design and application of ligand target differentiation map

... recognized during and after space travel (Nagaraja and Risin, 2013), and there is a substantial increase in the risk of carcinogenesis and of the development of degenerative diseases (Durante and Cucinotta, ... risks of breast cancer in women, and of leukemia, non-melanoma skin cancer, and lung cancer in both genders was found (Land et al., 1994; Little, 2009; Little and Charles, 1997; Schneider and Walsh, ... assessment of cancer risk and may provide targets for prevention 1.3 Effects of ionizing radiation on cells The biological effects of ionizing radiation on human beings are a consequence of physical and...

Ngày tải lên: 19/11/2015, 15:51

... Prah SK, James C The influence of physical factors on the survival and infectivity of miracidia of Schistosoma mansoni and S haematobium I Effect of temperature and ultraviolet light J Helminthol ... enzymatic degradation of the egg shell HigginsOptiz and Evers (1983) observed that hatching of eggs occurred as a result of the shell rupturing on one of the two lateral sides of the egg surface ... effect of physical and chemical agents on the cercariae of schistoma mansoni Puerto Rico J Public Health Trop Med 1994, 16, 26-44 Kusel JR Studies on the structure and hatching of the eggs of Schistosoma...

Ngày tải lên: 07/08/2014, 17:22

... Department of First Affiliated Hospital and the Institution of Genetic Disease Research of Xi’an Jiaotong University Authors’ contributions XC and XL designed the study, coordinated the work and drafted ... antagonist, the expression of b1- and b2-ARs was determined at both the mRNA and protein level in SGC-7901 and BGC-823 cells by RT-PCR and western blot Our results showed that b1- and b2-adrenergic receptors ... http://www.ro-journal.com/content/5/1/98 Page of Figure Expression of b-ARs in human gastric cell lines SGC-7901 and BGC-823 by RT-PCR and western blotting (A) Expression of bARs in human gastric cell lines SGC-7901 and BGC-823...

Ngày tải lên: 09/08/2014, 09:20

... the covariance of the populations i and j for a given year, and δi δj is the product of the standard deviations of the populations i and j The mean synchrony, or the average value of the cross-correlation ... techniques (Thompson and Page 1989; Quinn and Niebauer 1995; Pyper and Peterman 1998; Beaugrand and Reid 2003), or to compute new numbers of degrees of freedom before conducting the tests of association ... of association between the two matrices indicates the degree of fit of the model (Fortin and Gurevitch 1993, Legendre and Legendre 1998) Tests and test hypotheses of super-regional patterns of...

Ngày tải lên: 13/11/2014, 09:14

... research procedure, the scope of the study, the significance of the study and the design of the study Part 2: Development consists of Chapter one “Literature Review” and Chapter two “Action Research ... part which offered a summary and suggestions for more effective writing activities and some limitations and suggestions for further studies VII SIGNIFICANCE OF THE STUDY Writing, one of the two ... classroom” (Grebhard and Oprandy,1999) In the “Longman Dictionary of Language Teaching and Applied Linguistics” Richards, J.C and Platt, J.H gave the following definitions of action research:...

Ngày tải lên: 07/09/2013, 13:58

... number of thymocytes, splenocytes, weight ratios of the thymus and spleen, proliferative response of thymocytes non-stimulated or stimulated with Con A or PHA and CD subsets of thymocytes and splenocytes ... effects of DTC with zinc ions interaction on the total number of thymocytes and splenocytes and weight of the thymus and spleen in restrained mice As reported in Table 1, the total number of thymocytes ... reflected in the accelerated process of thymus gland and spleen size reversion, restoration of the total number of cells of these two lymphatic organs, the percentage of CD4+ 30 Bozena Obminska-Mrukowicz,...

Ngày tải lên: 07/08/2014, 18:21

... UNIVERSITY OF LANGUAGES AND INTERNATIONAL STUDIES FACULTY OF POST-GRADUATE STUDIES NGUYỄN DIỆU HUYỀN A STUDY ON THE EFFECTS OF PRE - LISTENING ACTIVITIES ON THE LISTENING PERFORMANCE OF NON-MAJOR ... Introduction Rationale 2 Objectives of the study Scope of the study Methods of the study Design of the study Part two: Development ... HANOI- 2010 Table of contents Declaration Acknowledgements Abstract Table of content i ii iii iv Lists of tables and charts ...

Ngày tải lên: 19/03/2015, 10:37

... combination of four skills While reading and writing are important ways of gaining and consolidating information, vocabulary and structures in language learning, listening and speaking are the means of ... explanation and definition in easier ways is used by all seven teachers: one always, two often and the others sometimes As teachers of English, we both provide the meanings of new words and structures and ... History-Geography and 10 Biology These lessons were carried out by three teachers with teaching experience of 25, 15 and years All of them are clearly aware of the importance of pre-listening activities and...

Ngày tải lên: 15/07/2015, 13:01

... and adipocytes (Huber et al., 2002; Morris et al., 1999) Fig 1.2 Domain structure and topology of Nogo (A) A schematic diagram of the three major splice isoforms of Nogo (Nogo-A, -B and -C) and ... regions, 14 exons and introns, and gives rise to three major splice isoforms (Nogo-A, -B and -C) and several other minor splice isoforms (Oertle et al., 2003a) Amongst these, an isoform was found ... and a proline-rich domain Nogo-A, in addition, contains the 2.4 kb exon that is uniquely present in this isoform only The exon has consensus sequences for PEST domains, SH3ligands and WW-ligands...

