depending on the sugar they contain

... sheet motif The percentage helical content of the peptides is shown on the right (B) 3D representations (ribbons mode on the left and bonds mode on the right) of the initial structures for the WT ... K; these stages served to remove any strain introduced on solvation without destroying the initial secondary structure A further ns simulation was then accumulated to study the response of the ... so that only the most significant a-helix-forming tendency emerges in the simulation While some fluctuation in the length of the helix was observed, the RR motif was consistently found at the beginning...

Ngày tải lên: 31/03/2014, 07:20

... signals To further examine the status of T cell activation in TLR3KO-SJL mice during early viral infection, the expression of the CD69 activation marker on T cells and MHC molecules on microglia ... function and leading to viral persistence On the other hand, further activation of TLR3 signaling after viral infection appears to enhance anti-viral T cell function by reducing the expression of ... perhaps through the development of a pathogenic immune response Therefore, our current results strongly warrant caution on the use of TLR3-mediated immune interventions against chronic viral diseases...

Ngày tải lên: 19/06/2014, 22:20

Ngày tải lên: 25/11/2015, 12:45

... formation, in fractions and 7, was abolished by the V19 mutation, verifying the nature of these complexes (Fig 5) These data indicate that the CCV1 Fig Gel filtration fractionation of the VEGF ... mutation of either the consensus CSD site or the downstream PTB sequence CSD proteins therefore recognize not only the expected consensus RNA sequence but also the VEGF PTB binding sequences The ... by the antiPTB Ig (PTB) but not by an irrelevant monoclonal antibody (anti-GMCSF; GM) (Fig 2E) Taken together, this data demonstrates that the CSDcontaining cytoplasmic complex forming on the...

Ngày tải lên: 19/02/2014, 12:20

... different conformations: one pointing towards the phosphate group of the ligand and the other pointing out into solution In the TcRpiB-wt (i.e ligand-free) structure, Arg113 is only in the latter conformation ... concentrations of All6P (upto 50 mm) were included; for these 798 reasons, only the phosphate moiety of the sugar has been modelled in the structure deposited Comparison of TcRpiB structures The ... subunits of the second dimer Hence, residues 113–122 interact with the equivalent regions in one subunit of the second dimer, whereas residues 92–95 make contacts with their equivalents in the other...

Ngày tải lên: 15/03/2014, 00:20

... is the rst demonstration of a function for a C domain from the large GH clan-H The work contributes to the unraveling of the molecular basis of multivalent enzymepolysaccharide interactions One ... Effects of sugar tongs mutation on adsorption to and hydrolysis of starch granules Starch granules are the natural substrate for barley a-amylases and it was hypothesized that the sugar tongs might ... Remarkably, comparison of the sugar tongs region indicated no conformational differences between AMY1 wild-type, S378P and Y380A acarbose complexes The only obvious difference was found for the Ala211-Pro218...

Ngày tải lên: 23/03/2014, 07:20

... Parliament (EP) for the new EU regulation on the provision of food information to consumers, which was adopted by the EP and the Council of the EU in October 2011 and whose provisions need to be transposed ... required where the name of the food refers to the allergen in question Additionally, the unintentional presence of allergens is not covered by the legislation; this implies cross contamination is an ... risk of contamination may never be used as an excuse for poor controls and hygiene management.” - Bo Nilsson, Swedish Food Federation The second panel discussion focused on the precautionary labelling...

Ngày tải lên: 30/03/2014, 16:20

Ngày tải lên: 12/06/2014, 11:37

... mutational status, TAp73 is induced by oxaliplatin (in monotherapy or in combination with cetuximab) when B-Raf is wild type On the contrary, B-Raf mutations inhibit the transcriptional activation ... Discussion P73 were cloned due to their structural similarity to p53 and have been shown to share functions with the tumor suppressor gene p53, but their contributions to the inhibition of tumor ... Cetuximab (recommended concentration by Merck and the most used concentration used in the literature) and μM Oxaliplatin (also the most frequent concentration used in the literature) Cell-viability...

Ngày tải lên: 18/06/2014, 16:20

... staff of the nurseries at Alice Holt Lodge and the Northern Research Station for raising the container seedlings, and the staff of the Newton field station for planting and maintaining the field ... each other, the effects of density on the growth of these seedlings were caused by the effects of mutual shading on the interception of light by seedlings and on changes in associated environmental ... relationship at all between height and density [ 1] .The basis for these differences between species in the way shoot elongation responds to density warrants further investigation Since the root...

Ngày tải lên: 09/08/2014, 04:20

... when ICU admission is necessary Refusal of ICU admission should not be based on the diagnosis of cancer as the underlying condition In contrast, these decisions should be based on the availability ... 5% in experienced centers [8] The outcome after major oncological surgery may be mostly related to the surgical procedure, more than to the critical care on the ICU Only limited data are available ... with cancer Despite these recent data, rates of refusal of ICU admission in cancer patients remain high [11] and the criteria on which triage decisions are based differ between oncologists and intensivists...

