dendrimers as drug and gene delivery systems
nanotechnology for cancer therapy, 2007, p.810
... low-power diode laser.40 2.3.4 MACROMOLECULAR AND RELATED DELIVERY Polymer-based drug delivery systems also favorably alter the pharmacokinetics and biodistribution of conjugated drugs and accumulate ... addition to serving as cancer drug delivery systems, liposomes have been shown to be an effective means for delivery of other agents such as genes and antisense oligonucleotides, and would allow ... means for intracellular drug delivery and delivery of proteins such as antibodies and genes, as well as providing a window for cellular imaging.17 In addition to liposomes as an example of the prototype...
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Báo cáo y học: "PARP-1 inhibitors: are they the long-sought genetically specific drugs for BRCA1/2-associated breast cancers"
... double-strand break repair Mol Cancer Res 2005; 3: 531-9 Cantor SB, and Andreassen PR Assessing the link between BACH1 and BRCA1 in the FA pathway Cell Cycle 2006; 5: 1647 Deng CX Tumorigenesis as a ... 2005; 23: 276-92 Brody LC, and Biesecker BB Breast cancer susceptibility genes BRCA1 and BRCA2 Medicine (Baltimore) 1998; 77: 208-26 Ellisen LW, and Haber DA Hereditary breast cancer Annu Rev Med ... future use of PARP-1 inhibitors as safe and efficacious agents in preventing the hereditary form of breast cancer and as sensitizing agents in the treatment of breast cancer seems bright Clinical...
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Báo cáo hóa học: " Studies on Preparation of Photosensitizer Loaded Magnetic Silica Nanoparticles and Their Anti-Tumor Effects for Targeting Photodynamic Therap" ppt
... spectroscopy and fluorescence spectroscopy The generation of singlet oxygen was monitored by RNO bleaching assay, and the photodynamic efficacy of the SMNPs to SW480 colon carcinoma cells was detected ... solvent was 0.1 mL the concentrated HCl and 2.9 mL ethanol The absorbance at 409 nm was used to validate the PS presence and estimate the PS encapsulation efficiency Each measurement was repeated ... increased absorption of PHPP and SMNPs mixture was caused by the Fig 10 UV spectra of the PHPP-SMNPs treated with HCl and ethanol 123 406 Fig 11 The standard curve of PHPP dissolved in HCl and...
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Web Application Firewalls: When Are They Useful?
... WAF features (and the remaining ones are coming soon) Popular and very widely used Fast, reliable and predictable OWASP AppSec Europe 2006 Apache + ModSecurity Deploy as reverse proxy: ... Clustering SSL termination and acceleration Caching and transparent compression URL rewriting and so on OWASP AppSec Europe 2006 WAF Identity Problem (4) Key factors: Application Assurance vendors ... (both horisontal and vertical) Reporting (giving Management what it wants): On-demand and scheduled reports with support for customisation XML: WAFs are expected to provide basic support...
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Managers and Leaders - Are They Different?
... to their ideas, as though the source of their authority, rather than their specific ideas, was at issue In one case, a chief executive officer, who was troubled by the aggressiveness and sometimes ... tasks at hand The only sure way an individual can interrupt reverielike preoccupation and self-absorption is to form a deep attachment to a great teacher or other person who understands and has ... appointment, and Eisenhower took advantage of the opportunity Unlike his performance in high school and West Point, his work at the Command School was excellent; he was graduated first in his class Psychological...
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What are they doing? Giáo án dự tuyển vào trường Cao đẳng tài nguyên và môi trường
... Tên : FASHION Vị trí: Bài học thuộc phần I Grammar, tiết 01 11 Fashion, tiết thứ 103 chương trình Life Lines Elementary dành cho sinh ... They’re playing basketball a - Are they doing something? Yes, they are They are having a party Oh It sounds good Yes, it is Are they dancing? No, they aren’t They are sitting and drinking b - ... good? Yes, she is looking very beautiful What are they doing? They are sitting and drinking Are they only sitting and drinking? No, they are also answering the interviewers - Are they enjoying...
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Tài liệu Give An Angry Customer Even More Than They Asked For doc
... time you are living in this house As long as I'm still in business, I'll clean your ducts again for free." Jeff's offer was generous and more than we would have asked for, or expected He proceeded ... other customers and alert them to the problem If they aren't satisfied, I'll go back to their homes and reclean their ducts as well." Jeff understands how to create a lifetime customer and a book ... Jeff understands the power of both positive, and negative word of mouth He understands that as a dissatisfied customer, I would have spread the word to my circle of influence to stay far and wide...
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Tài liệu Báo cáo khoa học: The most C-terminal tri-glycine segment within the polyglycine stretch of the pea Toc75 transit peptide plays a critical role for targeting the protein to the chloroplast outer envelope membrane ppt
... precursor (e.g., for AGA, compare lanes 19 and 20, 23 and 24, 27 and 28, and 31 and 32, respectively) Furthermore, trypsin-sensitivity of imported proteins was also consistent over the time course ... (psToc75) coding sequence and the plasmid pET-psToc75 as a template [12] were used to generate constructs for mutants GGA, GGE, GGL, GGN, GGD, GGS, and GGP cDNA sequences for GAA and AGA mutants were ... inhibitor (Sigma) was added Chloroplasts were re-isolated by 40% (v ⁄ v) Percoll, washed with the import buffer, and lysed with 10 mm Hepes ⁄ KOH, pH 8.0, and 10 mm MgCl2 Soluble and membrane fractions...
