descriptive epidemiology of alzheimer s disease

... 18 DeKosky S Early intervention is key to successful management of Alzheimer disease Alzheimer Dis Assoc Disord 2003;17(Suppl 4) :S9 9–104 19 Leifer BP Early diagnosis of Alzheimer s disease: clinical ... as AD progresses Behavioral and personality changes, including agitation, aggression, and psychosis, often emerge as the disease progresses Depressed mood often occurs with AD Brain autopsies ... Psychiatric Press, 2000 66 Morris JC, Mohs RC, Rogers H, et al Consortium to establish a registry for Alzheimer s disease (CERAD) clinical and neuropsychological assessment of Alzheimer s disease...

Ngày tải lên: 05/03/2014, 23:20

... is increased in cerebrospinal fluid in Alzheimer s disease but not Parkinson s disease Alzheimer Dis Assoc Disord 8, 190–197 Hye A, Lynham S, Thambisetty M, Causevic M, Campbell J, Byers HL, Hooper ... development is the result of an aberrant shift in activity of tau kinases and phosphatases [3] Thus, although targeting plaques and NFTs may ameliorate some of the consequences of AD and no doubt lessen ... inhibition of synaptic transmission is dependent on the presence of Ab oligomers, and that Ab monomers are relatively nontoxic in these assays [56,57] As described above, synaptically released Zn is required...

Ngày tải lên: 07/03/2014, 10:20

... from what Alzheimer s Disease 31 neuropathologists are now confirming as Alzheimer s disease (Consensus recommendations for the postmortem diagnosis of Alzheimer s disease The National Institute ... areas of Alzheimer s disease and dementia will find this book of interest, including physicians, medical students, psychologists, scientists, graduate students, and allied health professionals including ... treating Alzheimer s disease In 1984, the first clinical criteria for the diagnosis of Alzheimer s disease was published, and the first five Alzheimer s Disease Research Centers were established with...

Ngày tải lên: 14/03/2014, 21:20

... localization of these isoforms in the brain In order to try to understand how these isoforms may differ, we examined the expression of the isoforms known to be transcribed in brain tissue, isoforms RCAN1-1 ... the Alzheimer s Disease Research Center at the University of Southern California s Keck School of Medicine, Los Angeles, CA Brain tissues, with a postmortem interval of less than h, were fresh ... Importantly, this complements data from rat tissues showing that calcineurin is also expressed in neurons [14,15] RCAN1 gene expression is significant in several tissues, particularly human brain, spinal...

Ngày tải lên: 16/03/2014, 11:20

... caspases The striking similarity between the substrates for caspases and calpains raises the possibility that both protease families contribute to structural dysregulation and functional loss of ... apoptosis the hyperphosphorylation of neurofilaments and tau seen at early stages of AD Besides the alteration of the structure and properties of tau [the most studied member of the microtubuleassociated ... a-secretase substrate in the regulated APP a-processing [37,38] These results support the hypothesis of a decrease in calpain activity during aging leading to selective accumulation of its substrates...

Ngày tải lên: 23/03/2014, 10:21

... increased levels of cytokines in the brains of Alzheimer' s disease patients, and in transgenic mouse models of Alzheimer' s disease [10-12] However, all these reports have focused on a small number ... expressed in picograms per milligram of protein P < 0.05 was considered statistically significant Table 1: Quantification of Aβ levels in TgAPPsw and PS1/APPsw mouse brain slices Data expressed as ... model of Alzheimer' s disease J Neurosci 2001, 21:372-81 Araujo DM, Lapchak PA: Induction of immune system mediators in the hippocampal formation in Alzheimer' s and Parkinson 's diseases: selective...

Ngày tải lên: 19/06/2014, 22:20

... memory loss in a mouse transgenic model of Alzheimer' s disease J Neurosci 2002, 22:6331-6335 Selkoe DJ, Schenk D: Alzheimer' s disease: molecular understanding predicts amyloid-based therapeutics Annu ... of the numbers of Aβ-positive objects (or the sum of the areas of the Aβ positive objects) for the entire section and dividing by the sum of the areas of all ROIs This analysis was performed blinded ... traditional image analysis approach Thus, this method is shown to accurately assess amyloid burden in transgenic mouse models of AD In addition, the use of object-based analysis provides data not obtainable...

