delivery of therapeutic agents across the barriers

... rate of the PLGA copolymers are dependent on the molar ratio of the lactic and glycolic acids in the polymer chain, molecular weight of the polymer, the degree of the crystallinity, and the Tg of ... Functions of the Blood Brain Barrier The main function of the blood brain barrier is to protect the brain The BBB serves as an impermeable wall to prevent the entry of agents from outside of the brain ... determining the extent of the particles to cross the BBB To further investigate the potential for the nanoparticles to cross the BBB, animal testing is important and necessary The second part of the thesis...

Ngày tải lên: 26/11/2015, 22:48

... system, in the distal segment of the tubule Inhibition of glucose reabsorption in the kidney, mediated by the SGLT cotransport system, represents a promising therapeutic target for the control of hyperglycemia ... consider because they are not hydrolysed by β-glucosidases in the intestine and can be administered orally [27] Therefore, the aim of the present study was to evaluate the inhibitory effect of some thioglycosides ... hydrolysis-resistant, synthetic S-analogs of natural O-glucosides involved in the biosynthesis of chrysomelidial and salicin These substances are synthesized and secreted as part of a defense mechanism...

Ngày tải lên: 26/10/2012, 10:04

... protection from the toxicity of soman, an organophosphate acetylcholinesterase inhibitor, in the mouse J Pharmacol Exp Ther 1986, 239:43-46 Clement JG, Filbert M: Antidote effect of sodium fluoride ... Khurana D, Whig J, Mahajan R: Neurophysiological monitoring of pharmacological manipulation in acute organophopshate (OP) poisoning The effects of pralidoxime, magnesium sulphate and pancuronium Electroencephalogr ... 1983, 32:1803-1810 Milatovic D, Johnson MK: Reactivation of phosphoroamidated acetylcholinesterase and neuropathy target esterase by treatment of inhibited enzyme with potassium fluoride Chem Biol...

Ngày tải lên: 12/08/2014, 18:21

... Medicine Advantages of Polymer Therapeutics “Using advanced polymer chemistry and precision engineering at the molecular level, together with an appreciation of the pathophysiology of normal and disease ... realize the full therapeutic potential of the post-genomics era.” • • • • Increased solubility/stability Reduced immunogenicity Prolonged plasma half-lie through prevention and avoidance of RES ... applied to medicine will bring significant advancement to the treatment of cancer These hybrid systems can be viewed as the 1st generation of nanomedicines.” Duncan et al TRENDS in Biotechnology...

Ngày tải lên: 23/08/2015, 18:48

... and the skills framework and/or provide guidance for teachers of other subjects across the curriculum? What outcome will there be? Which of these (or other) success criteria are relevant to the ... and identify whether: • there is a range of writing forms • the writer shows a sense of knowing the audience and purpose of the piece • writing is of an appropriate length for the task • work ... • Over the past 10 years, the gap between boys’ and girls’ performance has increased, with the widest gap in writing • The content of the writing of many learners of all abilities is often marred...

Ngày tải lên: 10/03/2014, 05:20

... employed the luminal chamber as the loading chamber Effects of LPS, IL-6, and GM-CSF on the expression of tight junction proteins To examine the effects of LPS, IL-6, and GM-CSF on the expression of ... JNK 14 Discussion The present study evaluated whether the LPS-enhanced transcellular transport of HIV-1 across BMEC monolayers was mediated through the induction of the release of cytokines from ... act at the luminal, but not the abluminal, endothelial surface to increase the transcellular permeability of BMECs to HIV-1 Furthermore, the results suggest that the LPS-induced increase in the...

Ngày tải lên: 19/06/2014, 22:20

... analysis of raw experimental data Therefore the first part of this article is focused on the description of the experimental set-up Referring to the document of Perré and Aguiar [20], we point out the ... independent of the mechanical properties of the material It depends only on the load and on the sample geometry In the following, the value of σmax determined using equation (3) will allow the stress ... However, the calculation of the dimensionless AMOE permits all curves to be properly compared Note the excellent repeatability of the tests: during the first hours of test, the dimensionless curves of...

Ngày tải lên: 08/08/2014, 00:22

... innovation of the inverse method proposed here This feature is the key element of the identification procedure and guarantees the quality of the fitted parameters and the wide range of validity of the ... versus time is the same for all parts of the section This hypothesis is reasonable here because the temperature field can be assumed to be constant (the thermal time constant of the sample is ... dramatically the overall shape of the curve Therefore, even so the trend is stable, the value of one single parameter may depend strongly on the experimental data DISCUSSION Figure Creep tests in the...

Ngày tải lên: 08/08/2014, 00:22

... acid linker between the C-terminal of the single-chain Fv fragment and the N-terminal of human IL-10 A His6 tag was appended to the C-terminal of the fusion proteins and the resulting antibody ... for the fusion proteins were 60 μg of L19–IL-2, 15 μg of L19–TNF and 450 μg of L19–IL-10 per mouse The arthritic score was evaluated daily and expressed as the mean ± the standard error of the ... proteins The cloning and expression of the fusion proteins between single-chain Fv fragments of the L19 antibody (Fv(L19)) and IL-2 or TNF has been described before [1,2] To test the therapeutic...

Ngày tải lên: 09/08/2014, 10:20

... graph of the number of datasets contributing to the set of reference nucleosome positions (including hypothetical positions) (c) Illustration of the types of nucleosomes in the yeast genome, and their ... report may be the first such description of a systematic means of identifying 'soft' features in the genome The use of the term 'soft' for protein-DNA interactions reflects the fact the such interactions ... one extreme, the SOLiD platform (dataset 3) called 80% of the nucleosomes within 16 bp of the reference positions, while at the other extreme the Affymetrix platform called 80% of the nucleosomes...

