYSIS AND CONTROL FOR DAMS D, “Filter and Drain Design and Construction” File this change sheet in front of the publication of EM 1110-2-1901, for reference purposes FOR THE...
Ngày tải lên: 28/04/2014, 11:51
seepage analysis and control for dams - u.s. army corps of engineers- part b
... in the construction procedure to be made early in the project (Hallford 1983; Holland and Turner 1980; and Gerwick, Holland, and Komendant 1981) (7) Treatment at Top of Concrete Cutoff Wall As ... Ratios for Dams Founded on Pervious Foundations (a) Table 9-10 Minimum Bligh's Creep Ratio Material Very fine sand or silt 18 Fine to medium sand 15 Coarse sand 12 Fine gravel or sand and gravel ... yield of the well and the amount of sand infiltration Information from the pumping test is used to determine the acceptability of the well and for evaluating any changes in performance or loss...
Ngày tải lên: 28/04/2014, 11:51
scientific american - 2001 08 - cyber cells - simulating life for drug discovery
... is for a gene to code for multiple proteins What if someone applies for a patent for a gene that expresses a particular protein and someone else applies for a patent for the same gene coding for ... still brimming with ideas for enhancing fuel economy The problem is that the CAFE standard for cars has been frozen at 27.5 mpg for the past 12 years, and the standard for light trucks is stuck ... shook hands with him, and mutual expressions of kindness were passed Observing this, the landlord took the stranger aside and informed him that his friend was insane: he had been employing men for...
Ngày tải lên: 12/05/2014, 16:09
computational medicinal chemistry for drug discovery - p. bultinck, et al., (marcel dekker, 2004)
... with force elds, excellent tools for fast and reliable calculations of hydration energies and solvent eects on, e.g., conformational equilibria and ligandreceptor interactions The performance for ... axial and equatorial conformers for the dierent force elds All force elds correctly predict the equatorial Molecular Mechanics and Comparison of Force Fields Figure Calculated equatorialaxial conformational ... CVFF, CHARMm, and Dreiding force elds Et ẳ v cos nx 10ị where the periodicity n is the number of minima for the potential, usually for an sp3 sp3 bond and for a conjugated bond, and v is proportional...
Ngày tải lên: 12/05/2014, 17:28
technologies and applications for green growth
... TECHNOLOGIES AND APPLICATIONS FOR GREEN GROWTH Table 8: Cross-tabulated smart building applications and sensors HVAC Lighting Shadin g Temperature and heat detectors standard HH applications Security and ... efficiency codes and standards for buildings for comparison purposes (IEA G8 Gleneagles programme, 2008) Transport and logistics Introduction and overview of applications Information and communication ... information on the status of the grid and power quality and rapid information on instabilities and outages Finally, geographic information systems provide geographic, spatial and location information...
Ngày tải lên: 28/05/2014, 14:53
Báo cáo hóa học: " Research Article Jointly Decoded Raptor Codes: Analysis and Design for the BIAWGN Channel" pdf
... a Gaussian random variable with mean m and variance σ = 2m [14] We call information content (IC), the mutual information between a random variable representing a transmitted bit and another one ... asymptotic analysis of the joint decoding of Raptor codes on the BIAWGN channel The analysis is presented from the fountain point of view for our optimization purposes To perform this asymptotic analysis, ... tandem decoding (TD) is used: it consists in decoding the LT code first and then the precode independently, using the soft extrinsic information on the input symbols as a priori information for...
Ngày tải lên: 21/06/2014, 22:20
Báo cáo hóa học: "Editorial Advanced Communication Techniques and Applications for High-Altitude Platforms" pot
... coexistence performance assessment and techniques for WiMAX services from highaltitude platform and terrestrial deployments,” by Z Yang et al., the authors investigate the performance and coexistence ... served by a multi-antenna payload, and both uplink and downlink performances are analyzed The forth paper “Coexistence performance of highaltitude platform and terrestrial system using gigabit ... Communications and Networking In light of the above, it was therefore timely to propose a special issue exploring recent advances in communications and applications linked to HAPs and related systems...