Ngày tải lên: 19/06/2014, 22:20

... Presence No 280 (57.9%) Yes 204 (42.1%) - statistical mean Statistics Statistical analyses were performed with an SPSS program (version 14.0) Analyses for CRP SNPs and haplotypes used the most ... drugs; SNPs: single nucleotide polymorphisms; SP: senile plaques; TASTY: Tampere autopsy study; TMAs: tissue microarrays Acknowledgements Many thanks to Heini Huhtala and Ilkka Seppälä (for assistance ... development of lesions, which then leads to other processes and damage to neurons, thus setting off a chain of events leading to AD The absence of statistically significant associations between...

Ngày tải lên: 19/06/2014, 22:20

... longitudinal assessment of gene dysregulation at different disease stages This could assist in making diagnoses, tracking the disease course and evaluation of disease altering interventions Blood derived ... Cerebrovascular Pathology Contributes to the Heterogeneity of Alzheimer s Disease J Alzheimers Dis, 1(2), 119-134 Risk Factors for Disease Progression in Alzheimer' s Disease 15 Foster, N., Chase, ... proposed the use of a scale, consisting of the educational level, insight assessment, the presence of psychosis, the activities of daily living as well as MMSE Measured at baseline this scale might...

Ngày tải lên: 28/06/2014, 05:20

... characteristics of disease included neurofibrillary tangles and amyloid plaque Alzheimer' s disease was a neurodegenerative disease, indicated by memory loss, the most characteristic symptoms of disease ... Alzheimer sdisease patients and being as basisfor more extensive studies The results of this thesis gave new contributions for studies in the elderly especially on dementia and Alzheimer s diseaseand ... of Alzheimer s disease patients and related factors 4.1.1.1 Socio-demographiccharacteristics of Alzheimer s disease patients Age and gender of Alzheimer s disease patients In our study.Patients...

Ngày tải lên: 25/07/2014, 11:36

... development of useful therapies for this disease A similar strategy could also be useful in the studies involving transgenic mouse models of AD [56] Conclusions The pathogenesis of AD is complex ... cognitive assessments The adoption of a systems approach to study AD will demand integration of heterogeneous data (such as molecular and image data) and studies of disease- associated molecules and ... homeostasis, specifically ether lipid metabolism JL is senior research scientist in data mining His main research interests are in medical image analysis and decision support systems He is currently...

Ngày tải lên: 11/08/2014, 12:21

... elements in disease associated genes Figure Steps taken to analyze Alzheimer' s disease using laser capture microdissected microarray data Steps taken to analyze Alzheimer' s disease using laser capture ... annotation of these genes based on their association to human diseases resulted in the identification of 18 disease- related cardiovascular diseases (CVDs), AD/neurodegenerative diseases, stroke and ... complex diseases Most studies on AD first select a set of differentially expressed genes on which further analysis is performed However, comparing lists of genes from various AD studies is not...

Ngày tải lên: 14/08/2014, 21:20

... models of Alzheimer s disease dent differences in the speed of Ab accumulation Moreover, transgene expression can differ across generations and give rise to unstable Ab phenotypes because of loss ... relevance of cross-breeding experiments is strengthened if expression and deletion of the gene (s) results in the opposite outcome, or if the results are substantiated by in vitro studies or analyses of ... Authors Journal compilation ª 2010 FEBS 1391 Animal models of Alzheimer s disease O Philipson et al Transgenic animal models Models devoid of any disease- causing APP mutations Animal models expressing...

Ngày tải lên: 16/02/2014, 09:20

... V All reagents were supplied by Electron Microscopy Sciences (Hatfield, PA, USA) Assessement of SEC-isolated peptides by HPLC and SDS-PAGE Samples (100 lL) of peptides isolated by SEC were injected ... cost-effective than production of synthetic peptides, a bacterial expression system allows isotope labeling, which is essential for high-resolution structural analysis of Ab using NMR spectroscopy ... analysis and sequencing Amino acid analysis was performed at the Amino Acid Analysis Center, University of Uppsala, Sweden Sequence analysis was performed using an Applied Biosystems Procise 492...