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Guide to IVAs Are they worth it? doc
... use the right of offset For instance, Nat West and Royal Bank of Scotland are part of the same group, as are Halifax and Bank of Scotland, and HSBC and First Direct At the end of the period, you ... IVA, I assumed she was in major debt crisis so I asked her how big her debts were She said, “about £6,000” At what rate? “Mostly on 0% cards as you usually suggest.” I was gobsmacked as she earns ... be taken out by anyone who lives in England, Wales or Northern Ireland, with unsecured debts of (usually) at least £20,000 IVAs aren’t available in Scotland, where the nearest equivalent is something...
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Báo cáo khoa học: Amino acids Thr56 and Thr58 are not essential for elongation factor 2 function in yeast potx
... and the mammalian kinases occurred at the same site in yeast eEF2 [23] The endogenous yeast kinase was identified by Teige et al [24] as the Rck2 kinase, a Ser ⁄ Thr protein kinase homologous to ... increase the cellular energy demand [18– 21] Unicellular eukaryotes such as yeast appear to lack CaMPKIII [22] However, yeast eEF2 can serve as substrate for mammalian CaMPKIII [23] Donovan and ... expression levels and ribosome association of plasmid-encoded mutant and wild-type eEF2 Plasmid pCBG1202 containing mutant forms of eEF2 was inserted into Yor133w cells GA2 and GB2 cells expressing...
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Defining Business Rules ~ What Are They Really? doc
... often iterative and heuristic, where rules begin as general statements of policy Even if the policy is formal and specific, it is typically described in a general and informal fashion, and it often ... ACTION ASSERTION CLASSES As shown in Figure 10, every ACTION ASSERTION must be classified as either an AUTHORIZATION, a CONDITION, or an INTEGRITY CONSTRAINT Business Rule Action Assertion class ... of acquiring, maintaining and enforcing rules, • other systems of classification, such as: − mandates, policies, guidelines and corporate culture, − industry rules and corporate rules, • determining...
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Patients With Pulmonary Tuberculosis Are Frequently Positive for Anti–Cyclic Citrullinated Peptide Antibodies, but Their Sera Also React With Unmodified Arginine-Containing Peptide potx
... ever-expanding association between rheumatologic diseases and tuberculosis Am J Med 2006;119:470–7 Satoh M, Weintraub JP, Yoshida H, Shaheen VM, Richards HB, Shaw M, et al Fas and Fas ligand mutations ... (Figure 1B and Table 1) Time course of anti-CCP antibodies Certain drugs that are commonly used to treat TB, such as INH and RIF, are known to be associated with drug- induced lupus and the production ... serum samples and washing, wells were incubated for 30 minutes with NET/NP40 containing 0.15M, 0.375M, or 0.5M NaCl, and the protocol was then continued as above RESULTS Anti-CCP and anti-CAP...
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Microfinance services by savings banks in Africa - The sleeping giants have started moving, but where are they going? potx
... Client structure Subsaharan Middle Africa East and Northern Africa East Asia and the Pacific Southern Eastern Europe and Asia Central Asia Latin America and the Caribbean Borrowers 2.41 0.37 3.80 ... industry and used as a significant source of funds for lending5 And while growth has been slow with regard to credit outreach, deposit mobilisation has expanded significantly over the past years In general, ... Bangladesh, BRI Indonesia, Nabard India and GSB in Thailand) are the largest microcredit providers in Asia and are recognised and accepted as such although in some cases they administer subsidised government...
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Báo cáo khoa học: Complex alternative splicing of the hKLK3 gene coding for the tumor marker PSA (prostate-specific-antigen) ppt
... hybridization bands in the 6.1–0.6 kb range were detected with the exon Fig Expression of the hKLK3 gene in prostate tissue (A and B) and in LNCaP cells (C) Total RNA was analyzed by Northern blotting and ... (B and C) Autoradiography was performed for h (A) or days (B and C) The positions of the probes used are given in Fig The sizes of the bands are indicated The correspondence between the bands and ... molecular cloning and a database search to show that the hKLK3 gene produces at least 15 transcripts, of 0.7 to 6.1 kb, in prostate Thus, the expression and splicing of the hKLK3 gene is more complex...
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Báo cáo khoa học: "Why Are They Excited? Identifying and Explaining Spikes in Blog Mood Levels" potx
... from that found in the general language associated with the mood Then we form queries using these “overused” words as well as the date(s) of the peaking interval and run these as queries against ... long-term and short-term language models associated with a given mood to identify unusual word usage patterns Recent years have witnessed an increase in research on extracting subjective and other ... discover the reasons underlying mood changes we use corpus-based techniques to identify changes in language usage We compare two corpora: (1) the full set of blog posts, referred to as the standard corpus,...
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StartUp Secret Sauce Series: Are You Ready for Your First StartUp docx
... apparent as she is a dynamic leader, process-orientated, organized, disciplined, and a teacher as well as a student among professionals The founder and CEO of an Austin Ventures-funded and KPMG STANDOUT ... company, as well as career growth and evaluations Manages benefit programs, hiring, and dismissals • Marketing: The organization that understands your company market, customers, competitors, and your ... the company’s mission and vision These are the guiding lights of the company Those that measure new product ideas and new company ideas against the company purpose, vision and mission will maintain...
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Báo cáo khoa học: Sodium pump a1 and a3 subunit isoforms mediate distinct responses to ouabain and are both essential for survival of human neuroblastoma docx
... both a1 and a3 subunits are essential for survival, and that the a1 and a3 isoforms have distinct roles in SK-N -AS cells and loss of one cannot be compensated by the other Based on these and previous ... of the sodium pump and a local increase in intracellular [Na+] followed by a subsequent increase in [Ca2+] in the small space between the plasmalemma and endoplasmic ⁄ sarcoplasmic reticulum This ... of a subunit isoforms of Na+,K+-ATPase in SK-N -AS cells before and after transfection with StealthTM RNAi to silence a1 and a3 SK-N -AS is a cancerous neuroblastoma cell line that, like other neuronal...
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