Ngày tải lên: 21/06/2014, 23:20
Báo cáo hóa học: " Research Article View Influence Analysis and Optimization for Multiview Face Recognition" pptx
... Views used for training and registration 13 representative quasiviews are selected and used for training, and hence for registration The number of used features (especially, the features for subregions) ... to profile, we use holistic features and features for For details for our experiment, see Figures and For one view, one image is selected In the experiment for multiview descriptor optimization ... ) to (0◦ , 40◦ ), training views for the views (0◦ , −50◦ ) and (0◦ , 50◦ ), and training views for the views (0◦ , −60◦ ) and (0◦ , 60◦ ) Figure is obtained before adding neighboring images in...
Ngày tải lên: 22/06/2014, 19:20
Báo cáo hóa học: " Editorial Advanced Video Technologies and Applications for H.264/AVC and Beyond" ppt
... Communications and Image Processing in July 1991 and July 1993, an Associate Editor of the IEEE Transactions on Image Processing (1992–1994) and the IEEE Transactions on Circuits and Systems for Video ... the Chairman of the IEEE CAS Standards Committee and established the IEEE Inverse Discrete Cosine Transform Standard He received an Award of Excellence from Bellcore for his work on the digital ... framework for dynamic switching and frame EURASIP Journal on Applied Signal Processing scheduling The achievable performance gains over the constant bit-rate encoding are demonstrated for wireless...
Ngày tải lên: 22/06/2014, 23:20
Báo cáo hóa học: "Editorial Video Analysis and Coding for Robust Transmission" pot
... issue will help researchers and practitioners alike by providing focus and clear understanding of the status and challenges in the area of robust analysis and coding for video transmission Beatrice ... video/multimedia compression and transmission, video encoder optimization, robust content-based and object-based video analysis and coding, and visual quality She authored two books and coauthored over ... progressive and robust variable-length coding The paper “Progressive and error-resilient transmission strategies for VLC encoded signals over noisy channels” by H Jegou and C Guillemot performs a...
Ngày tải lên: 22/06/2014, 23:20
synthesis of novel heterocycles for drug discovery using radical cascade reactions
Ngày tải lên: 14/11/2014, 06:18
Existence theorems in nonlinear analysis and applications to optimization related models
... recent years (e.g., Anh and Khanh [1-7], Khanh and Luc [53], Xiang, Liu and Zhou [94], Yang and Yu [96], Preface VI Yu and Xiang [98], Yu, Yang and Xiang [99], Zhou, Xiang and Yang [101]) Based ... (y) = for y = and y = For other y ∈ [−2, 0], one has / −1 S2 (y) = {z ∈ Z | − z < y < 0} = ]-y, 2] 1.3 Applications 30 For calculating h∗1 α1 , we rewrite the above formula of f as follows, for ... other hand, for all N ∈ Y and x ∈]0, +∞[, taking y = max N if x ≤ α(N) x and y = N if x > α(N), we have (x, x) = (α(N ∪ {y}), α(N ∪ {y})) ∈ Λ Thus, X ⊂ Λ This and (1.1.1) imply that, for all...
Ngày tải lên: 24/08/2015, 21:24
Analysis and applications of the km algorithm in type 2 fuzzy logic control and decision making
... Algorithm and the EKM Iterative Algorithm128 Improved Algorithms for the FWA and the LWA 133 5.3.1 Strategies for Optimizing the KM / EKM Iterative Algorithm for Computing FWA and LWA ... fuzzy logic was introduced to handle the uncertainties and vagueness which widely exist due to inaccurate information, unmeasurable disturbance and noise in practical applications Fuzzy logic, also ... line for T1 FLS, the dotted line for IT2 FLS) 71 3.16 Case (a) The output of the system using T1 FLC and IT2 FLC (The dashed line for T1 FLC, the dotted line for...
Ngày tải lên: 09/09/2015, 18:49