Ngày tải lên: 18/02/2014, 13:20

... neurological, psychiatric and neuropsychological assessments were reviewed in a consensus conference comprised of neurologists, psychiatrists, and neuropsychologists Based on this review all participants ... It has been previously established that APOE variability is not associated with the rate of progression of Alzheimer s disease [51,59,67] The study was designed to address a specific question ... repetition of phrases from the Boston Diagnostic Aphasia Evaluation [19] Abstract reasoning was evaluated using WAIS-R Similarities subtest [66], and the non-verbal Identities and Oddities subtest of...

Ngày tải lên: 05/03/2014, 21:20

... OUT OF FOCUS: ALZHEIMER S DISEASE AND RELATED DISORDERS THE COST OF ALZHEIMER S DISEASE As you can imagine, Alzheimer s disease is very expensive The cost of medical care for its victims is only ... is essential in transmission of nerve impulses through the synapses of the brain and central nervous system (A synapse is the point at 33 LIFE OUT OF FOCUS: ALZHEIMER S DISEASE AND RELATED DISORDERS ... As the disease progresses, however, the entire library of memory closes down Memory loss is probably the most common sign associated with Alzheimer s disease In the initial stages of the disease, ...

Ngày tải lên: 05/03/2014, 23:20

... fluorescence We show the application of this assay to the testing of c-secretase inhibitors and PS1 mutants This assay allows for the first time the selection of cell populations and single cells ... assays based on APP or Notch c-secretase substrates can be used to specifically study modulation of c-secretase activity in parallel in various cell types Results of the inhibitor study suggest ... characterize c-secretase The advantage of this assay over existing systems is that it allows the isolation of cells with stable differences in c-secretase activity We established that the differences in...

Ngày tải lên: 08/03/2014, 08:20

... Foundation, SADF (Insamlingsstiftelsen for ¨ Alzheimer- och Demensforskning), Socialstyrelsens Stiftelser, Stiftelsen for Alderssjukdomar, and Svenska ¨ ˚ Lakaresallskapet ¨ ¨ FEBS Journal 272 ... expansions in Huntington disease, Huntington related diseases, and various forms of a-synuclein associated with Parkinson disease and synucleinopathies [27] Taken together with the findings that ... previously measured by indirect ELISA in the same set of tissues as dot blots [6] Immunohistochemistry Immunohistochemical staining was performed on 20-lM formalin-fixed frozen sections (two AD cases,...

Ngày tải lên: 16/03/2014, 22:20

... present study was set slightly higher than the previously reported community-based mean values In the present study the cognitive assessment also included the Alzheimer s Disease Assessment Scale ... PASW software (former SPSS software, version 17.0.1 for Windows, SPSS Inc., Chicago, IL, USA) Non-parametric tests were used because normal distribution could not be assumed in the groups Spearman ... dysfunction Abbreviations Ab: b-amyloid; AD: Alzheimer s disease; ADAS-cog: Alzheimer s Disease Assessment Scale; APOE: apolipoprotein E; AQT: A Quick Test of cognitive speed; CSF: cerebrospinal...

Ngày tải lên: 22/03/2014, 14:20

... chimeric viruses were purified and the expression of inserted antigens was tested As shown in Figure 1B, coomassie staining of SDS-PAGE resolved purified viruses revealed that the purity of both chimeric ... responses and this dose of vaccine have been used in our further experiments described below Kinetics of antibody responses in mice immunized with WSN-WT and WSN-Ab1-10 viruses The kinetics of ... using Prism 3.03 software (GraphPad Software, Inc., CA) Statistically significant differences were examined using a t-test or analysis of variance (ANOVA) and Tukey s multiple comparisons post-test...

Ngày tải lên: 18/06/2014, 22:20