Ngày tải lên: 11/09/2015, 10:06

... Dr Ruan Runsheng, A/Prof Mary Veronique Clement and A/Prof Bay Boon Huat for their constructive advice Prof Yeoh Kian Hian and Prof Tay Boon Keng for their support in my application for admission ... Radiation-induced generation of ROS is dose related 112 Figure 10 Overview of gene changes at 24 and 72 hrs after and 20 Gy of radiation 113 Western blot showing p53 and c-jun protein expression and phosphorylation ... individuals and appreciate their contributions to the success of this thesis: Supervisor A/Prof Wang De-Yun for his sound advice, kind guidance, constant encouragement and facilitation of funding Prof...

Ngày tải lên: 14/09/2015, 10:43

... Organ of Corti 1) not proliferate 2) require repeated microdissection and culture and 3) remain complex in terms of cell types and states of differentiation (Rivolta & Holley, 2002) 2.7.2 Use of ... consist of a group of MAP kinases that are activated by a variety of cellular insults, including excitotoxicity, radiation, and inflammatory cytokines (Cheng et al, 2005) JNK has isoforms (JNK 1, and ... so the effect of the overproduction of hair cells on cochlear function and the maturation of the Organ of Corti are not known (Matsui et al, 2005) Similarly, targeted deletion of p19/ink4d, another...

Ngày tải lên: 14/09/2015, 10:44

... vector of the electron (phonon), a+ n,p⊥ and an,p⊥ (bq and bq ) are the creation and the annihilation operators of electron (phonon), respectively q = (q⊥ , qz ), A(t) is the vector potential of ... section, we will evaluate, plot, and discuss the expression of the AC for the case of a doped superlattice with equal thickness dn = dp of the n- and p- doped layers, equal and constant doped concentration ... +i δ (7) Nq is the balanced distribution function of phonons, E01 and Ω1 are the intensity and frequency of a strong EMW (laser radiation), E02 and Ω2 128 NGUYEN THI THANH NHAN, LE THI LUYEN, NGUYEN...

Ngày tải lên: 30/10/2015, 20:52

... including reduction of thioredoxin and other low molecular weight substances, and reduction and detoxification of hydroperoxides [9] This reduction may be direct or by regeneration of antioxidants ... proteins: significance of identification and functional characterization of selenoproteins Biofactors 14, 87–92 ´ 11 Arner ES & Holmgren A (2000) Physiological functions of thioredoxin and thioredoxin ... prime target in cancer therapy [24–26] The aim of this study was to investigate the antioxidant effects of PycnogenolÒ on redox enzymes, with emphasis on the regulation of TrxR Results Effects of...

Ngày tải lên: 30/03/2014, 02:20

... The objective of this research was to evaluate the effect of stocking biomass of the two sizes of M lyrata on growth performance and survival to enhance the production and profit of cultivation ... production (Cigarrıa and Fernandez, 2000; Shpigel and Spencer, 1996; Zhang and Yan, 2006) and the use of clam as water quality improvement (Jara-Jara et al., 1997; Shpigel and Fridman, 1990) In ... highest net profit and investment return of the treatment T3 The stocking biomass of 0.2 kg.m2 therefore, was recommended to maximize profit of the clam cultivation Establishment of commercial...

Ngày tải lên: 21/06/2014, 05:20

... and Wf are mean of initial weight and final weight, respectively and t is number of experiment days Size variation of the clam was evaluated according to Wang et al (1998) in which the mean of ... uncontrollable and variable, stocking biomass becomes an important factor to increase growth and production The objective of this research was to evaluate the effect of stocking biomass of the two sizes of ... 0.20 and 0.30 kg.m-2 and named as T1, T2, T3 and T4 respectively The bigger size of clam seed at shell length of 1.7±0.1 cm were stocked at different stocking biomass: 0.34, 0.68, 1.36 and 2.03...

Ngày tải lên: 22/06/2014, 12:20

... of thoracic vertebrae Absence of ribs Fusion of ribs Bifurcation of ribs Shortening of ribs Displasia of sternebrae Missing of sternebrae Hypoplasia of sternebrae Curvature of tibia Absence of ... dilation of renal pelvis Fig Malformed head section of mouse fetus: dilation of lateral ventricles Fig Malformed digits of mouse fetus: ectrodactyly tion of the cerebral ventricle (Fig 2), and dilatation ... [11] and Rugh and Wohlfromm [28], and supports the earlier conclusions of Russell [29] and others [25, 33, 37] that the period of organogenesis is less sensitive to the lethal effects of radiation...

Ngày tải lên: 07/08/2014, 14:23

... Fusion of thoracic vertebrae Absence of ribs Fusion of ribs Wavy ribs Hypoplasia of ribs Displasia of sternebrae Missing of sternebrae Hypoplasia of sternebrae Curvature of tibia Absence of metatarsal ... after exposure to different doses of gamma-ray on 11.5 day of gestation Dose (Gy) Observations No of mother No of implants No of embryonic death No of fetal death No of resorption Prenatal mortality ... dilatation of cerebral ventricle, dilatation of renal pelvis and abnormalities of the extremities and tail With increasing radiation dose, cleft palate, dilatation of cerebral ventricle and abnormalities...

Ngày tải lên: 07/08/2014, 15:20

... according to the manufacturer’s protocol Preparation of cells and measurement of cell viability BMCs were harvested from the femurs and tibias of mice of C57BL/6 mice as described in previous report ... supernatants were harvested and used for the determination of IL-12 and TNF-alpha, the representative cytokines of cell-mediated and innate immunity The cytokine concentration of supernatant were measured ... production of IL-12 in fucoidan-treated BMCs compared to control BMCs and increased the production of TNF-alpha in fucoidan-treated BMCs and fucoidan-treated irradiated BMCs compared to control BMCs and...

Ngày tải lên: 07/08/2014, 23:22