Ngày tải lên: 09/08/2014, 20:20

... being in close vicinity of each other One of the serious side effects of doxorubicin as a chemotherapeutic agent is cardiotoxicity Therefore, targeted delivery of the chemotherapeutic drug to tumor ... approach for the delivery of chemotherapeutic drugs for the control of ovarian tumors Further exploration in this area will create the opportunity for the development of innovative chemotherapy regimens ... local delivery of chemotherapeutic drugs by tumor cells may require significantly less amount of drug to control ovarian cancer The success of the current study warrants further exploration of such...

Ngày tải lên: 10/08/2014, 05:21

... [9] The efficacy findings of the trial (Table 1) prompted the Independent Data Monitoring Committee to recommend unblinding the trial at the time of the interim analysis and the crossover of patients ... levels in the prostate of men with CRPC still remain nearly equivalent of those in non-castrate patients [13] The source of these androgens is thought to be derived from synthesis of the androgens ... to therapeutic intervention for patients with CRPC In view of the persistence of both AR and tissue androgens in recurrent prostate cancer, therapies that directly target the AR, or affect the...

Ngày tải lên: 10/08/2014, 21:23

... identify barriers to research utilization? The BARRIERS scale measures perceptions of barriers regarding the nurse, the setting, the research, and the presentation of research These four types of barriers ... In this study, the four subscales from the BARRIERS scale and the RU index from the RUQ were used The validity of three of the BARRIERS subscales is supported by the current study The reliability ... supported their scoring on the barriers subscales, i.e., they reported supportive factors mainly in accordance with their reported type of barriers Some of the items in the research subscale in the BARRIERS...

Ngày tải lên: 11/08/2014, 05:21

... identify barriers to research utilization? The BARRIERS scale measures perceptions of barriers regarding the nurse, the setting, the research, and the presentation of research These four types of barriers ... In this study, the four subscales from the BARRIERS scale and the RU index from the RUQ were used The validity of three of the BARRIERS subscales is supported by the current study The reliability ... supported their scoring on the barriers subscales, i.e., they reported supportive factors mainly in accordance with their reported type of barriers Some of the items in the research subscale in the BARRIERS...

Ngày tải lên: 11/08/2014, 16:21

... controls A majority of the suicide attempts were made in close connection to admission (often a cause of admission), 89% of the suicide attempts in the suicide group and 84% in the control group ... assumed, but not proven Time of the suicide attempt and thus age at the event could be stated with certainty in 84% of the controls and 89% of the suicide victims, as the attempts were made in connection ... attempts in older age The case records were performed for a thorough evaluation of the suicide victims and matched controls from the total sample, in which the rater was unaware of the suicidal outcome...

Ngày tải lên: 11/08/2014, 17:20

... on the direct cardiac effects of the applied induction agents The advantages of this method are to measure mechanical and metabolic properties in the absence of the confounding effects of other ... dependent Otherwise, as the mechanisms of the cardiac depressant effects of these induction agents is likely to involve Page of (page number not for citation purposes) attenuation of trans-sarcolemmal ... improve diastolic filling of the heart We recognise the limitations of this study Although the applied sepsis method has the advantages of inducing a 'natural' course of infection, it has limitations...

Ngày tải lên: 13/08/2014, 19:20

... therapeutics [21], these pores are narrow enough to prevent the effective transvascular passage of most nanoparticles [22-25] If the upper limit of the therapeutically relevant pore size of the BBTB could ... regions of interest were drawn on the basis of the dynamic contrast enhancement pattern of tumor tissue observed following the infusion of Magnevist These data were important for the drawing of accurate ... the therapeutically relevant upper limit of the BBTB pore size should range between 20 nm and 100 nm However, the effective transvascular delivery of nanoparticle-based drug carriers across the...

Ngày tải lên: 18/06/2014, 15:20

... However, in most cases, the modification of the drug molecules may change the therapeutic properties of the drug, resulting in the dysfunction of drug Therefore, a better drug delivery strategy is ... vectors, these two type antibiotics both have poor penetration rates through the BBB As the BBB represents an obstacle for the delivery of these antibiotics from the blood to the brain, therefore, these ... junctions, the latter limiting the paracellular flux (Rubin and Staddon, 1999) The permeability properties of the BBB greatly affect the therapy of the CNS inflammatory diseases The BBB is by far the...

Ngày tải lên: 11/09/2015, 09:10

... NANOPARTICLES OF BIODEGRADABLE POLYMERS FOR DELIVERY OF DIAGNOSTIC /THERAPEUTIC AGENTS: THEIR POTENTIAL APPLICATION IN BRAIN CANCER THERAPY YU QIANRU (B.Eng, Southeast University) A THESIS SUBMITTED FOR THE ... nutrition and isolates the CNS from toxic chemicals in the blood However, it also severely restricts the delivery of therapeutic agents into the brain Paclitaxel, one of the most widely used anti-cancer ... other parts of the body that can spread to the brain and cause secondary tumor through a process called metastasis The cells of a metastatic brain tumor resemble the cells of the organ where the...

Ngày tải lên: 26/11/2015, 22:41

... apply to the other types of agents as well 1.3 Two statements This thesis consists of two parts For each of these two parts a separate statement will be formulated The first part of the thesis ... 1.3 PART ONE - Theoretical and Practical Aspects of Agents and the Prospects of Agents in a Three Layer Model Intelligent Software Agents Theory Intelligent Software Agents Theory 2.1 Introduction ... Software Agents Theory Intelligent Software Agents in Practise Intelligent Software Agents in Practise 3.1 Applications of Intelligent Agents The current applications of agents are of a rather experimental...

Ngày tải lên: 08/10/2012, 15:22