derive the closed loop transfer function of positive feedback system
Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx
Ngày tải lên :
14/02/2014, 18:20
... posi-
tioned in the connecting loops. Approximately one-
third of all mutations in the BTK gene are missense
and some of these reduce the stability of the protein.
This is exemplified by mutations in the ... identify individuals
with mild disease, thereby providing the missing data.
The phenotype of XLA and the
potential of BTK and ITK inhibitors
The outcome of defective BTK signaling in humans
has ... regarding their potential function, it
was the identification of BTK, as the kinase affected in
XLA [9,10], which immediately made TFKs known to
the wider scientific community. In the same year, the
xid...
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Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx
Ngày tải lên :
14/02/2014, 19:20
... [9]. The KIND domain in these
proteins is localized to the N-terminal region, and their
specific functional domains are located in the C-termi-
nal region. The C-lobe of protein kinases mediates the
interaction ... that the core
sequence critical for the specific MAP2 binding resides
within the 32 residues (amino acids 456–487) of the
v-KIND KIND2 domain.
To examine whether the MAP2 binding core site of
v-KIND ... 3B). These
results indicate that the region spanning amino acids
600–1099 of MAP2 (i.e. around the middle part of
the CD) interacts with the endogenous v-KIND in
mouse cerebellum.
To verify whether...
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Tài liệu Which Bank Is the “Central” Bank? An Application of Markov Theory to the Canadian Large Value Transfer System doc
Ngày tải lên :
16/02/2014, 12:20
... order of magnitude). The BCLs are fairly symmetric since the minimum
through the 50th percentile of absolute differences of the BCLs between pairs
of banks are zero and even the 75 percentile of the ... quite
significant at the 10% confidence level (The p-value of the slope of the trend
line is .1009).
14
This is a problem of the likelihood not the method. In a classical exercise, like GMM,
the optimizer ... k
i
.
In a closed system the aggregate payment balances at any point must sum
to zero across all participants. Therefore the total potential liquidity in the
system is the sum of the T2NDCs....
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Tài liệu Báo cáo khoa học: Neuronal growth-inhibitory factor (metallothionein-3): evaluation of the biological function of growth-inhibitory factor in the injured and neurodegenerative brain pdf
Ngày tải lên :
16/02/2014, 15:20
... in all of these conditions [22]. In the trau-
matically injured brain, however, the synthesis of MT1
and MT2, as well as the synthesis of GIF, are up-regu-
lated by reactive astrocytes in the vicinity ... loss
in the AD brain. Further investigation of the increased
neurotrophic activity of the AD brain revealed that it
correlated with the loss of a specific neuroinhibitory
factor, rather than the presence ... inhibit neurite outgrowth (as described above).
The functional role of GIF synthesis and secretion
in the brain
Taken together, the regulation of GIF synthesis by
reactive astrocytes, and its subsequent...
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Tài liệu Body Size: The Structure and Function of Aquatic Ecosystems pptx
Ngày tải lên :
17/02/2014, 19:20
... W,is
simply the sum ofthe body mass of all individuals. For organisms ofsimilar size, it
can be estimated by taking the product of the population, N,andthebodymass,
M. Similarly, the store of each ... links
between the processing of energy and elements at the individual level to the
flux, storage and turnover of these elements at the level of ecosystems.
Our second example concerns the role of metabolism ... Size: The Structure and Function of Aquatic Ecosystems
Ecologists have long struggled to predict features of ecological systems, such as
the numbers and diversity of organisms. The wide range of...
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Tài liệu Báo cáo khoa học: Stefin A displaces the occluding loop of cathepsin B only by as much as required to bind to the active site cleft doc
Ngày tải lên :
18/02/2014, 04:20
... comparison of the structure of the unli-
ganded cathepsin B with the structure of the proenzyme, its complexes with
chagasin and stefin A shows that the magnitude of the shift of the occlud-
ing loop ... 1)
between stefin A and the different enzymes is the average
distance between the centre of mass of CA atoms of the
stefin molecule and the centre of mass of the CA atoms of
the reactive site cysteine ... the occluding loop is rather flexible and will
adapt to structural features of the inhibitors as well as
to the packing constraints of the environment. The lar-
ger and wider the features of the...
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Tài liệu Báo cáo khoa học: Activation loop 3 and the 170 loop interact in the active conformation of coagulation factor VIIa pdf
Ngày tải lên :
18/02/2014, 08:20
... the vicinity of the S1 pocket [11,34], in
the first part of activation loop 3, and in the area of
the TF-interactive helix and the 170 loop [8,35], areas
that are stabilized by TF [9,25,26]. The ... after 1 h. We then applied the technique
of N-terminal pegylation to visualize the relative sol-
vent exposure of the N-terminus of FVIIa. To the best
of our knowledge, this is the first time ... study of FVIIa
[13], and investigated the effects of the mutation on
the enzymatic maturation of FVIIa and on the
response of FVIIa to TF.
Our measurements, in both the presence and absence
of TF,...
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Tài liệu Báo cáo khoa học: Helix mobility and recognition function of the rat thyroid transcription factor 1 homeodomain – hints from 15N-NMR relaxation studies pdf
Ngày tải lên :
18/02/2014, 16:20
... interruption of the geometry
of the recognition helix for either Antp or the TTF-1
HD, the anomalous amide exchange pattern and the
NOE connectivity data of the C-terminal portion of
helix III ... respec-
tively. The proximity to one of the intercepts between
the theoretical and fitting curves reflects the relative
contribution of each component Lorentzian function
to the specific spectral density of ... conflict with the
global interpretation of the data. With the exclusion of
the N-terminal octapeptidyl and C-terminal nonapept-
idyl fragments of Glu17, Leu34 and Lys46, the average
of the {
1
H}–
15
N...
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Tài liệu Báo cáo khoa học: Chemical approaches to mapping the function of post-translational modifications ppt
Ngày tải lên :
18/02/2014, 17:20
... [11,12]. The study of these events is
taxing, as the biosynthesis of glycoproteins is not tem-
plate driven. This results in the formation of so-called
‘glycoforms’ [11,12], proteins with the same ... 1957
catalyze enhanced hydrolytic degradation of the target
protein.
More recently, the glycoMTS method has allowed
the synthesis of the first examples of a homogeneous
protein bearing symmetrically ... scaf-
fold. These terms reflect not only the linearity or
convergence of the chemical steps that may lead to a
given synthetic protein, but also the structural strategy
that links the (linear) segments of...
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