Ngày tải lên: 13/08/2014, 15:21

... the expression level for the same gene in the control group when using the lowest concentration, whereas there was no decrease in the expression was recorded when using the other concentrations ... quantity The effect of RNAi was only observed on the gene expression level and there was no alteration noticed on the phenotype or the pest movement This is due to the presence of the other sugar ... mix containing all the components was used for a multiple PCR reaction to avoid pipette error The PCR reaction was run under the following conditions: 40 seconds at 98 oC in the initiation step,...

Ngày tải lên: 08/11/2015, 00:04

... turning (Wong ST et al., 2002) However, the effect of MAG-induced Ca2+ on growth cone behavior is complex It may mediate growth cone repulsion or attraction depending on the exact concentration of ... and long distance axon regeneration (Yiu and He, 2006) A major reason why CNS neurons not regenerate lies in the non-permissive environment for neuritogenesis in the adult CNS The inhibition of ... INVESTIGATIONS ON THE TISSUE DISTRIBUTION, LOCALIZATION AND FUNCTIONS OF BRAIN-ENRICHED LEUCINE-RICH REPEATS (LRR) CONTAINING PROTEINS AMIGO AND NGR2 CHEN YANAN B.Sc.(Hons), NUS A THESIS SUBMITTED FOR THE...

Ngày tải lên: 08/11/2015, 17:08

... solution, the pressure signal (s) had to be set to zero by using the Coarse and Fine button controls on the dual channel pressure control unit before catheter insertion Then the cath on button on the ... the right heart, which pumps it into the pulmonary circulation, and then back into the left heart (Guyton & Hall, 2006) The function of the heart is based on the highly coordinated contraction ... over the whole cardiac muscle Propagation of APs follows the specialized conduction system of the heart as these cells allow the highest APconduction velocity (Boron, 2009) Function of the AP...

Ngày tải lên: 26/11/2015, 10:06

... figure The profiles for the generation of hydrogen gas in the solution containing TCE had the similar properties compared with the one in the solution having iron only In the solution containing ... iron corrosion rate than those in the solutions containing iron only Do prove this assumption, another experiment about the corrosion of iron in the solution containing 20 mM NaCl was also conducted ... promoters Their main effect on iron corrosion is the production of pits containing acidic microenvironments on the iron surface, which can stimulate metal dissolution However, the acceleration in iron...

Ngày tải lên: 13/05/2016, 10:16

... in the body part, especially in the news plentiful of content and the content expresses the reaction to the news Like the headline, it attracts the reader’s attentions to the main content of the ... language there is no common situation as there is in face-to-face interaction The situation, therefore, must be interfered from the text Naturally, readers only pay attention to the contents or ... Content features of the topic sentence It is the topic sentence that decides the whole structure of the news If its content cannot create a certain connection to the readers, they would stop their...

Ngày tải lên: 02/09/2012, 11:12

... in a plane, they have the same limits): that such are unequal, when they are both concave in the same direction and either one of them is wholly contained by the other and by the straight ... (Definition 1) – A disjunctive analysis (the real either wholly on one side of the ideal, or partly on it, but none on the other side) “Concave,” requiring the following considerations: – The idea ... being taken, the straight between the points either all fall on the same side of the line, or some fall on the same side, and some on the line itself, but none on the other side /3/...

Ngày tải lên: 21/09/2012, 11:00

... book of the same name.2 Since then, many standard works on the conXict have concentrated on western events, casting only occasional glances at developments on the other front.3 Norman Stone’s excellent ... Yet these illuminating examinations of the psychology of the frontexperience and its ramiWcations focused almost exclusively on only one half of the war, the Western Front Discussions of the ... administration Moving east and meeting Ostjuden, they were suddenly even more sensitive to their own diVerence as ‘‘Germans of the Mosaic confession.’’ They confronted what they agreed was their own...

Ngày tải lên: 21/09/2012, 11:02

... these insights manifest themselves in the case law of the European Court of Human Rights (hereafter the Court’) The focus on the European Convention on Human Rights (hereafter the Convention’) ... about the Convention I have two responses to the objection: first, there is a sense in which one can read whatever one wishes into the Convention (even if the post-modern ring of this observation ... ‘Look beyond the letter, you find nothing’ 30 32 33 34 xi xii Detailed table of contents The relative protection of the European Convention and the margin of appreciation Negating the Convention system?...

Ngày tải lên: 21/09/2012, 11:02

... population These particular other-half consumers report the highest degree of frustration with the Web of any population segment Although they drive much of the consumerinformation industry in other ... Practise section 3.2.2.1) One of the differences between these two agents is that the Info Agent focuses mainly on the user, whereas the Softbot focuses mainly on the requests of the user Another difference ... accounted for in the future, that are not using the WWW and the Internet right now: "Many informationintensive consumers in the US population are in the other-half population rather than the upstream...

Ngày tải lên: 08/10/2012, 15:22